id sid tid token lemma pos x059c536z9s 1 1 leishmaniasis leishmaniasis NOUN x059c536z9s 1 2 is be AUX x059c536z9s 1 3 a a DET x059c536z9s 1 4 devastating devastating ADJ x059c536z9s 1 5 group group NOUN x059c536z9s 1 6 of of ADP x059c536z9s 1 7 diseases disease NOUN x059c536z9s 1 8 causing cause VERB x059c536z9s 1 9 substantial substantial ADJ x059c536z9s 1 10 mortality mortality NOUN x059c536z9s 1 11 and and CCONJ x059c536z9s 1 12 morbidity morbidity NOUN x059c536z9s 1 13 throughout throughout ADP x059c536z9s 1 14 the the DET x059c536z9s 1 15 world world NOUN x059c536z9s 1 16 . . PUNCT x059c536z9s 2 1 leishmania leishmania PROPN x059c536z9s 2 2 are be AUX x059c536z9s 2 3 obligate obligate ADJ x059c536z9s 2 4 intracellular intracellular ADJ x059c536z9s 2 5 organisms organism NOUN x059c536z9s 2 6 infecting infect VERB x059c536z9s 2 7 and and CCONJ x059c536z9s 2 8 replicating replicate VERB x059c536z9s 2 9 inside inside ADJ x059c536z9s 2 10 hosts host NOUN x059c536z9s 2 11 ' ' PART x059c536z9s 2 12 macrophages macrophage NOUN x059c536z9s 2 13 ; ; PUNCT x059c536z9s 2 14 making make VERB x059c536z9s 2 15 them they PRON x059c536z9s 2 16 ideal ideal ADJ x059c536z9s 2 17 to to PART x059c536z9s 2 18 model model VERB x059c536z9s 2 19 and and CCONJ x059c536z9s 2 20 understand understand VERB x059c536z9s 2 21 interactions interaction NOUN x059c536z9s 2 22 between between ADP x059c536z9s 2 23 host host NOUN x059c536z9s 2 24 and and CCONJ x059c536z9s 2 25 parasite parasite NOUN x059c536z9s 2 26 . . PUNCT x059c536z9s 3 1 leishmania leishmania PROPN x059c536z9s 3 2 entry entry NOUN x059c536z9s 3 3 is be AUX x059c536z9s 3 4 receptor receptor NOUN x059c536z9s 3 5 mediated mediate VERB x059c536z9s 3 6 through through ADP x059c536z9s 3 7 engagement engagement NOUN x059c536z9s 3 8 of of ADP x059c536z9s 3 9 receptors receptor NOUN x059c536z9s 3 10 recognizing recognize VERB x059c536z9s 3 11 molecular molecular ADJ x059c536z9s 3 12 patterns pattern NOUN x059c536z9s 3 13 on on ADP x059c536z9s 3 14 parasites parasite NOUN x059c536z9s 3 15 surface surface NOUN x059c536z9s 3 16 , , PUNCT x059c536z9s 3 17 such such ADJ x059c536z9s 3 18 as as ADP x059c536z9s 3 19 lipophosphoglycan lipophosphoglycan PROPN x059c536z9s 3 20 ( ( PUNCT x059c536z9s 3 21 lpg lpg NOUN x059c536z9s 3 22 ) ) PUNCT x059c536z9s 3 23 . . PUNCT x059c536z9s 4 1 macrophages macrophage NOUN x059c536z9s 4 2 have have VERB x059c536z9s 4 3 several several ADJ x059c536z9s 4 4 cell cell NOUN x059c536z9s 4 5 surface surface NOUN x059c536z9s 4 6 receptors receptor NOUN x059c536z9s 4 7 recognizing recognize VERB x059c536z9s 4 8 pathogenic pathogenic ADJ x059c536z9s 4 9 organisms organism NOUN x059c536z9s 4 10 , , PUNCT x059c536z9s 4 11 in in ADP x059c536z9s 4 12 particular particular ADJ x059c536z9s 4 13 major major ADJ x059c536z9s 4 14 receptors receptor NOUN x059c536z9s 4 15 for for ADP x059c536z9s 4 16 leishmania leishmania PROPN x059c536z9s 4 17 entry entry NOUN x059c536z9s 4 18 are be AUX x059c536z9s 4 19 complement complement NOUN x059c536z9s 4 20 receptor receptor NOUN x059c536z9s 4 21 3 3 NUM x059c536z9s 4 22 ( ( PUNCT x059c536z9s 4 23 cr3 cr3 NOUN x059c536z9s 4 24 ) ) PUNCT x059c536z9s 4 25 , , PUNCT x059c536z9s 4 26 mannose mannose NOUN x059c536z9s 4 27 receptor receptor NOUN x059c536z9s 4 28 ( ( PUNCT x059c536z9s 4 29 mr mr PROPN x059c536z9s 4 30 ) ) PUNCT x059c536z9s 4 31 , , PUNCT x059c536z9s 4 32 fc fc PROPN x059c536z9s 4 33 receptor receptor NOUN x059c536z9s 4 34 ( ( PUNCT x059c536z9s 4 35 fcr fcr PROPN x059c536z9s 4 36 ) ) PUNCT x059c536z9s 4 37 , , PUNCT x059c536z9s 4 38 and and CCONJ x059c536z9s 4 39 toll toll NOUN x059c536z9s 4 40 - - PUNCT x059c536z9s 4 41 like like ADJ x059c536z9s 4 42 receptors receptor NOUN x059c536z9s 4 43 ( ( PUNCT x059c536z9s 4 44 tlrs tlrs ADV x059c536z9s 4 45 ) ) PUNCT x059c536z9s 4 46 . . PUNCT x059c536z9s 5 1 cr3 cr3 VERB x059c536z9s 5 2 recognizes recognize VERB x059c536z9s 5 3 complement complement NOUN x059c536z9s 5 4 , , PUNCT x059c536z9s 5 5 which which PRON x059c536z9s 5 6 coats coat VERB x059c536z9s 5 7 pathogens pathogen NOUN x059c536z9s 5 8 for for ADP x059c536z9s 5 9 clearance clearance NOUN x059c536z9s 5 10 by by ADP x059c536z9s 5 11 the the DET x059c536z9s 5 12 immune immune ADJ x059c536z9s 5 13 system system NOUN x059c536z9s 5 14 . . PUNCT x059c536z9s 6 1 while while SCONJ x059c536z9s 6 2 mr mr PROPN x059c536z9s 6 3 is be AUX x059c536z9s 6 4 involved involve VERB x059c536z9s 6 5 in in ADP x059c536z9s 6 6 recognizing recognize VERB x059c536z9s 6 7 sugar sugar NOUN x059c536z9s 6 8 side side NOUN x059c536z9s 6 9 chains chain NOUN x059c536z9s 6 10 present present ADJ x059c536z9s 6 11 on on ADP x059c536z9s 6 12 surfaces surface NOUN x059c536z9s 6 13 of of ADP x059c536z9s 6 14 pathogens pathogen NOUN x059c536z9s 6 15 leading lead VERB x059c536z9s 6 16 to to ADP x059c536z9s 6 17 phagocytosis phagocytosis NOUN x059c536z9s 6 18 by by ADP x059c536z9s 6 19 macrophages macrophage NOUN x059c536z9s 6 20 . . PUNCT x059c536z9s 7 1 the the DET x059c536z9s 7 2 fc fc PROPN x059c536z9s 7 3 receptor receptor NOUN x059c536z9s 7 4 ( ( PUNCT x059c536z9s 7 5 fcr fcr PROPN x059c536z9s 7 6 ) ) PUNCT x059c536z9s 7 7 , , PUNCT x059c536z9s 7 8 not not PART x059c536z9s 7 9 technically technically ADV x059c536z9s 7 10 a a DET x059c536z9s 7 11 pattern pattern NOUN x059c536z9s 7 12 recognition recognition NOUN x059c536z9s 7 13 receptor receptor NOUN x059c536z9s 7 14 like like ADP x059c536z9s 7 15 cr3 cr3 NOUN x059c536z9s 7 16 and and CCONJ x059c536z9s 7 17 mr mr PROPN x059c536z9s 7 18 , , PUNCT x059c536z9s 7 19 is be AUX x059c536z9s 7 20 integral integral ADJ x059c536z9s 7 21 for for ADP x059c536z9s 7 22 pathogen pathogen PROPN x059c536z9s 7 23 entry entry NOUN x059c536z9s 7 24 through through ADP x059c536z9s 7 25 recognition recognition NOUN x059c536z9s 7 26 of of ADP x059c536z9s 7 27 the the DET x059c536z9s 7 28 fc fc PROPN x059c536z9s 7 29 portion portion NOUN x059c536z9s 7 30 of of ADP x059c536z9s 7 31 antibodies antibody NOUN x059c536z9s 7 32 . . PUNCT x059c536z9s 8 1 this this DET x059c536z9s 8 2 dissertation dissertation NOUN x059c536z9s 8 3 focuses focus VERB x059c536z9s 8 4 on on ADP x059c536z9s 8 5 identification identification NOUN x059c536z9s 8 6 of of ADP x059c536z9s 8 7 host host NOUN x059c536z9s 8 8 cell cell NOUN x059c536z9s 8 9 signaling signal VERB x059c536z9s 8 10 and and CCONJ x059c536z9s 8 11 characterizing characterize VERB x059c536z9s 8 12 phagosome phagosome ADJ x059c536z9s 8 13 maturation maturation NOUN x059c536z9s 8 14 during during ADP x059c536z9s 8 15 leishmania leishmania PROPN x059c536z9s 8 16 infection infection NOUN x059c536z9s 8 17 . . PUNCT x059c536z9s 9 1 use use NOUN x059c536z9s 9 2 of of ADP x059c536z9s 9 3 mr mr PROPN x059c536z9s 9 4 has have AUX x059c536z9s 9 5 not not PART x059c536z9s 9 6 been be AUX x059c536z9s 9 7 well well ADV x059c536z9s 9 8 characterized characterize VERB x059c536z9s 9 9 such such ADJ x059c536z9s 9 10 as as ADP x059c536z9s 9 11 cr3 cr3 NOUN x059c536z9s 9 12 or or CCONJ x059c536z9s 9 13 fcr fcr NOUN x059c536z9s 9 14 during during ADP x059c536z9s 9 15 leishmania leishmania PROPN x059c536z9s 9 16 infection infection NOUN x059c536z9s 9 17 . . PUNCT x059c536z9s 10 1 our our PRON x059c536z9s 10 2 studies study NOUN x059c536z9s 10 3 indicate indicate VERB x059c536z9s 10 4 that that SCONJ x059c536z9s 10 5 mr mr PROPN x059c536z9s 10 6 is be AUX x059c536z9s 10 7 not not PART x059c536z9s 10 8 essential essential ADJ x059c536z9s 10 9 for for ADP x059c536z9s 10 10 in in ADP x059c536z9s 10 11 vivo vivo PROPN x059c536z9s 10 12 leishmania leishmania PROPN x059c536z9s 10 13 infection infection NOUN x059c536z9s 10 14 , , PUNCT x059c536z9s 10 15 wt wt PROPN x059c536z9s 10 16 or or CCONJ x059c536z9s 10 17 mr mr PROPN x059c536z9s 10 18 knock knock VERB x059c536z9s 10 19 out out ADP x059c536z9s 10 20 mice mouse NOUN x059c536z9s 10 21 infected infect VERB x059c536z9s 10 22 with with ADP x059c536z9s 10 23 l. l. PROPN x059c536z9s 10 24 major major ADJ x059c536z9s 10 25 or or CCONJ x059c536z9s 10 26 l. l. PROPN x059c536z9s 10 27 donovani donovani PROPN x059c536z9s 10 28 do do AUX x059c536z9s 10 29 not not PART x059c536z9s 10 30 display display VERB x059c536z9s 10 31 differences difference NOUN x059c536z9s 10 32 during during ADP x059c536z9s 10 33 infection infection NOUN x059c536z9s 10 34 . . PUNCT x059c536z9s 11 1 analysis analysis NOUN x059c536z9s 11 2 of of ADP x059c536z9s 11 3 cytokine cytokine NOUN x059c536z9s 11 4 production production NOUN x059c536z9s 11 5 and and CCONJ x059c536z9s 11 6 mapk mapk PROPN x059c536z9s 11 7 signaling signaling PROPN x059c536z9s 11 8 also also ADV x059c536z9s 11 9 are be AUX x059c536z9s 11 10 not not PART x059c536z9s 11 11 different different ADJ x059c536z9s 11 12 between between ADP x059c536z9s 11 13 wt wt PROPN x059c536z9s 11 14 and and CCONJ x059c536z9s 11 15 mr mr PROPN x059c536z9s 11 16 knock knock VERB x059c536z9s 11 17 out out ADP x059c536z9s 11 18 mice mouse NOUN x059c536z9s 11 19 . . PUNCT x059c536z9s 12 1 leishmania leishmania PROPN x059c536z9s 12 2 survive survive VERB x059c536z9s 12 3 inside inside ADP x059c536z9s 12 4 macrophages macrophage NOUN x059c536z9s 12 5 by by ADP x059c536z9s 12 6 delaying delay VERB x059c536z9s 12 7 phagosome phagosome ADJ x059c536z9s 12 8 maturation maturation NOUN x059c536z9s 12 9 through through ADP x059c536z9s 12 10 preventing prevent VERB x059c536z9s 12 11 fusion fusion NOUN x059c536z9s 12 12 with with ADP x059c536z9s 12 13 lysosomes lysosome NOUN x059c536z9s 12 14 . . PUNCT x059c536z9s 13 1 this this DET x059c536z9s 13 2 delay delay NOUN x059c536z9s 13 3 allows allow VERB x059c536z9s 13 4 parasites parasite NOUN x059c536z9s 13 5 time time NOUN x059c536z9s 13 6 to to PART x059c536z9s 13 7 differentiate differentiate VERB x059c536z9s 13 8 into into ADP x059c536z9s 13 9 more more ADV x059c536z9s 13 10 microbiocidal microbiocidal ADJ x059c536z9s 13 11 resistant resistant ADJ x059c536z9s 13 12 life life NOUN x059c536z9s 13 13 stage stage NOUN x059c536z9s 13 14 . . PUNCT x059c536z9s 14 1 our our PRON x059c536z9s 14 2 data datum NOUN x059c536z9s 14 3 is be AUX x059c536z9s 14 4 the the DET x059c536z9s 14 5 first first ADJ x059c536z9s 14 6 step step NOUN x059c536z9s 14 7 toward toward ADP x059c536z9s 14 8 characterizing characterize VERB x059c536z9s 14 9 a a DET x059c536z9s 14 10 role role NOUN x059c536z9s 14 11 for for ADP x059c536z9s 14 12 macrophage macrophage NOUN x059c536z9s 14 13 receptors receptor NOUN x059c536z9s 14 14 and and CCONJ x059c536z9s 14 15 their their PRON x059c536z9s 14 16 influence influence NOUN x059c536z9s 14 17 on on ADP x059c536z9s 14 18 phagosome phagosome ADJ x059c536z9s 14 19 maturation maturation NOUN x059c536z9s 14 20 . . PUNCT x059c536z9s 15 1 the the DET x059c536z9s 15 2 major major ADJ x059c536z9s 15 3 receptors receptor NOUN x059c536z9s 15 4 implicated implicate VERB x059c536z9s 15 5 in in ADP x059c536z9s 15 6 leishmania leishmania PROPN x059c536z9s 15 7 entry entry PROPN x059c536z9s 15 8 , , PUNCT x059c536z9s 15 9 mr mr PROPN x059c536z9s 15 10 , , PUNCT x059c536z9s 15 11 cr3 cr3 PROPN x059c536z9s 15 12 , , PUNCT x059c536z9s 15 13 fcγr fcγr PROPN x059c536z9s 15 14 , , PUNCT x059c536z9s 15 15 and and CCONJ x059c536z9s 15 16 tlrs tlrs NOUN x059c536z9s 15 17 , , PUNCT x059c536z9s 15 18 are be AUX x059c536z9s 15 19 all all ADV x059c536z9s 15 20 necessary necessary ADJ x059c536z9s 15 21 for for ADP x059c536z9s 15 22 delaying delay VERB x059c536z9s 15 23 phagosome phagosome ADJ x059c536z9s 15 24 maturation maturation NOUN x059c536z9s 15 25 and and CCONJ x059c536z9s 15 26 none none NOUN x059c536z9s 15 27 of of ADP x059c536z9s 15 28 these these DET x059c536z9s 15 29 receptor receptor NOUN x059c536z9s 15 30 deficient deficient ADJ x059c536z9s 15 31 macrophages macrophage NOUN x059c536z9s 15 32 exhibit exhibit VERB x059c536z9s 15 33 actin actin NOUN x059c536z9s 15 34 retention retention NOUN x059c536z9s 15 35 around around ADP x059c536z9s 15 36 leishmania leishmania PROPN x059c536z9s 15 37 phagosomes phagosome NOUN x059c536z9s 15 38 . . PUNCT x059c536z9s 16 1 using use VERB x059c536z9s 16 2 different different ADJ x059c536z9s 16 3 serum serum NOUN x059c536z9s 16 4 components component NOUN x059c536z9s 16 5 such such ADJ x059c536z9s 16 6 as as ADP x059c536z9s 16 7 complement complement NOUN x059c536z9s 16 8 and and CCONJ x059c536z9s 16 9 antileishmania antileishmania PROPN x059c536z9s 16 10 antibodies antibody NOUN x059c536z9s 16 11 allowed allow VERB x059c536z9s 16 12 us we PRON x059c536z9s 16 13 to to PART x059c536z9s 16 14 force force VERB x059c536z9s 16 15 parasites parasite NOUN x059c536z9s 16 16 through through ADP x059c536z9s 16 17 certain certain ADJ x059c536z9s 16 18 receptors receptor NOUN x059c536z9s 16 19 . . PUNCT x059c536z9s 17 1 thus thus ADV x059c536z9s 17 2 , , PUNCT x059c536z9s 17 3 receptor receptor NOUN x059c536z9s 17 4 engagement engagement NOUN x059c536z9s 17 5 and and CCONJ x059c536z9s 17 6 opsonization opsonization NOUN x059c536z9s 17 7 both both PRON x059c536z9s 17 8 influence influence VERB x059c536z9s 17 9 leishmania leishmania PROPN x059c536z9s 17 10 phagosome phagosome ADJ x059c536z9s 17 11 maturation maturation NOUN x059c536z9s 17 12 and and CCONJ x059c536z9s 17 13 potentially potentially ADV x059c536z9s 17 14 parasite parasite ADJ x059c536z9s 17 15 survival survival NOUN x059c536z9s 17 16 . . PUNCT