Notre Dame research reveals brain network connections | News | Notre Dame News | University of Notre Dame Skip To Content Skip To Navigation Skip To Search University of Notre Dame Notre Dame News Experts ND in the News Subscribe About Us Home Contact Search Menu Home › News › Notre Dame research reveals brain network connections Notre Dame research reveals brain network connections Published: July 13, 2011 Author: Marissa Gebhard Research conducted by Maria Ercsey-Ravasz and Zoltan Toroczkai of the University of Notre Dame’s Interdisciplinary Center for Network Science and Applications (iCeNSA), along with the Department of Physics and a group of neuroanatomists in France, has revealed previously unknown information about the primate brain. The researchers published an article in the journal Cerebral Cortex showing that the brain is characterized by a highly consistent, weighted network among the functional areas of the cortex, which are responsible for such functions as vision, hearing, touch, movement control and complex associations. The study revealed that such cortical networks and their properties are reproducible from individual to individual. Ercsey-Ravasz, a postdoctoral associate, and Toroczkai, professor of physics, analyzed 70 man-years’ worth of data on macaque brains collected by a large group led by Henry Kennedy in Lyon, France. The Kennedy team injected ink tracers into a portion of the brain and scanned thin brain slices to track the movement of the chemical through the nerve cells’ branches, called axons, to the soma of the cells. Kennedy enlisted iCeNSA for its expertise at analyzing networks, which has also been applied to fields as diverse as the spread of disease and the social networks. Their analysis identified the consistency of connectivity among the areas of the brain. Ercsey-Ravasz, in a study of the data that will be included in a later paper, also has demonstrated that the number of connections is greatest between areas that are closest, and the number declines in a consistent pattern as distance increases. The regularity of the patterns from animal to animal suggests that the connections are necessary, and the fewer long-distance connections likely are control switches that coordinate or modulate information exchange amongst the brain areas. The study is part of a broader investigation of brain function and intelligence that has accelerated in recent years as researchers abandoned the once-promising analogy between computer circuitry and human intelligence, a project that stalled in the 1970s. “It turns out the brain is not just this beautiful circuitry you could just back-engineer,” Toroczkai says. “It is an amazingly complex system, and this is why it is very hard to understand why it works.” The adult primate brain contains 100 billion neurons with branches that connect at more than 100 trillion points. A top-down approach called functional decomposition, identifying bundles within the brain, helps overcome the sheer data volume. The macaque brain has 83 such areas; the human brain more than 120. “What we find is a network of connections between the functional areas,” Toroczkai says. “That’s important because we now have more detailed information about how the brain is wired on a large-scale, functional level.” Toroczkai and Ercsey-Ravasz will continue research in the field with US and international collaborators, aimed at understanding how information received through the senses and converted to electric pulses is processed in the brain. “It looks like there is some sort of general algorithm that is being run in this brain network,” he says. “The wiring is very strange. It is not something you would expect. It constitutes one of the major motivations for this study.” Contact: Zoltan Toroczkai , toro@nd.edu, 574-631-2618 Posted In: Research Home Experts ND in the News Subscribe About Us Related October 05, 2022 Astrophysicists find evidence for the presence of the first stars October 04, 2022 NIH awards $4 million grant to psychologists researching suicide prevention September 29, 2022 Notre Dame, Ukrainian Catholic University launch three new research grants September 27, 2022 Notre Dame, Trinity College Dublin engineers join to advance novel treatment for cystic fibrosis September 22, 2022 Climate-prepared countries are losing ground, latest ND-GAIN index shows For the Media Contact Office of Public Affairs and Communications Notre Dame News 500 Grace Hall Notre Dame, IN 46556 USA Facebook Twitter Instagram YouTube Pinterest © 2022 University of Notre Dame Search Mobile App News Events Visit Accessibility Facebook Twitter Instagram YouTube LinkedIn