id	sid	tid	token	lemma	pos
s7526973772	1	1	antibiotic	antibiotic	ADJ
s7526973772	1	2	resistance	resistance	NOUN
s7526973772	1	3	in	in	ADP
s7526973772	1	4	the	the	DET
s7526973772	1	5	past	past	ADJ
s7526973772	1	6	50	50	NUM
s7526973772	1	7	years	year	NOUN
s7526973772	1	8	has	have	AUX
s7526973772	1	9	increasingly	increasingly	ADV
s7526973772	1	10	challenged	challenge	VERB
s7526973772	1	11	treatment	treatment	NOUN
s7526973772	1	12	of	of	ADP
s7526973772	1	13	bacterial	bacterial	ADJ
s7526973772	1	14	infections	infection	NOUN
s7526973772	1	15	.	.	PUNCT
s7526973772	2	1	a	a	DET
s7526973772	2	2	compelling	compelling	ADJ
s7526973772	2	3	example	example	NOUN
s7526973772	2	4	is	be	AUX
s7526973772	2	5	staphylococcus	staphylococcus	PROPN
s7526973772	2	6	aureus	aureus	PROPN
s7526973772	2	7	,	,	PUNCT
s7526973772	2	8	which	which	PRON
s7526973772	2	9	exhibited	exhibit	VERB
s7526973772	2	10	resistance	resistance	NOUN
s7526973772	2	11	to	to	ADP
s7526973772	2	12	penicillin	penicillin	NOUN
s7526973772	2	13	as	as	ADV
s7526973772	2	14	early	early	ADV
s7526973772	2	15	as	as	ADP
s7526973772	2	16	the	the	DET
s7526973772	2	17	1940s	1940	NOUN
s7526973772	2	18	.	.	PUNCT
s7526973772	3	1	this	this	DET
s7526973772	3	2	resistance	resistance	NOUN
s7526973772	3	3	was	be	AUX
s7526973772	3	4	initially	initially	ADV
s7526973772	3	5	addressed	address	VERB
s7526973772	3	6	in	in	ADP
s7526973772	3	7	1959	1959	NUM
s7526973772	3	8	,	,	PUNCT
s7526973772	3	9	with	with	ADP
s7526973772	3	10	the	the	DET
s7526973772	3	11	introduction	introduction	NOUN
s7526973772	3	12	of	of	ADP
s7526973772	3	13	methicillin	methicillin	PROPN
s7526973772	3	14	and	and	CCONJ
s7526973772	3	15	other	other	ADJ
s7526973772	3	16	semi	semi	ADJ
s7526973772	3	17	-	-	ADJ
s7526973772	3	18	synthetic	synthetic	ADJ
s7526973772	3	19	second	second	ADJ
s7526973772	3	20	-	-	PUNCT
s7526973772	3	21	generation	generation	NOUN
s7526973772	3	22	penicillins	penicillin	NOUN
s7526973772	3	23	.	.	PUNCT
s7526973772	4	1	only	only	ADV
s7526973772	4	2	two	two	NUM
s7526973772	4	3	years	year	NOUN
s7526973772	4	4	later	later	ADV
s7526973772	4	5	,	,	PUNCT
s7526973772	4	6	in	in	ADP
s7526973772	4	7	1961	1961	NUM
s7526973772	4	8	,	,	PUNCT
s7526973772	4	9	a	a	DET
s7526973772	4	10	new	new	ADJ
s7526973772	4	11	variant	variant	NOUN
s7526973772	4	12	of	of	ADP
s7526973772	4	13	resistant	resistant	ADJ
s7526973772	4	14	s.	s.	PROPN
s7526973772	4	15	aureus	aureus	PROPN
s7526973772	4	16	appeared	appear	VERB
s7526973772	4	17	,	,	PUNCT
s7526973772	4	18	which	which	PRON
s7526973772	4	19	became	became	AUX
s7526973772	4	20	known	know	VERB
s7526973772	4	21	as	as	ADP
s7526973772	4	22	methicillin	methicillin	NOUN
s7526973772	4	23	-	-	PUNCT
s7526973772	4	24	resistant	resistant	ADJ
s7526973772	4	25	s.	s.	PROPN
s7526973772	4	26	aureus	aureus	PROPN
s7526973772	4	27	(	(	PUNCT
s7526973772	4	28	mrsa	mrsa	PROPN
s7526973772	4	29	)	)	PUNCT
s7526973772	4	30	.	.	PUNCT
s7526973772	5	1	mrsa	mrsa	PROPN
s7526973772	5	2	strains	strain	VERB
s7526973772	5	3	today	today	NOUN
s7526973772	5	4	are	be	AUX
s7526973772	5	5	essentially	essentially	ADV
s7526973772	5	6	resistant	resistant	ADJ
s7526973772	5	7	to	to	ADP
s7526973772	5	8	the	the	DET
s7526973772	5	9	entire	entire	ADJ
s7526973772	5	10	class	class	NOUN
s7526973772	5	11	of	of	ADP
s7526973772	5	12	β	β	PROPN
s7526973772	5	13	-	-	PUNCT
s7526973772	5	14	lactam	lactam	NOUN
s7526973772	5	15	antibiotics	antibiotic	NOUN
s7526973772	5	16	.	.	PUNCT
s7526973772	6	1	only	only	ADV
s7526973772	6	2	vancomycin	vancomycin	PROPN
s7526973772	6	3	,	,	PUNCT
s7526973772	6	4	linezolid	linezolid	NOUN
s7526973772	6	5	,	,	PUNCT
s7526973772	6	6	ceftaroline	ceftaroline	NOUN
s7526973772	6	7	,	,	PUNCT
s7526973772	6	8	and	and	CCONJ
s7526973772	6	9	daptomycin	daptomycin	PROPN
s7526973772	6	10	are	be	AUX
s7526973772	6	11	left	leave	VERB
s7526973772	6	12	against	against	ADP
s7526973772	6	13	s.	s.	PROPN
s7526973772	6	14	aureus	aureus	PROPN
s7526973772	6	15	infections	infection	NOUN
s7526973772	6	16	and	and	CCONJ
s7526973772	6	17	resistant	resistant	ADJ
s7526973772	6	18	strains	strain	NOUN
s7526973772	6	19	against	against	ADP
s7526973772	6	20	these	these	DET
s7526973772	6	21	antibiotics	antibiotic	NOUN
s7526973772	6	22	have	have	AUX
s7526973772	6	23	already	already	ADV
s7526973772	6	24	been	be	AUX
s7526973772	6	25	reported	report	VERB
s7526973772	6	26	.	.	PUNCT
s7526973772	7	1	clostridium	clostridium	NOUN
s7526973772	7	2	difficile	difficile	NOUN
s7526973772	7	3	,	,	PUNCT
s7526973772	7	4	a	a	DET
s7526973772	7	5	gram	gram	NOUN
s7526973772	7	6	-	-	PUNCT
s7526973772	7	7	positive	positive	ADJ
s7526973772	7	8	spore	spore	NOUN
s7526973772	7	9	-	-	PUNCT
s7526973772	7	10	forming	form	VERB
s7526973772	7	11	and	and	CCONJ
s7526973772	7	12	toxin	toxin	NOUN
s7526973772	7	13	-	-	PUNCT
s7526973772	7	14	producing	produce	VERB
s7526973772	7	15	bacteria	bacteria	NOUN
s7526973772	7	16	,	,	PUNCT
s7526973772	7	17	is	be	AUX
s7526973772	7	18	another	another	DET
s7526973772	7	19	example	example	NOUN
s7526973772	7	20	of	of	ADP
s7526973772	7	21	a	a	DET
s7526973772	7	22	bacterial	bacterial	ADJ
s7526973772	7	23	pathogen	pathogen	NOUN
s7526973772	7	24	facing	face	VERB
s7526973772	7	25	the	the	DET
s7526973772	7	26	same	same	ADJ
s7526973772	7	27	destiny.i	destiny.i	NOUN
s7526973772	7	28	describe	describe	NOUN
s7526973772	7	29	herein	herein	ADV
s7526973772	7	30	the	the	DET
s7526973772	7	31	discovery	discovery	NOUN
s7526973772	7	32	of	of	ADP
s7526973772	7	33	two	two	NUM
s7526973772	7	34	classes	class	NOUN
s7526973772	7	35	of	of	ADP
s7526973772	7	36	antibiotic	antibiotic	ADJ
s7526973772	7	37	potentiators	potentiator	NOUN
s7526973772	7	38	,	,	PUNCT
s7526973772	7	39	the	the	DET
s7526973772	7	40	cinnamamide	cinnamamide	NOUN
s7526973772	7	41	and	and	CCONJ
s7526973772	7	42	cinnamonitrile	cinnamonitrile	ADJ
s7526973772	7	43	families	family	NOUN
s7526973772	7	44	,	,	PUNCT
s7526973772	7	45	and	and	CCONJ
s7526973772	7	46	one	one	NUM
s7526973772	7	47	antibacterial	antibacterial	NOUN
s7526973772	7	48	,	,	PUNCT
s7526973772	7	49	the	the	DET
s7526973772	7	50	picolinamide	picolinamide	NOUN
s7526973772	7	51	family	family	NOUN
s7526973772	7	52	,	,	PUNCT
s7526973772	7	53	to	to	PART
s7526973772	7	54	address	address	VERB
s7526973772	7	55	this	this	DET
s7526973772	7	56	issue	issue	NOUN
s7526973772	7	57	.	.	PUNCT
s7526973772	8	1	the	the	DET
s7526973772	8	2	first	first	ADJ
s7526973772	8	3	two	two	NUM
s7526973772	8	4	potentiate	potentiate	NOUN
s7526973772	8	5	the	the	DET
s7526973772	8	6	activity	activity	NOUN
s7526973772	8	7	of	of	ADP
s7526973772	8	8	oxacillin	oxacillin	NOUN
s7526973772	8	9	(	(	PUNCT
s7526973772	8	10	a	a	DET
s7526973772	8	11	penicillin	penicillin	NOUN
s7526973772	8	12	member	member	NOUN
s7526973772	8	13	of	of	ADP
s7526973772	8	14	the	the	DET
s7526973772	8	15	β	β	PROPN
s7526973772	8	16	-	-	PUNCT
s7526973772	8	17	lactam	lactam	NOUN
s7526973772	8	18	class	class	NOUN
s7526973772	8	19	)	)	PUNCT
s7526973772	8	20	such	such	ADJ
s7526973772	8	21	that	that	SCONJ
s7526973772	8	22	susceptibility	susceptibility	NOUN
s7526973772	8	23	of	of	ADP
s7526973772	8	24	s.	s.	PROPN
s7526973772	8	25	aureus	aureus	PROPN
s7526973772	8	26	to	to	ADP
s7526973772	8	27	oxacillin	oxacillin	NOUN
s7526973772	8	28	is	be	AUX
s7526973772	8	29	restored	restore	VERB
s7526973772	8	30	.	.	PUNCT
s7526973772	9	1	a	a	DET
s7526973772	9	2	total	total	NOUN
s7526973772	9	3	of	of	ADP
s7526973772	9	4	50	50	NUM
s7526973772	9	5	analogues	analogue	NOUN
s7526973772	9	6	of	of	ADP
s7526973772	9	7	the	the	DET
s7526973772	9	8	cinnamamide	cinnamamide	ADJ
s7526973772	9	9	family	family	NOUN
s7526973772	9	10	were	be	AUX
s7526973772	9	11	prepared	prepare	VERB
s7526973772	9	12	and	and	CCONJ
s7526973772	9	13	screened	screen	VERB
s7526973772	9	14	.	.	PUNCT
s7526973772	10	1	seven	seven	NUM
s7526973772	10	2	of	of	ADP
s7526973772	10	3	these	these	DET
s7526973772	10	4	compounds	compound	NOUN
s7526973772	10	5	showed	show	VERB
s7526973772	10	6	a	a	DET
s7526973772	10	7	dramatic	dramatic	ADJ
s7526973772	10	8	potentiation	potentiation	NOUN
s7526973772	10	9	of	of	ADP
s7526973772	10	10	the	the	DET
s7526973772	10	11	antibacterial	antibacterial	ADJ
s7526973772	10	12	activity	activity	NOUN
s7526973772	10	13	,	,	PUNCT
s7526973772	10	14	lowering	lower	VERB
s7526973772	10	15	the	the	DET
s7526973772	10	16	minimum	minimum	ADJ
s7526973772	10	17	-	-	PUNCT
s7526973772	10	18	inhibitory	inhibitory	ADJ
s7526973772	10	19	concentrations	concentration	NOUN
s7526973772	10	20	(	(	PUNCT
s7526973772	10	21	mics	mic	NOUN
s7526973772	10	22	)	)	PUNCT
s7526973772	10	23	for	for	ADP
s7526973772	10	24	the	the	DET
s7526973772	10	25	antibiotic	antibiotic	NOUN
s7526973772	10	26	by	by	ADP
s7526973772	10	27	as	as	ADV
s7526973772	10	28	much	much	ADJ
s7526973772	10	29	as	as	ADP
s7526973772	10	30	64to	64to	PROPN
s7526973772	10	31	128	128	NUM
s7526973772	10	32	-	-	ADJ
s7526973772	10	33	fold	fold	NOUN
s7526973772	10	34	.	.	PUNCT
s7526973772	11	1	of	of	ADP
s7526973772	11	2	the	the	DET
s7526973772	11	3	84	84	NUM
s7526973772	11	4	examples	example	NOUN
s7526973772	11	5	of	of	ADP
s7526973772	11	6	the	the	DET
s7526973772	11	7	cinnamonitrile	cinnamonitrile	ADJ
s7526973772	11	8	family	family	NOUN
s7526973772	11	9	,	,	PUNCT
s7526973772	11	10	five	five	NUM
s7526973772	11	11	compounds	compound	NOUN
s7526973772	11	12	showed	show	VERB
s7526973772	11	13	broad	broad	ADJ
s7526973772	11	14	potentiation	potentiation	NOUN
s7526973772	11	15	against	against	ADP
s7526973772	11	16	six	six	NUM
s7526973772	11	17	important	important	ADJ
s7526973772	11	18	strains	strain	NOUN
s7526973772	11	19	of	of	ADP
s7526973772	11	20	mrsa	mrsa	PROPN
s7526973772	11	21	,	,	PUNCT
s7526973772	11	22	one	one	NUM
s7526973772	11	23	vancomycin	vancomycin	PROPN
s7526973772	11	24	-	-	PUNCT
s7526973772	11	25	intermediate	intermediate	ADJ
s7526973772	11	26	s.	s.	PROPN
s7526973772	11	27	aureus	aureus	PROPN
s7526973772	11	28	(	(	PUNCT
s7526973772	11	29	visa	visa	NOUN
s7526973772	11	30	)	)	PUNCT
s7526973772	11	31	strain	strain	NOUN
s7526973772	11	32	,	,	PUNCT
s7526973772	11	33	and	and	CCONJ
s7526973772	11	34	one	one	NUM
s7526973772	11	35	linezolid	linezolid	NOUN
s7526973772	11	36	-	-	PUNCT
s7526973772	11	37	resistant	resistant	ADJ
s7526973772	11	38	s.	s.	PROPN
s7526973772	11	39	aureus	aureus	PROPN
s7526973772	11	40	strain	strain	NOUN
s7526973772	11	41	.	.	PUNCT
s7526973772	12	1	one	one	NUM
s7526973772	12	2	especially	especially	ADV
s7526973772	12	3	meritorious	meritorious	ADJ
s7526973772	12	4	compound	compound	NOUN
s7526973772	12	5	exhibited	exhibit	VERB
s7526973772	12	6	potentiation	potentiation	NOUN
s7526973772	12	7	of	of	ADP
s7526973772	12	8	&	&	CCONJ
s7526973772	12	9	gt;4,000	gt;4,000	PROPN
s7526973772	12	10	-	-	ADJ
s7526973772	12	11	fold	fold	VERB
s7526973772	12	12	(	(	PUNCT
s7526973772	12	13	reduction	reduction	NOUN
s7526973772	12	14	of	of	ADP
s7526973772	12	15	mic	mic	NOUN
s7526973772	12	16	from	from	ADP
s7526973772	12	17	256	256	NUM
s7526973772	12	18	to	to	PART
s7526973772	12	19	0.06	0.06	NUM
s7526973772	12	20	mg	mg	PROPN
s7526973772	12	21	l–1	l–1	PROPN
s7526973772	12	22	)	)	PUNCT
s7526973772	12	23	against	against	ADP
s7526973772	12	24	a	a	DET
s7526973772	12	25	linezolid	linezolid	NOUN
s7526973772	12	26	-	-	PUNCT
s7526973772	12	27	resistant	resistant	ADJ
s7526973772	12	28	mrsa	mrsa	NOUN
s7526973772	12	29	strain	strain	NOUN
s7526973772	12	30	at	at	ADP
s7526973772	12	31	8	8	NUM
s7526973772	12	32	µm	µm	NOUN
s7526973772	12	33	.	.	PUNCT
s7526973772	13	1	the	the	DET
s7526973772	13	2	antibacterial	antibacterial	ADJ
s7526973772	13	3	class	class	NOUN
s7526973772	13	4	represented	represent	VERB
s7526973772	13	5	by	by	ADP
s7526973772	13	6	the	the	DET
s7526973772	13	7	picolinamide	picolinamide	NOUN
s7526973772	13	8	family	family	NOUN
s7526973772	13	9	was	be	AUX
s7526973772	13	10	evaluated	evaluate	VERB
s7526973772	13	11	against	against	ADP
s7526973772	13	12	s.	s.	PROPN
s7526973772	13	13	aureus	aureus	PROPN
s7526973772	13	14	and	and	CCONJ
s7526973772	13	15	c.	c.	PROPN
s7526973772	13	16	difficile	difficile	PROPN
s7526973772	13	17	.	.	PUNCT
s7526973772	14	1	out	out	ADP
s7526973772	14	2	of	of	ADP
s7526973772	14	3	the	the	DET
s7526973772	14	4	111	111	NUM
s7526973772	14	5	derivatives	derivative	NOUN
s7526973772	14	6	prepared	prepare	VERB
s7526973772	14	7	,	,	PUNCT
s7526973772	14	8	one	one	PRON
s7526973772	14	9	emerged	emerge	VERB
s7526973772	14	10	for	for	ADP
s7526973772	14	11	its	its	PRON
s7526973772	14	12	positive	positive	ADJ
s7526973772	14	13	pharmacological	pharmacological	ADJ
s7526973772	14	14	attributes	attribute	NOUN
s7526973772	14	15	,	,	PUNCT
s7526973772	14	16	such	such	ADJ
s7526973772	14	17	as	as	ADP
s7526973772	14	18	activity	activity	NOUN
s7526973772	14	19	(	(	PUNCT
s7526973772	14	20	mic	mic	NOUN
s7526973772	14	21	against	against	ADP
s7526973772	14	22	c.	c.	PROPN
s7526973772	14	23	difficile	difficile	NOUN
s7526973772	14	24	of	of	ADP
s7526973772	14	25	0.12	0.12	NUM
s7526973772	14	26	mg	mg	PROPN
s7526973772	14	27	l–1	l–1	PROPN
s7526973772	14	28	)	)	PUNCT
s7526973772	14	29	,	,	PUNCT
s7526973772	14	30	solubility	solubility	NOUN
s7526973772	14	31	,	,	PUNCT
s7526973772	14	32	and	and	CCONJ
s7526973772	14	33	low	low	ADJ
s7526973772	14	34	toxicity	toxicity	NOUN
s7526973772	14	35	levels	level	NOUN
s7526973772	14	36	.	.	PUNCT
s7526973772	15	1	this	this	DET
s7526973772	15	2	compound	compound	NOUN
s7526973772	15	3	was	be	AUX
s7526973772	15	4	tested	test	VERB
s7526973772	15	5	on	on	ADP
s7526973772	15	6	an	an	DET
s7526973772	15	7	in	in	ADP
s7526973772	15	8	vivoc	vivoc	NOUN
s7526973772	15	9	.	.	PUNCT
s7526973772	16	1	difficile	difficile	ADJ
s7526973772	16	2	recurrent	recurrent	ADJ
s7526973772	16	3	infection	infection	NOUN
s7526973772	16	4	mouse	mouse	NOUN
s7526973772	16	5	models	model	NOUN
s7526973772	16	6	,	,	PUNCT
s7526973772	16	7	showing	show	VERB
s7526973772	16	8	better	well	ADJ
s7526973772	16	9	efficacy	efficacy	NOUN
s7526973772	16	10	(	(	PUNCT
s7526973772	16	11	survival	survival	NOUN
s7526973772	16	12	)	)	PUNCT
s7526973772	16	13	than	than	ADP
s7526973772	16	14	vancomycin	vancomycin	PROPN
s7526973772	16	15	.	.	PUNCT