id sid tid token lemma pos s7526973h5v 1 1 zebrafish zebrafish NOUN s7526973h5v 1 2 possess possess VERB s7526973h5v 1 3 the the DET s7526973h5v 1 4 ability ability NOUN s7526973h5v 1 5 to to PART s7526973h5v 1 6 regenerate regenerate VERB s7526973h5v 1 7 all all DET s7526973h5v 1 8 retinal retinal ADJ s7526973h5v 1 9 cell cell NOUN s7526973h5v 1 10 types type NOUN s7526973h5v 1 11 after after ADP s7526973h5v 1 12 damage damage NOUN s7526973h5v 1 13 . . PUNCT s7526973h5v 2 1 following follow VERB s7526973h5v 2 2 injury injury NOUN s7526973h5v 2 3 , , PUNCT s7526973h5v 2 4 müller müller NOUN s7526973h5v 2 5 glia glia NOUN s7526973h5v 2 6 dedifferentiate dedifferentiate NOUN s7526973h5v 2 7 and and CCONJ s7526973h5v 2 8 divide divide VERB s7526973h5v 2 9 asymmetrically asymmetrically ADV s7526973h5v 2 10 , , PUNCT s7526973h5v 2 11 producing produce VERB s7526973h5v 2 12 a a DET s7526973h5v 2 13 müller müller NOUN s7526973h5v 2 14 glia glia NOUN s7526973h5v 2 15 and and CCONJ s7526973h5v 2 16 a a DET s7526973h5v 2 17 neuronal neuronal ADJ s7526973h5v 2 18 progenitor progenitor NOUN s7526973h5v 2 19 cell cell NOUN s7526973h5v 2 20 ( ( PUNCT s7526973h5v 2 21 npc npc PROPN s7526973h5v 2 22 ) ) PUNCT s7526973h5v 2 23 . . PUNCT s7526973h5v 3 1 these these DET s7526973h5v 3 2 npcs npc NOUN s7526973h5v 3 3 then then ADV s7526973h5v 3 4 continue continue VERB s7526973h5v 3 5 to to PART s7526973h5v 3 6 proliferate proliferate VERB s7526973h5v 3 7 , , PUNCT s7526973h5v 3 8 and and CCONJ s7526973h5v 3 9 eventually eventually ADV s7526973h5v 3 10 migrate migrate VERB s7526973h5v 3 11 towards towards ADP s7526973h5v 3 12 the the DET s7526973h5v 3 13 site site NOUN s7526973h5v 3 14 of of ADP s7526973h5v 3 15 damage damage NOUN s7526973h5v 3 16 , , PUNCT s7526973h5v 3 17 at at ADP s7526973h5v 3 18 which which DET s7526973h5v 3 19 point point NOUN s7526973h5v 3 20 they they PRON s7526973h5v 3 21 differentiate differentiate VERB s7526973h5v 3 22 into into ADP s7526973h5v 3 23 the the DET s7526973h5v 3 24 lost lose VERB s7526973h5v 3 25 cell cell NOUN s7526973h5v 3 26 types type NOUN s7526973h5v 3 27 , , PUNCT s7526973h5v 3 28 allowing allow VERB s7526973h5v 3 29 for for ADP s7526973h5v 3 30 full full ADJ s7526973h5v 3 31 recovery recovery NOUN s7526973h5v 3 32 of of ADP s7526973h5v 3 33 retinal retinal ADJ s7526973h5v 3 34 function.numerous function.numerous ADJ s7526973h5v 3 35 pathways pathway NOUN s7526973h5v 3 36 regulating regulate VERB s7526973h5v 3 37 zebrafish zebrafish NOUN s7526973h5v 3 38 retinal retinal ADJ s7526973h5v 3 39 regeneration regeneration NOUN s7526973h5v 3 40 have have AUX s7526973h5v 3 41 been be AUX s7526973h5v 3 42 identified identify VERB s7526973h5v 3 43 , , PUNCT s7526973h5v 3 44 however however ADV s7526973h5v 3 45 despite despite SCONJ s7526973h5v 3 46 promising promise VERB s7526973h5v 3 47 studies study NOUN s7526973h5v 3 48 within within ADP s7526973h5v 3 49 the the DET s7526973h5v 3 50 mammalian mammalian PROPN s7526973h5v 3 51 retina retina NOUN s7526973h5v 3 52 , , PUNCT s7526973h5v 3 53 none none NOUN s7526973h5v 3 54 have have AUX s7526973h5v 3 55 induced induce VERB s7526973h5v 3 56 a a DET s7526973h5v 3 57 response response NOUN s7526973h5v 3 58 equal equal ADJ s7526973h5v 3 59 to to ADP s7526973h5v 3 60 that that PRON s7526973h5v 3 61 of of ADP s7526973h5v 3 62 the the DET s7526973h5v 3 63 zebrafish zebrafish NOUN s7526973h5v 3 64 . . PUNCT s7526973h5v 4 1 therefore therefore ADV s7526973h5v 4 2 , , PUNCT s7526973h5v 4 3 i i PRON s7526973h5v 4 4 analyzed analyze VERB s7526973h5v 4 5 the the DET s7526973h5v 4 6 zebrafish zebrafish NOUN s7526973h5v 4 7 retina retina NOUN s7526973h5v 4 8 during during ADP s7526973h5v 4 9 regeneration regeneration NOUN s7526973h5v 4 10 at at ADP s7526973h5v 4 11 the the DET s7526973h5v 4 12 single single ADJ s7526973h5v 4 13 cell cell NOUN s7526973h5v 4 14 level level NOUN s7526973h5v 4 15 . . PUNCT s7526973h5v 5 1 this this PRON s7526973h5v 5 2 led lead VERB s7526973h5v 5 3 to to ADP s7526973h5v 5 4 identification identification NOUN s7526973h5v 5 5 of of ADP s7526973h5v 5 6 multiple multiple ADJ s7526973h5v 5 7 novel novel ADJ s7526973h5v 5 8 transcription transcription NOUN s7526973h5v 5 9 factors factor NOUN s7526973h5v 5 10 which which PRON s7526973h5v 5 11 regulate regulate VERB s7526973h5v 5 12 retinal retinal ADJ s7526973h5v 5 13 regeneration regeneration NOUN s7526973h5v 5 14 , , PUNCT s7526973h5v 5 15 providing provide VERB s7526973h5v 5 16 further further ADJ s7526973h5v 5 17 targets target NOUN s7526973h5v 5 18 for for ADP s7526973h5v 5 19 study study NOUN s7526973h5v 5 20 within within ADP s7526973h5v 5 21 mammalian mammalian PROPN s7526973h5v 5 22 systems system NOUN s7526973h5v 5 23 . . PUNCT s7526973h5v 6 1 furthermore furthermore ADV s7526973h5v 6 2 , , PUNCT s7526973h5v 6 3 i i PRON s7526973h5v 6 4 identified identify VERB s7526973h5v 6 5 several several ADJ s7526973h5v 6 6 targets target NOUN s7526973h5v 6 7 for for ADP s7526973h5v 6 8 study study NOUN s7526973h5v 6 9 that that PRON s7526973h5v 6 10 may may AUX s7526973h5v 6 11 regulate regulate VERB s7526973h5v 6 12 very very ADV s7526973h5v 6 13 early early ADJ s7526973h5v 6 14 müller müller NOUN s7526973h5v 6 15 glia glia NOUN s7526973h5v 6 16 responses response NOUN s7526973h5v 6 17 to to ADP s7526973h5v 6 18 damage.multiple damage.multiple NOUN s7526973h5v 6 19 iron iron NOUN s7526973h5v 6 20 homeostasis homeostasis NOUN s7526973h5v 6 21 genes gene NOUN s7526973h5v 6 22 are be AUX s7526973h5v 6 23 differentially differentially ADV s7526973h5v 6 24 regulated regulate VERB s7526973h5v 6 25 within within ADP s7526973h5v 6 26 müller müller NOUN s7526973h5v 6 27 glia glia NOUN s7526973h5v 6 28 prior prior ADV s7526973h5v 6 29 to to ADP s7526973h5v 6 30 retinal retinal ADJ s7526973h5v 6 31 cell cell NOUN s7526973h5v 6 32 death death NOUN s7526973h5v 6 33 suggesting suggest VERB s7526973h5v 6 34 that that SCONJ s7526973h5v 6 35 iron iron NOUN s7526973h5v 6 36 might might AUX s7526973h5v 6 37 be be AUX s7526973h5v 6 38 a a DET s7526973h5v 6 39 key key ADJ s7526973h5v 6 40 regulator regulator NOUN s7526973h5v 6 41 of of ADP s7526973h5v 6 42 retinal retinal ADJ s7526973h5v 6 43 cell cell NOUN s7526973h5v 6 44 death death NOUN s7526973h5v 6 45 and and CCONJ s7526973h5v 6 46 the the DET s7526973h5v 6 47 müller müller NOUN s7526973h5v 6 48 glia glia NOUN s7526973h5v 6 49 response response NOUN s7526973h5v 6 50 . . PUNCT s7526973h5v 7 1 i i PRON s7526973h5v 7 2 show show VERB s7526973h5v 7 3 that that SCONJ s7526973h5v 7 4 ferrous ferrous ADJ s7526973h5v 7 5 iron iron NOUN s7526973h5v 7 6 can can AUX s7526973h5v 7 7 induce induce VERB s7526973h5v 7 8 significant significant ADJ s7526973h5v 7 9 retinal retinal ADJ s7526973h5v 7 10 damage damage NOUN s7526973h5v 7 11 , , PUNCT s7526973h5v 7 12 that that PRON s7526973h5v 7 13 induces induce VERB s7526973h5v 7 14 a a DET s7526973h5v 7 15 particularly particularly ADV s7526973h5v 7 16 strong strong ADJ s7526973h5v 7 17 regenerative regenerative ADJ s7526973h5v 7 18 response response NOUN s7526973h5v 7 19 . . PUNCT s7526973h5v 8 1 additionally additionally ADV s7526973h5v 8 2 , , PUNCT s7526973h5v 8 3 i i PRON s7526973h5v 8 4 demonstrate demonstrate VERB s7526973h5v 8 5 that that SCONJ s7526973h5v 8 6 iron iron NOUN s7526973h5v 8 7 contributes contribute NOUN s7526973h5v 8 8 to to ADP s7526973h5v 8 9 retinal retinal ADJ s7526973h5v 8 10 cell cell NOUN s7526973h5v 8 11 death death NOUN s7526973h5v 8 12 , , PUNCT s7526973h5v 8 13 with with ADP s7526973h5v 8 14 chelation chelation NOUN s7526973h5v 8 15 resulting result VERB s7526973h5v 8 16 in in ADP s7526973h5v 8 17 significantly significantly ADV s7526973h5v 8 18 less less ADJ s7526973h5v 8 19 photoreceptor photoreceptor NOUN s7526973h5v 8 20 death death NOUN s7526973h5v 8 21 during during ADP s7526973h5v 8 22 light light ADJ s7526973h5v 8 23 treatment treatment NOUN s7526973h5v 8 24 , , PUNCT s7526973h5v 8 25 and and CCONJ s7526973h5v 8 26 decreased decrease VERB s7526973h5v 8 27 müller müller NOUN s7526973h5v 8 28 glia glia NOUN s7526973h5v 8 29 proliferation proliferation NOUN s7526973h5v 8 30 . . PUNCT s7526973h5v 9 1 despite despite SCONJ s7526973h5v 9 2 this this DET s7526973h5v 9 3 contribution contribution NOUN s7526973h5v 9 4 of of ADP s7526973h5v 9 5 iron iron NOUN s7526973h5v 9 6 to to ADP s7526973h5v 9 7 retinal retinal ADJ s7526973h5v 9 8 cell cell NOUN s7526973h5v 9 9 death death NOUN s7526973h5v 9 10 , , PUNCT s7526973h5v 9 11 i i PRON s7526973h5v 9 12 demonstrate demonstrate VERB s7526973h5v 9 13 the the DET s7526973h5v 9 14 ferroptosis ferroptosis NOUN s7526973h5v 9 15 is be AUX s7526973h5v 9 16 not not PART s7526973h5v 9 17 a a DET s7526973h5v 9 18 major major ADJ s7526973h5v 9 19 contributor contributor NOUN s7526973h5v 9 20 to to ADP s7526973h5v 9 21 retinal retinal ADJ s7526973h5v 9 22 cell cell NOUN s7526973h5v 9 23 death death NOUN s7526973h5v 9 24 in in ADP s7526973h5v 9 25 the the DET s7526973h5v 9 26 light light ADV s7526973h5v 9 27 - - PUNCT s7526973h5v 9 28 treated treat VERB s7526973h5v 9 29 retina retina NOUN s7526973h5v 9 30 . . PUNCT s7526973h5v 10 1 i i PRON s7526973h5v 10 2 also also ADV s7526973h5v 10 3 show show VERB s7526973h5v 10 4 that that SCONJ s7526973h5v 10 5 a a DET s7526973h5v 10 6 key key ADJ s7526973h5v 10 7 regulator regulator NOUN s7526973h5v 10 8 of of ADP s7526973h5v 10 9 iron iron NOUN s7526973h5v 10 10 transport transport PROPN s7526973h5v 10 11 , , PUNCT s7526973h5v 10 12 tfr1b tfr1b PROPN s7526973h5v 10 13 , , PUNCT s7526973h5v 10 14 and and CCONJ s7526973h5v 10 15 a a DET s7526973h5v 10 16 regulator regulator NOUN s7526973h5v 10 17 of of ADP s7526973h5v 10 18 ferroptosis ferroptosis NOUN s7526973h5v 10 19 , , PUNCT s7526973h5v 10 20 gpx4b gpx4b VERB s7526973h5v 10 21 , , PUNCT s7526973h5v 10 22 are be AUX s7526973h5v 10 23 required require VERB s7526973h5v 10 24 for for ADP s7526973h5v 10 25 a a DET s7526973h5v 10 26 full full ADJ s7526973h5v 10 27 proliferative proliferative ADJ s7526973h5v 10 28 response response NOUN s7526973h5v 10 29 from from ADP s7526973h5v 10 30 müller müller NOUN s7526973h5v 10 31 glia.the glia.the DET s7526973h5v 10 32 alternative alternative PROPN s7526973h5v 10 33 ciliary ciliary ADJ s7526973h5v 10 34 neurotrophic neurotrophic ADJ s7526973h5v 10 35 factor factor NOUN s7526973h5v 10 36 receptor receptor NOUN s7526973h5v 10 37 ( ( PUNCT s7526973h5v 10 38 cntfr cntfr PROPN s7526973h5v 10 39 ) ) PUNCT s7526973h5v 10 40 ligands ligand VERB s7526973h5v 10 41 cardiotrophin cardiotrophin NOUN s7526973h5v 10 42 - - PUNCT s7526973h5v 10 43 like like ADJ s7526973h5v 10 44 cytokine cytokine NOUN s7526973h5v 10 45 factor factor NOUN s7526973h5v 10 46 1 1 NUM s7526973h5v 10 47 ( ( PUNCT s7526973h5v 10 48 clcf1 clcf1 NOUN s7526973h5v 10 49 ) ) PUNCT s7526973h5v 10 50 and and CCONJ s7526973h5v 10 51 cytokine cytokine NOUN s7526973h5v 10 52 - - PUNCT s7526973h5v 10 53 like like ADJ s7526973h5v 10 54 factor factor NOUN s7526973h5v 10 55 receptor receptor NOUN s7526973h5v 10 56 1a 1a NUM s7526973h5v 10 57 ( ( PUNCT s7526973h5v 10 58 crlf1a crlf1a SPACE s7526973h5v 10 59 ) ) PUNCT s7526973h5v 10 60 are be AUX s7526973h5v 10 61 significantly significantly ADV s7526973h5v 10 62 upregulated upregulated ADJ s7526973h5v 10 63 in in ADP s7526973h5v 10 64 müller müller NOUN s7526973h5v 10 65 glia glia NOUN s7526973h5v 10 66 prior prior ADV s7526973h5v 10 67 to to ADP s7526973h5v 10 68 cell cell NOUN s7526973h5v 10 69 death death NOUN s7526973h5v 10 70 . . PUNCT s7526973h5v 11 1 i i PRON s7526973h5v 11 2 show show VERB s7526973h5v 11 3 that that SCONJ s7526973h5v 11 4 these these DET s7526973h5v 11 5 ligands ligand NOUN s7526973h5v 11 6 are be AUX s7526973h5v 11 7 neuroprotective neuroprotective ADJ s7526973h5v 11 8 , , PUNCT s7526973h5v 11 9 decreasing decrease VERB s7526973h5v 11 10 photoreceptor photoreceptor NOUN s7526973h5v 11 11 cell cell NOUN s7526973h5v 11 12 death death NOUN s7526973h5v 11 13 during during ADP s7526973h5v 11 14 light light ADJ s7526973h5v 11 15 treatment treatment NOUN s7526973h5v 11 16 . . PUNCT s7526973h5v 12 1 i i PRON s7526973h5v 12 2 also also ADV s7526973h5v 12 3 show show VERB s7526973h5v 12 4 their their PRON s7526973h5v 12 5 requirement requirement NOUN s7526973h5v 12 6 for for ADP s7526973h5v 12 7 müller müller NOUN s7526973h5v 12 8 glia glia NOUN s7526973h5v 12 9 proliferation proliferation NOUN s7526973h5v 12 10 following follow VERB s7526973h5v 12 11 injury injury NOUN s7526973h5v 12 12 , , PUNCT s7526973h5v 12 13 as as SCONJ s7526973h5v 12 14 knockdown knockdown NOUN s7526973h5v 12 15 of of ADP s7526973h5v 12 16 the the DET s7526973h5v 12 17 receptor receptor NOUN s7526973h5v 12 18 , , PUNCT s7526973h5v 12 19 or or CCONJ s7526973h5v 12 20 associated associated ADJ s7526973h5v 12 21 ligands ligand NOUN s7526973h5v 12 22 results result VERB s7526973h5v 12 23 in in ADP s7526973h5v 12 24 significantly significantly ADV s7526973h5v 12 25 fewer few ADJ s7526973h5v 12 26 proliferating proliferate VERB s7526973h5v 12 27 müller müller NOUN s7526973h5v 12 28 glia glia NOUN s7526973h5v 12 29 . . PUNCT s7526973h5v 13 1 additionally additionally ADV s7526973h5v 13 2 , , PUNCT s7526973h5v 13 3 i i PRON s7526973h5v 13 4 show show VERB s7526973h5v 13 5 that that SCONJ s7526973h5v 13 6 clcf1 clcf1 NOUN s7526973h5v 13 7 / / SYM s7526973h5v 13 8 crlf1 crlf1 PROPN s7526973h5v 13 9 can can AUX s7526973h5v 13 10 induce induce VERB s7526973h5v 13 11 rod rod NOUN s7526973h5v 13 12 progenitor progenitor NOUN s7526973h5v 13 13 proliferation proliferation NOUN s7526973h5v 13 14 in in ADP s7526973h5v 13 15 an an DET s7526973h5v 13 16 igf-1r igf-1r ADJ s7526973h5v 13 17 -dependent -dependent ADJ s7526973h5v 13 18 manner manner NOUN s7526973h5v 13 19 . . PUNCT