id sid tid token lemma pos zp38w953s9c 1 1 during during ADP zp38w953s9c 1 2 metastasis metastasis NOUN zp38w953s9c 1 3 , , PUNCT zp38w953s9c 1 4 tumor tumor NOUN zp38w953s9c 1 5 cells cell NOUN zp38w953s9c 1 6 dissociate dissociate VERB zp38w953s9c 1 7 from from ADP zp38w953s9c 1 8 the the DET zp38w953s9c 1 9 primary primary ADJ zp38w953s9c 1 10 tumor tumor NOUN zp38w953s9c 1 11 , , PUNCT zp38w953s9c 1 12 disseminate disseminate VERB zp38w953s9c 1 13 through through ADP zp38w953s9c 1 14 the the DET zp38w953s9c 1 15 vasculature vasculature NOUN zp38w953s9c 1 16 , , PUNCT zp38w953s9c 1 17 arrest arrest NOUN zp38w953s9c 1 18 in in ADP zp38w953s9c 1 19 the the DET zp38w953s9c 1 20 capillary capillary ADJ zp38w953s9c 1 21 bed bed NOUN zp38w953s9c 1 22 , , PUNCT zp38w953s9c 1 23 and and CCONJ zp38w953s9c 1 24 colonize colonize VERB zp38w953s9c 1 25 secondary secondary ADJ zp38w953s9c 1 26 organs organ NOUN zp38w953s9c 1 27 . . PUNCT zp38w953s9c 2 1 although although SCONJ zp38w953s9c 2 2 at at ADP zp38w953s9c 2 3 all all PRON zp38w953s9c 2 4 of of ADP zp38w953s9c 2 5 these these DET zp38w953s9c 2 6 stages stage NOUN zp38w953s9c 2 7 surviving survive VERB zp38w953s9c 2 8 tumor tumor NOUN zp38w953s9c 2 9 cells cell NOUN zp38w953s9c 2 10 hold hold VERB zp38w953s9c 2 11 a a DET zp38w953s9c 2 12 potential potential NOUN zp38w953s9c 2 13 for for ADP zp38w953s9c 2 14 colonization colonization NOUN zp38w953s9c 2 15 , , PUNCT zp38w953s9c 2 16 mechanical mechanical ADJ zp38w953s9c 2 17 arrest arrest NOUN zp38w953s9c 2 18 is be AUX zp38w953s9c 2 19 particularly particularly ADV zp38w953s9c 2 20 important important ADJ zp38w953s9c 2 21 since since SCONJ zp38w953s9c 2 22 cell cell NOUN zp38w953s9c 2 23 entrapment entrapment NOUN zp38w953s9c 2 24 is be AUX zp38w953s9c 2 25 absolutely absolutely ADV zp38w953s9c 2 26 necessary necessary ADJ zp38w953s9c 2 27 for for ADP zp38w953s9c 2 28 tumor tumor NOUN zp38w953s9c 2 29 outgrowth outgrowth NOUN zp38w953s9c 2 30 . . PUNCT zp38w953s9c 3 1 however however ADV zp38w953s9c 3 2 , , PUNCT zp38w953s9c 3 3 the the DET zp38w953s9c 3 4 subcellular subcellular ADJ zp38w953s9c 3 5 response response NOUN zp38w953s9c 3 6 of of ADP zp38w953s9c 3 7 circulating circulate VERB zp38w953s9c 3 8 tumor tumor NOUN zp38w953s9c 3 9 cells cell NOUN zp38w953s9c 3 10 ( ( PUNCT zp38w953s9c 3 11 ctcs ctcs NOUN zp38w953s9c 3 12 ) ) PUNCT zp38w953s9c 3 13 to to ADP zp38w953s9c 3 14 the the DET zp38w953s9c 3 15 extreme extreme ADJ zp38w953s9c 3 16 shear shear ADJ zp38w953s9c 3 17 stress stress NOUN zp38w953s9c 3 18 exerted exert VERB zp38w953s9c 3 19 during during ADP zp38w953s9c 3 20 transit transit NOUN zp38w953s9c 3 21 through through ADP zp38w953s9c 3 22 the the DET zp38w953s9c 3 23 vasculature vasculature NOUN zp38w953s9c 3 24 prior prior ADV zp38w953s9c 3 25 to to ADP zp38w953s9c 3 26 and and CCONJ zp38w953s9c 3 27 during during ADP zp38w953s9c 3 28 mechanical mechanical ADJ zp38w953s9c 3 29 arrest arrest NOUN zp38w953s9c 3 30 remains remain VERB zp38w953s9c 3 31 largely largely ADV zp38w953s9c 3 32 unknown unknown ADJ zp38w953s9c 3 33 . . PUNCT zp38w953s9c 4 1 in in ADP zp38w953s9c 4 2 this this DET zp38w953s9c 4 3 work work NOUN zp38w953s9c 4 4 , , PUNCT zp38w953s9c 4 5 we we PRON zp38w953s9c 4 6 present present VERB zp38w953s9c 4 7 an an DET zp38w953s9c 4 8 integrative integrative ADJ zp38w953s9c 4 9 platform platform NOUN zp38w953s9c 4 10 that that PRON zp38w953s9c 4 11 combines combine VERB zp38w953s9c 4 12 the the DET zp38w953s9c 4 13 use use NOUN zp38w953s9c 4 14 of of ADP zp38w953s9c 4 15 a a DET zp38w953s9c 4 16 microfluidic microfluidic ADJ zp38w953s9c 4 17 device device NOUN zp38w953s9c 4 18 and and CCONJ zp38w953s9c 4 19 a a DET zp38w953s9c 4 20 computational computational ADJ zp38w953s9c 4 21 model model NOUN zp38w953s9c 4 22 . . PUNCT zp38w953s9c 5 1 together together ADV zp38w953s9c 5 2 , , PUNCT zp38w953s9c 5 3 they they PRON zp38w953s9c 5 4 serve serve VERB zp38w953s9c 5 5 as as ADP zp38w953s9c 5 6 a a DET zp38w953s9c 5 7 tunable tunable ADJ zp38w953s9c 5 8 system system NOUN zp38w953s9c 5 9 to to PART zp38w953s9c 5 10 reliably reliably ADV zp38w953s9c 5 11 reproduce reproduce VERB zp38w953s9c 5 12 the the DET zp38w953s9c 5 13 mechanical mechanical ADJ zp38w953s9c 5 14 arrest arrest NOUN zp38w953s9c 5 15 of of ADP zp38w953s9c 5 16 tumor tumor NOUN zp38w953s9c 5 17 cells cell NOUN zp38w953s9c 5 18 and and CCONJ zp38w953s9c 5 19 quantitatively quantitatively ADV zp38w953s9c 5 20 determine determine VERB zp38w953s9c 5 21 their their PRON zp38w953s9c 5 22 physical physical ADJ zp38w953s9c 5 23 response response NOUN zp38w953s9c 5 24 to to ADP zp38w953s9c 5 25 precisely precisely ADV zp38w953s9c 5 26 controlled control VERB zp38w953s9c 5 27 shear shear ADJ zp38w953s9c 5 28 stress stress NOUN zp38w953s9c 5 29 . . PUNCT zp38w953s9c 6 1 the the DET zp38w953s9c 6 2 design design NOUN zp38w953s9c 6 3 of of ADP zp38w953s9c 6 4 our our PRON zp38w953s9c 6 5 platform platform NOUN zp38w953s9c 6 6 is be AUX zp38w953s9c 6 7 based base VERB zp38w953s9c 6 8 on on ADP zp38w953s9c 6 9 biological biological ADJ zp38w953s9c 6 10 observations observation NOUN zp38w953s9c 6 11 of of ADP zp38w953s9c 6 12 ctc ctc NOUN zp38w953s9c 6 13 arrest arrest NOUN zp38w953s9c 6 14 within within ADP zp38w953s9c 6 15 the the DET zp38w953s9c 6 16 mouse mouse NOUN zp38w953s9c 6 17 brain brain NOUN zp38w953s9c 6 18 microcapillary microcapillary ADJ zp38w953s9c 6 19 bed bed NOUN zp38w953s9c 6 20 , , PUNCT zp38w953s9c 6 21 and and CCONJ zp38w953s9c 6 22 was be AUX zp38w953s9c 6 23 validated validate VERB zp38w953s9c 6 24 to to PART zp38w953s9c 6 25 be be AUX zp38w953s9c 6 26 physiologically physiologically ADV zp38w953s9c 6 27 relevant relevant ADJ zp38w953s9c 6 28 for for ADP zp38w953s9c 6 29 the the DET zp38w953s9c 6 30 animal animal NOUN zp38w953s9c 6 31 model model NOUN zp38w953s9c 6 32 used use VERB zp38w953s9c 6 33 . . PUNCT zp38w953s9c 7 1 using use VERB zp38w953s9c 7 2 this this DET zp38w953s9c 7 3 platform platform NOUN zp38w953s9c 7 4 , , PUNCT zp38w953s9c 7 5 we we PRON zp38w953s9c 7 6 show show VERB zp38w953s9c 7 7 for for ADP zp38w953s9c 7 8 the the DET zp38w953s9c 7 9 first first ADJ zp38w953s9c 7 10 time time NOUN zp38w953s9c 7 11 , , PUNCT zp38w953s9c 7 12 an an DET zp38w953s9c 7 13 insight insight NOUN zp38w953s9c 7 14 into into ADP zp38w953s9c 7 15 subcellular subcellular ADJ zp38w953s9c 7 16 responses response NOUN zp38w953s9c 7 17 of of ADP zp38w953s9c 7 18 ctcs ctcs NOUN zp38w953s9c 7 19 at at ADP zp38w953s9c 7 20 the the DET zp38w953s9c 7 21 stage stage NOUN zp38w953s9c 7 22 of of ADP zp38w953s9c 7 23 mechanical mechanical ADJ zp38w953s9c 7 24 arrest arrest NOUN zp38w953s9c 7 25 . . PUNCT zp38w953s9c 8 1 we we PRON zp38w953s9c 8 2 found find VERB zp38w953s9c 8 3 that that SCONJ zp38w953s9c 8 4 during during ADP zp38w953s9c 8 5 mechanical mechanical ADJ zp38w953s9c 8 6 arrest arrest NOUN zp38w953s9c 8 7 single single ADJ zp38w953s9c 8 8 tumor tumor NOUN zp38w953s9c 8 9 cells cell NOUN zp38w953s9c 8 10 experience experience VERB zp38w953s9c 8 11 extreme extreme ADJ zp38w953s9c 8 12 morphological morphological ADJ zp38w953s9c 8 13 deformations deformation NOUN zp38w953s9c 8 14 , , PUNCT zp38w953s9c 8 15 an an DET zp38w953s9c 8 16 increase increase NOUN zp38w953s9c 8 17 in in ADP zp38w953s9c 8 18 membrane membrane NOUN zp38w953s9c 8 19 stress stress NOUN zp38w953s9c 8 20 , , PUNCT zp38w953s9c 8 21 and and CCONJ zp38w953s9c 8 22 increased increase VERB zp38w953s9c 8 23 mitochondrial mitochondrial ADJ zp38w953s9c 8 24 fission fission NOUN zp38w953s9c 8 25 , , PUNCT zp38w953s9c 8 26 all all ADV zp38w953s9c 8 27 dependent dependent ADJ zp38w953s9c 8 28 on on ADP zp38w953s9c 8 29 the the DET zp38w953s9c 8 30 magnitude magnitude NOUN zp38w953s9c 8 31 of of ADP zp38w953s9c 8 32 fluid fluid ADJ zp38w953s9c 8 33 shear shear ADJ zp38w953s9c 8 34 stress stress NOUN zp38w953s9c 8 35 applied apply VERB zp38w953s9c 8 36 . . PUNCT zp38w953s9c 9 1 in in ADP zp38w953s9c 9 2 this this DET zp38w953s9c 9 3 work work NOUN zp38w953s9c 9 4 , , PUNCT zp38w953s9c 9 5 we we PRON zp38w953s9c 9 6 demonstrated demonstrate VERB zp38w953s9c 9 7 for for ADP zp38w953s9c 9 8 the the DET zp38w953s9c 9 9 first first ADJ zp38w953s9c 9 10 time time NOUN zp38w953s9c 9 11 that that PRON zp38w953s9c 9 12 shear shear ADJ zp38w953s9c 9 13 stress stress NOUN zp38w953s9c 9 14 can can AUX zp38w953s9c 9 15 trigger trigger VERB zp38w953s9c 9 16 mitochondrial mitochondrial ADJ zp38w953s9c 9 17 fragmentation fragmentation NOUN zp38w953s9c 9 18 in in ADP zp38w953s9c 9 19 ctcs ctcs NOUN zp38w953s9c 9 20 , , PUNCT zp38w953s9c 9 21 followed follow VERB zp38w953s9c 9 22 by by ADP zp38w953s9c 9 23 increased increase VERB zp38w953s9c 9 24 cleavage cleavage NOUN zp38w953s9c 9 25 of of ADP zp38w953s9c 9 26 pink1 pink1 PROPN zp38w953s9c 9 27 , , PUNCT zp38w953s9c 9 28 which which PRON zp38w953s9c 9 29 together together ADV zp38w953s9c 9 30 serve serve VERB zp38w953s9c 9 31 as as ADP zp38w953s9c 9 32 a a DET zp38w953s9c 9 33 self self NOUN zp38w953s9c 9 34 - - PUNCT zp38w953s9c 9 35 protective protective ADJ zp38w953s9c 9 36 mechanism mechanism NOUN zp38w953s9c 9 37 to to PART zp38w953s9c 9 38 inhibit inhibit VERB zp38w953s9c 9 39 mitochondrial mitochondrial ADJ zp38w953s9c 9 40 clearance clearance NOUN zp38w953s9c 9 41 . . PUNCT zp38w953s9c 10 1 a a DET zp38w953s9c 10 2 key key ADJ zp38w953s9c 10 3 finding finding NOUN zp38w953s9c 10 4 presented present VERB zp38w953s9c 10 5 in in ADP zp38w953s9c 10 6 this this DET zp38w953s9c 10 7 work work NOUN zp38w953s9c 10 8 is be AUX zp38w953s9c 10 9 the the DET zp38w953s9c 10 10 regulatory regulatory ADJ zp38w953s9c 10 11 role role NOUN zp38w953s9c 10 12 that that PRON zp38w953s9c 10 13 pten pten NOUN zp38w953s9c 10 14 has have VERB zp38w953s9c 10 15 on on ADP zp38w953s9c 10 16 maintaining maintain VERB zp38w953s9c 10 17 the the DET zp38w953s9c 10 18 mitochondrial mitochondrial ADJ zp38w953s9c 10 19 network network NOUN zp38w953s9c 10 20 structure structure NOUN zp38w953s9c 10 21 and and CCONJ zp38w953s9c 10 22 continued continued ADJ zp38w953s9c 10 23 mitophagy mitophagy NOUN zp38w953s9c 10 24 . . PUNCT zp38w953s9c 11 1 loss loss NOUN zp38w953s9c 11 2 of of ADP zp38w953s9c 11 3 pten pten NOUN zp38w953s9c 11 4 resulted result VERB zp38w953s9c 11 5 in in ADP zp38w953s9c 11 6 increased increase VERB zp38w953s9c 11 7 mitochondrial mitochondrial ADJ zp38w953s9c 11 8 fission fission NOUN zp38w953s9c 11 9 and and CCONJ zp38w953s9c 11 10 parkin parkin NOUN zp38w953s9c 11 11 downregulation downregulation NOUN zp38w953s9c 11 12 , , PUNCT zp38w953s9c 11 13 which which PRON zp38w953s9c 11 14 together together ADV zp38w953s9c 11 15 with with ADP zp38w953s9c 11 16 the the DET zp38w953s9c 11 17 cleavage cleavage NOUN zp38w953s9c 11 18 of of ADP zp38w953s9c 11 19 pink1 pink1 NOUN zp38w953s9c 11 20 demonstrate demonstrate VERB zp38w953s9c 11 21 enhanced enhance VERB zp38w953s9c 11 22 protection protection NOUN zp38w953s9c 11 23 from from ADP zp38w953s9c 11 24 mitophagy mitophagy NOUN zp38w953s9c 11 25 upon upon SCONJ zp38w953s9c 11 26 exposure exposure NOUN zp38w953s9c 11 27 of of ADP zp38w953s9c 11 28 ctcs ctcs NOUN zp38w953s9c 11 29 to to ADP zp38w953s9c 11 30 shear shear ADJ zp38w953s9c 11 31 stress stress NOUN zp38w953s9c 11 32 , , PUNCT zp38w953s9c 11 33 suggesting suggest VERB zp38w953s9c 11 34 it it PRON zp38w953s9c 11 35 as as ADP zp38w953s9c 11 36 a a DET zp38w953s9c 11 37 self self NOUN zp38w953s9c 11 38 - - PUNCT zp38w953s9c 11 39 protective protective ADJ zp38w953s9c 11 40 mechanism mechanism NOUN zp38w953s9c 11 41 to to PART zp38w953s9c 11 42 inhibit inhibit VERB zp38w953s9c 11 43 mitochondrial mitochondrial ADJ zp38w953s9c 11 44 clearance clearance NOUN zp38w953s9c 11 45 during during ADP zp38w953s9c 11 46 transit transit NOUN zp38w953s9c 11 47 through through ADP zp38w953s9c 11 48 the the DET zp38w953s9c 11 49 vasculature vasculature ADJ zp38w953s9c 11 50 and and CCONJ zp38w953s9c 11 51 mechanical mechanical ADJ zp38w953s9c 11 52 arrest arrest NOUN zp38w953s9c 11 53 . . PUNCT zp38w953s9c 12 1 although although SCONJ zp38w953s9c 12 2 not not PART zp38w953s9c 12 3 fully fully ADV zp38w953s9c 12 4 investigated investigate VERB zp38w953s9c 12 5 in in ADP zp38w953s9c 12 6 this this DET zp38w953s9c 12 7 work work NOUN zp38w953s9c 12 8 , , PUNCT zp38w953s9c 12 9 mitochondrial mitochondrial ADJ zp38w953s9c 12 10 fission fission NOUN zp38w953s9c 12 11 is be AUX zp38w953s9c 12 12 speculated speculate VERB zp38w953s9c 12 13 to to PART zp38w953s9c 12 14 be be AUX zp38w953s9c 12 15 drp1 drp1 NOUN zp38w953s9c 12 16 independent independent ADJ zp38w953s9c 12 17 . . PUNCT zp38w953s9c 13 1 an an DET zp38w953s9c 13 2 interesting interesting ADJ zp38w953s9c 13 3 finding finding NOUN zp38w953s9c 13 4 was be AUX zp38w953s9c 13 5 the the DET zp38w953s9c 13 6 loss loss NOUN zp38w953s9c 13 7 of of ADP zp38w953s9c 13 8 viability viability NOUN zp38w953s9c 13 9 in in ADP zp38w953s9c 13 10 pten pten ADJ zp38w953s9c 13 11 deficient deficient ADJ zp38w953s9c 13 12 ctcs ctcs NOUN zp38w953s9c 13 13 , , PUNCT zp38w953s9c 13 14 which which PRON zp38w953s9c 13 15 opposes oppose VERB zp38w953s9c 13 16 the the DET zp38w953s9c 13 17 protective protective ADJ zp38w953s9c 13 18 role role NOUN zp38w953s9c 13 19 that that SCONJ zp38w953s9c 13 20 mitochondrial mitochondrial ADJ zp38w953s9c 13 21 fragmentation fragmentation NOUN zp38w953s9c 13 22 and and CCONJ zp38w953s9c 13 23 mitophagy mitophagy NOUN zp38w953s9c 13 24 inhibition inhibition NOUN zp38w953s9c 13 25 offer offer VERB zp38w953s9c 13 26 . . PUNCT zp38w953s9c 14 1 our our PRON zp38w953s9c 14 2 data datum NOUN zp38w953s9c 14 3 suggests suggest VERB zp38w953s9c 14 4 that that SCONJ zp38w953s9c 14 5 loss loss NOUN zp38w953s9c 14 6 of of ADP zp38w953s9c 14 7 pten pten NOUN zp38w953s9c 14 8 may may AUX zp38w953s9c 14 9 induce induce VERB zp38w953s9c 14 10 an an DET zp38w953s9c 14 11 increased increase VERB zp38w953s9c 14 12 fragility fragility NOUN zp38w953s9c 14 13 in in ADP zp38w953s9c 14 14 plasma plasma NOUN zp38w953s9c 14 15 membrane membrane NOUN zp38w953s9c 14 16 upon upon SCONJ zp38w953s9c 14 17 exposure exposure NOUN zp38w953s9c 14 18 to to ADP zp38w953s9c 14 19 shear shear ADJ zp38w953s9c 14 20 stress stress NOUN zp38w953s9c 14 21 , , PUNCT zp38w953s9c 14 22 while while SCONJ zp38w953s9c 14 23 simultaneously simultaneously ADV zp38w953s9c 14 24 activating activate VERB zp38w953s9c 14 25 pro pro ADJ zp38w953s9c 14 26 - - ADJ zp38w953s9c 14 27 survival survival ADJ zp38w953s9c 14 28 mitochondrial mitochondrial ADJ zp38w953s9c 14 29 dynamics dynamic NOUN zp38w953s9c 14 30 . . PUNCT zp38w953s9c 15 1 together together ADV zp38w953s9c 15 2 , , PUNCT zp38w953s9c 15 3 our our PRON zp38w953s9c 15 4 investigation investigation NOUN zp38w953s9c 15 5 brings bring VERB zp38w953s9c 15 6 out out ADP zp38w953s9c 15 7 a a DET zp38w953s9c 15 8 novel novel ADJ zp38w953s9c 15 9 mechanism mechanism NOUN zp38w953s9c 15 10 where where SCONJ zp38w953s9c 15 11 ctcs ctcs NOUN zp38w953s9c 15 12 show show VERB zp38w953s9c 15 13 an an DET zp38w953s9c 15 14 adaptive adaptive ADJ zp38w953s9c 15 15 response response NOUN zp38w953s9c 15 16 to to ADP zp38w953s9c 15 17 shear shear ADJ zp38w953s9c 15 18 stress stress NOUN zp38w953s9c 15 19 through through ADP zp38w953s9c 15 20 remodeling remodeling NOUN zp38w953s9c 15 21 of of ADP zp38w953s9c 15 22 mitochondria mitochondria NOUN zp38w953s9c 15 23 and and CCONJ zp38w953s9c 15 24 inhibition inhibition NOUN zp38w953s9c 15 25 of of ADP zp38w953s9c 15 26 mitophagy mitophagy NOUN zp38w953s9c 15 27 , , PUNCT zp38w953s9c 15 28 and and CCONJ zp38w953s9c 15 29 where where SCONJ zp38w953s9c 15 30 loss loss NOUN zp38w953s9c 15 31 of of ADP zp38w953s9c 15 32 pten pten NOUN zp38w953s9c 15 33 plays play VERB zp38w953s9c 15 34 an an DET zp38w953s9c 15 35 essential essential ADJ zp38w953s9c 15 36 role role NOUN zp38w953s9c 15 37 modulating modulate VERB zp38w953s9c 15 38 parkin parkin NOUN zp38w953s9c 15 39 expression expression NOUN zp38w953s9c 15 40 to to PART zp38w953s9c 15 41 sustain sustain VERB zp38w953s9c 15 42 cell cell NOUN zp38w953s9c 15 43 viability viability NOUN zp38w953s9c 15 44 during during ADP zp38w953s9c 15 45 transit transit NOUN zp38w953s9c 15 46 through through ADP zp38w953s9c 15 47 the the DET zp38w953s9c 15 48 vasculature vasculature ADJ zp38w953s9c 15 49 and and CCONJ zp38w953s9c 15 50 mechanical mechanical ADJ zp38w953s9c 15 51 arrest arrest NOUN zp38w953s9c 15 52 . . PUNCT