id sid tid token lemma pos x633dz03j43 1 1 kidney kidney NOUN x633dz03j43 1 2 disease disease NOUN x633dz03j43 1 3 affects affect VERB x633dz03j43 1 4 300 300 NUM x633dz03j43 1 5 million million NUM x633dz03j43 1 6 people people NOUN x633dz03j43 1 7 worldwide worldwide ADV x633dz03j43 1 8 , , PUNCT x633dz03j43 1 9 representing represent VERB x633dz03j43 1 10 the the DET x633dz03j43 1 11 12th 12th ADJ x633dz03j43 1 12 leading lead VERB x633dz03j43 1 13 cause cause NOUN x633dz03j43 1 14 of of ADP x633dz03j43 1 15 death death NOUN x633dz03j43 1 16 . . PUNCT x633dz03j43 2 1 understanding understand VERB x633dz03j43 2 2 how how SCONJ x633dz03j43 2 3 nephrons nephron NOUN x633dz03j43 2 4 , , PUNCT x633dz03j43 2 5 the the DET x633dz03j43 2 6 simplest simple ADJ x633dz03j43 2 7 functional functional ADJ x633dz03j43 2 8 unit unit NOUN x633dz03j43 2 9 of of ADP x633dz03j43 2 10 the the DET x633dz03j43 2 11 kidney kidney NOUN x633dz03j43 2 12 , , PUNCT x633dz03j43 2 13 develop develop VERB x633dz03j43 2 14 will will AUX x633dz03j43 2 15 lend lend VERB x633dz03j43 2 16 insight insight NOUN x633dz03j43 2 17 into into ADP x633dz03j43 2 18 the the DET x633dz03j43 2 19 processes process NOUN x633dz03j43 2 20 that that PRON x633dz03j43 2 21 go go VERB x633dz03j43 2 22 awry awry ADJ x633dz03j43 2 23 during during ADP x633dz03j43 2 24 disease disease NOUN x633dz03j43 2 25 . . PUNCT x633dz03j43 3 1 the the DET x633dz03j43 3 2 zebrafish zebrafish NOUN x633dz03j43 3 3 pronephros pronephro NOUN x633dz03j43 3 4 provides provide VERB x633dz03j43 3 5 an an DET x633dz03j43 3 6 excellent excellent NOUN x633dz03j43 3 7 in in ADP x633dz03j43 3 8 vivo vivo ADJ x633dz03j43 3 9 system system NOUN x633dz03j43 3 10 for for ADP x633dz03j43 3 11 studying study VERB x633dz03j43 3 12 the the DET x633dz03j43 3 13 mechanisms mechanism NOUN x633dz03j43 3 14 of of ADP x633dz03j43 3 15 vertebrate vertebrate ADJ x633dz03j43 3 16 nephrogenesis nephrogenesis NOUN x633dz03j43 3 17 . . PUNCT x633dz03j43 4 1 when when SCONJ x633dz03j43 4 2 and and CCONJ x633dz03j43 4 3 how how SCONJ x633dz03j43 4 4 renal renal ADJ x633dz03j43 4 5 progenitors progenitor NOUN x633dz03j43 4 6 undergo undergo VERB x633dz03j43 4 7 tubulogenesis tubulogenesis NOUN x633dz03j43 4 8 to to PART x633dz03j43 4 9 form form VERB x633dz03j43 4 10 nephrons nephron NOUN x633dz03j43 4 11 is be AUX x633dz03j43 4 12 poorly poorly ADV x633dz03j43 4 13 understood understand VERB x633dz03j43 4 14 but but CCONJ x633dz03j43 4 15 is be AUX x633dz03j43 4 16 theorized theorize VERB x633dz03j43 4 17 to to PART x633dz03j43 4 18 involve involve VERB x633dz03j43 4 19 a a DET x633dz03j43 4 20 mesenchymal mesenchymal NOUN x633dz03j43 4 21 - - PUNCT x633dz03j43 4 22 to to ADP x633dz03j43 4 23 - - PUNCT x633dz03j43 4 24 epithelial epithelial ADJ x633dz03j43 4 25 transition transition NOUN x633dz03j43 4 26 ( ( PUNCT x633dz03j43 4 27 met meet VERB x633dz03j43 4 28 ) ) PUNCT x633dz03j43 4 29 . . PUNCT x633dz03j43 5 1 we we PRON x633dz03j43 5 2 determined determine VERB x633dz03j43 5 3 the the DET x633dz03j43 5 4 precise precise ADJ x633dz03j43 5 5 timing timing NOUN x633dz03j43 5 6 of of ADP x633dz03j43 5 7 these these DET x633dz03j43 5 8 events event NOUN x633dz03j43 5 9 in in ADP x633dz03j43 5 10 pronephros pronephros PROPN x633dz03j43 5 11 tubulogenesis tubulogenesis NOUN x633dz03j43 5 12 , , PUNCT x633dz03j43 5 13 including include VERB x633dz03j43 5 14 the the DET x633dz03j43 5 15 temporal temporal ADJ x633dz03j43 5 16 and and CCONJ x633dz03j43 5 17 spatial spatial ADJ x633dz03j43 5 18 expression expression NOUN x633dz03j43 5 19 of of ADP x633dz03j43 5 20 tight tight ADJ x633dz03j43 5 21 junction junction NOUN x633dz03j43 5 22 genes gene NOUN x633dz03j43 5 23 . . PUNCT x633dz03j43 6 1 as as SCONJ x633dz03j43 6 2 the the DET x633dz03j43 6 3 ternary ternary ADJ x633dz03j43 6 4 polarity polarity NOUN x633dz03j43 6 5 complex complex NOUN x633dz03j43 6 6 is be AUX x633dz03j43 6 7 an an DET x633dz03j43 6 8 essential essential ADJ x633dz03j43 6 9 regulator regulator NOUN x633dz03j43 6 10 of of ADP x633dz03j43 6 11 epithelial epithelial ADJ x633dz03j43 6 12 cell cell NOUN x633dz03j43 6 13 polarity polarity NOUN x633dz03j43 6 14 across across ADP x633dz03j43 6 15 tissues tissue NOUN x633dz03j43 6 16 , , PUNCT x633dz03j43 6 17 we we PRON x633dz03j43 6 18 performed perform VERB x633dz03j43 6 19 knockdown knockdown NOUN x633dz03j43 6 20 studies study NOUN x633dz03j43 6 21 to to PART x633dz03j43 6 22 assess assess VERB x633dz03j43 6 23 the the DET x633dz03j43 6 24 roles role NOUN x633dz03j43 6 25 of of ADP x633dz03j43 6 26 the the DET x633dz03j43 6 27 related related ADJ x633dz03j43 6 28 factors factor NOUN x633dz03j43 6 29 atypical atypical ADJ x633dz03j43 6 30 protein protein NOUN x633dz03j43 6 31 kinase kinase NOUN x633dz03j43 6 32 c c X x633dz03j43 6 33 iota iota NOUN x633dz03j43 6 34 and and CCONJ x633dz03j43 6 35 zeta zeta NOUN x633dz03j43 6 36 ( ( PUNCT x633dz03j43 6 37 prkcι prkcι NOUN x633dz03j43 6 38 ; ; PUNCT x633dz03j43 6 39 , , PUNCT x633dz03j43 6 40 prkcζ prkcζ PROPN x633dz03j43 6 41 ;) ;) PUNCT x633dz03j43 6 42 . . PUNCT x633dz03j43 7 1 we we PRON x633dz03j43 7 2 found find VERB x633dz03j43 7 3 that that SCONJ x633dz03j43 7 4 prkcι prkcι NOUN x633dz03j43 7 5 ; ; PUNCT x633dz03j43 7 6 and and CCONJ x633dz03j43 7 7 prkcζserve prkcζserve VERB x633dz03j43 7 8 partially partially ADV x633dz03j43 7 9 redundant redundant ADJ x633dz03j43 7 10 functions function NOUN x633dz03j43 7 11 to to PART x633dz03j43 7 12 establish establish VERB x633dz03j43 7 13 polarity polarity NOUN x633dz03j43 7 14 in in ADP x633dz03j43 7 15 the the DET x633dz03j43 7 16 nephron nephron PROPN x633dz03j43 7 17 tubule tubule NOUN x633dz03j43 7 18 . . PUNCT x633dz03j43 8 1 surprisingly surprisingly ADV x633dz03j43 8 2 , , PUNCT x633dz03j43 8 3 tubule tubule NOUN x633dz03j43 8 4 cells cell NOUN x633dz03j43 8 5 in in ADP x633dz03j43 8 6 prkcι/ζ prkcι/ζ NOUN x633dz03j43 8 7 ; ; PUNCT x633dz03j43 8 8 morphants morphant NOUN x633dz03j43 8 9 displayed display VERB x633dz03j43 8 10 ectopic ectopic ADJ x633dz03j43 8 11 expression expression NOUN x633dz03j43 8 12 of of ADP x633dz03j43 8 13 the the DET x633dz03j43 8 14 transcription transcription NOUN x633dz03j43 8 15 factor factor NOUN x633dz03j43 8 16 pax2a pax2a PROPN x633dz03j43 8 17 and and CCONJ x633dz03j43 8 18 the the DET x633dz03j43 8 19 podocyte podocyte NOUN x633dz03j43 8 20 - - PUNCT x633dz03j43 8 21 associated associate VERB x633dz03j43 8 22 genes gene NOUN x633dz03j43 8 23 wt1a wt1a PROPN x633dz03j43 8 24 , , PUNCT x633dz03j43 8 25 wt1b wt1b PROPN x633dz03j43 8 26 , , PUNCT x633dz03j43 8 27 and and CCONJ x633dz03j43 8 28 podxl podxl PROPN x633dz03j43 8 29 , , PUNCT x633dz03j43 8 30 suggesting suggest VERB x633dz03j43 8 31 that that SCONJ x633dz03j43 8 32 prkcι/ζ prkcι/ζ NOUN x633dz03j43 8 33 ; ; PUNCT x633dz03j43 8 34 are be AUX x633dz03j43 8 35 needed need VERB x633dz03j43 8 36 to to PART x633dz03j43 8 37 maintain maintain VERB x633dz03j43 8 38 renal renal ADJ x633dz03j43 8 39 epithelial epithelial ADJ x633dz03j43 8 40 identity identity NOUN x633dz03j43 8 41 . . PUNCT x633dz03j43 9 1 we we PRON x633dz03j43 9 2 identified identify VERB x633dz03j43 9 3 cell cell NOUN x633dz03j43 9 4 polarity polarity NOUN x633dz03j43 9 5 as as ADP x633dz03j43 9 6 serving serve VERB x633dz03j43 9 7 a a DET x633dz03j43 9 8 specific specific ADJ x633dz03j43 9 9 role role NOUN x633dz03j43 9 10 in in ADP x633dz03j43 9 11 maintaining maintain VERB x633dz03j43 9 12 epithelial epithelial ADJ x633dz03j43 9 13 integrity integrity NOUN x633dz03j43 9 14 and and CCONJ x633dz03j43 9 15 not not PART x633dz03j43 9 16 a a DET x633dz03j43 9 17 pleiotropic pleiotropic ADJ x633dz03j43 9 18 effect effect NOUN x633dz03j43 9 19 caused cause VERB x633dz03j43 9 20 by by ADP x633dz03j43 9 21 loss loss NOUN x633dz03j43 9 22 of of ADP x633dz03j43 9 23 cardiac cardiac ADJ x633dz03j43 9 24 contractility contractility NOUN x633dz03j43 9 25 and/or and/or CCONJ x633dz03j43 9 26 fluid fluid ADJ x633dz03j43 9 27 flow flow NOUN x633dz03j43 9 28 . . PUNCT x633dz03j43 10 1 pax2a pax2a PROPN x633dz03j43 10 2 knockdown knockdown NOUN x633dz03j43 10 3 was be AUX x633dz03j43 10 4 sufficient sufficient ADJ x633dz03j43 10 5 to to PART x633dz03j43 10 6 rescue rescue VERB x633dz03j43 10 7 ectopic ectopic ADJ x633dz03j43 10 8 tubule tubule NOUN x633dz03j43 10 9 gene gene NOUN x633dz03j43 10 10 expression expression NOUN x633dz03j43 10 11 in in ADP x633dz03j43 10 12 prkcι/ζ prkcι/ζ NOUN x633dz03j43 10 13 ; ; PUNCT x633dz03j43 10 14 morphants morphant NOUN x633dz03j43 10 15 . . PUNCT x633dz03j43 11 1 these these DET x633dz03j43 11 2 data datum NOUN x633dz03j43 11 3 suggest suggest VERB x633dz03j43 11 4 a a DET x633dz03j43 11 5 model model NOUN x633dz03j43 11 6 whereby whereby SCONJ x633dz03j43 11 7 the the DET x633dz03j43 11 8 redundant redundant ADJ x633dz03j43 11 9 activities activity NOUN x633dz03j43 11 10 of of ADP x633dz03j43 11 11 prkcι prkcι NOUN x633dz03j43 11 12 ; ; PUNCT x633dz03j43 11 13 and and CCONJ x633dz03j43 11 14 prkcζ prkcζ VERB x633dz03j43 11 15 ; ; PUNCT x633dz03j43 11 16 are be AUX x633dz03j43 11 17 essential essential ADJ x633dz03j43 11 18 to to PART x633dz03j43 11 19 maintain maintain VERB x633dz03j43 11 20 proper proper ADJ x633dz03j43 11 21 epithelial epithelial ADJ x633dz03j43 11 22 cell cell NOUN x633dz03j43 11 23 type type NOUN x633dz03j43 11 24 identity identity NOUN x633dz03j43 11 25 through through ADP x633dz03j43 11 26 inhibition inhibition NOUN x633dz03j43 11 27 of of ADP x633dz03j43 11 28 pax2a pax2a PROPN x633dz03j43 11 29 expression expression NOUN x633dz03j43 11 30 . . PUNCT x633dz03j43 12 1 pronephros pronephro NOUN x633dz03j43 12 2 segment segment NOUN x633dz03j43 12 3 patterning patterning NOUN x633dz03j43 12 4 was be AUX x633dz03j43 12 5 initially initially ADV x633dz03j43 12 6 intact intact ADJ x633dz03j43 12 7 in in ADP x633dz03j43 12 8 prkcι/ζ prkcι/ζ NOUN x633dz03j43 12 9 ; ; PUNCT x633dz03j43 12 10 morphant morphant NOUN x633dz03j43 12 11 embryos embryo NOUN x633dz03j43 12 12 suggesting suggest VERB x633dz03j43 12 13 that that SCONJ x633dz03j43 12 14 the the DET x633dz03j43 12 15 processes process NOUN x633dz03j43 12 16 of of ADP x633dz03j43 12 17 epithelialization epithelialization NOUN x633dz03j43 12 18 and and CCONJ x633dz03j43 12 19 nephron nephron NOUN x633dz03j43 12 20 patterning patterning NOUN x633dz03j43 12 21 occur occur VERB x633dz03j43 12 22 independent independent ADJ x633dz03j43 12 23 of of ADP x633dz03j43 12 24 one one NUM x633dz03j43 12 25 another another DET x633dz03j43 12 26 . . PUNCT x633dz03j43 13 1 to to PART x633dz03j43 13 2 better well ADV x633dz03j43 13 3 understand understand VERB x633dz03j43 13 4 the the DET x633dz03j43 13 5 conserved conserved ADJ x633dz03j43 13 6 patterning patterning NOUN x633dz03j43 13 7 of of ADP x633dz03j43 13 8 the the DET x633dz03j43 13 9 nephron nephron NOUN x633dz03j43 13 10 a a DET x633dz03j43 13 11 forward forward ADJ x633dz03j43 13 12 genetic genetic ADJ x633dz03j43 13 13 screen screen NOUN x633dz03j43 13 14 was be AUX x633dz03j43 13 15 performed perform VERB x633dz03j43 13 16 . . PUNCT x633dz03j43 14 1 mutants mutant NOUN x633dz03j43 14 2 with with ADP x633dz03j43 14 3 disrupted disrupt VERB x633dz03j43 14 4 pronephros pronephro NOUN x633dz03j43 14 5 patterning patterning NOUN x633dz03j43 14 6 were be AUX x633dz03j43 14 7 identified identify VERB x633dz03j43 14 8 by by ADP x633dz03j43 14 9 whole whole ADJ x633dz03j43 14 10 mount mount NOUN x633dz03j43 14 11 in in ADP x633dz03j43 14 12 situ situ NOUN x633dz03j43 14 13 hybridization hybridization NOUN x633dz03j43 14 14 ( ( PUNCT x633dz03j43 14 15 wish wish PROPN x633dz03j43 14 16 ) ) PUNCT x633dz03j43 14 17 analysis analysis NOUN x633dz03j43 14 18 . . PUNCT x633dz03j43 15 1 one one NUM x633dz03j43 15 2 mutant mutant NOUN x633dz03j43 15 3 exhibited exhibit VERB x633dz03j43 15 4 an an DET x633dz03j43 15 5 aberrant aberrant ADJ x633dz03j43 15 6 distal distal ADJ x633dz03j43 15 7 early early ADJ x633dz03j43 15 8 tubule tubule NOUN x633dz03j43 15 9 segment segment NOUN x633dz03j43 15 10 . . PUNCT x633dz03j43 16 1 dysfunction dysfunction NOUN x633dz03j43 16 2 of of ADP x633dz03j43 16 3 the the DET x633dz03j43 16 4 analogous analogous ADJ x633dz03j43 16 5 human human PROPN x633dz03j43 16 6 nephron nephron PROPN x633dz03j43 16 7 segment segment NOUN x633dz03j43 16 8 , , PUNCT x633dz03j43 16 9 termed term VERB x633dz03j43 16 10 the the DET x633dz03j43 16 11 thick thick ADJ x633dz03j43 16 12 ascending ascend VERB x633dz03j43 16 13 limb limb NOUN x633dz03j43 16 14 ( ( PUNCT x633dz03j43 16 15 tal tal PROPN x633dz03j43 16 16 ) ) PUNCT x633dz03j43 16 17 , , PUNCT x633dz03j43 16 18 is be AUX x633dz03j43 16 19 associated associate VERB x633dz03j43 16 20 with with ADP x633dz03j43 16 21 gitelman gitelman PROPN x633dz03j43 16 22 and and CCONJ x633dz03j43 16 23 bartter?s bartter?s PROPN x633dz03j43 16 24 syndrome syndrome NOUN x633dz03j43 16 25 , , PUNCT x633dz03j43 16 26 kidney kidney NOUN x633dz03j43 16 27 stone stone NOUN x633dz03j43 16 28 accumulation accumulation NOUN x633dz03j43 16 29 , , PUNCT x633dz03j43 16 30 and and CCONJ x633dz03j43 16 31 hypertension hypertension NOUN x633dz03j43 16 32 . . PUNCT x633dz03j43 17 1 these these DET x633dz03j43 17 2 studies study NOUN x633dz03j43 17 3 provide provide VERB x633dz03j43 17 4 a a DET x633dz03j43 17 5 foundation foundation NOUN x633dz03j43 17 6 for for ADP x633dz03j43 17 7 further further ADJ x633dz03j43 17 8 analysis analysis NOUN x633dz03j43 17 9 of of ADP x633dz03j43 17 10 met meet VERB x633dz03j43 17 11 during during ADP x633dz03j43 17 12 nephrogenesis nephrogenesis NOUN x633dz03j43 17 13 and and CCONJ x633dz03j43 17 14 have have VERB x633dz03j43 17 15 implications implication NOUN x633dz03j43 17 16 for for ADP x633dz03j43 17 17 understanding understand VERB x633dz03j43 17 18 nephron nephron NOUN x633dz03j43 17 19 epithelial epithelial ADJ x633dz03j43 17 20 cells cell NOUN x633dz03j43 17 21 during during ADP x633dz03j43 17 22 kidney kidney NOUN x633dz03j43 17 23 disease disease NOUN x633dz03j43 17 24 and and CCONJ x633dz03j43 17 25 regeneration regeneration NOUN x633dz03j43 17 26 . . PUNCT