New paper describes important advance in imaging of cell death | News | Notre Dame News | University of Notre Dame Skip To Content Skip To Navigation Skip To Search University of Notre Dame Notre Dame News Experts ND in the News Subscribe About Us Home Contact Search Menu Home › News › New paper describes important advance in imaging of cell death New paper describes important advance in imaging of cell death Published: January 29, 2010 Author: William G. Gilroy For quite some time, the “Holy Grail” in medical imaging has been the development of an effective method to image cell death as a means to intervene early in diseases and rapidly determine the effectiveness of treatments. A new paper by researchers at the University of Notre Dame and the Washington University School of Medicine describes important progress in using a synthetic probe to target dead and dying cells in mammary and prostate tumors in living animals. Bradley D. Smith, Emil T. Hofman Professor of Chemistry and Biochemistry at Notre Dame, points out that the group of researchers had previously discovered that synthetic zinc (II)-dipicolylamine (Zn-DPA) coordination complexes can selectively target the outer surfaces of anionic (negatively charged) cell membranes. Furthermore, fluorescent versions of these Zn-DPA complexes act as imaging probes that can distinguish dead and dying mammalian cells from healthy cells in a cell culture and also selectively target bacteria in contaminated samples. The researchers also recently demonstrated that a fluorescent near-infrared probe referred to as PSS-794 can be used to image bacterial infections in mice, indicating that PSS-794 has a notable ability to selectively target anionic cells in living animals. In the new paper, the researchers describe a significant expansion of the animal imaging capability of PSS-794 by showing that it can target the anionic dead and dying cells within tumors in rat and mouse models. The research is an important step toward the development of optical imaging probes that could determine, noninvasively, the amount and type of cell death in tumors. Such imaging techniques could help clinicians accurately determine the grade of tumors and the stage of cancers, as well as to measure the effectiveness of treatments. The researchers also believe that analogous probes can be developed that would allow for deep tissue imaging of cancers in humans. Smith points out that although the study focused on mammary and prostate tumors, imaging of cell death is broadly useful for treatment of numerous conditions, including cardiovascular disease, neurology, renal disease and even transplant rejection. The research, described in the Journal of the American Chemical Society, was supported by the National Institutes of Health, Notre Dame’s Walther Cancer Center and the Notre Dame Integrated Imaging Facility. The Notre Dame Integrated Imaging Facility was created in 2008 with major funding from the University’s Strategic Academic Planning Committee. It serves the science and engineering research communities by integrating three areas of Notre Dame’s imaging expertise: electron microscopy, optical microscopy and in vivo imaging. Contact: Bradley D. Smith, Emil T. Hofman Professor of Chemistry and Biochemistry, 574-631-8632, smith.115@nd.edu Posted In: Research Home Experts ND in the News Subscribe About Us Related October 05, 2022 Astrophysicists find evidence for the presence of the first stars October 04, 2022 NIH awards $4 million grant to psychologists researching suicide prevention September 29, 2022 Notre Dame, Ukrainian Catholic University launch three new research grants September 27, 2022 Notre Dame, Trinity College Dublin engineers join to advance novel treatment for cystic fibrosis September 22, 2022 Climate-prepared countries are losing ground, latest ND-GAIN index shows For the Media Contact Office of Public Affairs and Communications Notre Dame News 500 Grace Hall Notre Dame, IN 46556 USA Facebook Twitter Instagram YouTube Pinterest © 2022 University of Notre Dame Search Mobile App News Events Visit Accessibility Facebook Twitter Instagram YouTube LinkedIn