id sid tid token lemma pos sb397655n61 1 1 the the DET sb397655n61 1 2 phlebotomine phlebotomine ADJ sb397655n61 1 3 sand sand NOUN sb397655n61 1 4 flies fly NOUN sb397655n61 1 5 are be AUX sb397655n61 1 6 important important ADJ sb397655n61 1 7 vectors vector NOUN sb397655n61 1 8 for for ADP sb397655n61 1 9 human human ADJ sb397655n61 1 10 diseases disease NOUN sb397655n61 1 11 , , PUNCT sb397655n61 1 12 transmitting transmit VERB sb397655n61 1 13 different different ADJ sb397655n61 1 14 types type NOUN sb397655n61 1 15 of of ADP sb397655n61 1 16 pathogens pathogen NOUN sb397655n61 1 17 comprising comprise VERB sb397655n61 1 18 of of ADP sb397655n61 1 19 viruses virus NOUN sb397655n61 1 20 , , PUNCT sb397655n61 1 21 bacteria bacteria NOUN sb397655n61 1 22 and and CCONJ sb397655n61 1 23 protozoa protozoan NOUN sb397655n61 1 24 in in ADP sb397655n61 1 25 different different ADJ sb397655n61 1 26 parts part NOUN sb397655n61 1 27 of of ADP sb397655n61 1 28 the the DET sb397655n61 1 29 world world NOUN sb397655n61 1 30 . . PUNCT sb397655n61 2 1 the the DET sb397655n61 2 2 most most ADV sb397655n61 2 3 devastating devastating ADJ sb397655n61 2 4 of of ADP sb397655n61 2 5 the the DET sb397655n61 2 6 vectored vectore VERB sb397655n61 2 7 diseases disease NOUN sb397655n61 2 8 are be AUX sb397655n61 2 9 the the DET sb397655n61 2 10 leishmaniases leishmaniase NOUN sb397655n61 2 11 , , PUNCT sb397655n61 2 12 with with ADP sb397655n61 2 13 350 350 NUM sb397655n61 2 14 million million NUM sb397655n61 2 15 people people NOUN sb397655n61 2 16 at at ADP sb397655n61 2 17 risk risk NOUN sb397655n61 2 18 in in ADP sb397655n61 2 19 88 88 NUM sb397655n61 2 20 countries country NOUN sb397655n61 2 21 . . PUNCT sb397655n61 3 1 there there PRON sb397655n61 3 2 are be VERB sb397655n61 3 3 approximately approximately ADV sb397655n61 3 4 35 35 NUM sb397655n61 3 5 different different ADJ sb397655n61 3 6 sand sand NOUN sb397655n61 3 7 fly fly NOUN sb397655n61 3 8 species specie NOUN sb397655n61 3 9 transmitting transmit VERB sb397655n61 3 10 different different ADJ sb397655n61 3 11 species specie NOUN sb397655n61 3 12 of of ADP sb397655n61 3 13 leishmania leishmania PROPN sb397655n61 3 14 , , PUNCT sb397655n61 3 15 the the DET sb397655n61 3 16 causative causative ADJ sb397655n61 3 17 protozoa protozoan NOUN sb397655n61 3 18 for for ADP sb397655n61 3 19 leishmaniasis leishmaniasis NOUN sb397655n61 3 20 ; ; PUNCT sb397655n61 3 21 a a DET sb397655n61 3 22 diasese diasese NOUN sb397655n61 3 23 with with ADP sb397655n61 3 24 at at ADV sb397655n61 3 25 least least ADV sb397655n61 3 26 one one NUM sb397655n61 3 27 non non ADJ sb397655n61 3 28 - - ADJ sb397655n61 3 29 human human ADJ sb397655n61 3 30 reservoir reservoir NOUN sb397655n61 3 31 host host NOUN sb397655n61 3 32 . . PUNCT sb397655n61 4 1 the the DET sb397655n61 4 2 reservoir reservoir NOUN sb397655n61 4 3 differs differ VERB sb397655n61 4 4 with with ADP sb397655n61 4 5 different different ADJ sb397655n61 4 6 vector vector NOUN sb397655n61 4 7 species specie NOUN sb397655n61 4 8 . . PUNCT sb397655n61 5 1 the the DET sb397655n61 5 2 clinical clinical ADJ sb397655n61 5 3 manifestation manifestation NOUN sb397655n61 5 4 and and CCONJ sb397655n61 5 5 severity severity NOUN sb397655n61 5 6 of of ADP sb397655n61 5 7 leishmaniasis leishmaniasis NOUN sb397655n61 5 8 varies vary VERB sb397655n61 5 9 with with ADP sb397655n61 5 10 the the DET sb397655n61 5 11 different different ADJ sb397655n61 5 12 parasites parasite NOUN sb397655n61 5 13 from from ADP sb397655n61 5 14 self self NOUN sb397655n61 5 15 - - PUNCT sb397655n61 5 16 healing heal VERB sb397655n61 5 17 cutaneous cutaneous ADJ sb397655n61 5 18 lesions lesion NOUN sb397655n61 5 19 to to ADP sb397655n61 5 20 life life NOUN sb397655n61 5 21 - - PUNCT sb397655n61 5 22 threatening threaten VERB sb397655n61 5 23 visceral visceral NOUN sb397655n61 5 24 leshmaniasis leshmaniasis NOUN sb397655n61 5 25 . . PUNCT sb397655n61 6 1 two two NUM sb397655n61 6 2 other other ADJ sb397655n61 6 3 , , PUNCT sb397655n61 6 4 more more ADV sb397655n61 6 5 recent recent ADJ sb397655n61 6 6 , , PUNCT sb397655n61 6 7 factors factor NOUN sb397655n61 6 8 that that PRON sb397655n61 6 9 aggravate aggravate VERB sb397655n61 6 10 the the DET sb397655n61 6 11 disease disease NOUN sb397655n61 6 12 are be AUX sb397655n61 6 13 the the DET sb397655n61 6 14 presence presence NOUN sb397655n61 6 15 of of ADP sb397655n61 6 16 co co NOUN sb397655n61 6 17 - - NOUN sb397655n61 6 18 infection infection NOUN sb397655n61 6 19 with with ADP sb397655n61 6 20 the the DET sb397655n61 6 21 human human ADJ sb397655n61 6 22 immunodeficiency immunodeficiency NOUN sb397655n61 6 23 virus virus NOUN sb397655n61 6 24 ( ( PUNCT sb397655n61 6 25 hiv hiv PROPN sb397655n61 6 26 ) ) PUNCT sb397655n61 6 27 and and CCONJ sb397655n61 6 28 emergence emergence NOUN sb397655n61 6 29 of of ADP sb397655n61 6 30 resistance resistance NOUN sb397655n61 6 31 to to ADP sb397655n61 6 32 available available ADJ sb397655n61 6 33 drugs drug NOUN sb397655n61 6 34 . . PUNCT sb397655n61 7 1 the the DET sb397655n61 7 2 distribution distribution NOUN sb397655n61 7 3 of of ADP sb397655n61 7 4 leishmaniasis leishmaniasis NOUN sb397655n61 7 5 encompasses encompass VERB sb397655n61 7 6 the the DET sb397655n61 7 7 world world NOUN sb397655n61 7 8 , , PUNCT sb397655n61 7 9 being be AUX sb397655n61 7 10 present present ADJ sb397655n61 7 11 in in ADP sb397655n61 7 12 regions region NOUN sb397655n61 7 13 of of ADP sb397655n61 7 14 mediterranean mediterranean PROPN sb397655n61 7 15 basin basin PROPN sb397655n61 7 16 , , PUNCT sb397655n61 7 17 middle middle PROPN sb397655n61 7 18 east east PROPN sb397655n61 7 19 , , PUNCT sb397655n61 7 20 the the DET sb397655n61 7 21 indian indian PROPN sb397655n61 7 22 subcontinent subcontinent PROPN sb397655n61 7 23 and and CCONJ sb397655n61 7 24 south south PROPN sb397655n61 7 25 america america PROPN sb397655n61 7 26 , , PUNCT sb397655n61 7 27 however however ADV sb397655n61 7 28 the the DET sb397655n61 7 29 distribution distribution NOUN sb397655n61 7 30 across across ADP sb397655n61 7 31 socio socio ADJ sb397655n61 7 32 - - ADJ sb397655n61 7 33 economic economic ADJ sb397655n61 7 34 levels level NOUN sb397655n61 7 35 is be AUX sb397655n61 7 36 more more ADV sb397655n61 7 37 biased biased ADJ sb397655n61 7 38 towards towards ADP sb397655n61 7 39 the the DET sb397655n61 7 40 poorer poor ADJ sb397655n61 7 41 segment segment NOUN sb397655n61 7 42 of of ADP sb397655n61 7 43 the the DET sb397655n61 7 44 population population NOUN sb397655n61 7 45 . . PUNCT sb397655n61 8 1 the the DET sb397655n61 8 2 high high ADJ sb397655n61 8 3 costs cost NOUN sb397655n61 8 4 of of ADP sb397655n61 8 5 developing develop VERB sb397655n61 8 6 new new ADJ sb397655n61 8 7 drugs drug NOUN sb397655n61 8 8 , , PUNCT sb397655n61 8 9 along along ADP sb397655n61 8 10 with with ADP sb397655n61 8 11 the the DET sb397655n61 8 12 low low ADJ sb397655n61 8 13 level level NOUN sb397655n61 8 14 of of ADP sb397655n61 8 15 income income NOUN sb397655n61 8 16 in in ADP sb397655n61 8 17 the the DET sb397655n61 8 18 affected affected ADJ sb397655n61 8 19 population population NOUN sb397655n61 8 20 has have AUX sb397655n61 8 21 deterred deter VERB sb397655n61 8 22 pharmaceutical pharmaceutical ADJ sb397655n61 8 23 companies company NOUN sb397655n61 8 24 from from ADP sb397655n61 8 25 investing invest VERB sb397655n61 8 26 as as ADV sb397655n61 8 27 much much ADV sb397655n61 8 28 in in ADP sb397655n61 8 29 treating treat VERB sb397655n61 8 30 this this DET sb397655n61 8 31 disease disease NOUN sb397655n61 8 32 as as ADP sb397655n61 8 33 others other NOUN sb397655n61 8 34 . . PUNCT sb397655n61 9 1 while while SCONJ sb397655n61 9 2 there there PRON sb397655n61 9 3 are be VERB sb397655n61 9 4 available available ADJ sb397655n61 9 5 drugs drug NOUN sb397655n61 9 6 for for ADP sb397655n61 9 7 the the DET sb397655n61 9 8 treatment treatment NOUN sb397655n61 9 9 of of ADP sb397655n61 9 10 the the DET sb397655n61 9 11 different different ADJ sb397655n61 9 12 forms form NOUN sb397655n61 9 13 of of ADP sb397655n61 9 14 leishmaniasis leishmaniasis NOUN sb397655n61 9 15 , , PUNCT sb397655n61 9 16 they they PRON sb397655n61 9 17 are be AUX sb397655n61 9 18 expensive expensive ADJ sb397655n61 9 19 and and CCONJ sb397655n61 9 20 resistance resistance NOUN sb397655n61 9 21 to to ADP sb397655n61 9 22 them they PRON sb397655n61 9 23 is be AUX sb397655n61 9 24 emerging emerge VERB sb397655n61 9 25 the the DET sb397655n61 9 26 parasite parasite NOUN sb397655n61 9 27 . . PUNCT sb397655n61 10 1 at at ADP sb397655n61 10 2 this this DET sb397655n61 10 3 point point NOUN sb397655n61 10 4 , , PUNCT sb397655n61 10 5 the the DET sb397655n61 10 6 main main ADJ sb397655n61 10 7 control control NOUN sb397655n61 10 8 measure measure NOUN sb397655n61 10 9 of of ADP sb397655n61 10 10 the the DET sb397655n61 10 11 disease disease NOUN sb397655n61 10 12 is be AUX sb397655n61 10 13 based base VERB sb397655n61 10 14 on on ADP sb397655n61 10 15 vector vector NOUN sb397655n61 10 16 and and CCONJ sb397655n61 10 17 reservoir reservoir NOUN sb397655n61 10 18 host host NOUN sb397655n61 10 19 control control NOUN sb397655n61 10 20 . . PUNCT sb397655n61 11 1 due due ADP sb397655n61 11 2 to to ADP sb397655n61 11 3 the the DET sb397655n61 11 4 high high ADJ sb397655n61 11 5 diversity diversity NOUN sb397655n61 11 6 of of ADP sb397655n61 11 7 the the DET sb397655n61 11 8 reservoir reservoir NOUN sb397655n61 11 9 hosts host NOUN sb397655n61 11 10 , , PUNCT sb397655n61 11 11 which which PRON sb397655n61 11 12 include include VERB sb397655n61 11 13 both both CCONJ sb397655n61 11 14 wild wild ADJ sb397655n61 11 15 and and CCONJ sb397655n61 11 16 domestic domestic ADJ sb397655n61 11 17 animals animal NOUN sb397655n61 11 18 , , PUNCT sb397655n61 11 19 available available ADJ sb397655n61 11 20 to to PART sb397655n61 11 21 sand sand VERB sb397655n61 11 22 flies fly NOUN sb397655n61 11 23 , , PUNCT sb397655n61 11 24 disease disease NOUN sb397655n61 11 25 control control NOUN sb397655n61 11 26 through through ADP sb397655n61 11 27 animal animal NOUN sb397655n61 11 28 control control NOUN sb397655n61 11 29 is be AUX sb397655n61 11 30 considered consider VERB sb397655n61 11 31 to to PART sb397655n61 11 32 not not PART sb397655n61 11 33 be be AUX sb397655n61 11 34 cost cost VERB sb397655n61 11 35 effective effective ADJ sb397655n61 11 36 . . PUNCT sb397655n61 12 1 vector vector NOUN sb397655n61 12 2 control control NOUN sb397655n61 12 3 remains remain VERB sb397655n61 12 4 the the DET sb397655n61 12 5 main main ADJ sb397655n61 12 6 method method NOUN sb397655n61 12 7 for for ADP sb397655n61 12 8 disease disease NOUN sb397655n61 12 9 control control NOUN sb397655n61 12 10 yet yet ADV sb397655n61 12 11 , , PUNCT sb397655n61 12 12 in in ADP sb397655n61 12 13 spite spite NOUN sb397655n61 12 14 of of ADP sb397655n61 12 15 their their PRON sb397655n61 12 16 world world NOUN sb397655n61 12 17 - - PUNCT sb397655n61 12 18 wide wide ADJ sb397655n61 12 19 impact impact NOUN sb397655n61 12 20 , , PUNCT sb397655n61 12 21 sand sand NOUN sb397655n61 12 22 flies fly NOUN sb397655n61 12 23 remain remain VERB sb397655n61 12 24 relatively relatively ADV sb397655n61 12 25 understudied understudied ADJ sb397655n61 12 26 , , PUNCT sb397655n61 12 27 with with ADP sb397655n61 12 28 limited limited ADJ sb397655n61 12 29 laboratory laboratory NOUN sb397655n61 12 30 and and CCONJ sb397655n61 12 31 genomic genomic ADJ sb397655n61 12 32 resources resource NOUN sb397655n61 12 33 yet yet ADV sb397655n61 12 34 available available ADJ sb397655n61 12 35 . . PUNCT sb397655n61 13 1 while while SCONJ sb397655n61 13 2 many many ADJ sb397655n61 13 3 different different ADJ sb397655n61 13 4 leishmania leishmania PROPN sb397655n61 13 5 species specie NOUN sb397655n61 13 6 can can AUX sb397655n61 13 7 be be AUX sb397655n61 13 8 readily readily ADV sb397655n61 13 9 cultured cultured ADJ sb397655n61 13 10 and and CCONJ sb397655n61 13 11 manipulated manipulate VERB sb397655n61 13 12 in in ADP sb397655n61 13 13 the the DET sb397655n61 13 14 laboratory laboratory NOUN sb397655n61 13 15 , , PUNCT sb397655n61 13 16 sand sand NOUN sb397655n61 13 17 flies fly NOUN sb397655n61 13 18 are be AUX sb397655n61 13 19 notoriously notoriously ADV sb397655n61 13 20 difficult difficult ADJ sb397655n61 13 21 to to PART sb397655n61 13 22 colonize colonize VERB sb397655n61 13 23 and and CCONJ sb397655n61 13 24 maintain maintain VERB sb397655n61 13 25 . . PUNCT sb397655n61 14 1 with with ADP sb397655n61 14 2 the the DET sb397655n61 14 3 upcoming upcoming ADJ sb397655n61 14 4 genome genome NOUN sb397655n61 14 5 assemblies assembly NOUN sb397655n61 14 6 for for ADP sb397655n61 14 7 phlebotomus phlebotomus ADJ sb397655n61 14 8 papatasi papatasi NOUN sb397655n61 14 9 and and CCONJ sb397655n61 14 10 lutzomyia lutzomyia PROPN sb397655n61 14 11 longipalpis longipalpis PROPN sb397655n61 14 12 the the DET sb397655n61 14 13 available available ADJ sb397655n61 14 14 genomic genomic ADJ sb397655n61 14 15 resources resource NOUN sb397655n61 14 16 for for ADP sb397655n61 14 17 these these DET sb397655n61 14 18 important important ADJ sb397655n61 14 19 vectors vector NOUN sb397655n61 14 20 will will AUX sb397655n61 14 21 be be AUX sb397655n61 14 22 greatly greatly ADV sb397655n61 14 23 improved improve VERB sb397655n61 14 24 and and CCONJ sb397655n61 14 25 it it PRON sb397655n61 14 26 is be AUX sb397655n61 14 27 necessary necessary ADJ sb397655n61 14 28 to to PART sb397655n61 14 29 develop develop VERB sb397655n61 14 30 resources resource NOUN sb397655n61 14 31 that that PRON sb397655n61 14 32 would would AUX sb397655n61 14 33 help help VERB sb397655n61 14 34 with with ADP sb397655n61 14 35 the the DET sb397655n61 14 36 genome genome NOUN sb397655n61 14 37 annotation annotation NOUN sb397655n61 14 38 . . PUNCT sb397655n61 15 1 one one NUM sb397655n61 15 2 such such ADJ sb397655n61 15 3 resource resource NOUN sb397655n61 15 4 that that PRON sb397655n61 15 5 has have VERB sb397655n61 15 6 the the DET sb397655n61 15 7 potential potential NOUN sb397655n61 15 8 to to PART sb397655n61 15 9 improve improve VERB sb397655n61 15 10 future future ADJ sb397655n61 15 11 genome genome NOUN sb397655n61 15 12 annotation annotation NOUN sb397655n61 15 13 is be AUX sb397655n61 15 14 a a DET sb397655n61 15 15 transcript transcript NOUN sb397655n61 15 16 library library NOUN sb397655n61 15 17 . . PUNCT sb397655n61 16 1 in in ADP sb397655n61 16 2 chapter chapter NOUN sb397655n61 16 3 2 2 NUM sb397655n61 16 4 we we PRON sb397655n61 16 5 generate generate VERB sb397655n61 16 6 and and CCONJ sb397655n61 16 7 analyze analyze VERB sb397655n61 16 8 a a DET sb397655n61 16 9 normalized normalize VERB sb397655n61 16 10 est est X sb397655n61 16 11 library library NOUN sb397655n61 16 12 , , PUNCT sb397655n61 16 13 generated generate VERB sb397655n61 16 14 from from ADP sb397655n61 16 15 total total ADJ sb397655n61 16 16 rna rna NOUN sb397655n61 16 17 and and CCONJ sb397655n61 16 18 representing represent VERB sb397655n61 16 19 the the DET sb397655n61 16 20 different different ADJ sb397655n61 16 21 transcripts transcript NOUN sb397655n61 16 22 expressed express VERB sb397655n61 16 23 at at ADP sb397655n61 16 24 any any DET sb397655n61 16 25 point point NOUN sb397655n61 16 26 in in ADP sb397655n61 16 27 the the DET sb397655n61 16 28 sand sand NOUN sb397655n61 16 29 fly fly NOUN sb397655n61 16 30 lifetime lifetime NOUN sb397655n61 16 31 . . PUNCT sb397655n61 17 1 the the DET sb397655n61 17 2 est est PROPN sb397655n61 17 3 library library PROPN sb397655n61 17 4 was be AUX sb397655n61 17 5 generating generate VERB sb397655n61 17 6 using use VERB sb397655n61 17 7 all all DET sb397655n61 17 8 life life NOUN sb397655n61 17 9 stages stage NOUN sb397655n61 17 10 ( ( PUNCT sb397655n61 17 11 both both CCONJ sb397655n61 17 12 adult adult NOUN sb397655n61 17 13 and and CCONJ sb397655n61 17 14 immature immature ADJ sb397655n61 17 15 ) ) PUNCT sb397655n61 17 16 as as ADV sb397655n61 17 17 well well ADV sb397655n61 17 18 as as ADP sb397655n61 17 19 both both DET sb397655n61 17 20 genders gender NOUN sb397655n61 17 21 ( ( PUNCT sb397655n61 17 22 females female NOUN sb397655n61 17 23 and and CCONJ sb397655n61 17 24 males male NOUN sb397655n61 17 25 ) ) PUNCT sb397655n61 17 26 ; ; PUNCT sb397655n61 17 27 for for SCONJ sb397655n61 17 28 females female NOUN sb397655n61 17 29 both both CCONJ sb397655n61 17 30 sugar sugar NOUN sb397655n61 17 31 fed fed PROPN sb397655n61 17 32 and and CCONJ sb397655n61 17 33 blood blood NOUN sb397655n61 17 34 females female NOUN sb397655n61 17 35 were be AUX sb397655n61 17 36 used use VERB sb397655n61 17 37 . . PUNCT sb397655n61 18 1 the the DET sb397655n61 18 2 sequences sequence NOUN sb397655n61 18 3 generated generate VERB sb397655n61 18 4 from from ADP sb397655n61 18 5 sequencing sequence VERB sb397655n61 18 6 this this DET sb397655n61 18 7 library library NOUN sb397655n61 18 8 were be AUX sb397655n61 18 9 cleaned clean VERB sb397655n61 18 10 and and CCONJ sb397655n61 18 11 assembled assemble VERB sb397655n61 18 12 with with ADP sb397655n61 18 13 an an DET sb397655n61 18 14 in in ADP sb397655n61 18 15 house house NOUN sb397655n61 18 16 generated generate VERB sb397655n61 18 17 pipeline pipeline NOUN sb397655n61 18 18 combining combine VERB sb397655n61 18 19 several several ADJ sb397655n61 18 20 different different ADJ sb397655n61 18 21 available available ADJ sb397655n61 18 22 tools tool NOUN sb397655n61 18 23 . . PUNCT sb397655n61 19 1 also also ADV sb397655n61 19 2 in in ADP sb397655n61 19 3 chapter chapter NOUN sb397655n61 19 4 2 2 NUM sb397655n61 19 5 , , PUNCT sb397655n61 19 6 we we PRON sb397655n61 19 7 identify identify VERB sb397655n61 19 8 new new ADJ sb397655n61 19 9 proteins protein NOUN sb397655n61 19 10 potentially potentially ADV sb397655n61 19 11 involved involve VERB sb397655n61 19 12 in in ADP sb397655n61 19 13 digestion digestion NOUN sb397655n61 19 14 and and CCONJ sb397655n61 19 15 immune immune ADJ sb397655n61 19 16 response response NOUN sb397655n61 19 17 and and CCONJ sb397655n61 19 18 study study VERB sb397655n61 19 19 their their PRON sb397655n61 19 20 expression expression NOUN sb397655n61 19 21 levels level NOUN sb397655n61 19 22 across across ADP sb397655n61 19 23 different different ADJ sb397655n61 19 24 life life NOUN sb397655n61 19 25 stages stage NOUN sb397655n61 19 26 and and CCONJ sb397655n61 19 27 different different ADJ sb397655n61 19 28 feeding feeding NOUN sb397655n61 19 29 conditions condition NOUN sb397655n61 19 30 . . PUNCT sb397655n61 20 1 these these DET sb397655n61 20 2 new new ADJ sb397655n61 20 3 proteins protein NOUN sb397655n61 20 4 are be AUX sb397655n61 20 5 important important ADJ sb397655n61 20 6 because because SCONJ sb397655n61 20 7 of of ADP sb397655n61 20 8 their their PRON sb397655n61 20 9 potential potential ADJ sb397655n61 20 10 role role NOUN sb397655n61 20 11 in in ADP sb397655n61 20 12 the the DET sb397655n61 20 13 vector vector NOUN sb397655n61 20 14 - - PUNCT sb397655n61 20 15 parasite parasite NOUN sb397655n61 20 16 interaction interaction NOUN sb397655n61 20 17 . . PUNCT sb397655n61 21 1 the the DET sb397655n61 21 2 leishmania leishmania PROPN sb397655n61 21 3 parasite parasite NOUN sb397655n61 21 4 is be AUX sb397655n61 21 5 contained contain VERB sb397655n61 21 6 in in ADP sb397655n61 21 7 the the DET sb397655n61 21 8 sand sand NOUN sb397655n61 21 9 fly fly NOUN sb397655n61 21 10 midgut midgut NOUN sb397655n61 21 11 and and CCONJ sb397655n61 21 12 has have VERB sb397655n61 21 13 to to PART sb397655n61 21 14 evade evade VERB sb397655n61 21 15 both both CCONJ sb397655n61 21 16 the the DET sb397655n61 21 17 innate innate ADJ sb397655n61 21 18 host host NOUN sb397655n61 21 19 immune immune ADJ sb397655n61 21 20 response response NOUN sb397655n61 21 21 as as ADV sb397655n61 21 22 well well ADV sb397655n61 21 23 the the DET sb397655n61 21 24 digestive digestive ADJ sb397655n61 21 25 process process NOUN sb397655n61 21 26 . . PUNCT sb397655n61 22 1 targeting target VERB sb397655n61 22 2 processes process NOUN sb397655n61 22 3 at at ADP sb397655n61 22 4 these these DET sb397655n61 22 5 levels level NOUN sb397655n61 22 6 might might AUX sb397655n61 22 7 decrease decrease VERB sb397655n61 22 8 the the DET sb397655n61 22 9 chances chance NOUN sb397655n61 22 10 for for ADP sb397655n61 22 11 a a DET sb397655n61 22 12 successful successful ADJ sb397655n61 22 13 transmission transmission NOUN sb397655n61 22 14 of of ADP sb397655n61 22 15 the the DET sb397655n61 22 16 parasite parasite NOUN sb397655n61 22 17 to to ADP sb397655n61 22 18 a a DET sb397655n61 22 19 mammalian mammalian ADJ sb397655n61 22 20 host host NOUN sb397655n61 22 21 . . PUNCT sb397655n61 23 1 prior prior ADV sb397655n61 23 2 to to ADP sb397655n61 23 3 the the DET sb397655n61 23 4 genome genome NOUN sb397655n61 23 5 sequencing sequencing NOUN sb397655n61 23 6 , , PUNCT sb397655n61 23 7 a a DET sb397655n61 23 8 bacterial bacterial ADJ sb397655n61 23 9 artificial artificial ADJ sb397655n61 23 10 chromosomes chromosome NOUN sb397655n61 23 11 ( ( PUNCT sb397655n61 23 12 bacs bacs PROPN sb397655n61 23 13 ) ) PUNCT sb397655n61 23 14 library library NOUN sb397655n61 23 15 were be AUX sb397655n61 23 16 generated generate VERB sb397655n61 23 17 from from ADP sb397655n61 23 18 ph ph PROPN sb397655n61 23 19 . . PROPN sb397655n61 23 20 papatasi papatasi NOUN sb397655n61 23 21 containing contain VERB sb397655n61 23 22 large large ADJ sb397655n61 23 23 stretches stretch NOUN sb397655n61 23 24 of of ADP sb397655n61 23 25 genomic genomic PROPN sb397655n61 23 26 dna dna PROPN sb397655n61 23 27 . . PUNCT sb397655n61 24 1 fifteen fifteen NUM sb397655n61 24 2 of of ADP sb397655n61 24 3 these these DET sb397655n61 24 4 bacs bac NOUN sb397655n61 24 5 have have AUX sb397655n61 24 6 been be AUX sb397655n61 24 7 randomly randomly ADV sb397655n61 24 8 selected select VERB sb397655n61 24 9 and and CCONJ sb397655n61 24 10 sequenced sequence VERB sb397655n61 24 11 . . PUNCT sb397655n61 25 1 in in ADP sb397655n61 25 2 chapter chapter NOUN sb397655n61 25 3 3 3 NUM sb397655n61 25 4 we we PRON sb397655n61 25 5 take take VERB sb397655n61 25 6 a a DET sb397655n61 25 7 look look NOUN sb397655n61 25 8 at at ADP sb397655n61 25 9 15 15 NUM sb397655n61 25 10 fully fully ADV sb397655n61 25 11 sequenced sequence VERB sb397655n61 25 12 ph ph PROPN sb397655n61 25 13 . . PROPN sb397655n61 25 14 papatasi papatasi PROPN sb397655n61 25 15 bacs bac NOUN sb397655n61 25 16 in in ADP sb397655n61 25 17 attempt attempt NOUN sb397655n61 25 18 to to PART sb397655n61 25 19 understand understand VERB sb397655n61 25 20 more more ADJ sb397655n61 25 21 about about ADP sb397655n61 25 22 what what PRON sb397655n61 25 23 to to PART sb397655n61 25 24 expect expect VERB sb397655n61 25 25 from from ADP sb397655n61 25 26 this this DET sb397655n61 25 27 genome genome NOUN sb397655n61 25 28 regarding regard VERB sb397655n61 25 29 the the DET sb397655n61 25 30 number number NOUN sb397655n61 25 31 and and CCONJ sb397655n61 25 32 distribution distribution NOUN sb397655n61 25 33 of of ADP sb397655n61 25 34 repeats repeat NOUN sb397655n61 25 35 and and CCONJ sb397655n61 25 36 genes gene NOUN sb397655n61 25 37 . . PUNCT sb397655n61 26 1 in in ADP sb397655n61 26 2 the the DET sb397655n61 26 3 same same ADJ sb397655n61 26 4 chapter chapter NOUN sb397655n61 26 5 ( ( PUNCT sb397655n61 26 6 chapter chapter NOUN sb397655n61 26 7 3 3 NUM sb397655n61 26 8 ) ) PUNCT sb397655n61 26 9 , , PUNCT sb397655n61 26 10 we we PRON sb397655n61 26 11 make make VERB sb397655n61 26 12 a a DET sb397655n61 26 13 first first ADJ sb397655n61 26 14 attempt attempt NOUN sb397655n61 26 15 to to PART sb397655n61 26 16 analyze analyze VERB sb397655n61 26 17 the the DET sb397655n61 26 18 newly newly ADV sb397655n61 26 19 released release VERB sb397655n61 26 20 genome genome NOUN sb397655n61 26 21 assembly assembly NOUN sb397655n61 26 22 with with ADP sb397655n61 26 23 regards regard NOUN sb397655n61 26 24 to to ADP sb397655n61 26 25 possible possible ADJ sb397655n61 26 26 miss miss NOUN sb397655n61 26 27 - - PUNCT sb397655n61 26 28 assemblies assembly NOUN sb397655n61 26 29 , , PUNCT sb397655n61 26 30 inversions inversion NOUN sb397655n61 26 31 and and CCONJ sb397655n61 26 32 gaps gap NOUN sb397655n61 26 33 . . PUNCT sb397655n61 27 1 it it PRON sb397655n61 27 2 is be AUX sb397655n61 27 3 believed believe VERB sb397655n61 27 4 that that SCONJ sb397655n61 27 5 a a DET sb397655n61 27 6 better well ADJ sb397655n61 27 7 understanding understanding NOUN sb397655n61 27 8 of of ADP sb397655n61 27 9 the the DET sb397655n61 27 10 sand sand NOUN sb397655n61 27 11 fly fly NOUN sb397655n61 27 12 genome genome NOUN sb397655n61 27 13 will will AUX sb397655n61 27 14 help help VERB sb397655n61 27 15 generate generate VERB sb397655n61 27 16 possible possible ADJ sb397655n61 27 17 targets target NOUN sb397655n61 27 18 for for ADP sb397655n61 27 19 vector vector NOUN sb397655n61 27 20 control control NOUN sb397655n61 27 21 and and CCONJ sb397655n61 27 22 in in ADP sb397655n61 27 23 help help NOUN sb397655n61 27 24 with with ADP sb397655n61 27 25 better well ADJ sb397655n61 27 26 understanding understanding NOUN sb397655n61 27 27 of of ADP sb397655n61 27 28 these these DET sb397655n61 27 29 organisms organism NOUN sb397655n61 27 30 in in ADP sb397655n61 27 31 general general ADJ sb397655n61 27 32 . . PUNCT sb397655n61 28 1 one one NUM sb397655n61 28 2 class class NOUN sb397655n61 28 3 of of ADP sb397655n61 28 4 possible possible ADJ sb397655n61 28 5 targets target NOUN sb397655n61 28 6 for for ADP sb397655n61 28 7 insecticides insecticide NOUN sb397655n61 28 8 ( ( PUNCT sb397655n61 28 9 vector vector NOUN sb397655n61 28 10 control control NOUN sb397655n61 28 11 method method NOUN sb397655n61 28 12 ) ) PUNCT sb397655n61 28 13 , , PUNCT sb397655n61 28 14 in in ADP sb397655n61 28 15 sand sand NOUN sb397655n61 28 16 flies fly NOUN sb397655n61 28 17 as as ADV sb397655n61 28 18 well well ADV sb397655n61 28 19 as as ADP sb397655n61 28 20 other other ADJ sb397655n61 28 21 vectors vector NOUN sb397655n61 28 22 , , PUNCT sb397655n61 28 23 are be AUX sb397655n61 28 24 g g NOUN sb397655n61 28 25 - - PUNCT sb397655n61 28 26 protein protein NOUN sb397655n61 28 27 couple couple NOUN sb397655n61 28 28 receptors receptor NOUN sb397655n61 28 29 ( ( PUNCT sb397655n61 28 30 gpcrs gpcrs PROPN sb397655n61 28 31 ) ) PUNCT sb397655n61 28 32 . . PUNCT sb397655n61 29 1 gpcrs gpcrs PROPN sb397655n61 29 2 are be AUX sb397655n61 29 3 7 7 NUM sb397655n61 29 4 - - PUNCT sb397655n61 29 5 transmembrane transmembrane ADJ sb397655n61 29 6 protein protein NOUN sb397655n61 29 7 that that PRON sb397655n61 29 8 connect connect VERB sb397655n61 29 9 the the DET sb397655n61 29 10 extracellular extracellular ADJ sb397655n61 29 11 world world NOUN sb397655n61 29 12 to to ADP sb397655n61 29 13 the the DET sb397655n61 29 14 intracellular intracellular ADJ sb397655n61 29 15 one one NOUN sb397655n61 29 16 , , PUNCT sb397655n61 29 17 transducing transduce VERB sb397655n61 29 18 a a DET sb397655n61 29 19 high high ADJ sb397655n61 29 20 number number NOUN sb397655n61 29 21 of of ADP sb397655n61 29 22 external external ADJ sb397655n61 29 23 stimuli stimulus NOUN sb397655n61 29 24 into into ADP sb397655n61 29 25 intracellular intracellular ADJ sb397655n61 29 26 responses response NOUN sb397655n61 29 27 . . PUNCT sb397655n61 30 1 in in ADP sb397655n61 30 2 chapter chapter NOUN sb397655n61 30 3 4 4 NUM sb397655n61 30 4 we we PRON sb397655n61 30 5 analyze analyze VERB sb397655n61 30 6 and and CCONJ sb397655n61 30 7 validate validate VERB sb397655n61 30 8 a a DET sb397655n61 30 9 set set NOUN sb397655n61 30 10 of of ADP sb397655n61 30 11 predicted predict VERB sb397655n61 30 12 gpcrs gpcrs PROPN sb397655n61 30 13 for for ADP sb397655n61 30 14 three three NUM sb397655n61 30 15 different different ADJ sb397655n61 30 16 vector vector NOUN sb397655n61 30 17 species specie NOUN sb397655n61 30 18 : : PUNCT sb397655n61 30 19 aedes aedes PROPN sb397655n61 30 20 aegypti aegypti PROPN sb397655n61 30 21 , , PUNCT sb397655n61 30 22 a a DET sb397655n61 30 23 mosquito mosquito NOUN sb397655n61 30 24 responsible responsible ADJ sb397655n61 30 25 for for ADP sb397655n61 30 26 transmission transmission NOUN sb397655n61 30 27 of of ADP sb397655n61 30 28 dengue dengue PROPN sb397655n61 30 29 virus virus NOUN sb397655n61 30 30 , , PUNCT sb397655n61 30 31 anopheles anophele VERB sb397655n61 30 32 gambiae gambiae NOUN sb397655n61 30 33 , , PUNCT sb397655n61 30 34 another another DET sb397655n61 30 35 mosquito mosquito PROPN sb397655n61 30 36 , , PUNCT sb397655n61 30 37 responsible responsible ADJ sb397655n61 30 38 for for ADP sb397655n61 30 39 the the DET sb397655n61 30 40 spread spread NOUN sb397655n61 30 41 of of ADP sb397655n61 30 42 plasmodium plasmodium ADJ sb397655n61 30 43 falciparum falciparum NOUN sb397655n61 30 44 , , PUNCT sb397655n61 30 45 a a DET sb397655n61 30 46 malaria malaria NOUN sb397655n61 30 47 parasite parasite NOUN sb397655n61 30 48 present present ADJ sb397655n61 30 49 in in ADP sb397655n61 30 50 africa africa PROPN sb397655n61 30 51 and and CCONJ sb397655n61 30 52 pediculus pediculus PROPN sb397655n61 30 53 humanus humanu NOUN sb397655n61 30 54 , , PUNCT sb397655n61 30 55 a a DET sb397655n61 30 56 tick tick NOUN sb397655n61 30 57 . . PUNCT sb397655n61 31 1 our our PRON sb397655n61 31 2 method method NOUN sb397655n61 31 3 for for ADP sb397655n61 31 4 identifying identify VERB sb397655n61 31 5 gpcrs gpcrs PROPN sb397655n61 31 6 results result NOUN sb397655n61 31 7 in in ADP sb397655n61 31 8 novel novel ADJ sb397655n61 31 9 sequences sequence NOUN sb397655n61 31 10 for for ADP sb397655n61 31 11 all all DET sb397655n61 31 12 three three NUM sb397655n61 31 13 vector vector NOUN sb397655n61 31 14 species specie NOUN sb397655n61 31 15 that that PRON sb397655n61 31 16 can can AUX sb397655n61 31 17 at at ADP sb397655n61 31 18 a a DET sb397655n61 31 19 later later ADJ sb397655n61 31 20 time time NOUN sb397655n61 31 21 considered consider VERB sb397655n61 31 22 for for ADP sb397655n61 31 23 their their PRON sb397655n61 31 24 potential potential NOUN sb397655n61 31 25 as as ADP sb397655n61 31 26 insecticide insecticide NOUN sb397655n61 31 27 targets target NOUN sb397655n61 31 28 . . PUNCT sb397655n61 32 1 in in ADP sb397655n61 32 2 conclusion conclusion NOUN sb397655n61 32 3 , , PUNCT sb397655n61 32 4 these these DET sb397655n61 32 5 studies study NOUN sb397655n61 32 6 greatly greatly ADV sb397655n61 32 7 add add VERB sb397655n61 32 8 to to ADP sb397655n61 32 9 our our PRON sb397655n61 32 10 knowledge knowledge NOUN sb397655n61 32 11 about about ADP sb397655n61 32 12 phlebotomine phlebotomine ADJ sb397655n61 32 13 sand sand NOUN sb397655n61 32 14 flies fly NOUN sb397655n61 32 15 genome genome NOUN sb397655n61 32 16 and and CCONJ sb397655n61 32 17 transcriptome transcriptome NOUN sb397655n61 32 18 and and CCONJ sb397655n61 32 19 are be AUX sb397655n61 32 20 hope hope NOUN sb397655n61 32 21 to to PART sb397655n61 32 22 help help VERB sb397655n61 32 23 improve improve VERB sb397655n61 32 24 the the DET sb397655n61 32 25 genome genome NOUN sb397655n61 32 26 annotation annotation NOUN sb397655n61 32 27 now now ADV sb397655n61 32 28 available available ADJ sb397655n61 32 29 in in ADP sb397655n61 32 30 genbank genbank PROPN sb397655n61 32 31 . . PUNCT