id	sid	tid	token	lemma	pos
sb397656c2f	1	1	organ	organ	NOUN
sb397656c2f	1	2	development	development	NOUN
sb397656c2f	1	3	requires	require	VERB
sb397656c2f	1	4	precise	precise	ADJ
sb397656c2f	1	5	coordination	coordination	NOUN
sb397656c2f	1	6	of	of	ADP
sb397656c2f	1	7	extrinsic	extrinsic	ADJ
sb397656c2f	1	8	and	and	CCONJ
sb397656c2f	1	9	intrinsic	intrinsic	ADJ
sb397656c2f	1	10	stimuli	stimulus	NOUN
sb397656c2f	1	11	at	at	ADP
sb397656c2f	1	12	a	a	DET
sb397656c2f	1	13	cellular	cellular	ADJ
sb397656c2f	1	14	level	level	NOUN
sb397656c2f	1	15	.	.	PUNCT
sb397656c2f	2	1	however	however	ADV
sb397656c2f	2	2	,	,	PUNCT
sb397656c2f	2	3	the	the	DET
sb397656c2f	2	4	underlying	underlie	VERB
sb397656c2f	2	5	principles	principle	NOUN
sb397656c2f	2	6	of	of	ADP
sb397656c2f	2	7	how	how	SCONJ
sb397656c2f	2	8	cell	cell	NOUN
sb397656c2f	2	9	signaling	signaling	NOUN
sb397656c2f	2	10	is	be	AUX
sb397656c2f	2	11	coordinated	coordinate	VERB
sb397656c2f	2	12	within	within	ADP
sb397656c2f	2	13	the	the	DET
sb397656c2f	2	14	organ	organ	NOUN
sb397656c2f	2	15	context	context	NOUN
sb397656c2f	2	16	is	be	AUX
sb397656c2f	2	17	poorly	poorly	ADV
sb397656c2f	2	18	understood	understand	VERB
sb397656c2f	2	19	.	.	PUNCT
sb397656c2f	3	1	many	many	ADJ
sb397656c2f	3	2	components	component	NOUN
sb397656c2f	3	3	of	of	ADP
sb397656c2f	3	4	the	the	DET
sb397656c2f	3	5	chemical	chemical	NOUN
sb397656c2f	3	6	signaling	signal	VERB
sb397656c2f	3	7	pathways	pathway	NOUN
sb397656c2f	3	8	that	that	PRON
sb397656c2f	3	9	regulate	regulate	VERB
sb397656c2f	3	10	organ	organ	NOUN
sb397656c2f	3	11	development	development	NOUN
sb397656c2f	3	12	have	have	AUX
sb397656c2f	3	13	been	be	AUX
sb397656c2f	3	14	identified	identify	VERB
sb397656c2f	3	15	through	through	ADP
sb397656c2f	3	16	the	the	DET
sb397656c2f	3	17	genetic	genetic	ADJ
sb397656c2f	3	18	manipulation	manipulation	NOUN
sb397656c2f	3	19	of	of	ADP
sb397656c2f	3	20	model	model	NOUN
sb397656c2f	3	21	organisms	organism	NOUN
sb397656c2f	3	22	.	.	PUNCT
sb397656c2f	4	1	however	however	ADV
sb397656c2f	4	2	,	,	PUNCT
sb397656c2f	4	3	defining	define	VERB
sb397656c2f	4	4	how	how	SCONJ
sb397656c2f	4	5	stimuli	stimulus	NOUN
sb397656c2f	4	6	are	be	AUX
sb397656c2f	4	7	integrated	integrate	VERB
sb397656c2f	4	8	at	at	ADP
sb397656c2f	4	9	the	the	DET
sb397656c2f	4	10	scale	scale	NOUN
sb397656c2f	4	11	of	of	ADP
sb397656c2f	4	12	multicellular	multicellular	ADJ
sb397656c2f	4	13	systems	system	NOUN
sb397656c2f	4	14	has	have	AUX
sb397656c2f	4	15	proven	prove	VERB
sb397656c2f	4	16	challenging	challenge	VERB
sb397656c2f	4	17	due	due	ADP
sb397656c2f	4	18	to	to	ADP
sb397656c2f	4	19	the	the	DET
sb397656c2f	4	20	difficulties	difficulty	NOUN
sb397656c2f	4	21	with	with	ADP
sb397656c2f	4	22	simultaneous	simultaneous	ADJ
sb397656c2f	4	23	stimulation	stimulation	NOUN
sb397656c2f	4	24	and	and	CCONJ
sb397656c2f	4	25	visualization	visualization	NOUN
sb397656c2f	4	26	of	of	ADP
sb397656c2f	4	27	delicate	delicate	ADJ
sb397656c2f	4	28	tissues	tissue	NOUN
sb397656c2f	4	29	.	.	PUNCT
sb397656c2f	5	1	this	this	DET
sb397656c2f	5	2	thesis	thesis	NOUN
sb397656c2f	5	3	describes	describe	VERB
sb397656c2f	5	4	several	several	ADJ
sb397656c2f	5	5	milestones	milestone	NOUN
sb397656c2f	5	6	that	that	PRON
sb397656c2f	5	7	advance	advance	VERB
sb397656c2f	5	8	the	the	DET
sb397656c2f	5	9	state	state	NOUN
sb397656c2f	5	10	of	of	ADP
sb397656c2f	5	11	the	the	DET
sb397656c2f	5	12	art	art	NOUN
sb397656c2f	5	13	for	for	ADP
sb397656c2f	5	14	analyzing	analyze	VERB
sb397656c2f	5	15	multicellular	multicellular	ADJ
sb397656c2f	5	16	systems	system	NOUN
sb397656c2f	5	17	,	,	PUNCT
sb397656c2f	5	18	including	include	VERB
sb397656c2f	5	19	insect	insect	PROPN
sb397656c2f	5	20	micro	micro	NOUN
sb397656c2f	5	21	-	-	NOUN
sb397656c2f	5	22	organs	organ	NOUN
sb397656c2f	5	23	,	,	PUNCT
sb397656c2f	5	24	tissue	tissue	NOUN
sb397656c2f	5	25	biopsies	biopsy	NOUN
sb397656c2f	5	26	,	,	PUNCT
sb397656c2f	5	27	and	and	CCONJ
sb397656c2f	5	28	thromboses	thrombose	NOUN
sb397656c2f	5	29	(	(	PUNCT
sb397656c2f	5	30	blood	blood	NOUN
sb397656c2f	5	31	clots	clot	NOUN
sb397656c2f	5	32	)	)	PUNCT
sb397656c2f	5	33	.	.	PUNCT
sb397656c2f	6	1	these	these	DET
sb397656c2f	6	2	advances	advance	NOUN
sb397656c2f	6	3	include	include	VERB
sb397656c2f	6	4	a	a	DET
sb397656c2f	6	5	detailed	detailed	ADJ
sb397656c2f	6	6	analysis	analysis	NOUN
sb397656c2f	6	7	of	of	ADP
sb397656c2f	6	8	how	how	SCONJ
sb397656c2f	6	9	cell	cell	NOUN
sb397656c2f	6	10	geometries	geometry	NOUN
sb397656c2f	6	11	impact	impact	VERB
sb397656c2f	6	12	the	the	DET
sb397656c2f	6	13	propagation	propagation	NOUN
sb397656c2f	6	14	of	of	ADP
sb397656c2f	6	15	intercellular	intercellular	ADJ
sb397656c2f	6	16	calcium	calcium	NOUN
sb397656c2f	6	17	transients	transient	NOUN
sb397656c2f	6	18	(	(	PUNCT
sb397656c2f	6	19	chapter	chapter	NOUN
sb397656c2f	6	20	2	2	NUM
sb397656c2f	6	21	)	)	PUNCT
sb397656c2f	6	22	.	.	PUNCT
sb397656c2f	7	1	this	this	DET
sb397656c2f	7	2	study	study	NOUN
sb397656c2f	7	3	implicated	implicate	VERB
sb397656c2f	7	4	the	the	DET
sb397656c2f	7	5	distribution	distribution	NOUN
sb397656c2f	7	6	of	of	ADP
sb397656c2f	7	7	mechanical	mechanical	ADJ
sb397656c2f	7	8	stress	stress	NOUN
sb397656c2f	7	9	in	in	ADP
sb397656c2f	7	10	a	a	DET
sb397656c2f	7	11	tissue	tissue	NOUN
sb397656c2f	7	12	as	as	ADP
sb397656c2f	7	13	an	an	DET
sb397656c2f	7	14	important	important	ADJ
sb397656c2f	7	15	input	input	NOUN
sb397656c2f	7	16	to	to	ADP
sb397656c2f	7	17	calcium	calcium	NOUN
sb397656c2f	7	18	propagation	propagation	NOUN
sb397656c2f	7	19	.	.	PUNCT
sb397656c2f	8	1	this	this	PRON
sb397656c2f	8	2	prompted	prompt	VERB
sb397656c2f	8	3	the	the	DET
sb397656c2f	8	4	development	development	NOUN
sb397656c2f	8	5	of	of	ADP
sb397656c2f	8	6	a	a	DET
sb397656c2f	8	7	microfluidic	microfluidic	ADJ
sb397656c2f	8	8	device	device	NOUN
sb397656c2f	8	9	to	to	PART
sb397656c2f	8	10	allow	allow	VERB
sb397656c2f	8	11	for	for	ADP
sb397656c2f	8	12	more	more	ADV
sb397656c2f	8	13	detailed	detailed	ADJ
sb397656c2f	8	14	exogenous	exogenous	ADJ
sb397656c2f	8	15	stimulation	stimulation	NOUN
sb397656c2f	8	16	at	at	ADP
sb397656c2f	8	17	the	the	DET
sb397656c2f	8	18	organ	organ	NOUN
sb397656c2f	8	19	scale	scale	NOUN
sb397656c2f	8	20	(	(	PUNCT
sb397656c2f	8	21	chapter	chapter	NOUN
sb397656c2f	8	22	3	3	NUM
sb397656c2f	8	23	)	)	PUNCT
sb397656c2f	8	24	.	.	PUNCT
sb397656c2f	9	1	the	the	DET
sb397656c2f	9	2	device	device	NOUN
sb397656c2f	9	3	lead	lead	VERB
sb397656c2f	9	4	to	to	ADP
sb397656c2f	9	5	the	the	DET
sb397656c2f	9	6	discovery	discovery	NOUN
sb397656c2f	9	7	that	that	SCONJ
sb397656c2f	9	8	it	it	PRON
sb397656c2f	9	9	is	be	AUX
sb397656c2f	9	10	the	the	DET
sb397656c2f	9	11	release	release	NOUN
sb397656c2f	9	12	,	,	PUNCT
sb397656c2f	9	13	and	and	CCONJ
sb397656c2f	9	14	not	not	PART
sb397656c2f	9	15	the	the	DET
sb397656c2f	9	16	application	application	NOUN
sb397656c2f	9	17	,	,	PUNCT
sb397656c2f	9	18	of	of	ADP
sb397656c2f	9	19	mechanical	mechanical	ADJ
sb397656c2f	9	20	loading	loading	NOUN
sb397656c2f	9	21	that	that	PRON
sb397656c2f	9	22	stimulates	stimulate	VERB
sb397656c2f	9	23	an	an	DET
sb397656c2f	9	24	intercellular	intercellular	ADJ
sb397656c2f	9	25	calcium	calcium	NOUN
sb397656c2f	9	26	response	response	NOUN
sb397656c2f	9	27	–	–	PUNCT
sb397656c2f	9	28	a	a	DET
sb397656c2f	9	29	distinction	distinction	NOUN
sb397656c2f	9	30	that	that	PRON
sb397656c2f	9	31	is	be	AUX
sb397656c2f	9	32	inaccessible	inaccessible	ADJ
sb397656c2f	9	33	by	by	ADP
sb397656c2f	9	34	previously	previously	ADV
sb397656c2f	9	35	developed	develop	VERB
sb397656c2f	9	36	methods	method	NOUN
sb397656c2f	9	37	.	.	PUNCT
sb397656c2f	10	1	the	the	DET
sb397656c2f	10	2	device	device	NOUN
sb397656c2f	10	3	is	be	AUX
sb397656c2f	10	4	generalizable	generalizable	ADJ
sb397656c2f	10	5	to	to	ADP
sb397656c2f	10	6	many	many	ADJ
sb397656c2f	10	7	model	model	NOUN
sb397656c2f	10	8	systems	system	NOUN
sb397656c2f	10	9	and	and	CCONJ
sb397656c2f	10	10	is	be	AUX
sb397656c2f	10	11	a	a	DET
sb397656c2f	10	12	multi	multi	ADJ
sb397656c2f	10	13	-	-	ADJ
sb397656c2f	10	14	modal	modal	ADJ
sb397656c2f	10	15	tool	tool	NOUN
sb397656c2f	10	16	for	for	ADP
sb397656c2f	10	17	analyzing	analyze	VERB
sb397656c2f	10	18	how	how	SCONJ
sb397656c2f	10	19	exogenous	exogenous	ADJ
sb397656c2f	10	20	stimuli	stimulus	NOUN
sb397656c2f	10	21	impact	impact	NOUN
sb397656c2f	10	22	cell	cell	NOUN
sb397656c2f	10	23	behavior	behavior	NOUN
sb397656c2f	10	24	and	and	CCONJ
sb397656c2f	10	25	organ	organ	NOUN
sb397656c2f	10	26	development	development	NOUN
sb397656c2f	10	27	.	.	PUNCT
sb397656c2f	11	1	further	far	ADV
sb397656c2f	11	2	,	,	PUNCT
sb397656c2f	11	3	this	this	DET
sb397656c2f	11	4	device	device	NOUN
sb397656c2f	11	5	led	lead	VERB
sb397656c2f	11	6	to	to	ADP
sb397656c2f	11	7	the	the	DET
sb397656c2f	11	8	creation	creation	NOUN
sb397656c2f	11	9	of	of	ADP
sb397656c2f	11	10	an	an	DET
sb397656c2f	11	11	automated	automate	VERB
sb397656c2f	11	12	platform	platform	NOUN
sb397656c2f	11	13	for	for	ADP
sb397656c2f	11	14	staining	stain	VERB
sb397656c2f	11	15	and	and	CCONJ
sb397656c2f	11	16	imaging	image	VERB
sb397656c2f	11	17	tissue	tissue	NOUN
sb397656c2f	11	18	biopsy	biopsy	ADJ
sb397656c2f	11	19	samples	sample	NOUN
sb397656c2f	11	20	in	in	ADP
sb397656c2f	11	21	3d	3d	NOUN
sb397656c2f	11	22	(	(	PUNCT
sb397656c2f	11	23	chapter	chapter	NOUN
sb397656c2f	11	24	4	4	NUM
sb397656c2f	11	25	)	)	PUNCT
sb397656c2f	11	26	.	.	PUNCT
sb397656c2f	12	1	this	this	DET
sb397656c2f	12	2	advance	advance	NOUN
sb397656c2f	12	3	provides	provide	VERB
sb397656c2f	12	4	an	an	DET
sb397656c2f	12	5	avenue	avenue	NOUN
sb397656c2f	12	6	for	for	SCONJ
sb397656c2f	12	7	diagnosticians	diagnostician	NOUN
sb397656c2f	12	8	to	to	PART
sb397656c2f	12	9	more	more	ADV
sb397656c2f	12	10	accurately	accurately	ADV
sb397656c2f	12	11	analyze	analyze	VERB
sb397656c2f	12	12	patient	patient	ADJ
sb397656c2f	12	13	biopsy	biopsy	ADJ
sb397656c2f	12	14	samples	sample	NOUN
sb397656c2f	12	15	.	.	PUNCT
sb397656c2f	13	1	finally	finally	ADV
sb397656c2f	13	2	,	,	PUNCT
sb397656c2f	13	3	the	the	DET
sb397656c2f	13	4	optical	optical	ADJ
sb397656c2f	13	5	clearing	clearing	NOUN
sb397656c2f	13	6	strategies	strategy	NOUN
sb397656c2f	13	7	employed	employ	VERB
sb397656c2f	13	8	in	in	ADP
sb397656c2f	13	9	chapter	chapter	NOUN
sb397656c2f	13	10	4	4	NUM
sb397656c2f	13	11	were	be	AUX
sb397656c2f	13	12	modified	modify	VERB
sb397656c2f	13	13	to	to	PART
sb397656c2f	13	14	optically	optically	ADV
sb397656c2f	13	15	clear	clear	ADJ
sb397656c2f	13	16	human	human	ADJ
sb397656c2f	13	17	blood	blood	NOUN
sb397656c2f	13	18	clots	clot	NOUN
sb397656c2f	13	19	and	and	CCONJ
sb397656c2f	13	20	enable	enable	VERB
sb397656c2f	13	21	deep	deep	ADJ
sb397656c2f	13	22	3d	3d	NOUN
sb397656c2f	13	23	imaging	imaging	NOUN
sb397656c2f	13	24	(	(	PUNCT
sb397656c2f	13	25	chapter	chapter	NOUN
sb397656c2f	13	26	5	5	NUM
sb397656c2f	13	27	)	)	PUNCT
sb397656c2f	13	28	.	.	PUNCT
sb397656c2f	14	1	this	this	PRON
sb397656c2f	14	2	revealed	reveal	VERB
sb397656c2f	14	3	a	a	DET
sb397656c2f	14	4	distinct	distinct	ADJ
sb397656c2f	14	5	difference	difference	NOUN
sb397656c2f	14	6	in	in	ADP
sb397656c2f	14	7	the	the	DET
sb397656c2f	14	8	fibrin	fibrin	NOUN
sb397656c2f	14	9	structure	structure	NOUN
sb397656c2f	14	10	between	between	ADP
sb397656c2f	14	11	contracted	contract	VERB
sb397656c2f	14	12	and	and	CCONJ
sb397656c2f	14	13	non	non	ADJ
sb397656c2f	14	14	-	-	ADJ
sb397656c2f	14	15	contracted	contract	VERB
sb397656c2f	14	16	clots	clot	NOUN
sb397656c2f	14	17	and	and	CCONJ
sb397656c2f	14	18	will	will	AUX
sb397656c2f	14	19	lead	lead	VERB
sb397656c2f	14	20	to	to	ADP
sb397656c2f	14	21	new	new	ADJ
sb397656c2f	14	22	insights	insight	NOUN
sb397656c2f	14	23	into	into	ADP
sb397656c2f	14	24	pathological	pathological	ADJ
sb397656c2f	14	25	thrombosis	thrombosis	NOUN
sb397656c2f	14	26	.	.	PUNCT
sb397656c2f	15	1	opportunities	opportunity	NOUN
sb397656c2f	15	2	for	for	ADP
sb397656c2f	15	3	further	far	ADV
sb397656c2f	15	4	advancing	advance	VERB
sb397656c2f	15	5	each	each	DET
sb397656c2f	15	6	discovery	discovery	NOUN
sb397656c2f	15	7	are	be	AUX
sb397656c2f	15	8	discussed	discuss	VERB
sb397656c2f	15	9	in	in	ADP
sb397656c2f	15	10	the	the	DET
sb397656c2f	15	11	concluding	conclude	VERB
sb397656c2f	15	12	chapter	chapter	NOUN
sb397656c2f	15	13	(	(	PUNCT
sb397656c2f	15	14	chapter	chapter	NOUN
sb397656c2f	15	15	6	6	NUM
sb397656c2f	15	16	)	)	PUNCT
sb397656c2f	15	17	.	.	PUNCT