id sid tid token lemma pos w089280462m 1 1 gene gene NOUN w089280462m 1 2 expression expression NOUN w089280462m 1 3 during during ADP w089280462m 1 4 embryogenesis embryogenesis NOUN w089280462m 1 5 impacts impact NOUN w089280462m 1 6 adult adult NOUN w089280462m 1 7 mosquito mosquito NOUN w089280462m 1 8 fitness fitness NOUN w089280462m 1 9 , , PUNCT w089280462m 1 10 the the DET w089280462m 1 11 ability ability NOUN w089280462m 1 12 of of ADP w089280462m 1 13 an an DET w089280462m 1 14 organism organism NOUN w089280462m 1 15 to to PART w089280462m 1 16 survive survive VERB w089280462m 1 17 and and CCONJ w089280462m 1 18 transmit transmit VERB w089280462m 1 19 its its PRON w089280462m 1 20 genotype genotype NOUN w089280462m 1 21 to to ADP w089280462m 1 22 offspring offspring NOUN w089280462m 1 23 as as SCONJ w089280462m 1 24 compared compare VERB w089280462m 1 25 to to ADP w089280462m 1 26 competing compete VERB w089280462m 1 27 organisms organism NOUN w089280462m 1 28 . . PUNCT w089280462m 2 1 sequencing sequence VERB w089280462m 2 2 of of ADP w089280462m 2 3 the the DET w089280462m 2 4 ae ae PROPN w089280462m 2 5 . . PUNCT w089280462m 3 1 aegypti aegypti PROPN w089280462m 3 2 genome genome NOUN w089280462m 3 3 has have AUX w089280462m 3 4 made make VERB w089280462m 3 5 possible possible ADJ w089280462m 3 6 the the DET w089280462m 3 7 characterization characterization NOUN w089280462m 3 8 of of ADP w089280462m 3 9 many many ADJ w089280462m 3 10 genes gene NOUN w089280462m 3 11 , , PUNCT w089280462m 3 12 but but CCONJ w089280462m 3 13 analysis analysis NOUN w089280462m 3 14 of of ADP w089280462m 3 15 developmental developmental ADJ w089280462m 3 16 genes gene NOUN w089280462m 3 17 has have AUX w089280462m 3 18 proven prove VERB w089280462m 3 19 challenging challenging ADJ w089280462m 3 20 , , PUNCT w089280462m 3 21 largely largely ADV w089280462m 3 22 as as ADP w089280462m 3 23 a a DET w089280462m 3 24 result result NOUN w089280462m 3 25 of of ADP w089280462m 3 26 technical technical ADJ w089280462m 3 27 difficulties difficulty NOUN w089280462m 3 28 encountered encounter VERB w089280462m 3 29 when when SCONJ w089280462m 3 30 manipulating manipulate VERB w089280462m 3 31 mosquito mosquito NOUN w089280462m 3 32 embryos embryo NOUN w089280462m 3 33 . . PUNCT w089280462m 4 1 first first ADV w089280462m 4 2 , , PUNCT w089280462m 4 3 techniques technique NOUN w089280462m 4 4 that that PRON w089280462m 4 5 focused focus VERB w089280462m 4 6 on on ADP w089280462m 4 7 handling handle VERB w089280462m 4 8 / / SYM w089280462m 4 9 manipulation manipulation NOUN w089280462m 4 10 of of ADP w089280462m 4 11 embryos embryo NOUN w089280462m 4 12 and and CCONJ w089280462m 4 13 various various ADJ w089280462m 4 14 analytics analytic NOUN w089280462m 4 15 were be AUX w089280462m 4 16 designed design VERB w089280462m 4 17 ( ( PUNCT w089280462m 4 18 chapter chapter NOUN w089280462m 4 19 2 2 NUM w089280462m 4 20 ) ) PUNCT w089280462m 4 21 . . PUNCT w089280462m 5 1 with with ADP w089280462m 5 2 these these DET w089280462m 5 3 techniques technique NOUN w089280462m 5 4 i i PRON w089280462m 5 5 was be AUX w089280462m 5 6 able able ADJ w089280462m 5 7 to to PART w089280462m 5 8 properly properly ADV w089280462m 5 9 rear rear VERB w089280462m 5 10 , , PUNCT w089280462m 5 11 fix fix NOUN w089280462m 5 12 , , PUNCT w089280462m 5 13 stain stain NOUN w089280462m 5 14 and and CCONJ w089280462m 5 15 perform perform VERB w089280462m 5 16 functional functional ADJ w089280462m 5 17 analyses analysis NOUN w089280462m 5 18 on on ADP w089280462m 5 19 embryos embryo NOUN w089280462m 5 20 . . PUNCT w089280462m 6 1 even even ADV w089280462m 6 2 with with ADP w089280462m 6 3 these these DET w089280462m 6 4 techniques technique NOUN w089280462m 6 5 , , PUNCT w089280462m 6 6 genes gene NOUN w089280462m 6 7 important important ADJ w089280462m 6 8 to to ADP w089280462m 6 9 organismal organismal ADJ w089280462m 6 10 development development NOUN w089280462m 6 11 remained remain VERB w089280462m 6 12 fairly fairly ADV w089280462m 6 13 uncharacterized uncharacterized ADJ w089280462m 6 14 . . PUNCT w089280462m 7 1 second second ADV w089280462m 7 2 , , PUNCT w089280462m 7 3 we we PRON w089280462m 7 4 used use VERB w089280462m 7 5 comparative comparative ADJ w089280462m 7 6 genomics genomic NOUN w089280462m 7 7 to to PART w089280462m 7 8 study study VERB w089280462m 7 9 genes gene NOUN w089280462m 7 10 in in ADP w089280462m 7 11 ae ae PROPN w089280462m 7 12 . . PUNCT w089280462m 7 13 aegypti aegypti PROPN w089280462m 7 14 that that PRON w089280462m 7 15 are be AUX w089280462m 7 16 found find VERB w089280462m 7 17 to to PART w089280462m 7 18 be be AUX w089280462m 7 19 homologous homologous ADJ w089280462m 7 20 to to ADP w089280462m 7 21 developmental developmental ADJ w089280462m 7 22 genes gene NOUN w089280462m 7 23 in in ADP w089280462m 7 24 drosophila drosophila NOUN w089280462m 7 25 melanogaster melanogaster NOUN w089280462m 7 26 , , PUNCT w089280462m 7 27 a a DET w089280462m 7 28 genetic genetic ADJ w089280462m 7 29 model model NOUN w089280462m 7 30 organism organism NOUN w089280462m 7 31 . . PUNCT w089280462m 8 1 doing do VERB w089280462m 8 2 so so ADV w089280462m 8 3 i i PRON w089280462m 8 4 was be AUX w089280462m 8 5 able able ADJ w089280462m 8 6 to to PART w089280462m 8 7 show show VERB w089280462m 8 8 that that DET w089280462m 8 9 netrin netrin NOUN w089280462m 8 10 / / SYM w089280462m 8 11 frazzled frazzle VERB w089280462m 8 12 signaling signaling NOUN w089280462m 8 13 at at ADP w089280462m 8 14 the the DET w089280462m 8 15 cns cns PROPN w089280462m 8 16 midline midline NOUN w089280462m 8 17 was be AUX w089280462m 8 18 conserved conserve VERB w089280462m 8 19 ( ( PUNCT w089280462m 8 20 chapter chapter NOUN w089280462m 8 21 3 3 NUM w089280462m 8 22 ) ) PUNCT w089280462m 8 23 between between ADP w089280462m 8 24 the the DET w089280462m 8 25 mosquito mosquito NOUN w089280462m 8 26 and and CCONJ w089280462m 8 27 fruit fruit NOUN w089280462m 8 28 fly fly NOUN w089280462m 8 29 . . PUNCT w089280462m 9 1 i i PRON w089280462m 9 2 showed show VERB w089280462m 9 3 via via ADP w089280462m 9 4 rnai rnai ADJ w089280462m 9 5 , , PUNCT w089280462m 9 6 immunohistochemistry immunohistochemistry NOUN w089280462m 9 7 and and CCONJ w089280462m 9 8 in in ADP w089280462m 9 9 situ situ ADJ w089280462m 9 10 hybridization hybridization NOUN w089280462m 9 11 that that PRON w089280462m 9 12 frazzled frazzle VERB w089280462m 9 13 ( ( PUNCT w089280462m 9 14 fra fra X w089280462m 9 15 ) ) PUNCT w089280462m 9 16 expression expression NOUN w089280462m 9 17 is be AUX w089280462m 9 18 important important ADJ w089280462m 9 19 for for ADP w089280462m 9 20 proper proper ADJ w089280462m 9 21 axon axon NOUN w089280462m 9 22 guidance guidance NOUN w089280462m 9 23 . . PUNCT w089280462m 10 1 in in ADP w089280462m 10 2 d. d. PROPN w089280462m 10 3 melanogaster melanogaster NOUN w089280462m 10 4 axon axon NOUN w089280462m 10 5 guidance guidance NOUN w089280462m 10 6 genes gene NOUN w089280462m 10 7 are be AUX w089280462m 10 8 known know VERB w089280462m 10 9 to to PART w089280462m 10 10 control control VERB w089280462m 10 11 salivary salivary ADJ w089280462m 10 12 gland gland NOUN w089280462m 10 13 migration migration NOUN w089280462m 10 14 during during ADP w089280462m 10 15 development development NOUN w089280462m 10 16 . . PUNCT w089280462m 11 1 salivary salivary ADJ w089280462m 11 2 glands gland NOUN w089280462m 11 3 are be AUX w089280462m 11 4 critical critical ADJ w089280462m 11 5 to to ADP w089280462m 11 6 disease disease NOUN w089280462m 11 7 transmission transmission NOUN w089280462m 11 8 in in ADP w089280462m 11 9 mosquitoes mosquito NOUN w089280462m 11 10 . . PUNCT w089280462m 12 1 although although SCONJ w089280462m 12 2 there there PRON w089280462m 12 3 was be VERB w089280462m 12 4 a a DET w089280462m 12 5 level level NOUN w089280462m 12 6 of of ADP w089280462m 12 7 gene gene NOUN w089280462m 12 8 conservation conservation NOUN w089280462m 12 9 shown show VERB w089280462m 12 10 in in ADP w089280462m 12 11 cns cns PROPN w089280462m 12 12 development development PROPN w089280462m 12 13 , , PUNCT w089280462m 12 14 development development NOUN w089280462m 12 15 of of ADP w089280462m 12 16 the the DET w089280462m 12 17 salivary salivary ADJ w089280462m 12 18 glands gland NOUN w089280462m 12 19 is be AUX w089280462m 12 20 different different ADJ w089280462m 12 21 ( ( PUNCT w089280462m 12 22 chapter chapter NOUN w089280462m 12 23 4 4 NUM w089280462m 12 24 ) ) PUNCT w089280462m 12 25 . . PUNCT w089280462m 13 1 lastly lastly ADV w089280462m 13 2 , , PUNCT w089280462m 13 3 there there PRON w089280462m 13 4 are be VERB w089280462m 13 5 populations population NOUN w089280462m 13 6 of of ADP w089280462m 13 7 ae ae PROPN w089280462m 13 8 . . PROPN w089280462m 13 9 aegypti aegypti PROPN w089280462m 13 10 , , PUNCT w089280462m 13 11 that that PRON w089280462m 13 12 show show VERB w089280462m 13 13 differences difference NOUN w089280462m 13 14 in in ADP w089280462m 13 15 susceptibilities susceptibility NOUN w089280462m 13 16 to to ADP w089280462m 13 17 pathogens pathogen NOUN w089280462m 13 18 . . PUNCT w089280462m 14 1 the the DET w089280462m 14 2 noticeable noticeable ADJ w089280462m 14 3 physiological physiological ADJ w089280462m 14 4 difference difference NOUN w089280462m 14 5 between between ADP w089280462m 14 6 the the DET w089280462m 14 7 two two NUM w089280462m 14 8 is be AUX w089280462m 14 9 body body NOUN w089280462m 14 10 size size NOUN w089280462m 14 11 . . PUNCT w089280462m 15 1 body body NOUN w089280462m 15 2 size size NOUN w089280462m 15 3 in in ADP w089280462m 15 4 all all DET w089280462m 15 5 organisms organism NOUN w089280462m 15 6 is be AUX w089280462m 15 7 controlled control VERB w089280462m 15 8 by by ADP w089280462m 15 9 insulin insulin NOUN w089280462m 15 10 signaling signaling NOUN w089280462m 15 11 ( ( PUNCT w089280462m 15 12 iis iis PROPN w089280462m 15 13 ) ) PUNCT w089280462m 15 14 . . PUNCT w089280462m 16 1 developmental developmental ADJ w089280462m 16 2 stressors stressor NOUN w089280462m 16 3 are be AUX w089280462m 16 4 shown show VERB w089280462m 16 5 to to PART w089280462m 16 6 decrease decrease VERB w089280462m 16 7 overall overall ADJ w089280462m 16 8 body body NOUN w089280462m 16 9 size size NOUN w089280462m 16 10 , , PUNCT w089280462m 16 11 but but CCONJ w089280462m 16 12 increase increase VERB w089280462m 16 13 longevity longevity NOUN w089280462m 16 14 and and CCONJ w089280462m 16 15 pathogen pathogen PROPN w089280462m 16 16 resistance resistance PROPN w089280462m 16 17 . . PUNCT w089280462m 17 1 stress stress NOUN w089280462m 17 2 during during ADP w089280462m 17 3 development development NOUN w089280462m 17 4 modulates modulates PROPN w089280462m 17 5 iis iis PROPN w089280462m 17 6 . . PUNCT w089280462m 18 1 stress stress NOUN w089280462m 18 2 signaling signaling NOUN w089280462m 18 3 is be AUX w089280462m 18 4 activated activate VERB w089280462m 18 5 by by ADP w089280462m 18 6 c c PROPN w089280462m 18 7 - - PUNCT w089280462m 18 8 jun jun PROPN w089280462m 18 9 n n ADJ w089280462m 18 10 - - PUNCT w089280462m 18 11 terminal terminal ADJ w089280462m 18 12 kinase kinase NOUN w089280462m 18 13 ( ( PUNCT w089280462m 18 14 jnk jnk PROPN w089280462m 18 15 ) ) PUNCT w089280462m 18 16 and and CCONJ w089280462m 18 17 regulated regulate VERB w089280462m 18 18 by by ADP w089280462m 18 19 puckered pucker VERB w089280462m 18 20 ( ( PUNCT w089280462m 18 21 puc puc NOUN w089280462m 18 22 ) ) PUNCT w089280462m 18 23 phosphatase phosphatase NOUN w089280462m 18 24 . . PUNCT w089280462m 19 1 i i PRON w089280462m 19 2 found find VERB w089280462m 19 3 the the DET w089280462m 19 4 smaller small ADJ w089280462m 19 5 less less ADV w089280462m 19 6 susceptible susceptible ADJ w089280462m 19 7 moyo moyo ADJ w089280462m 19 8 - - PUNCT w089280462m 19 9 r r NOUN w089280462m 19 10 subpopulation subpopulation NOUN w089280462m 19 11 expresses express VERB w089280462m 19 12 higher high ADJ w089280462m 19 13 levels level NOUN w089280462m 19 14 of of ADP w089280462m 19 15 jnk jnk PROPN w089280462m 19 16 at at ADV w089280462m 19 17 all all DET w089280462m 19 18 stages stage NOUN w089280462m 19 19 of of ADP w089280462m 19 20 development development NOUN w089280462m 19 21 when when SCONJ w089280462m 19 22 compared compare VERB w089280462m 19 23 to to ADP w089280462m 19 24 the the DET w089280462m 19 25 larger large ADJ w089280462m 19 26 more more ADV w089280462m 19 27 susceptible susceptible ADJ w089280462m 19 28 moyo moyo NOUN w089280462m 19 29 - - PUNCT w089280462m 19 30 s s NOUN w089280462m 19 31 subpopulation subpopulation NOUN w089280462m 19 32 ( ( PUNCT w089280462m 19 33 chapter chapter NOUN w089280462m 19 34 5 5 NUM w089280462m 19 35 ) ) PUNCT w089280462m 19 36 . . PUNCT w089280462m 20 1 in in ADP w089280462m 20 2 future future ADJ w089280462m 20 3 studies study NOUN w089280462m 20 4 , , PUNCT w089280462m 20 5 we we PRON w089280462m 20 6 intend intend VERB w089280462m 20 7 to to PART w089280462m 20 8 show show VERB w089280462m 20 9 rnai rnai NOUN w089280462m 20 10 of of ADP w089280462m 20 11 puc puc PROPN w089280462m 20 12 in in ADP w089280462m 20 13 moyo moyo PROPN w089280462m 20 14 - - PUNCT w089280462m 20 15 s s PROPN w089280462m 20 16 will will AUX w089280462m 20 17 lead lead VERB w089280462m 20 18 to to ADP w089280462m 20 19 smaller small ADJ w089280462m 20 20 and and CCONJ w089280462m 20 21 less less ADV w089280462m 20 22 susceptible susceptible ADJ w089280462m 20 23 mosquitoes mosquito NOUN w089280462m 20 24 . . PUNCT