id sid tid token lemma pos ws859c7193m 1 1 albeit albeit SCONJ ws859c7193m 1 2 nontrivial nontrivial ADJ ws859c7193m 1 3 , , PUNCT ws859c7193m 1 4 the the DET ws859c7193m 1 5 long long ADJ ws859c7193m 1 6 withstanding withstand VERB ws859c7193m 1 7 challenge challenge NOUN ws859c7193m 1 8 of of ADP ws859c7193m 1 9 developing develop VERB ws859c7193m 1 10 new new ADJ ws859c7193m 1 11 chemical chemical ADJ ws859c7193m 1 12 space space NOUN ws859c7193m 1 13 for for ADP ws859c7193m 1 14 natural natural ADJ ws859c7193m 1 15 products product NOUN ws859c7193m 1 16 of of ADP ws859c7193m 1 17 biological biological ADJ ws859c7193m 1 18 importance importance NOUN ws859c7193m 1 19 depends depend VERB ws859c7193m 1 20 heavily heavily ADV ws859c7193m 1 21 on on ADP ws859c7193m 1 22 the the DET ws859c7193m 1 23 development development NOUN ws859c7193m 1 24 of of ADP ws859c7193m 1 25 new new ADJ ws859c7193m 1 26 synthetic synthetic ADJ ws859c7193m 1 27 methods method NOUN ws859c7193m 1 28 . . PUNCT ws859c7193m 2 1 with with ADP ws859c7193m 2 2 the the DET ws859c7193m 2 3 increase increase NOUN ws859c7193m 2 4 in in ADP ws859c7193m 2 5 drug drug NOUN ws859c7193m 2 6 - - PUNCT ws859c7193m 2 7 resistance resistance NOUN ws859c7193m 2 8 today today NOUN ws859c7193m 2 9 , , PUNCT ws859c7193m 2 10 the the DET ws859c7193m 2 11 expansion expansion NOUN ws859c7193m 2 12 of of ADP ws859c7193m 2 13 chemical chemical ADJ ws859c7193m 2 14 knowledge knowledge NOUN ws859c7193m 2 15 within within ADP ws859c7193m 2 16 the the DET ws859c7193m 2 17 realm realm NOUN ws859c7193m 2 18 of of ADP ws859c7193m 2 19 natural natural ADJ ws859c7193m 2 20 products product NOUN ws859c7193m 2 21 continues continue VERB ws859c7193m 2 22 to to PART ws859c7193m 2 23 play play VERB ws859c7193m 2 24 a a DET ws859c7193m 2 25 vital vital ADJ ws859c7193m 2 26 role role NOUN ws859c7193m 2 27 in in ADP ws859c7193m 2 28 biomedical biomedical ADJ ws859c7193m 2 29 research research NOUN ws859c7193m 2 30 . . PUNCT ws859c7193m 3 1 to to ADP ws859c7193m 3 2 this this DET ws859c7193m 3 3 end end NOUN ws859c7193m 3 4 , , PUNCT ws859c7193m 3 5 strategies strategy NOUN ws859c7193m 3 6 that that PRON ws859c7193m 3 7 develop develop VERB ws859c7193m 3 8 five five NUM ws859c7193m 3 9 - - PUNCT ws859c7193m 3 10 membered membered NOUN ws859c7193m 3 11 carboor carboor ADJ ws859c7193m 3 12 heterocyclic heterocyclic NOUN ws859c7193m 3 13 compounds compound NOUN ws859c7193m 3 14 are be AUX ws859c7193m 3 15 of of ADP ws859c7193m 3 16 interest interest NOUN ws859c7193m 3 17 to to ADP ws859c7193m 3 18 the the DET ws859c7193m 3 19 synthetic synthetic ADJ ws859c7193m 3 20 community community NOUN ws859c7193m 3 21 because because SCONJ ws859c7193m 3 22 of of ADP ws859c7193m 3 23 their their PRON ws859c7193m 3 24 prominence prominence NOUN ws859c7193m 3 25 in in ADP ws859c7193m 3 26 natural natural ADJ ws859c7193m 3 27 products product NOUN ws859c7193m 3 28 and and CCONJ ws859c7193m 3 29 pharmaceuticals.in pharmaceuticals.in ADV ws859c7193m 3 30 contrast contrast VERB ws859c7193m 3 31 to to ADP ws859c7193m 3 32 common common ADJ ws859c7193m 3 33 [ [ PUNCT ws859c7193m 3 34 n+2]-annulation n+2]-annulation NOUN ws859c7193m 3 35 strategies strategy NOUN ws859c7193m 3 36 , , PUNCT ws859c7193m 3 37 in in ADP ws859c7193m 3 38 generating generate VERB ws859c7193m 3 39 three three NUM ws859c7193m 3 40 , , PUNCT ws859c7193m 3 41 and and CCONJ ws859c7193m 3 42 five five NUM ws859c7193m 3 43 - - PUNCT ws859c7193m 3 44 membered membered ADJ ws859c7193m 3 45 motifs motif NOUN ws859c7193m 3 46 , , PUNCT ws859c7193m 3 47 we we PRON ws859c7193m 3 48 demonstrate demonstrate VERB ws859c7193m 3 49 the the DET ws859c7193m 3 50 use use NOUN ws859c7193m 3 51 of of ADP ws859c7193m 3 52 carbenoid carbenoid ADJ ws859c7193m 3 53 strategies strategy NOUN ws859c7193m 3 54 , , PUNCT ws859c7193m 3 55 via via ADP ws859c7193m 3 56 an an DET ws859c7193m 3 57 [ [ X ws859c7193m 3 58 n+1 n+1 X ws859c7193m 3 59 ] ] X ws859c7193m 3 60 strategy strategy NOUN ws859c7193m 3 61 , , PUNCT ws859c7193m 3 62 provide provide VERB ws859c7193m 3 63 an an DET ws859c7193m 3 64 alternative alternative NOUN ws859c7193m 3 65 to to ADP ws859c7193m 3 66 accessing access VERB ws859c7193m 3 67 structural structural ADJ ws859c7193m 3 68 motifs motif NOUN ws859c7193m 3 69 of of ADP ws859c7193m 3 70 biological biological ADJ ws859c7193m 3 71 importance importance NOUN ws859c7193m 3 72 . . PUNCT ws859c7193m 4 1 we we PRON ws859c7193m 4 2 highlight highlight VERB ws859c7193m 4 3 the the DET ws859c7193m 4 4 successful successful ADJ ws859c7193m 4 5 implementation implementation NOUN ws859c7193m 4 6 of of ADP ws859c7193m 4 7 our our PRON ws859c7193m 4 8 strategy strategy NOUN ws859c7193m 4 9 , , PUNCT ws859c7193m 4 10 in in ADP ws859c7193m 4 11 developing develop VERB ws859c7193m 4 12 fully fully ADV ws859c7193m 4 13 substituted substitute VERB ws859c7193m 4 14 carbon carbon NOUN ws859c7193m 4 15 centers center NOUN ws859c7193m 4 16 , , PUNCT ws859c7193m 4 17 with with ADP ws859c7193m 4 18 a a DET ws859c7193m 4 19 focus focus NOUN ws859c7193m 4 20 on on ADP ws859c7193m 4 21 two two NUM ws859c7193m 4 22 classes class NOUN ws859c7193m 4 23 of of ADP ws859c7193m 4 24 heterocycles heterocycle NOUN ws859c7193m 4 25 : : PUNCT ws859c7193m 4 26 the the DET ws859c7193m 4 27 c3 c3 PROPN ws859c7193m 4 28 - - PUNCT ws859c7193m 4 29 spirofused spirofuse VERB ws859c7193m 4 30 oxindole oxindole NOUN ws859c7193m 4 31 , , PUNCT ws859c7193m 4 32 and and CCONJ ws859c7193m 4 33 the the DET ws859c7193m 4 34 2,3 2,3 NUM ws859c7193m 4 35 - - PUNCT ws859c7193m 4 36 dihydrobenzfuran dihydrobenzfuran PROPN ws859c7193m 4 37 . . PUNCT