id sid tid token lemma pos rv042r3989q 1 1 zebrafish zebrafish NOUN rv042r3989q 1 2 is be AUX rv042r3989q 1 3 an an DET rv042r3989q 1 4 excellent excellent ADJ rv042r3989q 1 5 model model NOUN rv042r3989q 1 6 organism organism NOUN rv042r3989q 1 7 to to PART rv042r3989q 1 8 study study VERB rv042r3989q 1 9 the the DET rv042r3989q 1 10 molecular molecular ADJ rv042r3989q 1 11 basis basis NOUN rv042r3989q 1 12 of of ADP rv042r3989q 1 13 retinal retinal ADJ rv042r3989q 1 14 regeneration regeneration NOUN rv042r3989q 1 15 . . PUNCT rv042r3989q 2 1 damage damage NOUN rv042r3989q 2 2 - - PUNCT rv042r3989q 2 3 induced induce VERB rv042r3989q 2 4 apoptosis apoptosis NOUN rv042r3989q 2 5 of of ADP rv042r3989q 2 6 retinal retinal ADJ rv042r3989q 2 7 neurons neuron NOUN rv042r3989q 2 8 in in ADP rv042r3989q 2 9 adult adult NOUN rv042r3989q 2 10 zebrafish zebrafish NOUN rv042r3989q 2 11 stimulates stimulate VERB rv042r3989q 2 12 mì_ller mì_ller NOUN rv042r3989q 2 13 glia glia NOUN rv042r3989q 2 14 within within ADP rv042r3989q 2 15 the the DET rv042r3989q 2 16 inner inner ADJ rv042r3989q 2 17 nuclear nuclear ADJ rv042r3989q 2 18 layer layer NOUN rv042r3989q 2 19 to to ADP rv042r3989q 2 20 dedifferentiate dedifferentiate NOUN rv042r3989q 2 21 and and CCONJ rv042r3989q 2 22 divide divide VERB rv042r3989q 2 23 giving give VERB rv042r3989q 2 24 rise rise NOUN rv042r3989q 2 25 to to ADP rv042r3989q 2 26 undifferentiated undifferentiated ADJ rv042r3989q 2 27 transiently transiently ADV rv042r3989q 2 28 amplifying amplify VERB rv042r3989q 2 29 multipotent multipotent ADJ rv042r3989q 2 30 neuronal neuronal ADJ rv042r3989q 2 31 progenitor progenitor NOUN rv042r3989q 2 32 daughter daughter NOUN rv042r3989q 2 33 cells cell NOUN rv042r3989q 2 34 . . PUNCT rv042r3989q 3 1 these these DET rv042r3989q 3 2 cells cell NOUN rv042r3989q 3 3 continue continue VERB rv042r3989q 3 4 to to PART rv042r3989q 3 5 proliferate proliferate VERB rv042r3989q 3 6 and and CCONJ rv042r3989q 3 7 migrate migrate VERB rv042r3989q 3 8 to to ADP rv042r3989q 3 9 the the DET rv042r3989q 3 10 damaged damage VERB rv042r3989q 3 11 retinal retinal ADJ rv042r3989q 3 12 layer layer NOUN rv042r3989q 3 13 where where SCONJ rv042r3989q 3 14 they they PRON rv042r3989q 3 15 differentiate differentiate VERB rv042r3989q 3 16 into into ADP rv042r3989q 3 17 functional functional ADJ rv042r3989q 3 18 and and CCONJ rv042r3989q 3 19 integrated integrated ADJ rv042r3989q 3 20 retinal retinal ADJ rv042r3989q 3 21 neurons neuron NOUN rv042r3989q 3 22 . . PUNCT rv042r3989q 4 1 the the DET rv042r3989q 4 2 mechanisms mechanism NOUN rv042r3989q 4 3 in in ADP rv042r3989q 4 4 which which PRON rv042r3989q 4 5 mì_ller mì_ller NOUN rv042r3989q 4 6 glia glia NOUN rv042r3989q 4 7 are be AUX rv042r3989q 4 8 induced induce VERB rv042r3989q 4 9 to to PART rv042r3989q 4 10 divide divide VERB rv042r3989q 4 11 by by ADP rv042r3989q 4 12 the the DET rv042r3989q 4 13 apoptotic apoptotic ADJ rv042r3989q 4 14 neurons neuron NOUN rv042r3989q 4 15 during during ADP rv042r3989q 4 16 the the DET rv042r3989q 4 17 initiation initiation NOUN rv042r3989q 4 18 of of ADP rv042r3989q 4 19 regeneration regeneration NOUN rv042r3989q 4 20 are be AUX rv042r3989q 4 21 unknown unknown ADJ rv042r3989q 4 22 . . PUNCT rv042r3989q 5 1 following follow VERB rv042r3989q 5 2 retinal retinal ADJ rv042r3989q 5 3 damage damage NOUN rv042r3989q 5 4 , , PUNCT rv042r3989q 5 5 the the DET rv042r3989q 5 6 expression expression NOUN rv042r3989q 5 7 of of ADP rv042r3989q 5 8 transcription transcription NOUN rv042r3989q 5 9 factors factor NOUN rv042r3989q 5 10 signal signal VERB rv042r3989q 5 11 transducer transducer NOUN rv042r3989q 5 12 and and CCONJ rv042r3989q 5 13 activator activator NOUN rv042r3989q 5 14 of of ADP rv042r3989q 5 15 transcription transcription NOUN rv042r3989q 5 16 3 3 NUM rv042r3989q 5 17 ( ( PUNCT rv042r3989q 5 18 stat3 stat3 NOUN rv042r3989q 5 19 ) ) PUNCT rv042r3989q 5 20 and and CCONJ rv042r3989q 5 21 achaete achaete ADJ rv042r3989q 5 22 - - PUNCT rv042r3989q 5 23 scute scute NOUN rv042r3989q 5 24 complex complex NOUN rv042r3989q 5 25 - - PUNCT rv042r3989q 5 26 like like ADJ rv042r3989q 5 27 1a 1a NUM rv042r3989q 5 28 ( ( PUNCT rv042r3989q 5 29 ascl1a ascl1a SPACE rv042r3989q 5 30 ) ) PUNCT rv042r3989q 5 31 are be AUX rv042r3989q 5 32 upregulated upregulate VERB rv042r3989q 5 33 in in ADP rv042r3989q 5 34 mì_ller mì_ller NOUN rv042r3989q 5 35 glia glia NOUN rv042r3989q 5 36 and and CCONJ rv042r3989q 5 37 are be AUX rv042r3989q 5 38 each each PRON rv042r3989q 5 39 required require VERB rv042r3989q 5 40 for for ADP rv042r3989q 5 41 maximal maximal ADJ rv042r3989q 5 42 mì_ller mì_ller NOUN rv042r3989q 5 43 glia glia NOUN rv042r3989q 5 44 proliferation proliferation NOUN rv042r3989q 5 45 following follow VERB rv042r3989q 5 46 retinal retinal ADJ rv042r3989q 5 47 damage damage NOUN rv042r3989q 5 48 . . PUNCT rv042r3989q 6 1 to to PART rv042r3989q 6 2 examine examine VERB rv042r3989q 6 3 the the DET rv042r3989q 6 4 requirement requirement NOUN rv042r3989q 6 5 of of ADP rv042r3989q 6 6 each each PRON rv042r3989q 6 7 of of ADP rv042r3989q 6 8 these these DET rv042r3989q 6 9 factors factor NOUN rv042r3989q 6 10 for for ADP rv042r3989q 6 11 regeneration regeneration NOUN rv042r3989q 6 12 and and CCONJ rv042r3989q 6 13 their their PRON rv042r3989q 6 14 hierarchal hierarchal NOUN rv042r3989q 6 15 relationship relationship NOUN rv042r3989q 6 16 , , PUNCT rv042r3989q 6 17 morpholino morpholino NOUN rv042r3989q 6 18 - - PUNCT rv042r3989q 6 19 mediated mediate VERB rv042r3989q 6 20 knockdowns knockdown NOUN rv042r3989q 6 21 were be AUX rv042r3989q 6 22 performed perform VERB rv042r3989q 6 23 . . PUNCT rv042r3989q 7 1 this this DET rv042r3989q 7 2 analysis analysis NOUN rv042r3989q 7 3 revealed reveal VERB rv042r3989q 7 4 a a DET rv042r3989q 7 5 complex complex ADJ rv042r3989q 7 6 signaling signal VERB rv042r3989q 7 7 cascade cascade NOUN rv042r3989q 7 8 involving involve VERB rv042r3989q 7 9 three three NUM rv042r3989q 7 10 separate separate ADJ rv042r3989q 7 11 populations population NOUN rv042r3989q 7 12 of of ADP rv042r3989q 7 13 mì_ller mì_ller NOUN rv042r3989q 7 14 glia glia NOUN rv042r3989q 7 15 that that PRON rv042r3989q 7 16 have have VERB rv042r3989q 7 17 differential differential ADJ rv042r3989q 7 18 requirements requirement NOUN rv042r3989q 7 19 for for ADP rv042r3989q 7 20 the the DET rv042r3989q 7 21 expression expression NOUN rv042r3989q 7 22 of of ADP rv042r3989q 7 23 stat3 stat3 NOUN rv042r3989q 7 24 , , PUNCT rv042r3989q 7 25 ascl1a ascl1a PUNCT rv042r3989q 7 26 and and CCONJ rv042r3989q 7 27 proliferation proliferation NOUN rv042r3989q 7 28 ( ( PUNCT rv042r3989q 7 29 nelson nelson PROPN rv042r3989q 7 30 et et PROPN rv042r3989q 7 31 al al PROPN rv042r3989q 7 32 . . PROPN rv042r3989q 7 33 , , PUNCT rv042r3989q 7 34 in in ADP rv042r3989q 7 35 press press NOUN rv042r3989q 7 36 ) ) PUNCT rv042r3989q 7 37 . . PUNCT rv042r3989q 8 1 to to PART rv042r3989q 8 2 examine examine VERB rv042r3989q 8 3 the the DET rv042r3989q 8 4 mechanism mechanism NOUN rv042r3989q 8 5 in in ADP rv042r3989q 8 6 which which PRON rv042r3989q 8 7 mì_ller mì_ller NOUN rv042r3989q 8 8 glia glia NOUN rv042r3989q 8 9 are be AUX rv042r3989q 8 10 signaled signal VERB rv042r3989q 8 11 to to PART rv042r3989q 8 12 divide divide VERB rv042r3989q 8 13 , , PUNCT rv042r3989q 8 14 retinal retinal ADJ rv042r3989q 8 15 lysates lysate NOUN rv042r3989q 8 16 were be AUX rv042r3989q 8 17 collected collect VERB rv042r3989q 8 18 at at ADP rv042r3989q 8 19 the the DET rv042r3989q 8 20 peak peak NOUN rv042r3989q 8 21 of of ADP rv042r3989q 8 22 photoreceptor photoreceptor NOUN rv042r3989q 8 23 apoptosis apoptosis NOUN rv042r3989q 8 24 , , PUNCT rv042r3989q 8 25 homogenized homogenize VERB rv042r3989q 8 26 and and CCONJ rv042r3989q 8 27 injected inject VERB rv042r3989q 8 28 into into ADP rv042r3989q 8 29 the the DET rv042r3989q 8 30 intravitreal intravitreal ADJ rv042r3989q 8 31 space space NOUN rv042r3989q 8 32 of of ADP rv042r3989q 8 33 undamaged undamaged ADJ rv042r3989q 8 34 eyes eye NOUN rv042r3989q 8 35 . . PUNCT rv042r3989q 9 1 the the DET rv042r3989q 9 2 light light ADV rv042r3989q 9 3 - - PUNCT rv042r3989q 9 4 damaged damage VERB rv042r3989q 9 5 retinal retinal ADJ rv042r3989q 9 6 homogenates homogenate NOUN rv042r3989q 9 7 stimulated stimulate VERB rv042r3989q 9 8 mì_ller mì_ller NOUN rv042r3989q 9 9 glia glia NOUN rv042r3989q 9 10 proliferation proliferation NOUN rv042r3989q 9 11 , , PUNCT rv042r3989q 9 12 which which PRON rv042r3989q 9 13 demonstrated demonstrate VERB rv042r3989q 9 14 that that SCONJ rv042r3989q 9 15 a a DET rv042r3989q 9 16 mì_ller mì_ller NOUN rv042r3989q 9 17 glia glia NOUN rv042r3989q 9 18 proliferation proliferation NOUN rv042r3989q 9 19 - - PUNCT rv042r3989q 9 20 stimulating stimulate VERB rv042r3989q 9 21 factor factor NOUN rv042r3989q 9 22 was be AUX rv042r3989q 9 23 present present ADJ rv042r3989q 9 24 during during ADP rv042r3989q 9 25 the the DET rv042r3989q 9 26 peak peak NOUN rv042r3989q 9 27 of of ADP rv042r3989q 9 28 photoreceptor photoreceptor NOUN rv042r3989q 9 29 apoptosis apoptosis NOUN rv042r3989q 9 30 . . PUNCT rv042r3989q 10 1 to to PART rv042r3989q 10 2 identify identify VERB rv042r3989q 10 3 candidate candidate NOUN rv042r3989q 10 4 protein protein NOUN rv042r3989q 10 5 signaling signal VERB rv042r3989q 10 6 pathways pathway NOUN rv042r3989q 10 7 that that PRON rv042r3989q 10 8 could could AUX rv042r3989q 10 9 be be AUX rv042r3989q 10 10 responsible responsible ADJ rv042r3989q 10 11 for for ADP rv042r3989q 10 12 the the DET rv042r3989q 10 13 initiation initiation NOUN rv042r3989q 10 14 of of ADP rv042r3989q 10 15 mì_ller mì_ller NOUN rv042r3989q 10 16 glia glia NOUN rv042r3989q 10 17 proliferation proliferation NOUN rv042r3989q 10 18 , , PUNCT rv042r3989q 10 19 i i PRON rv042r3989q 10 20 performed perform VERB rv042r3989q 10 21 a a DET rv042r3989q 10 22 maldi maldi PROPN rv042r3989q 10 23 - - PUNCT rv042r3989q 10 24 tof tof PROPN rv042r3989q 10 25 mass mass NOUN rv042r3989q 10 26 spectrometry spectrometry NOUN rv042r3989q 10 27 proteomic proteomic ADJ rv042r3989q 10 28 analysis analysis NOUN rv042r3989q 10 29 comparing compare VERB rv042r3989q 10 30 proteins protein NOUN rv042r3989q 10 31 of of ADP rv042r3989q 10 32 undamaged undamaged ADJ rv042r3989q 10 33 retinas retina NOUN rv042r3989q 10 34 to to ADP rv042r3989q 10 35 those those PRON rv042r3989q 10 36 isolated isolate VERB rv042r3989q 10 37 during during ADP rv042r3989q 10 38 the the DET rv042r3989q 10 39 peak peak NOUN rv042r3989q 10 40 of of ADP rv042r3989q 10 41 light light ADJ rv042r3989q 10 42 - - PUNCT rv042r3989q 10 43 induced induce VERB rv042r3989q 10 44 photoreceptor photoreceptor NOUN rv042r3989q 10 45 apoptosis apoptosis NOUN rv042r3989q 10 46 . . PUNCT rv042r3989q 11 1 tumor tumor NOUN rv042r3989q 11 2 necrosis necrosis NOUN rv042r3989q 11 3 factor factor NOUN rv042r3989q 11 4 & & CCONJ rv042r3989q 11 5 # # SYM rv042r3989q 11 6 945 945 NUM rv042r3989q 11 7 ; ; PUNCT rv042r3989q 11 8 ( ( PUNCT rv042r3989q 11 9 tnfα tnfα ADP rv042r3989q 11 10 ;) ;) PUNCT rv042r3989q 11 11 signaling signal VERB rv042r3989q 11 12 proteins protein NOUN rv042r3989q 11 13 were be AUX rv042r3989q 11 14 increased increase VERB rv042r3989q 11 15 in in ADP rv042r3989q 11 16 expression expression NOUN rv042r3989q 11 17 in in ADP rv042r3989q 11 18 the the DET rv042r3989q 11 19 light light ADV rv042r3989q 11 20 - - PUNCT rv042r3989q 11 21 damaged damage VERB rv042r3989q 11 22 retinas retina NOUN rv042r3989q 11 23 . . PUNCT rv042r3989q 12 1 tnfα tnfα ADJ rv042r3989q 12 2 ; ; PUNCT rv042r3989q 12 3 expression expression NOUN rv042r3989q 12 4 was be AUX rv042r3989q 12 5 increased increase VERB rv042r3989q 12 6 by by ADP rv042r3989q 12 7 apoptotic apoptotic ADJ rv042r3989q 12 8 photoreceptors photoreceptor NOUN rv042r3989q 12 9 and and CCONJ rv042r3989q 12 10 later later ADV rv042r3989q 12 11 in in ADP rv042r3989q 12 12 mì_ller mì_ller NOUN rv042r3989q 12 13 glia glia PROPN rv042r3989q 12 14 . . PUNCT rv042r3989q 13 1 knockdown knockdown NOUN rv042r3989q 13 2 of of ADP rv042r3989q 13 3 tnfα tnfα PROPN rv042r3989q 13 4 ; ; PUNCT rv042r3989q 13 5 significantly significantly ADV rv042r3989q 13 6 decreased decrease VERB rv042r3989q 13 7 the the DET rv042r3989q 13 8 expression expression NOUN rv042r3989q 13 9 of of ADP rv042r3989q 13 10 ascl1a ascl1a NOUN rv042r3989q 13 11 and and CCONJ rv042r3989q 13 12 stat3 stat3 NOUN rv042r3989q 13 13 and and CCONJ rv042r3989q 13 14 significantly significantly ADV rv042r3989q 13 15 reduced reduce VERB rv042r3989q 13 16 the the DET rv042r3989q 13 17 number number NOUN rv042r3989q 13 18 of of ADP rv042r3989q 13 19 mì_ller mì_ller NOUN rv042r3989q 13 20 glia glia NOUN rv042r3989q 13 21 stimulated stimulate VERB rv042r3989q 13 22 to to PART rv042r3989q 13 23 reenter reenter VERB rv042r3989q 13 24 the the DET rv042r3989q 13 25 cell cell NOUN rv042r3989q 13 26 cycle cycle NOUN rv042r3989q 13 27 , , PUNCT rv042r3989q 13 28 but but CCONJ rv042r3989q 13 29 did do AUX rv042r3989q 13 30 not not PART rv042r3989q 13 31 affect affect VERB rv042r3989q 13 32 levels level NOUN rv042r3989q 13 33 of of ADP rv042r3989q 13 34 photoreceptor photoreceptor NOUN rv042r3989q 13 35 death death NOUN rv042r3989q 13 36 . . PUNCT rv042r3989q 14 1 this this DET rv042r3989q 14 2 study study NOUN rv042r3989q 14 3 identifies identify VERB rv042r3989q 14 4 the the DET rv042r3989q 14 5 tnfα tnfα ADJ rv042r3989q 14 6 ; ; PUNCT rv042r3989q 14 7 signaling signal VERB rv042r3989q 14 8 pathway pathway NOUN rv042r3989q 14 9 as as ADP rv042r3989q 14 10 a a DET rv042r3989q 14 11 novel novel ADJ rv042r3989q 14 12 participant participant NOUN rv042r3989q 14 13 that that PRON rv042r3989q 14 14 is be AUX rv042r3989q 14 15 induced induce VERB rv042r3989q 14 16 by by ADP rv042r3989q 14 17 retinal retinal ADJ rv042r3989q 14 18 damage damage NOUN rv042r3989q 14 19 which which PRON rv042r3989q 14 20 acts act VERB rv042r3989q 14 21 upstream upstream ADV rv042r3989q 14 22 of of ADP rv042r3989q 14 23 ascl1a ascl1a NOUN rv042r3989q 14 24 and and CCONJ rv042r3989q 14 25 stat3 stat3 NOUN rv042r3989q 14 26 during during ADP rv042r3989q 14 27 danio danio PROPN rv042r3989q 14 28 rerio rerio PROPN rv042r3989q 14 29 photoreceptor photoreceptor PROPN rv042r3989q 14 30 regeneration regeneration PROPN rv042r3989q 14 31 . . PUNCT