key: cord-0005958-96qomb5o authors: Chiumello, D.; Marino, A.; Lazzerini, M.; Caspani, M. L.; Gattinoni, L. title: Lung recruitability in ARDS H1N1 patients date: 2010-07-15 journal: Intensive Care Med DOI: 10.1007/s00134-010-1955-9 sha: 8e0e448c4e3a9156c5997dc6427fde6a3967f706 doc_id: 5958 cord_uid: 96qomb5o nan Dear Editor, In 2009, a newly identified H1N1 virus rapidly led to a worldwide pandemic infection [1] . The mortality rate was 5-7% in hospitalized patients and approximately 20% among those admitted to the intensive care unit (ICU) [2] . The H1N1 infection occasionally developed into acute respiratory distress syndrome (ARDS), and in some cases the hypoxemia was so severe as to require advanced rescue therapies, such as extracorporeal support. To the best of our knowledge, however, the quantitative characteristics of the ARDS due to the H1N1 virus as assessed by computed tomography (CT) have not yet been reported. We report here three patients with severe ARDS associated to H1N1 infection who were admitted to our ICU and in whom lung weight, edema, and recruitability were evaluated by a lung CT scan and subsequently by the PEEP test. Patient 1 was aged 49 years and had a body mass index (BMI) and a PaO 2 / FiO 2 of 42.5 kg/m 2 and 170 at PEEP 10 cmH 2 O, respectively; patient 2 was aged 42 years and had a BMI and a PaO 2 /FiO 2 of 34.7 kg/m 2 and 108 at PEEP 10 cmH 2 O, respectively; patient 3 was aged 49 years and had a BMI and a PaO 2 /FiO 2 of 26.2 kg/m 2 and 225 at PEEP 10 cmH 2 O, respectively. The real time PCR test for H1N1 in the nasopharyngeal swab was positive for all three patients, while all blood and tracheal cultures were negative. Oseltamivir and empiric antibiotic agents were used in the first week of admission to the ICU. One patient due to clinical deterioration also required extracorporeal support. Two patients survived the infection and were eventually discharged from the hospital. At 6, 10, and 10 days post-admission, two lung CT scans at 5 and 45 cmH 2 O of airway pressure were performed in all three patients, and the lung recruitability was computed as the amount of not aerated lung tissue at 5 cmH 2 O which regained aeration at 45 cmH 2 O [3] . Within 1-2 h following the CT scan, we randomly performed the PEEP test at PEEP 5 and 15 cmH 2 O maintaining a constant minute ventilation and inspiratory oxygen fraction. The gas exchange and respiratory mechanics were recorded 20 min after each PEEP change. Examination of the lung CT scan showed bilateral consolidations and ground glass opacity areas with minimal pleural effusions. The total lung weight and volume were almost twofold greater than normal at 5 cmH 2 O of PEEP [3] . The weight of lung of each patient recruited to aeration when the airway pressure was increased to 45 cmH 2 O corresponded to 18.5, 31.0, and 16.3% of the total lung weight, respectively. All of these values are higher than the median values of recruitability that we found in previous series of ARDS patients (12%) [3] . Respiratory mechanics, gas exchange, and lung recruitability values are reported in Table 1 . The dissociation between recruitability and gas exchange is not surprising and likely reflects changes in pulmonary blood flow distribution, -010-1955-9 Extracorporeal membrane oxygenation for 2009 Influenza A(H1N1) acute respiratory distress syndrome influenza A (H1N1): a clinical review Lung recruitment in patients with the acute respiratory distress syndrome Rianimazione (Intensiva e Subintensiva) e Terapia del Dolore, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Italy e-mail: chiumello@libero.it Tel CORRESPONDENCE which cannot be measured in clinical practice.