Common cholesterol drugs could slow spread of breast cancer to brain | News | Notre Dame News | University of Notre Dame Skip To Content Skip To Navigation Skip To Search University of Notre Dame Notre Dame News Experts ND in the News Subscribe About Us Home Contact Search Menu Home › News › Common cholesterol drugs could slow spread of breast cancer to brain Common cholesterol drugs could slow spread of breast cancer to brain Published: June 16, 2020 Author: Deanna Csomo McCool Research. Photo by Matt Cashore/University of Notre Dame. A new study from the University of Notre Dame shows drugs used to treat high cholesterol could interfere with the way breast cancer cells adapt to the microenvironment in the brain, preventing the cancer from taking hold. Patients with breast cancer who experience this type of metastasis typically survive for only months after diagnosis. Statins, a group of drugs commonly prescribed for those with high cholesterol, were shown to interfere with a pathway that allows a cancer cell to recycle cell surface proteins and therefore make it easier for cancer cells to live within the brain. Siyuan Zhang “It normally takes a decade to develop new medications. Instead of waiting, we can repurpose medications people are already taking,” said Siyuan Zhang, the Dee Associate Professor in the Department of Biological Sciences, and principal investigator of the study published in Nature Communications. “Statins are relatively safe drugs, and they can even be given, if doctors choose, to try to prevent metastasis.” The protein Rab11b brings “recycled” proteins back to the surface like a fast-moving Ferris wheel, Zhang said. Statins suppress breast cancer survival in the brain by inhibiting the ability of Rab11b to recycle surface proteins. As a result of less recycling, the surface of metastatic tumor cells is less sticky. This limits the survival of cancer cells, and ultimately slows the rate of tumor colonization in the brain microenvironment. To complete the research, Zhang’s lab completed gene profiling to screen for genes that were functionally important in inhibiting the way tumor cells adapted to the brain, Zhang said. Then, they used a fruit fly tumor model to perform a genetic tumor growth screen, allowing the team to quickly narrow down a subset of genes that might be important for tumor formation in the brain. “We knew Rab11b sits downstream of an enzyme that is important for cholesterol synthesis, so once we recognized its role, we thought that statins could knock Rab11b back from its role in pushing the other proteins up to the surface in metastatic breast cancer in the brain,” said Zhang, who is affiliated with the Harper Cancer Research Institute. Zhang’s lab seeks uses of already-FDA-approved drugs to target cancer metastasis because they are already known to be safe, which allows for quicker testing without waiting several years for new therapeutics to be developed and tested. Collaborators on the study include lead author Erin Howe, a postdoctoral fellow in Zhang’s lab; Jeremiah J. Zartman, associate professor of chemical and biomolecular engineering, Crislyn D’Souza-Schorey, the Morris Pollard Professor in the Department of Biological Sciences, and Jun Li, associate professor in the Department of Applied and Computational Mathematics and Statistics at Notre Dame; Victoria Hedrick and Uma K. Aryal at Purdue University; former Notre Dame postdoctoral scholars Miranda Burnette, Patricia M. Schnepp, Ian Guldner, Alicia Lamere and James Clanc, and former undergraduate student Melanie Justice. Funding for the project was provided through an Advancing Basic Cancer Research Grant from the Walther Cancer Foundation, the Department of Defense and the National Institutes of Health.   Contact: Jessica Sieff, assistant director of media relations, 574-631-3933, jsieff@nd.edu Posted In: Research Home Experts ND in the News Subscribe About Us Related October 05, 2022 Astrophysicists find evidence for the presence of the first stars October 04, 2022 NIH awards $4 million grant to psychologists researching suicide prevention September 29, 2022 Notre Dame, Ukrainian Catholic University launch three new research grants September 27, 2022 Notre Dame, Trinity College Dublin engineers join to advance novel treatment for cystic fibrosis September 22, 2022 Climate-prepared countries are losing ground, latest ND-GAIN index shows For the Media Contact Office of Public Affairs and Communications Notre Dame News 500 Grace Hall Notre Dame, IN 46556 USA Facebook Twitter Instagram YouTube Pinterest © 2022 University of Notre Dame Search Mobile App News Events Visit Accessibility Facebook Twitter Instagram YouTube LinkedIn