key: cord-0009095-qjpjxm1w authors: nan title: Pharmaceutical applications date: 2004-08-26 journal: Curr Opin Biotechnol DOI: 10.1016/0958-1669(91)90025-z sha: a2839e41535c28b2ef99d605eb518458e171a211 doc_id: 9095 cord_uid: qjpjxm1w nan Cispentacin, a New Antifungal Antibiotic. 1L In Vitro and in Vtvo AnttOangal Activities. J Antthiot (Tokyo) lmmunolRev 1989, 112:115-132 . SAKANAKA S, KIM M, TANIGUCHI M, yAMAMOTO T: Antibacterial Substances in Japanese Green Tea Extract A~in~t Streptoccoccus-mutsns, a Cariogenic Bacterium. Agr/c Biol C~em 1989 , 53:2307 -2312 . SAMUEISON // 1989, 59:257-271 . USUKU K, NISH1ZAWA M, MATSUK1 K, TOKUNAGA K, TAKAHASm K, EIRAKU N, SUEHARA M, JuJ1 T, OSAME M, TABIRA T: Association of a Particular Aminu Acid Sequence of the HIA-Dr Beta-1 Chain with HTLV-I-Aasociated Myelopathy. Eur J Immunol 1990 , 20:1603 -1606 EMBO J 1990 EMBO J , 9:1035 Response to Interleukln-2 and LAK Cells [editorial] . Immunol Today 1990, 11:113-115 J Interferon Res 1989, 9:419-424. Preliminary X-Ray Crystallosraphic A~talysis of Holotoxin from Bordetella-Pertussis Clotx{n s and Expression of a protective Antigen from the Cattle Tick Boophilus Mi6~oplu& Proc Natl Acad Sci Chromosomal Aberrations in Germ Cells of Male Mice lmmunised with Attenuated Viral Vaccines (human) On the Mechanism for FA~clent Repression of the Interleukin-6 Promoter by Glucocorticnids -I~nh~neer, Tata BoX, and RNA Start Site (Inr Motif) Occlusion MonOcional Antibodies A oain~t an HL&-B27-Derlved Peptlde React with an Epitope Present on Bacterial Proteins Use of Urine for HIV-1 Antibody Screening AdjLn~antlcity of Recombinant Bovine Interleukin-l-Beta -Influence on immunity, Infection, and I~tency in a Bovine Herpesvtrns-1 Infection A Recombinant Surface Protein Of Babes/a Bov/s Elicits Bovine Antibodies that React with Live Mefozoites Recombinant Granulocyte-Macrophage Colony-StImulating Factor Restores Deficient Immune Responses in Mice with Chronic Trypanosoma-Cruzi Infections Extensive Interference of DNA Packaging Processes Affected by Chemotherapeutic Drugs Inhibition of HIV Prosresslon by Dlthincarb A Malaria Heat-Shock-Like Determinant Expressed on the Infected Hepatocyte Surface is the Target of Antibody-Dependent Ceil-Mediated Cytotoxic Mechanisms by Nonparenchymal Liver Cells Inhibition of Expression of Human Immonodeflclency Virus-1 Invitro by Antibody-Targeted Ltposomes Containing Antisense RNA to the Env Region Dimerization of Human Immnnodeficiency Virus Type-1 Reverse Transcrtptase. A Target for Chemotherapeutic Intervention 13:103~110. RHODES ~b JAMES W: Inhibition of Human Immunodeficiency Virus Replication in Cell culture by Endogenously Synthesized Antisense RNA Soluble Chromogenic Substrates for HIV-1 Proteinase Cloning of Spiramycin Biosynthetic Genes and Their use In Constructing Streptomyces Ambofadens Mutants Defective in SpiramycIn Biosynthesis Measuring Cellular Immune Respmmes to Malaria Antigens in Endemic Populations -Epidemiological, Parasitological and Physiological Factors Which Influence Invitro Assays Affinity Purification of HIV-1 and HIV-2 Protesses from Recombinant E-Colt Strains Using Pepstatin-Asarose Synthetic Peptide Vaccines Against Pathogens and Biological Mediators Rational Design of Peptide-based HIV Proteinase Inhibitors The Effect of Antibiotics that Inhibit Cell-wall, ProteIn, and DNA Synthesis on the Growth and Morphology of Le~onella Pneumophila Cyclic Cholecystokinin Analogues that are Highly Selective for Rat and Guinea Pig Central Cholecystokinin Receptors New Angucycllne Antibiotics from Streptomyces Fradia~ VI Protection of • woodchucks from Infection with woodchuck Hepatitis Virus by immunisation with Recombinant Core Protein Immunopathogenic Mechanisms of HIV Infection --Cytokine Induction of HIV Expression The Cyt_otoxic ProteIn YopE Of Yersinia Obstructs the Primary Host Defence. Mol Mi6robio11990 RNA Enzymes (riboizymes) as Antiviral Therapeutic Agents Comparison of Inactivated, Live and Recombinant DNA Vaccines Against Influeoza Vitals in a Mouse Model Oligodeoxynucleotides as Anti-sense Inhibltors of Gene Expression: Therapeutic Implications Responses of T-Cells from Sensitized Donors to Recombinant and Synthetic Peptides Corresponding to Sequences of the Plasmodium-Falciparum Seep Antigen. lmmunol Lett Rapid Detection of Herpes-sImplex-virus DNA in Cerebrospinal Fluid of Patients with Herpes Simplex Encephalitis ARG-Gly-AsP-Conmtning Peptide from Bothrops-Atrox, is a Potent Inhibitor of platelet Aggregation and Cell Interaction with Fibronecttn Inhibition of Protein Kfoase C and Antl-CD3-induced Ca z+ Influx in Jurkat T Cells by a Synthetic Peptide with Sequence Identity to HIV-1 GWtl Monoclonal Antibodies Against the Flagellar Fraction of Eptmastigotes of Trypanosoma Cruz~ Immunoprotection Against Metacyclic Trypomastisotes Obtained by Immunization of Mice with an MBnity-purified Antigen Vaccination with a Live Retrovfrus -the Nature of the Protective Immune Response Amino Acid Sequences Recognized by T-Cells -Studies on a Merozolte Surface Antigen from the Fcq-27 Pug Isolate of Plasmodium-Falclparum. lmmunol Lett Syt~tthetic Peptide Immunosens Eliciting Antibodies to Plasmodinm-Falciparum Sporozoite and Merozoite Surface Antigens In H-2B and H-2K Mice Analysis of Human T-cell Response to Two Piasmodiunsf~rum Merozoite Surface Antisens CDNA Cloning and Characterization of Interleukin-2-Induced Genes in a Cloned T-Helper Lymphocyte Evidence for a T cell-dependent, Interferon T-independant Mechanism Overproduction of Human Immunodeflciency Virus T~e-I Reverse Transerlptase in Eseherlchla-Coll and Purification of the Enzyme SHANN F: Pneumoccoccus and Influenza ROBEY F~ CD4-Derlved Synthetic Peptide Blocks the Binding of HIV-1 Gpl20 to CD4-Bearing Cells and Prevents HIV-1 Infection Synthesis and Secretion of Hepatitis B Middle Surface Antigen by the Methylotrophic Yesst Hansenula Polymorpha Tumour Necrosis Factor to Treat Chronic Hepatitis-B Virus Infection Suppression of HIV Antigenaemia by AL721 Production of Human lmmunodeficiency virus (HIV)-Iike Particles from Cells Infected with Recombinant Vaccinia Viruses Carrying the &agGene of HIV Phosphonoacetic Acid Inhibits Replication of Human Herpeswfrus-6 Experimentalscale Measles and Mumps Vaccine Production on Microcarrier-grown Ceils 8tructnral Diversity of Plasmodium-Falciparum Gp200 is Detected by T-cells A Deleted Variant of Bacillus Anthracts Protective Antigen is Nontoxic and Blocks Anthrax Toxin Action in Vivot f Perils of Switch to Inactivated Pollovaccine Antivtral and Antiprollferative Properties of Liposome-assoclated Human Interferon-7 Chemically Synthesized Peptides Elicit Neutralizing Antibody to Bovine Enterovirus. f Gen Viro11990 Inhibtion of Simian Varicella Virus Infection of Monkeys by 1-(20Deoxy-2-Fluoro-l-~-D-Arabinofuranosyl)-5-Ethyluracll (FEAU) and Synergistic Effects of Combination with Human Recombinant Inteferon-~ OKUYAMA & Inhibition of Influenza Vfrus-A/Wsn Replication by a Trypsin Inhibitor, 6-Amidlno-2-Naphthyl P-Guanidlnobenzoate Activation of Transcription by HIV-1 Tat Protein Tethered to Nascent RNA Through Another Protein The Cloning and Expression in Escherichia Coil of Sequences Coding for P24, the Core Protein of Human Immunodeficiency Virus, end the use of the Recombinant Protein in Characterizing a Panel of Monoclonal Antibodies AgainSt the Viral P24 Protein The Expression in Escher/ch/a Coliof Sequences Coding for the P18 Protein of Human Immunodefielency Virus, and the use of the Recombinant Proteins in Characterizing a Panel of Monoclonal Antiodies Against the Viral PI8 Protein Protective Effect of llhinovirus Receptor Blocking Antibody in Human Fibroblast Cells Specificity and Inhibitory Activity of Antibodies TO Piasmodium Falciparum Aldolase Recruitment of Allorcactive Cytotoxtc Lymphocyte-T by an Antigenic Peptide A General Strategy for Polymerization, Assembly and Expression of Epitope-Carrying Peptides Applied to the Plasmodlum-Falciparum Antigen Pf155/Resa The Arrangement of the Immtmoglobulln-like Domains of ICAM-1 and the Binding Sites for LFA-1 and Rhinovtrus The Selective Augmentation by Recombinant Human Turnout Necrosis Factoralpha of Neutrophil Responses to Pathogenic Escherichia-coH Lipid Conjugates of Antiretrovtral Agents.1. Azidothymidtne-Monophosphate-Dlgiycertde -Anti-HIV Activity, Physical Properties, and Interaction with Plasma Proteins UV-Induced DNA Damage is an Intermediate Step in UV-induced Expression of Human Immtmodeficiency Virus Type 1, Collagenase, c-fo& and Metallothionein phosphorothioate Oltgodeoxynucleotides are Potent Sequence Nonspeelllc Inhibllors of de NOt~ Infection by HIV Antimicroblal Actions of Calcium Binding Leucocyte L1 Protein ANDERSEN PP~ Biochemical and Immunological Characterization of the Major Structural Proteins of Feline Immunodefielency Virus Development and Production Aspects of a Recombinant Yeast-derived Hepatitis B Vaccine. Vaccine Role of Interferon-Gamma and Tumor Necrosis Factor in Host Resistance to Plasmodium-Chabandl As New Shapes in HIV Protease Inhibitors Secondary Analyses of the Efficacy of Two Acellular Pertussis Vaccines Evaluated in a Swedish Phase HI Trial Similarities Between TNF-alpha and Interleukin Alteration of the Humoral Immune Besponse Against Muscle Acetylcholine Receptor by Timed Administration of Mpha-(1-~3)Dextran Monoclonal Antibody Against Alpha-(1-~3) Dextm Transfers Suppression of the Immune Response to the Acetylcholine Receptor DR~ Peptides Block the Antigen-specific Response But not the Alloresponse of a Dual-reactive Tcell Clone Autoimmune T Cells: Immune Recognition of Normal and Variant Peptide Epitopes and Peptide-based Therapy Autoantibodies from Patients with Systemic Lupus Erythematosus can Affect DNA and RNA Synthesis in Cultured Cells Chemotacttc Properties of interieukin-1 [letter Recombinant Soluble Receptors for the Fcgamma Portion inhibit Antibody production tnvitro~ ELLINGSWORTH IJ~ Antagonistic and Agonistic Effects of Transforming Growth Factor-Beta and Ill in Rheumatoid Synovium Deletion of Lysine-84 to Lysine-89 Enhances the Cytotoxicity and the Receptor Binding Affinity of Human Lymph•toxin Severe Combined • Immunodeficiency Due to a Specific Defect in the Production of interleukin-2 KAPSENBERG MI2 Comparison of Diversity and Function of House Dust Mite-Specific Lymphocyte-T Clones from Atoplc and Non-Atopic Donors Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptidemediated Immunotherapy ImmnlnOIOgiCal Properties of Lectins from Green Shells of Winged Bean, and N-terminal Amino Acid Sequence of Basic Seed Lectin-like Green Shell Lectin Piirification and characterization of Soluble Human I1-6 Receptor Expressed in CHO Cells Synergistic • Potentiation of in Vivo Antitumor Activity of Anti-human T-Lenkemia Immunotoxins by Recombinant m-Interferon and Daunorubicin Molecular Analysis of a Germ Line-Encoded ldiotypic Marker of Pathogenic Human Lupus Autoantibodies. f lmmuno1199o Reconstitution of Peripheral Benzodiazepine Receptor Expression in X-Linked Chronic Granulomatous Disease by interferon-Gamma Drug delivery and in vivo properties Related review: Drug delivery Delivery of peptide • • Drugs: Effect of Particle Size on Bloavallabllity of Leuprollde Acetate in Healthy Male Volunteers Site-directed Mutagenesis in Human Tissue-plasminogen Activator. Distinguishing Sites in the Amino-terminal Region Required for Full Flbrtnolytic Activity and Rapid Clearance from the Circulation protection of Adult Rabbits and Monkeys for Lethal Shisellosis by Oral Immunization with a Thymine-requiring and Temperatuee-sensitive Mutant of Sbigella Flexneri Y. Vaccine Laboratory Properties of Cold-adapted Influenza B Live Vaccine Strains Developed in the US and USSR, and Their B/Ann Arbor/l/86 Cold-adapted Reassortant Vaccine Candidates CHARDS Pd~ Liposomes Containing Llpid-Aa Potent Nontoxic Adjuvant for a Human Malaria Sporozoite Vaccine Overview of a 5-year clinical Experience with a Yeast-derived Hepatitis B Vaccine. Vaccine Llposomes with Entrapped Doxorubicin Exhibit Extended Blood Residence Times Purified Chick-embryo-cell (PCEC) Rabies Vaccine: Its Potency Performance in Different Test Systems and in Humans Fv)-Pe40 -a Bifunctional Toxin Cytotoxic for Ceils with EGF or IL2 Receptors Antitumor Activity in Mice of an Immunotoxin Made with Antittansferrin Receptor and a recombinant Form of Pseudomonas Exotoxtn Up-Regulation of the Intestinal 1,25-Dthydroxyvitamin-D Receptor During Hypervitaminosis-D --a Comparison Between Vitamin-D2 and Vitamin-D3 Autoantibodies to Cytokines --Friends or Foes? Lactosyiated Low Density Lip•protein: a Potential Carrier for the Site-specific Delivery of Drugs to Kupffer Cells Efficacy of One or Two Doses of Ty21a Salmonella Typbi Vaccine in Enteric-coated Capsules in a Controlled Field Trial Is Interferon Effective after Oral • Administration? the State of the Art Chemical Modification of the Recombinant Human e.A-and ~-interferons BOEISTERU U& Effect of Enzyme Induction on Sandimmun• (cyclosporin A) ifiotransfurmation and Hepatotoxicity in Cultured Rat Hepatucytes and in Vivo~ Biochem Pharmaco11990 Turnout Imaging with Labelled Iaposomes SILVlOS JPc Mechanisms of Delivery of Liposome-encapsulated Cytosine Arabinoside to CV-1 Cells in Vitro. Fluorescence-microscopic and Cytoxicity Studies The Immunosenicity of Chimeric Antibodies Immunotherapy of Cancer Using Local Administration of Lymphoid Cells Transformed by IL-2 CDNA and Constitutively Producing IL-2 Prodrugs of Peptides. 6. • Bioreversible Derivatives of Thyrotropinreleasing Hormone (TRH) with Increased Hpophllicity and Resistance to Cleavage by the TRH-specific Serum Enzyme characterization of a Modified Human Tissue Piasminogen Activator Comprising a Kringle-2 and a Protease Domain ~-lactam Antibiotic-induced Piatelet Dysfunction --Evidence for Irreversible Inhibition of Platelet Activation invitro and Invtvo after Prolonged Exposure to Penicillin Use of an Anti-pan T-lymphocyte Rtein-A Chain Immunotoxin in Steroid-resistant Acute Graft-versus-host Disease Identification of Immunogenic Regions of the Major Coat Protein of Human Papillomavirus Type 16 that Contain Typerestricted Epltopes Fate of Interleukin-6 in the Rat --involvement of Skin in Its Catabolism Monoclonai Antibodies Specific for Human IgE-producing B Cells --a Potential Therapeutic for IgE-medlated Allergic Diseases A Bispeclfic Antibody I~nhances the Ftbrinolytic Potency of Single-Chain Urokinase Jp~ Secretory lmmunoglobulin a Antibody Response is Conserved in Aged Mice Following Oral ImmnnlT~tlon with Influenza Virus Vaccine Ice: a New Dosage Form of an Old Drug Oral Delivery of Insulin Distribution of Injected Monoclonal Antibody in Lymphoma-Infiltrated Spleen Intraleslonal Immunotherapy of Brain Tumors with Combined Corynebacterium-Parvum and Recombinant Interleuktn-2 in Mice Alpha-difluorumethylornithine Resistance In Leishnuinla Donovani is Associated with Increased Ornithine Deearboxylase Activity Transferrin Polycatlon-Medlated Introduction of DNA into Human Leukemic Cells ---Stimulation by Agents that Affect the Survival of Transfected DNA or Modulate Transferetn Receptor Levels Release of Peptides • from Sustained Delivery Systems (Microcapsules and Micropartlces) in Vivo Receptor-mediated Internalization and Degradation of Urokinase is Caused by Its Specific Inhibitor Overcoming Barriers to the Oral • Administration of Peptlde Drugs Recombinant Lip•proteinassociated Coagulation Inhibitor Inhibits Tissue Thromboplastin-induced Intravaseular Coagulation in the Rabbit. B/~od Regulation of Gene Expression Invtvo by Lip•some-Mediated Delivery of a Purified Transcription Factor Role of the Membrane-associated Folate Binding Protein (folate Receptor Readily Available Fluorescein lsothiocyanate-conjugated Antibodies can be Easily Converted into Targeted Phototoxic Agents for Antibacterial, Antlviral, and Antlcancer Therapy The Molecular • Weight Dependence of Nasal Absorption: the Effect of Absorption Enhancers AMIDON Gk Absorption of • Polyethylene Glycols 600 Through 2000: the Molecular Weight Dependence of Gastrointestinal and Nasal Absorption Two-year Comparative Trial on the Immunogenicity and Adverse Effects of Purified Chick Embryo Cell Rabies Vaccine for Pre-exposure Immunization C~clo~portn Wash for Oral Lichen Planns ILLUM l~ Nasal • • Administration of InsuIin Using Bloadhesive Mtcrnspheres as a Delivery System Cytokine-related Syndrome Following Injection of Anti-CD3 Monoclonal Antibody --Further Evidence for Transient invivo T-cell Activation Specific Itntnune Response in Humans Following Rectal Delivery of Live Typhoid Vaccine. Vaccine 1990, 8:209212. FRANKS CP, V~VEm LT ETA& Reconstitution of Interleuktn-2 [letter Protective Efi~cacy of a Novel Hepatitis-B Vaccine Consisting of M(Pre-S2 + s) Protein Particles (A 3rd Generation Vaccine) Pharmacoktnetics and Tissue Distribution of Doxorubicin Encapsulated in Stable Ltposomes with Long Circulation Times Site-directed Pegylation of • Recombinant Interleukin-2 at Its Glycosylatlon Site TRUCHOT l~ Differential Action of Thyroid Hormones and Chemically Related Compounds on the Activity of UDP-Glucuronosyhransferases and Cytochrome Isozymes in Rat Liver Comparison of Recombinant Tissuetype Piasminogen Activator (rt-PA) Expressed in Mouse C127 Cells and Human Vascular Plasmtnogen Activator (HV-PA) Reconstitution of Interleukin-2 with Albumin for Infusion Targeted Drug Delivery: a • Two-compartment Growth Inhibition Assay Demonstrates that Fluorodeoxyuridine and Fluorodeoxyuridine Moo•phosphate are Lip•some-independent Drugs Comparison of Antl-tac and Anti-transferrin Receptor-conjugated Liposomes for Specific Drug Delivery to Adult T-cell Leukemia. B/00d 1989 Inhibition of Stress-Induced Gastric Mucosal Injury by a Long Acting Superuxide Dlsmutase that Circulates Bound to Albumin Physical and Biological Characterization of Antigen Presenting Lip•some Formulations: Relative Efficacy for the Treatment of Recurrent Genital HSV-2 in Guinea Pigs Stere•selective Pharmacokinetics and Metabolism of the Enantiomers of Cyelophosphamide. Preliminary Results in Humans and Rabbits Induction of Mx-related Protein in Cat Peripheral Blood Moo•nuclear Cells after Administration of Recombinant Human Interferon Hybrid Treatment of a Murine Model of Systemic Candidiases with Liposomal Amphotericin B Bearing Antibody to Candida Albtcan& Recombinant Interferonalfa-2B in Refractory Idiopathic Immune Thrombocytopenta Antipeptide Antibodies to Two Distinct Regions of the Androgen Receptor Localize the Receptor Protein to the Nuclei of Target Cells in the Rat and Human Prostate Nasal • Administration of a Cognition I~nh~ncer provides Improved Bioavallahillty But not Enhanced Brain Delivery Enhanced Nasal Absorption of Insulin in Rats Using Lysophosphatidylcholine./m Investigation of the Nasal Absorption of Biosynthetic Human Growth Hormone in Sheep --use of a Bloadhesive Mtcrosphere Delivery System Enhancement of interleukin-2 Activity by IAposomes Identification of a Specific Domain in the Beta-Adrenergtc Receptor Required for Phorbol Ester-Induced Inhibition of Catecholamine-Stimulated Adenylyl Cyclase Comparison of Insulin Analogue B9AspB27GIu and Soluble Human Insulin in Insulin-treated Diabetes Heteroconjugate Antibody-directed Ktllln S of Autologous Human Renal Carcinoma Cells by Invitro-activated Lymphocytes Polyethylene Glycol Modification of the Monoclonal Antibody A7 Enhances Its Tumor Localization Comparative Chemotherapeutic Activity of Cefpirome and lmipenem in Experimental Infections Biochemical characterization of the Cholecystoktnin Receptor on Chp212 Human Neuroblastoma Cells. Mol Pharma~o11990 KONI~D M: Immunogenicity of Proteins Administered to Humans for Therapeutic Purposes. Trends Biotechno11989 LANGER l~ New Methods of Drug Delivery Pharlnacological Modulators of DNA-interactive Antltumor Drugs A Study of the Mechanism of Resistance to Adriamycin® in Vivo~ Glutathlone Metabolism. P-giycoprotein Expression, and Drug Transport Penetration and Enzymatic • • Barriers to Peptide and protein Absorption Antibody-targeted LIposomes Containing Oll8odeoxyrlbonucleotides Complementary to Viral RNA Selectively Inhibit Viral Replication. proc Natl Acad Sei U S A SILVlUS JP~ Interactions of MalDmalian Cells with Lipid Dispersions Containing Novel Metabolizable Cationic Amphiphlles Evaluation of Rlcin a chain-containing Immunotoxtns Directed Against Different Epltopes on the 5-chain of Cell Surfaceassociated lgD on Murine II Cells Enhancement of the Protective Efficacy of Inactivated Influenza-A Virus Vaccine in Aged Mice by 11-2 Liposomes Mechanisms of Multidrug Resistance in HL60 Cells. Analysis of Resistance Associated Membrane Proteins and Levels of mdr Gene Expression Recombinant Human Interferun-C~mma --Adverse Effects in High-Risk Stage-I and Stage-lI Cutaneous Malignant Melanoma Drug Targetin s --Anti HSV-1 Activity of Mannosylated Polymer-bound 9 Reconstitution of Interleukin-2 with Albumin for Infusion Characterization of Paracetamol UDP-glucuronosyltransferase Activity in Human Liver Mlcrosomas. Bi~bem Pharmaco11990 Induction of Antigen-specific Immunity with Monocloual Anti-ldiotyplc Antibodies invlvo --Differences in Potency and Comparison of Immunochemlcal Properties Molecular Targets for AIDS Therapy Differential Properties of • Organ-specific Serum Opsonins for Liver and Spleen Macrophages Efficacy of Intranasal Human Calcttonin in Patients with Paget's Disease Refractory to Salmon Calcitonin Interaction of Purified Bovine Brain A1-Adenosine Receptors with Guanine Nucleotide-Binding Proteins of Human Platelet Membranes Following Reconstitution. Mol Pha rnuw~11990 Cytotoxiclty of Glucose Oxidase Conjugated with Antibodies to Target Cells -Killing Efficiency Depends on the Conjugate intern~ltT~tion characterization of a Nucleic Acid Probe for the Diagnosis of Human Corouavirus 229E Infections Endocytosis-Independent Uptake of Liposome-Encalmulated Superuxide Dismutase Prevents the Killing of Cultured Hepatocytes by Tert-Butyl Hydroperoxide Development of a New Type of Influenza Subunit Vaccine Made by Muramyldipeptide Liposome -Enhancement of Humoral and Cellular Immune Responses Lipid Conjugates of Antiretroviral Agents.2. Dltm~lum Palmityl Phosphonoformate -Anti-HIV Activity, Physical Properties, and Interaction with Plasma Proteins Evaluation in Children of Cold-adapted Influenza B Live Attenuated Intranasal Vaccine Prepared by Reassortment Between Wild-type B/Ann Arbor/I/86 and Cold Absorption of Peptides and • Proteins from the Respiratory Tract and the Potential for Development of Locally Administered Vaccines. CRC Critical Reviews in Therapeutic Drug Carrwr Systems Mleroparticles as Potentially orally Active Immunological Adjuvants. Vac6ine Problems in the Investigated Study and Clinical use of Cancer lmmunotherapy. lmmunol Today IS the Brunchus-associated o• Lymphoid Tissue (BALT) an Integral Structure of the Lung in Normal Mammals, Including Humans? Chimeric Peptides --Transport Through the Blood-brain Barrier in V/vo and Cleavage of Disulfide Linkage by Brain. Endoev/n0/0gy The Controlled Parenteral Delivery of • Polypeptides and Proteins Comparison of a Recombinant DNA Hepatitis B vaccine Alone or in Combination with Hepatitis B Immune Globulin for the Prevention of Pertnatal Acquisition of Hepatitis B Carriage Recombinant interferonalfa-2B in Refractory Idiopathic Immune Thrombocytopenia-Response [letter Antbiaminin Receptor Antibody Targeting of Liposomes with Encapsulated Doxorublcin to Human Breast Cancer Cells /n RAJKOWSm K~ Comparison of Graphical Procedures for Estimating the Intrinsic MoLar Fluorescence of Protein-bound Drugs for Drug-binding Studies. A Reevaluation of Existing Plots hod Introduction of Two Inverse Hyperbolic Plots Antibody-Targeted Photolysis --Invitro Studies with So(IV) Chlorin E6 Covalently Bound to Monoclonal Antibodies Using a Modified Dextran Carrier Chromosomal Aberrations in Germ Cells of Male Mice Immunised with Attenuated Viral Vaccines (human) Internalization of the Cytotoxic Molecules of T101 F(Ab')2-(Ricin-A-Chain) Immunotoxin into Human T-Leukemic Cells Dimerizatinn of Human Immunodeflctency Virus Typed Reverse Transcriptase. A Target for Chemotherapeutic intervention lLLUM l~ Vaginal • Administration of Gentamycin to Rats. Pharmaceutical and Morphological Studies Using Absorption I~nhancers Endocytosis Mediated by Monocyte and Macrophage Membrane Lectins --Application to Antiviral Drug Targeting. Res Viro11990 Geue Transfer into Humans --Immunothempy of Patients with Advanced Melanoma, Using Tumor-infiltrating Lymphocytes Modified by Retroviral Transduetion Influence of Average • Molecular Weights of Puly(DL-lactic Acid-coglycolic Acid) Copolymers 50/50 on Phase Separation and in V/tro Drug Release from Microspheres SJ: Lymphokine Gene Therapy for Cancer Pharmacoktnetic • study of IAposome-encapsulated Human Interferon after Intravenous and Intramuscular Injection in Mice Drug Delivery Systems and Routes of • Administration of Peptide and Protein Drugs Vitro and in Vivo Antibacterial Activity of KT3777, a New Orally Active Carbacephem Inhibition of Type-1 Diabetes in BB Rats with Recombinant Human Tumor Necrosis Factur-Alph& J Immuno11990 BROWN e~ use of Beta-galactosldase as a Selectable Marker Effect of Molecular • Weight on the Lymphatic Absorption of Watersoluble Compounds Following Subcutaneous Administration Inhibition of HIV-1 in Monocyte/Macrophage cultures by 2',3'-Hldeoxycytidine-5'-Triphosphate, Free and in Liposomes Controiled-release Prost~=olandin E 2 Pessary Activation of the Complement System During Immunotherapy with Recombinant IL-2: Relation to the Development of Side Effects Anti-Viral Immunity Induced by Recombinant Nucleoprotein of Influenza-A Virus.3. Delivery of Recombinant Nucleoprotein to the Immune System Using Attenuated Salmonella-Typhimurium as a Live Carrier The Role of Catrt~hydrate in Recombinant Human Erythropoletin Autulogous Bone Marrow Transplantation in High-risk Remission T-lineage Acute Lymphoblasttc Leukemia Using lmmtmotoxins Plus 4-hydroperoxycydophosphamide for Marrow Purging Production of a protein A-lymphotoxin Hybrid Protein for Cancer-targeted Therapy Phase I • Trial of 5-Fluorout~tcil and Recombinant ~2 a -Interferon in Patients with Advanced Colorectal Carcinoma Oral Activity of the Growth Hormone Releasing Peptide HIS-D-TRP-D-PHE-LYS-NIt2 in Rats, Dogs and Monkeys Studies on the Hepatotoxielty of Galactosamine/endotoxin or Galactosamine/TNF in the Perfused Mouse Liver Relationship Between Reductive Drug Metabolism tn Tumour Tissue of Anthracycllnes in Microspherical Form and Anti-tumour Activity. Bioehem Pbarmaco11990 Carbodlimtde Crossllnking of Human Clq and Rabbit igG. Mol lmmuno11990 Detection of the Tumorassociated Glycoprotein Antigen (TAG-72) in Premall~nt~nt Lesions of the Colon Purification and Characterization of Soluble Human II-6 Receptor Exp~ in CliO Cells Inhibition of HIV Replication by Pokeweed Antiviral Protein Targeted to CD4 + Cells by Monoclonal Antibodies Receptur-medtated Endocytosis of Transferrin Polycation Conjugates --an Efficient Way to Introduce DNA into Hematopoietic Cells Comparison of Enzymic • Activities of Tissues l.lning Portals of Drug Absroption, Using the Rat as a Model Cancer Related review: Growth factors and receptors in cancer High-Dose Recombinant lnterleukin-2 Alone -a Regimen with Limited Activity in the Treatment of Advanced Renal Cell Carcinoma Ent~Dertved Gp55 Gene of Friend Spleen Focus-Forming Virus Specifically induces Neoplastic Proliferation of Erythroid Progenitor Cells Long Term Survival of Adoptively Transferred Tumor-Infiltrating Lymphocytes in Mice increased Intracellular Glycerophosphulnosttol is a Biochemical Marker for Transformation by Membrane-Associated and Cytoplasmic Oncogenes lnhibltfon of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metailoproteinases Cell-Cell Adhesion Mediated by Binding of Membrane-anchored Transforming Growth Factor uto Epidermal Growth Factor Receptors Promotes Ceil Proliferation ANONYMOUS: Incidence of Response and Long-term Follow-up in Patients with Hairy Cell Leukemia Treated with Recombinant interferon cx-2a Home Therapy with Recombinant interleuktn-2 and Interferon-Alpha-2B in Advanced Human Malignancies Treatment of Cancer Patients with Recombinant interferon-Gamma Induces Release of Endogenous Tumor Necrosis Factor-Alpha Dolastatin-10, a Powerful Cytostatic Peptide Derived from a Marine #ttlm~ll --Inhibition of Tubulin Polymerization Mediated Through the Vinca Alkaloid Binding Domain Supresston of Human Colorectal Carcinoma Cell Growth by Wild-type P53 AtuolOlgOUS Bone Marrow Transplantation for Acute Myelold Leukemia Using Monoclonal Antibody-purged Bone Marrow Selective Displacement of Nuclear Proteins by Antitumor Drugs Having Amntty for Nucleic Acids Pe40 -a Bifonctional Toxin Cytotoxic for Cells with EGF or IL2 Receptors Antitumor Activity in Mice of an Immunotoxin Made with Antitransferrtn Receptor and a recombinant Form of Pseu domonas Exotoxin incidence of Response and Long-term Followup in Patients with Hairy Cell Leukemia Treated with Recombinant Interferon-alfa-2a Prolonged Survival of Mice with Myeloid Leukemia by Subcutaneous Injection of Recombinant Human C~CSF Hematologic and Immunologic Effects of the Systemic Administration of Recombinant Interleukin-2 after Autolougous Bone Marrow Transplantation. B/0od 1990 Hepatitis B Virus and Primary Hepatocelluiar Carcinoma --Treatment of HBV Carriers with l~ilantbl~ Amaru& Vaccine Turnout Imaging with Labelled Hposomes Site-specific Recombination of The ta/-1 Gene is a Common Occurence in Human T Cell Leukemia GM-CSF Incubation Prior to Treatment with Cytarahine or Doxoeabicin l~nhances Drug Activity Against AML Cells invitro -a Model for Leukemia Chemotherapy IEVY Pc Idiotype Vaccination Against Murine B-Cell Lymphoma -Humoral and Cellular Requirements for the Full Expression of Antitumor Immunity DEGOS I2 All-trans Retinoic Acid as a Differentiation Therapy for Acute Promyelocytic Leukemia. L Clinical Results on the Variables Affecting Toxicity of Hybrid Toxins. The Effect of Different Target Cell Receptor Distribution and Toxin Binding Chain Growth Modulatory Effects of a Liver-derived Growth Inhibitor, Transforming Growth Factor J31, and Recombinant Tumor Necrosis Factor ~, in Normal and Neoplastic Cells Ail-tfans Retinolc Acid as a differentiation Therapy for Acute Promyelocytic Leukemia. H. in Vitro Studies: Structure Function Relationship. B/cod Cispiatin-resistant Cells Express increased Levels of a Factor that Recognizes Damaged DNA Progesterone Receptor Regulation by Retinoic Acid in the Human Breast Cancer Cell Line T-47D Distribution of injected Monoclonal Antibody in Lymphomainfiltrated Spleen characterization of Pp85, a Target of Oncogenes and Growth Factor Receptors Ceil Proliferation tn Carcinogenesis invivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein Intralesinnal Immunotherapy of Brain Tumors with Combined Corynebacterium-Parvum and Recombinant interieukin-2 in Mice Tumor Ceil Snrface Beta-l-4-Ltnked Galactose Binds to Lectin(S) on Microvascular Endothelial Cells and Contributes to Organ Colonization Transferrifi Polycation-Mediated introduction of DNA into Human Leukemic Cells ---Stimulation by Agents that Affect the Survival of Transfected DNA or Modulate Transferrin Receptor Levels Induction of Tumor Cytotoxic Immune Cells Using a Protein from the Bitter Melon (Momordtca Charantla) Topoisomerase-targetlng Antitumor Drugs. Biochl)n Biophys Acta Monoclonal-antibody-medlated DEGC6 I= Differentiating Agents in the Treatment of Leukemia DEGOS I= Differentiating Agents in the Treatment of Leukemia and Myelodysplastic Syndromes Readily Available Fluorescein Isothincyanate-conjugated Antibodies can be Easily Converted into Targeted Phototoxic Agents for Antibacterial, Antiviral, and Antlcancer Therapy Understanding of the Molecular Basis of Drug Resistance in Cancer Reveals New Targets for Chemotherapy Receptors for Tumor Necrosis Factor on Neoplastic B Cells from Chronic Lymphocytic Leukemia are Expressed in Vitro But not in Vlvo. B/0od 1990 Recombinant Interleukln-2 and Adoptive Immunotherapy Alternated with Dacarbazine Therapy in Melanoma -a National Blotherapy Study Group Trial • Mechanisms by Which EGF Receptor and TGF-~Contribute to Malignant Transformation Tumor Necrosis Factor Modulates Epidermal Growth Factor Receptor Phosphorylatlon and Kinase Activity in Human Tumor Cells. Correlation with Cytotoxicity Ceramide I-phosphate, a Novel Phosphollpld in Human Leukemia (HL-60) Cells -Synthesis Via Ceramide from Sphlngomyelln Oncogenes, Growth • Factors and Signal Ttansduction Kinetics of Receptor-mediated Uptake and Processing of Interferon~2a and Tumor Necrosis Factor-u by Human Tumor Cells The Porine Path to Chemotherapy Superactive Estrogen Receptors -Potent Activators of Gene Expression Role of Membrane Liplds in the interaction of Daunomyctn with Plasma Membranes from Tumor Cells: Implications in Drug-resistance Phenomena Treatment of Poorprognosis, Newly Diagnosed Acute Myelold Leukemia with ARA-c and Recombinant Human Granulocyte-Macrophage Colony-stimulating Factor Non-Activated Bat Neutrophils Kill Syngeneic Colon Tumor Cells by the Release of a Low Molecular Weight Factor A Specific Inhibitor of Protein Klnase-C induces Differentiation of Neuroblastoma Cells Targeted Toxin Therapy for • the Treatment of Cancer Case Report -Development of Hodgkins Disease in Patient Receiving Long-Term Administration of Dacarbazine and Interleukin-2 fur Metastatic Melanoma Identification of the Multidrug Resistance-related Pglycoprotein as a Cyclosporine Binding Protein Structural Comparison of Anticancer Drug-DNA Complexes: Adrlamycln and Daonomycin Tumour Necrosis Factor, Steroids, and Meningitis Novel Cytocidal Antibiotics, Glucopiericidinols A 1 and A 2. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Characteristics Selective Expression of Purkinje-Cell Antigens in Tumor Tissue from Patients with Paraneopiastic Cerebellar Degeneration Detection of Residual bcr/abi Translocation by Polymerase Chain Reaction in Chronic Myeloid Leukaemia Patients after Bonemarrow Transplantation Interferon-inducced Enhancement of 2',5'-oligoadenylate Synthetase in Mid-gut Carctnold Tumours NEELON Pc Modulation of DoxorubicinAnduced Chromosomal Damage by Calmodulln Inhihitors and Its Relationship to Cytotoxicity in Progressively Doxorubicin-Resistant Tumor Ceils Effects of Recombinant Human interleuktn-3 in Patients with Myelodysplastlc syndromes. B/ood Phase-I Study of High-Dose Continuous-Infusion Recombinant interleuktn-2 and Autologoos Lymphokine-Activated Killer Cells in Patients with Metastatic or Utxresectable Malignant Melanoma and Renal Cell Carcinoma ~H/AMS RI2 Production of Leukemia Inhibitory Factor in Eacherl4agia Coli by a Novel Procedure and Its use in Maintaining Embryonic Stem Cells in Culture Effect of Interferon-alpha on the Expression and Release of the CD23 Molecule in Hairy Cell Leukemia Vaccination with Membrane-Associated Idiotype Provides Greater and More Prolonged Protection of Animals from Tumor Challenge Than the Soluble Form of Idintype The Effect of a Prolonged invttro Exposure to 1-beta-D Arabinofuranosylcytosine and Dloxycytidine on the Survival of Normal (CFU-GM) and Leukemic (L-CFI 0 Human Myeluld Progenitor Cells in Suspension Culture Identification and Immunogenic Properties of an 80-kDa Surface Antigen on a Drug-treated Tumor Variant --Relationship to MuLV Gp70 Cloning and Expression of a CDNA Encoding Human Placental Protein-11, a Potatlve Serine Protease with Diagnostic Significance as a Tumor Marker Recombinant Lymphotoxin Enhances the Growth of Normal, But not of Chronic Myeluld Leukemic KnxIs & Detection of Minority Point Mutations by Modified PCR Technique: a New Approach for a Sensitive Diagnosis of Tumor-progeession Markers Producing Organism, Fermentation and Isolation. JAntibiot (Tokyo) 1989 A Transcribed Gene, Containing a Variable Number of TANDEM Repeats, Codes for a Human Epithelial Tumor Antigen --CDNA Cloning, Expression of the Transfected Gene and Over-Expression in Breast Cancer Tissue Macrophage Tumor Necrosis Factor-Alpha Release is Induced by Contact with Some Tumors Activated Natural Killer Cells after Bone Marrow Transplantation for Chronic Myeiogenous Leukemia Comparison of Anti-tac and Anti-transferrin Receptor-conjugated IAposomes for Specific Drug Delivery to Adult T-cell Leukemia. B/ood 1989 Erythropoietin for Chemotherapy Patient Refusing Blood Transfusion Effects of Retinotc Acid, 1,25-dihydroxyvitamin D3, Cytosine Arabinoside and ix-interferon on Bone Marrow Cells from Patients with Myelodyspiastlc Syndromes Structure of the Integrln VLA4 and Its Cell-cell and Cellmatrix Adhesion Functions The Detection of Normal Hidden Stem Cells During the Development of Leukemia --Assays with PGK lsozyme Identification of Immunodominant Regions of Transforming Growth Factor u. Implications of Structure and Function Production of Antitumor Mononuclear Blood Cells in Tumor-bearing Mice by interferon-uA/D Therapy Regulation of Cell Growth by Recombinant Oncostatin M Topoisomerase H-mediated DNA Cleavage by Amonalide and Its Structural Analogs. Mol Pharmaco11989 Cyclic AMP Analogs and Retinolc Acid Influence the Expression of Retinolc Acid Receptor u, ~, and T MRNAs in F9 Teratocarcinoma Cells Mutational Alteration of the Breakage/resealing Subtmit of Bacteriophage T4 DNA Topoisomerase Confers Resistance to Antlmmor Agent m-AMSA Anti-synthetic Peptlde Antibody Reacting at the Fusion Junction of Deietinnmutant Epidermal Growth Factor Receptors in Human Antipeptide Antibodies to Two Distinct Regions of the Androgen Receptor Localize the Receptor Protein to the Nuclei of Target Cells in the Rat and Human Prostate Establishnlent of lluman Monoclonal Antibody Recognizing a New Tumor-Associated Antigen from a Patient with small Cell Lung CarcInoma Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence Rational use of Biological Response Modifiers in Hematological Malignancies --a Review of Treatment with Interferon, Cytotoxic Cells and Antibodies HLA-Dr Antigens in Gastric Carcinoma Positive and Negative Regulation of a Tumor Necrosis Factor Response In Melanoma Cells Antttumor Promotion and Antilnflammatinn-Down-Modulation of Ap-1 (Fos Jun) Activity by Glucocorticoid Hormone Bryostatin-1, a Unique Biologic Response Modifier --Anti-leukemic Activity Invitro. B/0od 1990 Mechanism of Interaction Between Interferon-wamma and Antineoplastie Agent on the Differentiation of ~ Promyelocytic Cells. Exp Hemato11990 Progeaterone Receptor Stimulates Ttanscrfptinn of Mouse Mammary Turnout Virus in a cell-free System Cell Tumor Therapy with Moneclonal Antibody Directed to the V~ chain of T Cell Antigen Receptor F~GF ~-Receptor Stimulates Tyrosine Phosphorylation of GAP and Association of GAP with a Signaling Complex Phase H Study of Recombinant Human Interferon Comma for Treatment of Cutaneous T-cell Lymphoma Cloning of Three Human Tyrosine Phosphatases Reveals a Multigene Family of Receptor-linked ProteIntyrosine-phosphatases Expressed in Brain Basement Membrane Collagen-Degrading Activity from a Malignant Tumor is Inhibited by Anthracycllne Antibiotics Cyclosporin-A Suppresses Cisplatin-Induced C-Fos Gene Expression in Ovarian Carcinoma Cells RC6ENBERG S~ Human C=ene Transfer: Characterization of Human Tumor-Infiltrating Lymphocytes as Vehicles for Betroviral-mediated Gene Transfer in Man Eradication of Adenovirus El-induced Tumors by EIA-specHic Cytotoxlc T Lymphocytes Antttumor Activity of T Ceils In Lymphoid Organs Induced by Interferon In Tumor-bearing Mice Synergistic Inhibition of Lymphoid Tumor Growth In Vitro by Combined Treatment with the Iron Chelator Deferoxamine and an Immunogiobulin G Monoclonal Antibody Against the Transferrtn Receptor Synthesis of Tetrahydroblopterin In Friend Fa'ythroleukemta Cells and Its Modulator Effect on Cell Proliferation Heteroconjugate Antibody-directed Killing of Autologous Human Renal Carcinoma Cells by lnvitro-activated Lymphocytes Polyethylene Glycol Modification of the Monoclonal Antibody A7 I~nhances Its Tumor Localization A Novel Monoclonal Antibody Induces the Differentiation of Monocyte Leukemic Ceils PASTAN 1:i1-2-pe40 Prevents the Development of Tumors in Mice Injected with 11-2 Receptor Expressing El4 Tt-ansfectant Tumor Cells Synergistic Effects of Vinbiaatine and Recombinant Interferon-Beta on Renal Tumor Cell Lines Aetivtion of ras Oncogenes Preceding the Onset of Neoplasia Interferon Alfa-2a Combined with Phototherapy in the Treatment of Cutaneous T-cell Lymphoma Stimulation of Cellular Alkaline Phosphatase Activity and Its Messenger RNA Level in a Human Osteosarcoma Cell Line By 1,25-dihydroxyvitalnin D 3 Approaches to the Therapy of Multiple Myeloma Antibody 624H12, Which Detects Lung Cancer at Early Stages, Recognizes a Sugar Sequence in the Glyeosphingolipid Difialcosyineolactonorhexaosyleeramide (V31~ucllI3FuclxLc6Cer) Association Between the PDGF Receptor and Members of The src Family of Tyrosine Kinases Growth Inhibition by TGF-~Idllked to Suppression of Retinoblastoma ProteIn Phosphorylation Improved Tumor Targeting with Radlolabeled, Recombinant, Single-Chain, Antigen-Binding Protein k Molecular Model for the Enzyme Cytochrome-P45017-Alpha, a Major Target for the Chemotherapy of Prostatic Cancer Pharmacological Modulators of DNA-Interactive Antitumor Drugs A Rapid in Vitro Method for the Evaluation of Potenital Antitumor Drugs Requiring Metabolic Activation by Hepatic $9 A Study of the Mechanism of Resistance to Adriamycin• in Vtvo Epidermal Growth Factor Stimulates the Anchorage-independent Growth of Haman Squamous Cell Carcinomas Overexpressin 8 Its Receptors BUURMAN W& IFN-Gamma Regulates the Expression of the Adhesion Molecule Elam-I and II-6 Production by Human Endothelial Cells invitro Oestrogen Receptor B-region Polymorphtsm and Spontaneous Abortion in Women with Breast Cancer Response to Intermediate and Standard Doses of EFN-Beta ill Hairy-Cell Leukaemia IVl~RTELSMANN Pc Hematologic Effects of Recombinant Human Granulocyte Colonystimulating Factor in Patients with Malignancy Human Paplllomavirus Type 56: a New Virus Detected in Cervical Cancers KALLENBACH NPC Drug Binding by Branched DNA --Selective Interaction of the Dye Stains-all with an Immobile Junction Marked Difference in the Invivo Antitumor Efficacy Between 2 Immunotoxins Targeted to Different Epitopes of Common Acute Lymphoblastic Leukemia Antigen (Cdl0) -Mechanisms Involved in the Differential Activities of Immunotoxins Direct Interaction of a Llgand for the ErbB-20ncogene Product with the EGF Receptor and P185 ErbB-2 Two G Protein Oncogenes in Human Endocrine Tumours Human T-Cell Leukemia Virus Type-I Prevents Cell Surface Expression of the T-Cell Receptor Through Down-Regulation of the CD3-Gamma, CD3-Delta, CD3-Epsllon, and CD3-Zeta Genes Maintenance Treatment with Recombinant Interferon Alfa-2b in Patients with Multiple Myeloma Responding to Conventional Induction Chemotherapy New Clue to Cancer Metastasis Found Novel Antitumor Antibiotic Produced by a Nocardiodes Sp, Production, Isolation, Characterization and Binlogieal Properties AT2433-A2, AT2433-B1, and AT2433-B2 Novel Antltumour Antibiotic Compounds Produced by ActOtomadura Melliaura. Taxonomy, Fermentation, Isolation and Biological Properties. JAntthiot (Tokyo) 1989 Turnout-specific Inhibition of Lymphoma Growth by an Antisense Oligodeoxynucleotide Vacdnia Recombhmnts Expressing Early Bovine Papilloma Virus (Bpvl) Proteins --Retardation of Bpvl Tumour Development MRSSINA JI~ Insulins Regulation of C-Fos Gene Trans4eription In Hepatoma Cells Recombtl~int Human Interfet~0n-Cg, tmma-Adverse Effects in High-Risk Stage-1 and Stage-If Cutaneous Mall enant Melanoma Duration of Response after interferon Treatment of Hairy Cell Leukemia Adjuvant Tamnxifen in Postmenopaosal Stage H Breast Cancer Five Years on Tumor Growth-Inhibitory Glycoprotein Secreted from the Mouse Brain at Terminal Stage of the Ontogeny -Molecular Homogeneity and Requirement of the Retained Protein Conformation for Exhibition of the Cytotoxic Action Curability of Tumors Bearing Herpes Thymidine Ktna~ Genes Transferred by Retrovfral Vectors T-cell Clones that React A oain~t Autologous Human Tumors Antitumor Activity of Recombinant Interleukin 6 in Mice Lectin-binding Properties of Burkitt's Lymphoma Cell Lines --Application to Bone Marrow Purging EffL~ts of Pacenteral Recombinant Human Maerophage Colony-stimulating Factor on Monocyte Number, Phenotype, and Antitumor Cytotoxiclty in Nonhuman Primates Casein Klnase-II is Elevated in Solid Human Turnouts and Rapldly Proliferating Nonneoplastic Tissue CytotoxlC~ty of Glucose oxidase Conjugated with Antibodies to Target Cells -Killing Efficiency Depends on the Conjugate intet'naltTation ISHIHAMA KONNO I~ Inhibition of InfloenZa Virus Infection by Pine Cone Antltumor SubStances The Role of Major Histocompatibllity Complex Class I Antigens in Tomorigenesis: Future Applications in Cancer Therapy Maintenance Treatment of patients with Myelodysplasttc Syndromes Using Recombinant Human Granulocyte Colony-Stimulating Factor APPELBAUM FP~ Use of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Graft Failure after Bone Marrow Transplantation Mutations in the P53 Gene Occur in Diverse Human Turnout Types NAGATA S: Multiple Elements in the Promoter of Granulocyte Colony-stimulating Factor Gene Regulate Its Constitutive Expression in Human Carcinoma Cells Antibody to a Mitotic Microtubule-Associated Protein Blocks Mitotic Progression Predominant Expression of T Cell Receptor V~ 7 in Tumor Infiltrating Lymphocytes of Uveal Melanoma Quantative Analysis of ?,/DR/ (multidrug Resistance) Gene Expression in Human Tumors by Polymerase Chain Reaction In Vtvo Activation of Human Neutrophil Functions by Administration of Recombinant Human Granulocyte Colonystimulating Factor in Patients with Malignant Lymphoma Tumor Associated Myelopolesis Inhibiting Factors Effect of Autolymphocyte Therapy on Survival and Quality of Life in Patients with Metastatic Renalcell Carcinoma Problems in the investigated Study and clinical use of Cancer Immonotherapy Cellular Inlmune Response Against Autologous Human Malignant Melanoma: ace in Vitro Studies Providing a Framework for a More Effecttve Immunotherapy Survival Enhancement and Hemopuletic Regeneration Following Radiation Exposure -Therapeutic Approach Using Glucan and Gra~ulocyte Colony-Sttmolating Factor Specific Antisense RNA Inhibition of Growth Hormone Production in Differentiated Rat Pituitary Tumour Cells A Truncated, Secreted Form of the Epidermal Growth Factor Receptor is Encoded by an Mternatively Spliced Transcript in Normal Rat Tissue lmmunodetection with a Monoclonal Antibody of Gintathlone ~transferase Mu in Patients with and without Carcinomas. Biocbem P~rm~o11990 Bioactive Human Recombinant Tumor Necrosis Factor-alpha --an Unstable Dimer Biochemical and Histological Characterization of Antigens Preferentially Expressed on the Surface and Cytoplasm of Breast Carcinoma Cells Identified by Monoclonal Antibodies Against the Human Milk Fat Globule The Amphfregulln Gene Encodes a Novel Epidermal Growth Factor-related Protein with Tumourinhibitory Activity Prospects for Genetic Diagnosis of Inherited Predisposition to Cancer Homan Monorlonal Antibodies Reactive with Cell Surface Antigens on Human Leukemia Cell Lines --Many Antibodies Are (auto)antibodies Hydroxyesorublcin -Synthesis and Antittmaor Activity. JAn tibiot (Toyko) Production of a Monoclonal Antibody (K-931) to a Squamous Cell Carcinoma Associated Antigen Identified as the 17-1A Antigen Anti-lamintn Receptor Antibody Targeting of Liposomes with Encapsulated Doxorubicin to Human Breast Cancer Cells in Vitr~ internalization of the Cytotoxic Molecules of TI01 F(Ab')2-(Pdcin-A-Chaln) Immunotoxin into Human T-Leukemic Cells Identification of a Novel Nucleotide-sensitive Mlcrotubule-binding Protein in HeLa Cells Association Between Poor Prognosis in Early. stage Invasive Cervical Carcinomas and Nondetection of HPV DNA Stabilization of the Topulsomel-m~ II-DNA Cleavage Complex by Antineoplastic Drugs: Inhibition of Enzyme-mediated DNA Rellgation by Using Tumor-lnfilirating Lymphocytes Modified by Retroviral Transductinn Growth Inhibitory Effects of Interferon-~ But not interferon-~ on Human Glioma Cells --Correlation of Receptor Binding, 2',5'-oligoadenyiate Synthetase and Protein Klnase Activity Lymphoktne Gene Therapy for Cancer The Role of Lipocortin-I in Macrophage-Mediated lmmunosuppresslon in Tumor-Bem'lng Mice Overexpresslon of TGFain Transgenic Mice: induction of Epithelial Hyperplasia, Pancreatic Metaplasta, and Carcinoma of the Breast Regulation of Purine Deoxynucleostde Phosphorylation by Deoxycyfldine Klnase from Human Leukemic Blast Cells Growth Factor Receptor Monoclonal Antibodies and Cancer Immunotherapy Characterization of the Activation of Latent TGF-Beta by CO-Cultures of Endothelial Cells and Pericytes or Smooth Muscle CelLs -a Self-Regulating System Allogenelc Bone Marrow TranspLantation for Leukemia with Marrow Grafts Depleted of Lymphocytes by Counterllow Centrifilgation Characterization of the Synergistic Antlproltferative Effects of Interferon-T and Tumor Necrosis Factor on Human Colon Carcinoma Cell Lines Protective Activity of Recombinant Murine Tumor Necrosis Factor-u and interferon-y Against Experimental Murine Lung Carcinoma Metastases VADAS M& A Novel Tumor Necrosis Factor-responsive Transcription Factor Which RecOgnizes a Regulatory Element in Hemopuletic Growth Factor Genes Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4 Angiogenic and Invasive Properties of Neurofibroma Schwann Cells Insulin-resistant Diabetes Associated with Partial Deletion of Insulinreceptor Gene Cellspecific Toxicity of a Chimeric Protein Composed of interleukin-6 and Pseudomonas Exotoxtn (1L6-PE40) on Tumor Cells Studies of the HER-2neu Protooncogene in Human Breast and Ovarian Cancer. Science Effective Purging of Bone Marrow by a Combination of Immunorosette Depletion and Complement Lysis LIposome-aasoclated Human Interferon-T Cloning and Sequence Analysis of the V H and V L Regions of an Anti-myelln/DNA Antibody from a Patient with Peripheral Neuropathy and Chronic Lymphocytic Leukemia. j lmmuno11990 Cytotoxiclty of a Low Molecular Weight Cn2Zn 2 Superoxide Dismutase Active Center Analog in Human Erythroleukemia Cells. B/0ckem Mediated Gene Transfer into Bone Marrow Progenitor Cells: use of Beta-galactosldase as a Selectable Marker Human T Cell Responses to Human Papillomavirus Type 16 LI and E6 Synthetic Peptides: Identification of T Cell Determinants, HI.A-DR Restriction and Virus Type Specificity Effects of Prolonged Exposure to Interferon-Alpha on the Viability, Proliferation, Differentiation, and Tumorigenicity of HL-60 Promyelocytic Leukemia Cells EffectS of Cytokines from Virus-Induced Human Lymphoblosts on the Growth and Viability of the Promyelocyttc Leukemia Cell Line HL.60 Cysteine Proteinase Inhibitor in the Ascitic Fluid of Sarcom-180 Tumor-Bearing Mice is a Low Molecular Weight Kininogen --Partial NH2-Terminal and CO•H-Terminal Sequences and Susceptibility to Various Glandular Kallikreins Eponemycin, a New Antibiotic Active A~in~t B16 Melanoma. 1. Production, Isolation, Structure and Biological Activity Resorthinmycin, a Novel Antitumor Antibintic.1. Taxonomy, Isolation and Biological Activity. JAnttbi0t (Toyko) Mtemicldin, a New Acaricidal and Antitumour Substance. I. Taxnnomy, Fermentation, Isolation and Physico-chemical and Biological Properties Protection of Mice Against Tumor Growth by Immunization with an Oncogene-Encoded Growth Factor. prc~ Natl Acad Sci Cytostatic Effect of Antiestrogens in Lymphoid Cells: Relationship to High Affinity Antiestrogenbinding Sites and Cholesterol. B~'m Biot~ys Acta Effects of Recombinant Human Granulocyte Colony-stimulating Factor on the Hematologic Recovery and Survival of Irradiated Mice Autocrine Regulation of Human Tumor Cell Proliferation by Insulin-Like Growth Factor-I1 --an Invttro Model Isolation of CDNAs Encoding a Human Protein that Binds Selectively to DNA Modified by the Anticancer Drug e/sdtammlqedichloroplatinum(II) ROW1~ DA: A Highly Immunogenic Tumor Transfected with a Murine Transforming Growth Factor Type [~1 CDNA Escapes lmmnne Surveillance Interleuktn-7 is a Growth Factor of Precursor-B and Precursor-T Acute Lymphobiastic Leukemia Antibody to Hepatitis C Virus in Hepatoreliniar Carcinoma Structure of Gone Mtsl, Transcribed in Metastatic Mouse Tumor Cells Autofogous Bone Marrow Transplantation in High-risk Remission T-lineage Acute Lymphoblastic Leukemia Using Immunotoxins Plus 4-hydroperoxycyclophosphamide for Marrow Purging Signal Transductinn by Synergistic AntiVumor Activity of Etoposide and Human Interleukin-10tAgainst Human Melanoma Cells. j Natl Cancer Inst Chemo-Enzymatic Synthesis of Optically Pure L-Leucovorin, an Augmentor Of 5-Fluorouracll Cytotoxtclty Against Cancer Use of Anticontamination Primers in the Polymerase chain Reaction for the Detection of Human Papilloma Virus Genotypes In Cervical Serapes and Biopsies Versus High-dose Interferon Alfa-Za in Relapsed Indolent Non-Hodgkin's Lymphoma Identification of an Endothelial Cell Growthinhibitory Activity Produced by Human Monocytes Production of a Protein A-lymph•toxin Hybrid Protein for Cancer-targeted Therapy Intermolecuiar Association • • of the PlaSneu Protein and EGF Receptor Modulates EGF Receptor Function Bone Marrow Graft Engineering by COunterflow Centrifugal Elutrtatinn --Results of a Phase-I41 CHntcal Trial Induction of ltaptotactic Migration of Melanoma Cells by Neutrophil Activating ProteIn Interleukin-8 IFN-~ and IFN-T can Affect Both Monorytes and Tumor Cells to Modulate Monocyte-medlated Cytotoxicity The • AppHcatinn of the Polymerase chain Reaction to Cloning Members of the Protein Tyrosine Kinase Family Relationship Between Reductive Drug Metabolism in Tumour Tissue of Anthracyclines in Mlcrosphertcal Form and Anti-tumour Activity. BioJ~m Pharmaco11990 Tumor Necrosis Factormediated Cytotoxicity by Tumor-associated Macrophages Detection of the Tumorassociated Glycoprotein Antigen (TAG-72) in Premallglmnt Lesions of the Colon Expression of C-erbB-20ncoprotein: a Prognostic Indicator in Breast Cancer An lmmunogenic M r 23,000 Integral Membrane Protein Of &~istosoma Mansoni Worms that Closely Resembles a Human Tumor-associated Antigen Studies on the Suppression of ~ Cell Growth in V@ro by Low Molecular Weight Suppressor of Human Fetal Liver Origin Significance of the Histidine Residue at the High Afl!lnity Saccharide-binding Site of Rlcin E Receptor-mediated Endocytosis of Transfecrin Polycatinn Conjugetes --an Efficient Way to Introduce DNA into Hematopoietic Cells NH2-terminal Amino Acid Sequence and Glycosylation Variants Heterogeneity in interleukin (EL)-1 Receptors Expressed on Human B-cell Lines --Differences in the Molecular Properties of EL-l-Alpha and ID1-Beta Binding Sites Ligand-sated Ion Channels in the Brain: the • Amino Acid Receptor Superfamlly Affinity Labeling of tt Optoid Receptors by Suilhydryl &lkylating Derivatives of Morphine and Morphinone Purification and Characterization of Interleukin-1 Receptor Level Antagonist Proteins from Thp-1 Cells The Modes of Binding of Llgauds to Cardiac Muscarhflc Receptors Assembly and Function of the T-cell Antigen Receptor -Requirement of Either the Lysine or Ar~nlne Residues in the Transmembrane Region of the Alpha-Chain Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes correction Therapeutic Potential for New Selective Adenosine Receptor Llgands and Metabolism inhtbitors Human Estrogen Receptor Forms Multiple Protein-DNA Complexes Phosphorylation of the 1,25-Dlhydroxyvitamin-D3 Receptor --a Primary Event In 1,25-Dthydroxyvttamin-D3 Action Some Considerations of Receptor Specificity Different Regions of the Estrogen Receptor are Required for Synergistic Action with the Glucocortieold and Progesterone Receptors 82-microglobulin Enhances InsulinAlke Growth Factor I receptor Levels and Synthesis in Bone Cell Cultures Study on the Variables Affecting Toxicity of Hybrid Toxins. The Effect of Different Target Cell Receptor Distribution and Toxin Binding Chain The Nicotinic Acetylcholine Receptor: • an Ailosteric Protein Prototype of Ltgand-gated Ion Channel ~sation and Characterisation of Three Different ~-adrenergic Receptors Expressed in Escher/d~a Colt EurJ B/0~em A Second Molecular Form of D 2 Dopamine Receptor in Rat and Bavtne Caudate Nucleus Functional Diversity of Bioactive Peptides in the Nervous System Itself: 'how the Brain Progesterone Receptor Regulation by Retinolc Acid in the Human Bre~t Cancer Cell Line T-47D Characterization of Pp85, a Target of Oncogenes and Growth Factor Receptors Retinold Receptor Antisense DNAs Inhibit Alkaline Phosphatase Induction and Clonogentcity in Malignant Keratinocytes A New Cytokine Receptor Superfamlly Transferrtn Polycation-Medtated Introduction of DNA into Human Leukemic Cells ---StImulation by Agents that Affect the Survival of Transfected DNA or Modulate Transferrin Receptor Levels Elatelet Thromboxane-A2 Prostaglandin-H2 Receptors in Human Volunteers on Low Doses of Aspirin. Biochem Pharmaco11990 Recombinant Interferon-Y. Differences in Glycosylation and Proteolytic Processing Lead to Heterogeneity in Batch Culture Receptor Interconverslon Model of Hormone Action. 2. Requirement of Both Kinase and Phosphatase Activities for Conferring Estrogen Binding Activity to the Estrogen Receptor Molecular Cloning and Expression of the Gene for a Human D 1 Dopamine Receptor Epidermal Growth Factor and Transforming Growth Factor-~ Induce Differential Processing of the Epidermal Growth Factor Receptor Receptors for Tumor Necrosis Factor on Neoplastic B Ceils from Chronic Lymphocytic Leukemia are Expressed in Vitro But not in Vivo EAA PHARMACOLOGY: Excitatory Amino Acid Receptors in Epilepsy Role of Extracellular Disulfide-bonded Cysteines in the Llgand Binding Function of the ~2-adrenergtc Receptor. B/cchemBtry Superactlve Estrogen Receptors -Potent Activators of Gene Expression Antibodies to a Soluble Form of a Tumor Necrosis Factor (TNF) Receptor have TNF-Llke Activity Receptors and the Common Cold Three Dimensional Modelling • of G Protein-linked Receptors Contrasting Developmental and Tissue-specific Expression of ~ and [3 Thyroid Hormone Receptor Genes Purification and Biochemical Characterization of a Soluble Human Interferon-Gamma Receptor Expressed in Eacherichla-Coli Direct Measurement of Agonist Binding to Genetically Engineered Peptldes of the Acetylcholtne Receptor by Selective T 1 NMR Relaxation Site Directed Mutagenesis of M 1 Musearittic Acetylcholine Receptors: Conserved Aspactic Acids Play Important Roles in Receptor Functions. Mol Fharmaco11989 Purification and Characterization of the Receptor for Murtne Granulocyte Colony-Stimulating Factor Human Interferon-T Receptor. Mapping of Epltopes Recognized by Neuttultzing Antibodies Using Native and Recombinant Receptor Proteins Effect of Interferon-alpha on the Expression and Release of the CD23 Molecule in Hairy Cell Leukemia More Selective Ugands at Elcosanold Receptor Subtypes Improve Prospects in Inflammatory and Cardiovascular Research cDNA • Cloning of the Human Dopaminergic D 3 Receptor and Chromosome Identification. C/~ Acad Sci Alternative Splicing Directs the Expression of Two D 2 Dopamine Receptor Isoforms The Tyrosine Klnase Activity of the Epidermal-growth-factor Receptor is Necessary for Phospholipase A 2 Activation. B/ochem J 1990 Coexpresston of the Genes for Platelet-derived Growth Factor and Its Receptor in Human Tcell Lines Infected with HTLV-I Expression of lmmtmoglobulin-T-cell Receptor Chimeric Molecules as Functional Receptors with Antibody-type Specificity Cloning and Expression of a Rat Brain GABA Transporter The LDL Receptor Pathway Delivers Arachtdonic Acid for Eicosanoid Formation in ceils Stimulated by Platelet-Derived Growth Factor LANSBURY PT JP~ Molecular Determinants of Amylold Deposition in Alzhetmer's Disease: Conformational Studies of Synthetic ~-protein Fragments. B/0chemistry 1990 Model for the Structure of Bacteriorhodopstn Based on High Resolution Electron Cryomirroscopy Treatment of Corticosteroid Resistant Acute Graft-versus-Host Disease By invivo Administration of Anti-interleukin-2 Receptor Monoclonal Antibody (B-B10) CRAGOE Factor Stimulates the Anchorage-independent Growth of Human Squamoos ceil Carcinomas Overexpressing Its Receptors Isolation and Characterization of the ¢~ Platelet-dcrived Growth Factor Receptor from Rat olfactory Epithelium A 22-Amino-Acid Peptide Restores DNA-Bindtng Activity to Dimerlaation-Defective Mutants of the Estrogen Receptor •estrogen Receptor B-region Polymorphtsm and Spontaneous Abortion in Women with Breast Cancer LENT~ Tk The Recognition Event Between Virus and Host Ceil Receptor: a Target for Antiviral Agents Thteonine 1336 of the Human Insulin Receptor is a Major Target for Phosphorylatinn by Protein Kinase C Cloning, sequencing and Expression of the Human Thyrotropin (TSH) Receptor: Evidence for Binding of Autoantibodies Distinct Requirements for Activation at CCK-A and CCK-B/gastrin Receptors: Studies with a C-tcrmtnal Hydrazide Analogue of Cholecystoklnln Tetrapeptide (30-33) Cerebellar GABA A Receptor Selective for a Behavioural Alcohol Antagonist Structural and Functional Characterization of a Cell Surface Binding Protein of Vaccinia Virus A Cetebeilar Porkinje Cell Marker P400 Protein is an Inosltol 1,4,5-trisphosphate (InsP3) Receptor Protein. Purification and Characterization of h~P 3 Receptor Complex PhotoaMnlty Receptur Antagonist for Human Platelet Thromboxane-A2 Prostaglandin-H2 Receptors Cytoldne Receptors and B Cell Functions. I. Recombinant Soluble Receptors Specifically Inhibit IL-1 and IL-4-1nduced B Cell Activation in Vitro Characterization of the MRC OX40 Antigen of Activated CD4 PosRive T Lymphocytes --a Molecule Related to Nerve Growth Factor Receptor Nuclear Receptor that Identifies a Novel Retinolc Acid Response Pathway Heterogeneity of Cell Surface F~adothelin Receptors Expression of Human Beta-1 and Beta-2 Adre2nergic Receptors ha Jgcoli as a New Tool for Ligand Sereeulng Selective Binding of Llgands to ~182 or Chimeric 81/82 Adrenergtc Receptors Involves Multiple Subsites Structure nfa Cannabinold Receptor and Functional Expression of the Cloned CDNA Dissection of the Growth versus Metabolic Effects of Insulin and Insulin-like Growth Factor-I in Transfected Cells Expressing Klnase-defective Human Insulin Receptors Mechanisms of Multidrug Resistance in HL60 Cells. Analysis of Resistance Associated Membrane Proteins and Levels of mdr Gene Expression Receptor Interconversinn Model of Hormone Action. 1. Purification of a Factor Involved in Conferring Estradiol Binding Properties to the Estrogen Receptor Viral Receptors, or Perverted Recogniton. Recherc~ Intecleukin 2-induced Tyrostne Phosphorylation. Interleukin 2 Receptor 8 is Tyrosine Phosphorylated A Model for the interaction of Muscacinic Receptors, Antgonists, and Two Distinct Effector Substances Cloning, Sequencing and Expression of Human TSH Receptor Multiple D z Dopamtne Receptors Produced by Mternative RNA Splicing Proteolytic Fragments of the Nicotinic Acetylcholine Receptor Identified by Mass Spectrometry: Implications for Receptor Topography Estrogen Receptor Mediated Repression of Reporter Gene Activity in A431 Cells Molecular • Cloning, Sequence and Functional Expression of the CDNA for the Human Thyrotropin Receptor The Transformed Glucocorticoid Receptor Has a Lower Steriod-bindtng Amnlty Than the Nontransformed Receptor RAt NA~ STEINMAN ]2 Predominant Expression of T Cell Receptor V~ 7 in Tumor Infiltrating Lymphocytes of Uveal Melanoma Insulin-like Growth Factor-H Mannose 6-phosphate Receptor is Incapable of Activating GTP-binding Proteins in Response to Mannose 6-phosphate, But Capable in Response to Insulinlike Growth Factor-II. Bioc)2em Heterogeneity of Rearranged T-cell Receptor Vc¢ Transcripts in Brains of Multiple Sclerosis Patients Molecular Biology of GABA A • Receptors Mort•el•hal Antibody to Interleuldn-2 Receptor in Liver Graft Rejection Thyroid Hormone Receptor Expression in 'sick Euthyroid' Syndrome [letter The use of Proteolysis and Direct N-terminal sequence Analysis to Study Human Interleuktn-2/receptor Interaction on Solid Support Baculovtru$-Directed Expression of the Human Insulin Receptor and an Insulin-Binding Ectodomatn Expression • and Pharmacological charactertsation of the Human M1 Muscarinic Receptor in Saccharomyces Cerevisiae Isolation and Properties of the ~-latrotoxin Receptor Two Adjacent MyoDl-binding Sites Regulate Expression of the Acetylcholinc Receptor c~-subunli Gene Ideotlllcation of Epitopes on the Human Insulin Receptor ReactIng with Rabbit Polyclonal Antisera and Mouse Monoclonal Antibodies CD4 + T Cell Response to the Human Acetylcholine Receptor ~ Subunit In Myasthenla Gravi~ a Study with Synthetic Peptldes J& Detection and Analysis of Interferon-Alpha Receptors on Plasma Membranes and In Detergent Extracts The Nonacttvated Progesterone Receptor is a Nuclear HeterooHgomer The Noncompetitive Blocker iH-3~Chlorpromazine Labels 3 Amino Acids of the Acetylcholine Receptor Gamma-Subunit --Implications for the Alpha-Helical Organization of Regions-Mli and for the Structure of the Ion channel Thrombin Receptor Antagonists. Structureactivity Relationships for the Platelet ThrombIn Receptor and Effects on Prostacyclin Synthesis by Human Umbilical Vein Endothelial Cells. Biochem Pharmaco11990 Interleuktn 8 (monocyte-derived Neutrophil Chemotactic Factor) Dynamically Regulates Its Own Receptor Expression on Human Neutrophils The Deslgu of Full Agonists for the Cortical Muscarinlc Receptor Binding of the Snake Venom-Derived Proteins Applaggtn and Echistatin to the Argtnine-GlycIne-Aspartic Acid Recognition Site(S) on Platelet GlycoproteinAlb.Illa Complex Inhibits Receptor Function CM: Brain 5-HTIA Receptor Agonism: a Novel Mechanism for Antihypertensive Action Deletion Analysis of the Human Insulin Receptor Ectodomain Reveals Indepeodentiy Folded Soluble Subdomains and Insulin Binding by a Monomeric Alpha Reconstitution of Solubllized Delta-Opiate Receptor Binding Sites in Lipid Vesicles The Major Dopamine !)2 Receptor: Molecular Analysis of the Human D2as a Subtype Regulation of Muscarinic Acetylcholine Receptor Function in Cardiac Cells and In Cells Expressing Cloned Receptor Genes Insulin-resistant Diabetes Associated with Partial Deletion of Insulinreceptor Gene Molecular Cloning and Characterisatlon of a Novel Dopsmine Receptor (1)3) as a Target for Neuroleptics Flip and Flop: a Cell Specific l~nctlonal Switch In Gletamate-operated Channels in the CNS Interleukin-3 Stimdiates the Tyrosine Phosphorylation of The 140-1dlodaltot~ Interleukin-3 Receptor Protective Effect of Rhin~ Receptor Blocking Antibod~ in Human Flbroblast Cells The Divergent Receptors for TNF The Arrangement of the Immunoglobulin-like Domains of ICAM-1 and the Binding Sites for LFA-1 and Rhinovtrus Neuroscience: a Finger on Brain Receptors Aspects of the Structure of the D 2 • Dopamine Receptor Interesting Times for Dopamine • Receptors Nicotinic • Acetylcholine Receptor Snperfamily of Ltgand-gated Ion Channels ~7: Evidence for PhosphatidylInositol-Llnked Forms of Human a~d Aria• Ftbrunectin Receptors Functional Analysis of the Murine T-Cell Receptor-Beta Enhancer and characteristics of Its DNA-Binding Proteins A Domain of the Insulin Receptor Required for Endocytosis In Rat Fibroblasts The DopamIne D z Receptor: Two Molecular Forms Generated by Alternative SplicIng • Domain of the ~-adrenergtc Receptor with a Fluorescent Antasonist Carszolol BOUILtON Fc T Lymphocytes and Their CD4 Subset are Direct Targets for the Inhibitory Effect of Calclirlol Recombinant Soluble Receptors for the Fcgamma Portion Inhibit Antibody Production invitro A Monoclooal Antibody Against PDGF B-Chain Inhibits PDGF-Induced DNA Synthesis in C3H Flbroblasts and Prevents BInding of PDGF to Its Receptor Molecular Deternflnants of the BenzodlazepIne Receptor Affinities and Antlconvnlsant Activities Modulation of Trypanosoma Cruz/Adhesion to Host Muscle Cell Membranes by Ltgands of Muscarinic Cholinergic and Beta Adrenergic Receptors An Insertinn In the Human ThyrotropIn Receptor Critical for High AtHnity Hormone BIndIng Stere•selectivity of the Interaction of Moscarinic Antagonists with Their Receptors Regulation of Epidermal Growth Factor Receptor Signal Transductlon -Role of Gangliosides Soluble Human Complement Receptor Type 1: In Vlvo Inhibitor of Complement SuppressIng Post-ischemlc Myocardial Inflammation and Necrosis. Sdem Mother • Mechanism for Creating Diversity in y-amino Butyrate Type a Receptors: RNA Splic/Lng Directs Expression of Two $orras Of y2 Subtmit One of Which Contains a ProteIn !ctna~ue. C Phosphorylation Site. pro¢ Effects of Polyamines on the Binding of [3H]MK-801 to The gmethyl-D-aspsrtate Receptor: Pharmacological Evidence for the Existence of a Polyamine Recognition Site Evidence for the • importance of a Carboxyl Group in Ligand BInding to the D 2 Dopamine Receptor Identllicatioo of an Alternate Type I Insulin-like Growth Factor Receptor [~ Subunit MRNA Transcript Reconstitutino of Peripheral Benzodlazepine Receptor Expression In X-Linked chronic Gfanulomatuns Disease by Interferon-Gamma Receptor-mediated Endocytosis of Transferrin Polycation Conjugates --an Efficient Way to Introduce DNA Into Hematopoletic Cells Cloning and Expression of Human and Rat D1 Dopamine Receptors Discrete Mutations • Introduced in the Predicted Nucleotide-btnding Sites of The mdr~l Gene Abolish Its Ability to Confer Multldrug Resistance Design of DNA Interealators to Overcome Topolsomerase ffmediated Multldrug Resistance Functional Expression of Murine Multidrug Resistance in Xenopus-Laevts Oocytes Correlation • of Protein Kinas¢ C Translocation, P-Glycoprotein Phnsphorylatinn and Reduced Drug Accumulation In Multidrug Resistant Human KB Cells Protein • Kitmse C phosphorylates P-Glycoprotein in Multidrug Resistant Human KB Carcinoma Cells • RON1NSON 113: Gem•role Organization of the Human Multidrug Resistance (MDR) Gene and Origin of P-Glycoprotetn Cisplatin-resistant Cells Express Increased Levels of a Factor that Recognizes Dalnaged DNA Two Members of the Mouse malt Gene Family Confer Multidrug Resistance with OverlappIng But DistInct Drug Speclticliies MHC Class II Region Encoding Proteins Related to the Multidrug Resistance Emily of Transmembrane Transporters Understanding of the Molecular Basis of Drug Resistance in Cancer Reveals New Targets for Chemotherapy Role of Membrane Ltptds in the Interaction of Daunomycin with plasma Membranes from Tumor Cells: Implications In Drug-resistance Phenomena Multidrug Resistance in Cells Transfected with Human Genes Encoding a Variant P-Glycoprotein and Glutathione S-Trat~ferase-PL Mol Pharmaco11990 Amino Acids ill the Dihydrofolate Reductase-thymidylate Synthase Gene of Plasmodtum-falclparum Involved In Cyclog~mnll Resistance Differ from those Involved In Pyrtmethamine Resistance Several Alleles of the Multidrug-resistance Gene are Closely Linked to Chloroquine In Plasmodium Falclparum Ideotlfication of the Multtdrug Resistance-related Pglycoprotein as a Cyclosporine Binding Protein. Mol pharma~11989 Expression of a Human Multidrug Resistance CDNA (MDR/) in the Bone Marrow of Transgenic Mice: Resistance to Daunomycin-tnduced Leukopenia NEEIDN Pc Modulation of Doxorublcin-lnduced chromosomal Damage by Calmodulin Inhibitors and Its Relationship to Cytotoxicity in Progressively Doxorublcin-Resistant Tumor cells Expression of the Human Multidrug Transporter in Insect Cells by a Recombinant Baculovirus Binding Protein-dependent Transport Systems Structural Analysis of the Mouse MdrlA (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Moltidrug-Resistant J774.2 Cells Structural Model of AT]P-binding Proteins Associated with Cystic Fibrosis, Multidrug Resistance and Bacterial Transport The Blestieldin-S Resistance Gene (Bar) &electable in a Single Copy State in the Bacifius-Subtilis chromosome The 70 KD Peroxisomal Membrane Protein is a Member of the Mdr (P-Glycoprotein)-related ATP-binding Protein Superfamily Mathematical Models of Gene Amplification with Applications to Ceilular Drug Resistance and Tumorigenicity Cloning by Gene Amplification of Two LOCI Conferring Multiple Drug Resistance in Sacchacomyces Characterization of Gentamicin-Resistant Respiratory-Deficient (RES-) Variant Strains of Staphylococcus-Aureus Genetic Elements Involved in Tn21 Site-specific Integration, a novel Mechanism for the Dissemination of Antibiotic Resistance Genes Multidrug Resistance Associated with Altered Topoisomerase H Activity --Topoisomerases H as Targets for Rational Drug Design Use of the Polym~ chain Reaction in the Quantitation of mdr~l Gene Expression BRK/0em/stry Glutathione ~transferase x as a Determinant of Drug Resistance in Transfectant Ceil Lines Quantitative Analysis Of MDR/ (Multidrug Resistance) Gene Expression in Human Tumoues by polymerase chain Reaction Essential l~eatuges of the Pglycoprotetn Pharmacophore as Defined by a Series of Reserpine Analogs that Modulate Multidrug Resistance. pro6 Natl Acad Sei U S A S1NHA BK: P-Glycoprutein-Independent Mechanism of Resistance to Vp-16 in Multidrug-Resistant Pharmaceutical applications Antisense technology 337 Tumor Ceil Lines --phacmacoklnetic and Photoufl~**tty Labeling studies Photosensitized Labeling of a Functional Multldrug Transporter in Living Drug-resistant Tumor Cells Cell-Specific Activity of Cis-Acting Regulatory Elements in the Promoter of the Mouse Mnitidrug Resistance Gene Mdrl Physical Mapping, Amplification, and Overexpressinn of the Mouse mdr Gene Family in Multidrugresistant Ceils Identification of the Cystic Fibrosis Gene: Cloning and characterization of Complementary DNA Molecular Basis of Preferential Resistance to Colchicine in Multidrug-resistant Human Cells Conferred by Gly186-Va1185 Substitution in P-Glycoprotein Emetineresistant Mutants of Entamoeba-histolytica Overexpress Messenger RNAs for Multidrug Resistance A Gene in the Human Major Histocompatibility Complex class II Region Controlling the class I Antigen Presentation Pathway characterization • of a Membrane-associated Protein Ktnase of Multidrug Resistant HL60 Cells Which Phosphoryiates P-Glycoprotein Use of Recombinant p-giycoprutein Fragments to Produce Antibodies to the Multifirug Transporter Over-• Expression of the Mnitidrug Resistance Gene radr3 in Spontaneous and Chemically Induced Mouse Hepatocelluiar Carcinomas Sequences Encoded in the Class 1I Region of the MHC Related to the 'ABC' Supef4~mlly of Transporters Chloroquine Resistance not Linked to mdr.ltke C~nes in a Plasmodtum Falalmrum Cross What Determines the Substrate Specificity of the Multi-drug-resistance Pump? Cross-Resistance to Anti-HIV Nucleoalde Analogs in Multidrug-Resistant Human Ceils Conservation Between Yeast and Man of a Protein Associated with U5 Small Nuclear Rlbonuclenprotein Proliferation of Human Malignant Melanomas is Inhibited by Antisense Oligodeoxynucleotides Targeted Against Basic Flbroblast Growth Factor Synthesis and Applications of Oligorlbonucleotides with Selected 2'-Omethyiation Using The 2'-O-[1-(2-fluorophenyl)-4-methoxyplperidin-4-ylk] Protecting Group Inhibition of Neurite Polarity by Tall Anttsense Oligonocleotides in Primary Cerebeliar Neurons Organ-Specific Modulation of Gene Expression in Transgenie Plants Using Antisene RNA Designing Antlsense Oiigonucleotldes as phartnaeeutical Agents Retinotd Receptor Anttsense DNAs Inhibit Alkaline Phosphatase Induction and Clonogenictty in Malignant Keratinocytes CULLEN BPc The HIV-1 TAT Protein: an RNA Sequeneeoo specific Processivity Factor? Regulation of Gene Expression Invtvo by Liposome-Mediated Delivery of a Purified Transcription Factor Antivtral Activity and Possible Mechan|gm$ of Action of Oligonucleotides-ply(L-lysine) Conjugates Targeted to Vesicular Stomathis Virus MRNA and Genomlc RNA Antisense Agents in Pharmacology Complementary Oglinnucleotide Sequence Inhibits Both Vmw65 Gene Expression and Replication of Herpes Simplex Virus Highly Specific Inhibition of IGF-I-Stlmulated Differentiation by an Antisense Oligodeoxyribonucleotide to Myogenin Messenger RNA -no Effects on Other Actions of IGF-L Mechanisms of Inhibition of Herp~ Simplex Virus Type 2 Growth by 28-mer Phosphorothioate Oligodeoxycytldine Specific Regulation of Gene Expression by Antlsense, Sense and Antigene Nucleic Acids Catalysis of RNA Cleavage by the • • Tetrahymena Thermoph//a Ribozyme. 1. Kinetic Description of the Reaction of an RNA Substrate Complementary to the Active Site. B/~hem/stry Melting and Chemical • • Modification ofa Cyclized Self-splicing Group I Intron A New Class of Antivtrals --Antisense Oligonucleotides Combined with a hydrophobic Substituent Effectively Inhibit InfluenZa Virus Reproduction and Synthesis of Virus-specific Proteins in MDCK Cells An Antisense RNA involved in P53 MRNA Maturation in Murine Erythroleukemia Cells Induced to Differentiate Molecular Cloning Of Xenoitma Fibriilarin, a Consetwed U3 Small Nuclear Ribonucleoprotein Recognized by Antisera from Humans with Autoimmune Disease Antisense-fos RNA Causes Partial Reversion of the Transformed Phenotypes induced by the C-Ha-ras Oncogane Expression of Antisense RNA Fails to Inhibit Influenza Virus Replication Modulation of Interleukin-1-beta Gene Expression Using Antisense Phosphorothioate Oligonucleotides Turnout-specific Inhibition of Lymphoma Growth by an Antisense Oligodenxynucleotide Sterochemistry of RNA • • Cleavage by the Tetrabymena Rlbozyme and Evidence that the Chemical Step is not Rate-limitIng Pharmaceutical applications Fundamental research and rational drug design MIROSHN1CHENKO O1 Cells by Antisense RNAs Against the Viral Ela Region Regulatioo of Plant Gene Expr~c~slon by Antisense RNA Specific Antisense RNA Inhibition of Growth Hormone Production in Differentiated Rat Pituitary Turnout Ceils Sugar Modified Olt8onucleotides. 1. Carbooligodenxynudeotides as Potential Antisense Agents MUH£R WEC~ Inhibition of Expression of Human lmmunodeflclency Virus-1 lnvitro by Antibody-Targeted Ltposomes Containing Antisense RNA to the Env Region Inhibition of Human lmmunodeficiency Virus Replication in Ceil Culture by Endogenously Synthesized Antisense RNA An~ HA Inhibition of 6-glucuronidase Gene Expression in Transgenic Tobacco can be Transiently Overcome Using a Heat-inducible ~-glucuronidase Gene Construct Oilgodeoxynudeotides as Anti-sense Iohibitors of Gene Expression: Therapeutic Implications Reduction of N-myc Expression by AnttseJase RNA is Amplified by Interferon -Possible involvement of the 2-5A System Specific Inhibition of Human Immunodeficiency Virus Type-1 Replication by RNA Transcribed in Sense and Antlsense Orientation from the 5'-Leader GAG Region Site Specific Cleavage of a oo Yeast Chromosome by oltgonucleotide-directed Triple-helix Formation Post4ranscrtptional Events are Responsible for Low Expression of Myelin Basic Protein in Myelin Deficient Mice: Role of Natural Antisense RNA Antisense OHgonucleotides: OO a New Therapeutic Principle Reduction of EGF Receptor Levels in Human Tumor Cells Tratmfected with an Antisense RNA Expression Vector Fundamental research and rational drug design AOA GI~ The Immunological Principles of Vaccination Uptake of 2', 3'-dideoxyadenosine in Human Immunodeficlancy Virus-infected and Noninfected Human Cells Site-dfrected Mutagenesis in Human Tlssue-plasminogen Activator. Distinguishing Sites in the Amino-terminal Region Required for Full Fibrinolytic Activity and Rapid Clearance from the Circulation Hulnan Splenic Galaptin --Carbohydrate-Binding Specificity and CharacterlTmllon of the Combining Site Insulin Receptor Internalization Defect in an Insulinresistant Mouse Melanoma Cell Line Transgeulc Mice with Intracelular Immunity to Influenza Virus interaction of DNA Intercalator 3-nitrobenzothlazolo (3,2-a)qulnolintum with DNA Topoisomerases --a possible-mechanism for Its Biological Activity Design of DNA intercalators to Overcome Topoisomerase Hmediated Multidrug Resistance Inactivation of Viral Antigens for Vaccine Preparation with Particular Reference to the Application of Binary Ethylenlmine Dolastatin-10. a Powerfnl Cytostatic Peptide Derived from a Marine Animal --Inhibition of Tubulin Polymerization Mediated Through the Vinca Alkaloid Binding Domain Synthesis and Characterizatioo of ~t-conotoxtn IIla A Linear Amino Acid Sequence Involved in the Interaction of T-PA with Its Endothelial Ceill Receptor. B/o0d 1989 Purification of Bone Morphogenetic Protein Derived from Bovine Bone Matrix Chemical Modification of the Recombinant Human aLA-and f~-interferons Formulation and Characterization of a Multiple Emulsion for use as a Red Blood Ceil Substitute The Biological Activity of interferon-~ is Influenced by Two Distinct Regions in the Protein From Jenner to Genes --the New Vaccines Characterization of a Modified Human Tissue Plasminogen Activator Comprising a Kringle-2 and a Protease Domain Protein and Carbohydrate Structural Analysis of a Recombinant Soluble CD4 Receptor by Mass Spectrometry JPc Evidence that Chemical Modification of a Positively Charged Residue at Position 189 Causes the Loss of Catalytic Activity of Iron-containing and Mansanese-containing Superoxide Dismu~ Study on the Variables Affecting Toxicity of Hybrid Toxins. The Effect of Different Target Ceil Receptor Distribution and Toxin Binding Chain Purification and characterization of the Erythropoietin-sensitive Membrane Phosphoprotein, Pp43 Modifications of Positon 12 in Parathyroid Hormone and Parathyroid Hormone Related Protein: Toward the Design of Higldy Potent Antagonists A Synthetic Peptide Corresponding to Human FSH ~-subunit 33-53 Binds to FSH Receptor, Stimulates Basal Estradiol Biosynthesis, and is a Partial Antagonist of FSH Substitution of Prollne with Plpecoic Acid at the Sclsslle Bond Converts a Peptide Substrate of HIV Proteinase into a Selective Inhibitor Expression and Secretion of a Functional Scorpion Insecticidal Toxin in Cultured Mouse Cells Pseudomonas Aeruglnosa Exotoxin-A --Alterations of Biological and Biochemical Properties Resulting from Mutation of Glutamic Acid-553 to Aspartir Acid Correction of the Cystic Fibrosis Defect Invttro by Retrovtrus-Medlated Gene Transfer The Purtue Path to Chemotherapy Non-Activated Rat Neuteophils Kill Syngenelc Colon Tumor Cells by the Release of a Low Molecular Weight Factor Characterization of Gonadotropinreleasing Hormone (GnRIt) Binding Sites in the Pituitary and Testis of the Frog Medicinal Plants (in French) Structural Comparison of Anticancer Drug-DNA Complexes: Adrlamycin and Daunomycin The Functional Site of Placental Anticoagulant Protein --Essential Hlstidine Residue of Placental Anticoagulant Protein All Essential Role for Constitutive Schtff Base-forming Ligands in Antigen Presentation to Murine T Cell Clones Muscartnic Agonists for Senile Dementia: Past Experience and Future Trends Detection of New Mutation Disease in Man and Mouse Purification and characterization of Angiotensin-binding Protein from Porcine Liver Cytosolic Fraction Characterization of Recombinant Human Lymphotoxin (tumor Necrosis Factor-B) Produced by a Mammalian Cell Line Purification and Characterization of an insulin-like Growth Factor H Variant from Human Plasma Expression and Kinetic Characterization of Variants of Human Beta-l-Beta-1 Alcohol Dehydrogenase Containing Substitutions at Amino Acid-47 Structurefunction Studies of Nerve Growth Factor: Functional Importance of Highly Conserved Amino Acid Residues Oral Adjuvants for Viral Vaccines in Humans Immunogenicity of Plasmodinm-Falclparum Sexual Stage Antigens -Implications for the Design of a Transmission Blocking Vaccine Structure, Expression and Function of a Schwannomaderived Growth Factor Immunogenieity of Proteins Administered to Humans for Therapeutic Purposes. Trends Biotedmo11989 Mltochondrial Diseases --Gene Mapping and Gene Therapy Site-specific Alteration of GLY-24 in Streptokinese: Its Effect on Plasminogen Activation Threonine 1336 of the Human Insulin Receptor is a Major Target for Phosphorylation by Protein Klnase C. B:~chem~try 1990 Drug Inhibltors of RNA Polymersse H Transcription KALLENBACH NPC Drug Binding by Branched DNA --Selective Interaction of the Dye Stains-all with an Immobile Junction Nerve and Epidermal Growth Factors Induce the Release of the Alzhetmer Amyloid Precursor from PC12 Cell Cultures Inhibition of Expression of Hulnan lmmunodefieieflcy Vtrus-I Invitro by Antibody-Targeted Liposomes Containing Antisense RNA to the Env Region Cyclic Cholecystoktnin Analogues that are Highly Selective for Rat and Guinea Pig Central Cholecystoldnin Receptors ROBEY F& CD4-Derived Synthetic Peptlde Blocks the Binding of HIV-1 Gp120 to CD4. Bearing Cells and Prevents HIV-1 Infection Human Splenic Galaptin --physicochemical Characterization Genetically Engineered P450-monooxygenases ----Construction of Bovine P450c17/yeast lleductsse Fused Enzymes Complete Amino Acid Sequence of Tenebrosin-C, a Cardiac Stimulatory and Haemolytic ProteIn from the Sea Anemone Actinla-Tenebrosa Protein-based Medical Adhesives. Trends Biotechno11990 Collagen Degradation in Ischaemic Rat Hearts The Dopamine D 2 Receptor: Two Molecular Forms Generated by Alternative Splicing Soluble FactOrs Including Protetnases Released from Damaged Cells May Trigger the Wound Healing Process Pathophysinlogical Significance of Integrtn Expression by Vascular Endothelial Cells Interleukin-1 Induces Ferrttin Heavy Chain in Human Muscle Cells Functionally Distinct Agoulst and Receptor-binding Regions in Human Chorionic Gonadotropin. Development of a Tertiary Structure Model Active-Site Mutations of Diphtheria Toxin -Effects of Replacing Glutamic Acid-148 with Aspartic Acid, Glutamine, or Serine Requirements for the Adoptive Transfer of Antibody Responses to a Priming Antigen in Man ANONYMOUS: Comparison of a Recombinant DNA Hepatitis II Vaccine Alone or in Combination with Hepatitis B immune Globulin for the Prevention of Perinatal Acquisition of Hepatitis B Carriage --Discussion Variable Effect of Human Recombinant Granulocyte Macrophage Colony-stimulating Factor on Bone Marrow Fibrosis in Patients with Myelodysplasta Treatment of Cancer Patients with Recombinant Interferon-Gamma Induces Release of Endogenous Tumor Necrosis Factor-Alpha. lmmunobiology Inactivation of Viral Antigens for Vaccine Preparation with Particular Reference to the Application of Binary Ethylenimine Purified Chick-embryo-cell (PCEC) Rabies Vaccine: Its Potency Performance in Different Test Systems and in Humans CIARKSON B: Incidence of Response and Long-term Followup in Patients with Hairy Cell Leukemia Treated with Recombinant Interferon-alfa-2a~ B/00d 1990 Dtscrtmination Between Protective and Enhancing HIV Antibodies GERMAr~R PC Efficacy of One or Two Doses of Ty21a Salmonella Typbf Vaccine in Enteric-coated Capsules in a Controlled Field Trial Hematologic and Immunologic Effects of the Systemic Administration of Recombinant Interleukin-2 after Autolougous Bone Marrow Transplantation. B/00d 1990 A New Vaccine Against Tick-borne Encephalitis: Initial Trial in Man Ineluding a dose-response Study The Immunogenieity of Chimeric Antibodies Effects of Different Dose Levels and vaccination Schedules on Immune Response to a Recombinant DNA Hepatitis B Vaccine in ELaemodialysls Patients Characterization of a Modified Human Tissue Plasminogen Activator Comprising a Krlngie-2 and a Protease Domain ~-lactaln Antibiotic-induced Platelet Dysfunction --Evidence for Irreversible Inhibition of Platelet Activation Invitro and Invivo after Prolonged Exposure to Penicillin Vaccineinduced Escape Mutant of Hepatitis B Virus Identification of Immunogenic Regions of the Major Coat Protein of Human Papifiomavirns Type 16 that Contain Tyl~-restricted Epitopes DEGOS k All-trans Retinoic Acid as a Differentiation Therapy for Acute Promyelocytic Leukemia. I. Clinical Results Field Trial of Oral Cholera VaccInes in Bangladesh -Evaluation Pharmaceutical applications Screening and clinical trials of Anti-Bacterial and Anti-Toxic Breast-Milk Immunity in Response to Ingestion of the Vaccines inviVO Tumor Targeting of a Recombinant Single-Chain Antisen-Binding Protein. f Natl Cartcer lnst Evaluation in Chimpanzees of Vaccinia Virus Recombinants that Express the Surface Glycoprotetns of Human Respiratory Synctlal Virus Molecular Pathogenesis of Neural Lesions Induced by Poliovtrus Type 1 Platelet Thromboxane-A2 Prostaglandin-H2 Receptors in Human Volunteers on Low Doses of Aspirin Induction of Tumor Cytotoxic Immune Cells Using a Protein from the Bitter Melon (Momordica Cbarantla) Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa: a multicenter Randomized, Controlled Trial Enhanced Endogenous Leokotriene Biosynthesis in Patients Treated with Granulocyte-macrophage Clonoy-stimulating Factor Recombinant Interferon Alfa Therapy for Chronic Hepatitis C: a Randomized, Double-blind, Placebo-controlled Trial Effect of Priming with Carrier on Response to Conjugate Vaccine Recombinant Interleukin-2 and Adoptive lmmtmotherapy Alternated with Dacarbazine Therapy in Melanoma -a National Blotherapy Study Group Trial. f Natl Cancer lint Two-year Comparative Trial on the lmmunogenicity and Adverse Effects of Purified Chick Embryo Cell Rabies Vaccine for Pre-exposure immunization Treatment of Poorprognosis, Newly Diagnosed Acute Myelotd Leukemia with ARA-c and Recombinant Human Granulocyte-Macrophage Colony-stimulating Factor Effect of Recombinant Human Granulocyte-macrophage Colony-stimulating Factor Administration on the Lymphocyte Subsets of Patients with Refractory Aplasttc Anemia Cytokine-related Syndrome Following Injection of Anti-CD3 Monoclonal Antibody --Further Evidence for Transient invivo T-ce II Activation Measles Mumps Vaccination in the FRG -an Empirical Analysis after 14 years of Use.2. Tolerabllity and Analysis of Spontaneously Reported Side Effects MolecuLar Mimicry -a Herpes Virus Glycoprotein Antlgenically Related to a Cell-Surface Glycoprotein Expressed by Macrophages Case Report -Development of Hed~ktn~ Disease in Patient Receivin s Lons-Tecm Administration of Dacarbazine and Interleukin-2 for Metastatic Melanoma Synthesis and Antitumor Activity of New Anthracyclines Novel Cytocidal Antibiotics, Glucopiericidinols A 1 and A 2. Taxonomy, Fermentation, Isolation Effects of Recombinant Human Interieukin-3 in Patients with Myelodysplastic Syndromes. B/0od Phase-I Study of High-Dose Continuous~Infusion Recombinant Interleukin-2 and Autologous Lymphokine-Acttvated Killer Cells in Patients with Metastatic or Unresectable Malignant Melanoma and Renal Cell Carcinoma A Novel Screening System for yeast Strains Capable of Secreting Tissue Plasminogen Activator Protective Efficacy of a Recombinant DNA Vaccine Against Hepatitis B in Male Homosexuals --Results at 36 Months. Vaccine Substrate Specificity of Recombinant Human Renal Renin Effect of Htstidine in the Pz-subsite on PH Dependence A Phase l/lI Trial Recombinant Granulocyte-macrophage Clony-stimulating Factor for children with Aplastic Anemia Characterization of Recombinant Human Lymphotoxin (tumor Necrosis Eactor-~) Produced by a Mammalian Cell Line A Comparison of Treatment of Canine Cyclic Hematopotesis with Recombinant Human Granulocyte-macrophage Colony-stimulating Factor Antibody Responses in Recipients of Varicella Vaccine Assayed by Immunoblotting Vascular Anticoagulant ~: a Novel Human Ca 2 +/phosphollpid Binding Protein that Inhibits Coagulation and Phnspholipase A 2 Activity --Its Molecular Cloning, Expression and Comparison with VAC-oL Defined Epitope Blocking with Murray Valley Encephalitis Virus and Monoclonal Antibodies -Laboratory and Field studies Treatment of Corttcosteroid Resistant Acute Graft-versus-Host Disease By intrivo Administration of Anti-interleukin-2 Receptor Monoclonal Antibody (B-B10) Scfutn IgG Subclass Responses of Humans to Inactivated and Live Influenza a Vaccines Compared to Natural Infections with Influenza A CM: Stereoselective Pharmacokineties and Metabolism of the Enantiomers of Cyclophosphamide. Preliminary Results in Humans and Rabbtts. Bi~ p~arm~o11990 A Novel Series of Mllbemycin Antibiotics From Streptomyc~ Strain E225. I. Discovery, Fermentation and Anthelmintic Activity Inhibitory Effect of Selected Antiviral Compounds on Measles (SSPE) Virus Replication in Vitro Plant Photosensitizers with Antiviral Properties Anti-PreS2 Antibody Assay for Evaluating Immune Responses Among Recipients of Recombinant Hepatitis B PreS2 + S Vaedne Recombinant Interferonalfa-2B in Refractory Idiopathic Immune Thrombocytopenia Physicochemical and Biological Comparison of Recombinant Human Erythropotetin with Human Urinary Erythropoletin Invivo Admtdistration of Cytoklne in Allogeneic Bone Marrow Chimeras. lmmunobiology Effect of Recombinant Granulocytemacrophage Colony-Stimulating Factor on Murine Thrombocyinpoiesis in Vitro and in Vivo Oral Adjuvants for Viral Vaccines in Humans FR109615, a New Antifungal Antibintic from Streptomyces-setonil --Taxonomy, Fermentation, Isolation, Physicochemical Properties and Biological Activity Bryostatin-1, a Unique Biologic Response Modifier --AntiAeukemic Activity lnvitro Comparison of Insull~ Analogue B9AspB27GIu and Soluble Human Insulin in Insulin-treated Diabetes The Gp120-CD4 Interface: Structural, Immunological and Pathological Considerations Treatment of Chronic Non-A Non B Hepatitis with Human interferon B: a Preliminary Study Antiplatelet Effects of Chelerythrtne Chloride Isolated from Zanthoxylum-Stmulans Structural Characterization of Natural and Recombinant Human Granniocyte Colonystimulating Factors A Rapid in Vitro Method for the Evaluation of Potenital Antitumor Drugs Requiring Metabolic Activation by Hepatic $9 Eozymes. B/ochem Pharmaco11989 Response to intermediate and Standard Doses of IFN-Beta in Hairy-Cell Leukaemla Characterization of the clinical Effects after the 1st Dose of Bacterially Synthesized Recombinant Human Granniocyte-macrophage Colony-stimulating Factor Vaccine Candidate Strains with Two Attenuatin s Markers. H. Preliminary Results of Vaccination of Adult Volunteers Hematologic Effects of Recombinant Human Granniocyte Colonystimulating Factor in Patients with M~ignancy Analysis of Eibrtnogen Au-f~sion Proteins. Mutants Which Inhibit Thrombin Equivalently are not Equally Good Substrates Arenavirus Infection in the Guinea Pig Model: Antivfral Therapy with Recombinant Interferon-or, the Immunomodulator CL246, 738 and Ribavirin Long-term Cardiorespiratory Effects of Amelioration of Renal Anaemia by Erythropoletin Expression of Human Beta-1 and Beta-2 Adrenerglc Receptors in IS-colt as a New Tool for Ligand Screening. Biotechnolog7 SMITH iI2 Pharmacoktnetics and Effects of Recombinant Human Erythropoietin after Intravenous and Subcutaneous Injections in Healtyh Volunteers. B/ood Characterization of a Nonglycosylated Single Chain Urinary Plasminogen Activator Secreted from Yeast Evaluation of the Safety, Recovery, Half-life and Clinical Efficacy of Antithrombinm (human) in Patients with Hereditary Antithrombin-m Deficiency. B/0od Comparative Evaluation on Mouse Na.~l Immunogenicity of Aryimethaneinactivated, Xanthene-inactivated, Quinoneimine-inacttvated, and Acridine-inactivated Dye-inactivated Sendal Virus Vaccines Isoty~ Responses of Infected, Virus-Vaccinated and Peptide-Vaccinated Cattle to Foot-and-Mouth Disease Virus Effects of Parenteral Recombinant Human Macrophage Colony-stimulating Factor on Monocyte Number, Phenotype, and Antitmnor Cytotoxicity in Nonhuman Primates. B/ood Characterization of a Nucleic Acid Probe for the Diagnosis of Human Corouavirus 229E Infectious Protective Effect of Recombinant Tumor Necrosis Fact~r-~ in Murine Salmonelloals Novel Antifungal Antibiotics Maniwamycins a and B. L Taxonomy of the Producing Organism, Fermentation, Isolation, Physlco~chemtcal Properties and Biological properties Evaluation of Live Trivalent Vaccine of Measles Alk-C Strain, Mumps Hoshino Strain and Rubella Tak~ha~hi Strain, by Virus-Specific Interferon-Gamma Production and Antibody Response Widespread lntradermal Accumulation of Mononuclear Leukocytes in Lepromatous Leprosy Patients Treated Systemically with Recombinant Inuerferon-Gamma Evaluation in children of Cold-adapted Influenza B Live Attenuated Intranasal Vaccine Prepared by Reassortment Between Wild-type B/Ann Arbor/I/86 and Cold In givo Activation of Human Neutrophil Functions by Administration of Recombinant Human Granulocyte Colonystimulating Factor in Patients with Malignant Lymphoma Effect of Autolymphocyte Therapy on Survival and Quality of Life in Patients with Metastatic Renalcell Carcinoma Effects of Recombinant Human Interleukin-3 on Human Hematopotetic Progenitor and Precursor Cells in Vlvo. B/ood An Explanation of the Variable Clinical Response to Interleuktn-2 and LAK Cells Cellular Immune Response Against Autologous Human Malignant Melanoma: are in Vitro studies Providing a Framework for a More Effective lmmunotherapy Survival Enhancement and Hemopoletic Regeneration Following Radiation Exposure -Therapeutic Approach Using Glucan and Granulocyte Colony-Stimulating Factor Subcutaneous Recombinant Granulocyte-Macrophage Colony-stimulating Factor used as a Single Agent and in an Alternating Regimen with Azidothymidine in Leukopenic Patients with Severe Human Immunodefictency Virus Infection Comparison of a Recombinant DNA Hepatitis B vaccine Alone or in Combination with Hepatitis B Immune Globulin for the Prevention of perinatal Acquisition of Hepatitis B Carriage Recombinant Interferonalfa-gB in Refractory Idiopathic Immone Thrombocytopenta --Respoose Protection of Mice Against Yellow Fever Virus Encephalitis by Immunization with a Vaccinia Virus Recombinant Encoding the Yellow Fever Virus Non-Structural Proteins, Nsl, NS2A and Ns2B Crystallization and Preliminary X-ray Investigation of Recombinant Human Granulocyte-macrophage Colony-stimulating Factor Purification and Characterization of Recombinant plasminogen Activator Inhibitor-1 from Escher/daa Soluble Chromogenic Substrates for HIV-1 Proteina~ New Angacycline Antibiotics from Streptomyces Fradla~ VI. Structure Elucidation and Biosynthetie Investigations on Urdamycin H. JAntibiot (Tokyo) 1989 SINGER ~ Specific Prolongation of IVlHC Clas~lI Disparate Skin Alingrafts by Invivo Administration of Anti-IFN-Gamma Monoclonal Antibody Gelle Transfer into Humans --immunotherapy of Patients with Advanced Melanoma, Using Tumor-infiltratin 8 Comparison of Inactivated, Live and Recombinant DNA Vaccines Against Influenza Virus in a Mouse Model. VirusRes New clinical Trials with Interieukin-2: Rationale for Regional Administration Effects of Human Growth Hormone in Men Over 60 Years Old Lymphokine Gent Therapy for Cancer Analysis of Human T-cell Response to Two Plasmodiunvfaictparum Meroznite Surface Antigens Allogenelc Bone Marrow Transplantation for Leukemia with Marrow Grafts Depleted of Lymphocytes by Counterflow Centrffugatinn Immune Responses to Insulin and Lymphocyte Subclasses at Diagnosis of Insulin-Dependent Diabetes and One Year Later Recombinant Human Granulocyte Colony-stimulating Factor Accelerates Hematopoietic Recovery after DLAidentical Littermate Marrow Transplants in Dogs LAZARUS R& Decorsin --a Potent Glycoprotein-Iib-Iila Antagonist and Platelet Aggregation Inhibitor from the Leech Macrobdella-Decora WILL1AMS Pc Tumoor Necrosis Factor to Treat Chronic Hepatitts-B Virus Infection The Slalylated Oligosaccharides of Recombinant Bovine Lutropin Modulate Hormone Bioacttvity L-carnitine Delays the Killing of Cultured Hepatocytes By 1-methyl-4-phenyl-l,2,3,6-tetrahydropyrldine The Cloning and Expression in ~ Coil of Sequences Coding for P24, the Core Protein of Human lmmunodeficlency Virus, and the use of the Recombinant Protein in Characterizing a Panel of Monoclonal Antibodies Against the Viral P24 Protein HIGI-n~LD PE: The Expression In Escher/~/a Colt of Sequences Coding for the P18 Protein of Hnman lmmunodeficlency Virus, and the use of the Recombinant Proteins in Characterizing a Panel of Monoclonal Antiodles Against the Viral PlS Protein Secondary Analyses of the Efficacy of 2 Acellular Pertussis Vaccines Evaluated in a Swedish Phase-rll Trial Evaluation of a Reassortant Rhesus Rotavirns Vaccine in Young children Hepatitis-C Viral CDNA Clones Isolated from a Healthy C~rier Donor Implicated in Post Effects of interleuktn-4 on the invttro Growth of Human Lymphoid and plasma Cell Neoplasms. B/o0d 1990 Activation of the Complement System During Immunotherapy with Recombinant IL-2: Relation to the Development of Side Effects A Monoclonal Antibody that Neutralizes Elmtein-Barr Virus, Pharmaceutical applications Quality control and regulatory issues -Production-purification and expression systems Human Cytomegalovtrus, Human Herpesvirus 6, and Bacteriophage T4 DNA Polymerases Soluble Factors Including Proteinases Released from D~m~ged Cells May Trigger the Wound Healing Process Invivo Hematologic Effects of Recombina~t Human Macrophage Colony-stimulating Factor Stimulation of Myelopoiesis in a Patient with Congenital Neutroprnia --Biology and Nature of Response to Recombinant Human Granulocyte-macrophage Colony-stimulating Factor Synthesis and Antlviral Activity Evaluation Of 3'-fluoro-3"-deoxyrtbonucleosides: Broad-spectrum Antiviral Activity of 3'-fluorodeoxyadenosine Side-effects of Measles-mumps Vaccination Bone Marrow Graft Engineering by Counterllow Centrifugal Elutrlation --Results ofa Phase-I-H Clinical Trial Hepatitis B VaccIne in the Prevention of Perinatally Transmitted Hepatitis B Virus Infection: Final Report on a West Midlands Pilot Study Yeast-Derived Hepatllis-B Vaccine in Dental Students --a 3-year Follow-Up Study Quality control and regulatory issues ANONYMOUS: Safety of Antlthrombin m Concentrate: Real or A~t? Better Dis¢~mtnatlon Between Protective and Enhancing tllV Antibodies False-Positive Identification of Escherichia4goll O157 by Commercial Latex Agslutination Tests Key Issues in the Selection of an Expression System for Vaccine Antigens Measles Mumps Vaccination in the FRG -an Empirical Analysis after 14 Years of Use.2. Tulerabllity and Analysis of Spontaneously Reported Side Effects BOIME I: invitro and Invivo Bloactivity of Recombinant Human Follicle-Stimulating Hormone and Partially Deglycosylated Variants Secreted by Transfected Eukaryotic Cell Ll~es Comparison of Recombinant Tissuetype Plasminogen Activator (rt-PA) Expressed in Mouse C127 Cells and Human Vascular plasminogen Activator (HV-PA) Precedent, and Progress in the Development of Mammalian Cell Culture Systems for Preparing Vaccines --Safety Considerations Revisited HOPSO~EIDER PH: Vaccines, Cells, and Nucleic Acids General Conclusions Physlcochemical and Biological Comlmrison of Recombit~nt Human Erythropotetin with Human Urinary ~pniettn Bovine Growth Hormone: Human Food Safety Evaluation Isolation and Structural characterization of Three lsoforms of Recombinant Consensus ~x-interferon proteolytic Activation of Human Factors IX and X by Structural Characterization of Natural and Recombinant Human Granulocyte Colony-stimulatIng Factors Virus to Vaccine --Recombinant Mammalian Cell Lines as Substrates for the Production of Herpes Simplex virus Vaccines LUGOSI 12 Analysis of Variables of Plasmifi Transformation of a Bacterial Vaccine Conceptual Design of a Cellular Filter to Remove Trace Viral Contaminants in Blood Lack of Inhibitor to Monoclo~ml-Antibody Purified Fvlli Concentrate Search for Epitope-specific Antibody Responses to the Human Immunodeficlency Virus Envelope Glycoproteins Signifying Resistance to Disease Development Inhibition of Expression of Human Immunodeficlency Virus-1 Invttro by Antibody-Targeted Llposomes Containing Antisens¢ RNA to the Env Region Characterization of Recombinant Factor X'llIa Produced in $accharomyces C~ Biotechnology Perils of Switch to Inactivated Poliovaccine Safety of Pertussis Vaccine Secondary Analyses of the Efficacy of 2 AceHular Pertussis Vaccines Evaluated in a Swedish Phase-HI Trial The Role of Carbohydrate in Recombinant Human Erythropoietin Side-effects of Measles-mumps Vaccination ZUCKE~ AJ, DEE~IA~T F: VaccInes, Cells, and Nucleic Acids --Conclusions Identification of Residues in the Insulin Molecule Important for Binding to Insulin-Degrading Enzyme. Bt~hem/stry Purity Analysis of Protein Pharmaceuticals produced by Recombinant DNA Technology TASHJ1AN AHJP~ ProTRH-gene Expression by A Novel Blood Coagulation Factor IX/factur X-binding Protein with Anticoagulant Activity from the Venom of Trlmeresurus F/avov/r/d/s (Habu Snake): Isolation and characterization Secretory Synthesis of Human Interleukin-2 by Streptomyces Llvidan& Gene A Recombinant snake Neurotoxin Generated by Chemical Cleavage of a Hybrid Protein Recovers Full Biological Properties Antigenic Parvovfrus B19 Coat Proteins VP1 and VIr2 Produced in Large Quantities In a Baculovirus Expression System ~rlth at Sub-optimal Temperatures Allows the Production of INincttonal, Antigenbinding Fab Fragments in ~ Colt The Improving Prospects for Yield Increase by Genetic Engineering In Antibioticproducing Streptomycetes A Rapid Method of Cloning Functional Variable-region Antibody Genes in Escherichla-coll as Single-chain Immunotuxlns High-level Synthesis of Recombh~nt HIV-1 proteuse and the Recovery of Active Falzyme from Inclusion Bodies Bacterial Expression of Antibody Fragments that Block Human Rhinovirus Infection of Cultured Cells Effect of Preinduction Specific Growth Rate on Recombinant Alpha Consensus Interferon Synthesis in Escher/ch/a COIL Coil Expression and processing of Human interieukln-l~ Fused to Signal Peptides Crystallizable HlV-1 protease Derived from Expression of the Viral poi Isolation and Characterization of Biologically Active Murine Interieukin The 15 Amino Acid Residues preceding the Amino Terminus of the Envelope Protein in the Yellow Fever Virus Pulyprotein Precursor Act as a Signal Peptide Nutritional Control of Actinorhodin Production by Streptomyce~ coel/co/or A3(2) --Suppressive Effects of Nitrogen and Phosphate Key Issues in the Selection of an Expression System for Vaccine Antigens Human Diploid Cell Rabies Vaccine Purified by Zonal CenteLfugation: a Controlled Study of Antibody Reponse and Side Effects Following Primary and Booster Preexposure Immunizations Expression of Human Plasminogen Activator Inhibitor Type-1 Soluble Protein Comprised of Active and Latent Forms. Isolation and Crystallization of Latent PALL Bio~im Bi~,ysActa The Human Growth Hormone Receptor. Secretion from Es~berichta Coliand Disulfide Bonding Pattern of the Extracellular Binding Domain A Potent Antibacterial Protein in Royal Jelly --Purification and Determination of the Primary Strucmre of Royaltsin Novel Cytocidal Antibiotics, Gincopiericidinois A 1 and A 2. Taxonomy, Fermentation, Isolation Efficient Secretion of Human Parathyroid Hormone by 8accharomyces-Cerevlalae Invitro and Invivo Bioactivity of Recombinant Human Follicle-StimuLating Hormone and Partially Deglycosylated Variants Secreted by Transfected Eukaryotic Cell Lines Production of Leukemia Itlhibitory Factor in ~ Colihy a Novel Procedure and Its use in Maintaining Embryonic Stem Ceils in Culture RANIX)LPH & Replacement of a Labile Aspartyl Resldue Increases the Stability of Human Epidermal Growth Factor A Novel Screening System for Yeast Strains Capable of Secreting Tissue Plasminogen Activator Use of Macrosorb Kieselguhr Composite and CM-sepharose Fast Flow for the Large-scale Purification of L-aspara~in~¢e from Erwinia-chry~tthemi Producing Orsantsm , Fermentation and Isolation. JAntibiot (Tokyo) 1989 DARKE PI~ Affinity Purification of the BLIV Precedent, and Progress in the Development of Mammalian Ceil Culture Systems for Preparing Vaccines --Safety Considerations Revisited FK409, a novel Vasodllator Isolate! from the Acid-treated Fermentation Broth of Streptomycss Gr/seosporeu& I. Taxonomy. Fermentation, Isolation, and Phystco-chemical and Biological Characteristics HOFSCHNEIDER PH: Vaccines, Cells, and Nucleic Acids --General Conclusions Expression of Human IVarathyroid Hormone in Eschecichia-coll Expression and Characterization of a recombinant Human Parathyroid Hormone Secreted by Eacher/ch/a coli Employing the Staphylococcal Protein a Promoter and Signal Sequence A Novel Series of Mllbemycin Antibiotics From $~ces Strain E225. I. Discovery, Fermentation and Antheirnintic Activity. JAntibiot (Tokyo) 1989 Physlcochemical and Biological Comparison of Recombinant Human Erythropoietin with Human Urinary Fa'ythropoletin Synthesis of Hepatitis B Virus E antigen in K Co//. V/rus Res 1989 FR109615, a New Antifungal Antibiotic from Streptomyce&seton// --Taxonomy, Fermentation, Isolation, Physlcochemical Properties and Biological Activity Purification and Characterization of Binlogically Active Recombinant Human Nerve Growth Factor Altromycins, Novel Pluramycin-like/mtibioties.I. Taxonomy of the Producing Organism, Fermentation and Antibacterial Activity Synthesis of Human Coagulation Factor XIII in Yeast Pc Development of Specific IgGproducing Human Hybridomas by Fusions of Lymphocytes from Actively Immunized Persons Human Recombinant Imterieukin-l~ Isolated from Es~lh~rl~la Coil by Simple Osmotic Shock Synthesis and Secretion of Human Nerve Growth Factor By Sae~aaromyces C~ Gene Effect of Intercalating Dyes on the Production of Antibiotics By M~a Rosaria and MK-romonospora Purpurem Enzyme Microbiol Techno11990 Nonrtbosomal Biosynthesis of Peptide Antibiotics Antibiotics -Cloning of Biosynthetic Pathways Novel Antibiotics, Furaquinocin a and Furaquinocin B. Taxouomy, Fermeutatton, Isolation and Physico-chemlcal and Biological Characteristics Virus to Vaccine --Recombinant Mammalian Ceil Lines as Substrates for the Production of Herpes Simplex Virus Vaccines Production, Purification and Biological Properties of an ~ Colgderived Recombinant Porcine Alpha Interferon Phosphate Control Sequences Involved in Transcriptional Regulation of Antibiotic Biosynthesis. Trends Bioteclmo11990 Structure-Fuuction Atlalyals of the Human Interferon-Gamma -the COOH Terminus is not Essential for Functional Activity LL-D49194 Antibiotics. a Novel Family of Antitumor Agents --Taxonomy, Fermentation and Biological Properties Cloning and Expression in a Hetecologous Host of the Complete Set of Genes for Biosynthesis of the Streptomyces-CoeHcolor Antibiotic Undecylprodlgiosin Novel Antitumor Antibiotic Produced by a Nocardiodes Sp. Production, Isolation, Characterization and Biological Properties AT2433-A2, AT2433-lil, and AT2433-B2 Novel Antltumour Antibiotic Compoonds Produced by Actinomadura Melliaura. Taxonomy, Fermentation, Isolation and B|ologieal Properties Characterization of a Nongiycosylated Single chain Urinary Plasminogen Activator Secreted from Yeast Structure of Recombinant Human Interleukin-5 Produced by Chinese Hamster Ovary Cells. JBiocbem (Tokyo) Overproduction of Human Insulin-like Growth Factor-Ii in Escherichla-colt Conceptual Design of a Cellular Filter to Remove Trace Viral Contaminants in Blood Cloning, Characterization of the Acyl-CoA-6-Amino penicillanic Acid Acyltratlsferase Geue of Asperglllus-Nidulans arid Linkage to the lsopenicillin-N Synthase Geoe INlmllactdin, a Complex of New Antivfral Antibiotics. Production, Isolation, Chemical Properties, Structure and Biological Activity Conversion of Recombinant Hirudin to the Natural Form by Invitro Tyrosine Sulfation --Differential Substrate Spectficittes of Leech and Bovine Tyrosylprotein Sulfotransferases Comparison of Biological Activities of Endothelin-1, -2, and -3 in Murine and Human Flbroblast Cell Lines Expression of Three Recombinant Homodlmeric isoforms of PDGF in Saccharomyess Cerevista~ Evideuce for Difference in Receptor Binding and Functional Activities Cloning and Expression of Daunorublcin Biosynthesis Genes from Streptomyces Peucetlus and S Peuce~us Subsp Cae~u& J Bacterio11990 Baculovirus-Directed Expression of the Human Insulin Receptor and an Insulin-Binding Ectodomain Recombinant Human Extrinsic Pathway Inhibitor -Production, Isolation, and Characterization of Its Inhibitory Activity on Tissue Factor-Initiated Coagulation Reactions Preparation and Characterization of Human Interleukin-5 Expressed in Recombinant Eschetichia-ColL BiochemJ Production of a Monoclonal Antibody (K-931) to a Squamous Cell Carcinoma Associated Antigen Identified as the 17-1A Antigen Purification and Chat-dcterlaation of Recombinant Plasmtnogeu Activator Inhibitor-1 from E~ colt Purification and Characterization of Recombinant Human Activlu B Establishment of Different T-Cell Sublines Using Either Interleukin-2 or Intecleukin-4 as Growth Factors Synthesis and Secretion of Hepatitis B Middle Surface Antigen by the Methylotropbic Yeast Hansenula Polymorpim Yeast Mutants Conferring Resistance to Toxic Effects of Cloned Human Insulin-like Growth Factor I Experimental scale Measles and Mumps Vaccine Production on Microcarrier-grown Cells A General Strategy for Polymerization, Assembly and Expression of Epltope-Carryin 8 Peptldes Applied to the Plasmodium-Falciparum Antigen Pf155/Resa Development and Production Aspects of a Recombinant Yeast-derived Hepatitis B Vaccine. Vaccine Elimination of Disulfide Bonds Affects Assembly and Secretion of the Human Chorionic Gonadotropin Subunit Eponemycin, a New Antibiotic Active Against B16 Melanoma. 1. Production, Isolation, Structure and Biological Activity Altemicldin, a New Acaricidal and Antitumour substance. I. Taxonomy, Fermentation, Isolation and Physlco-cliemical and lllologlcal Properties Usttlago Maydis KP6 Killer Toxin --Structure, Expression in Saccharomyces Cerev/s/a~ and Relatiouship to Other Cellular Toxins Rattlesnake and Scorpion Antivenoms from the Egg Yolks of Immunized Hens. B/otechno/ogy Molecular Cloning of the 130-Kllodalton Mosqultocidal A-Endotoxtn Gene of Bacalns T/mr/ng/ensis Subsp lsrae/ens/s in Bacillus Sldsaericu& Appl Environ Mierobio11990 Expression of the Outer Capsld Protein, VP2, from ~t Full Length CDNA Clone of Genome Segment 2 of Bluetongue Serotype 1 from South Africa, Using Both Sp6 and Vaccinla Expreaslon Systems and a Comparison of the Nucleic Acid Sequence of This Segment with those of Other Serotypes ZUCKERMAN AJ: Vaccines, Cells, and Nucleic Acids --Workshop on Vaccines Prepared in Continuous Mammalian Cell Lines and by Recombinant Systems Vaccines, Cells, and Nucleic Acids --Conclusions Lactosylated LOW Density IApoprotein: a Potential Carrier for the Site-specific Delivery of Drugs to Kupffer Cells JPc Evidence that Chemical Modification of a Positively Charged Residue at Posltion 189 Causes the Loss of Catalytic Activity of Iron-containing and Manganese-containing Superoxide Dismutases Modifications of Poslton 12 in Parathyroid Hormone and Parathyroid Hormone Determination of the Secondary Structure of Interleuktn-8 by Nuclear Magnetic Resonance Spectroscopy The Photochemical Binding of Blthlonol to Soluble Proteins and Peptides Invitro and Invivo Bloactlvity of Recombinant Human Follicle-Stimulating Hormone and Partially Deglycosylated Variants Secreted by Transfected Eukaryotic Cell Lines Role of Llpids in Maintaining the Structural and Antigenic Properties of Protein Components Substrate Specificity of Recombinant Human Renal Rentn --Effect of Histidine in the P2-subslte on PH Dependence Development of Antibodies to Unprotected Glycosylation Sites on Recombinant Human GM-CSF Trcatment of a Murine Model of Systemlc Candidizses with Llposomal Amphotericin B Bearing Antibody to Cand~_d~ Albion& Alteration of the Specificity of the Stt~ptorayces Subtilisin Inhibitor by Gene Enginecring Site-specific Alteration of GLY-24 in Streptokinase: Its Effect on Plasmtnogen Activation Dlmertzatlon of Hepatitis B Viral X Protein Synthesized in a Cell-free System Selective Killln s of HIV-infected Cells by Anti-gp 120 ~unotoxllts Selective I~limlnation of Malaria Infected Erythrocytes by a Modified Phospholipase A 2 lnvitro SCHOLTEHERMANN Pc Hemoregulatory Peptlde Pglu-Glu-AsP-Cys-Lys -a New Synthetic Derivative for Avoiding Dimerlzation and Loss of Inhibitory Activity. M0/ Phamnaco11990 Reaction of Porcine Pancreatic Elastase with 7-substituted 3-alkoxy-4-chloroisocoumartns --Design of Potent inbibitors Using the Crystal Structure of the Complex Formed with 4-chloro-3-ethoxy-7-guanidinotsocoumarin Antibody-Targeted Photolysis --Invitro Studies with Sn(IV) Chlorin E6 Covalentiy Bound to Monoclonal Antibodies Using a Modified Dextran Carrier Activation of Human Lymphocytes-B by Nanogram Concentrations of Antl-IgM-Dextran Conjugates Carbohydrate Characterization of Recombinant Glycoproteins of Pharmaceutical interest Cytotoxtclty of a Low Molecular Weight Cu2Zn z Superoxtde Dismutase Active Center Analog in Human Erythroleukemta Cells. Bioct~ra Pha~11990 Elimination of Disulfide Bonds Affects Assembly and Secretion of the Human Chorionic Gonadotropin [~ Subunit The Role of Carbohydrate in Recombinant Human Erythropoletin Alterations in the Domain Strncture of Tissue-type Plasminogen Activator change the Nature of Asparagine Glycosylation Glycosylation at Asn-184 Inhibits the Conversion of Single-Chain to 2-chain Tissue-type Plasminogen Activator by Plasmin Significance of the Hlstidine Residue at the High Affinity Saccharide-binding Site of Rlcin E Preparation of a Diphtheria Toxin-puliulan Conjugate that Elicits Good lgG Antibody Production with Poor IgE Synthesis Chemical Modification of Urokinase with Human Serum Albumin Fragments Stabilization of Disulfide Linkage in Drug-polymeJqmmtmoglobulin Conjugate by Microenvironmental Control 64000 M r Autoantibodies as Predictors of Insulin-dependent Diabetes Detection of Antl-listerlolysin O for Serodlagnosis of Human Listerfosis Dry Instant Blood Typing Plate for Bedside Use Testing for Huntington Disease in childhood: Challenges and Implications --Opinion Analysis of Parvovtrus Infectious Using Strandspecific Hybridization Probes Fiber Optic Evanescent Wave Immunosensors for Medical Diagnostics. Trends Biot~tmo11990 False-Positive Identification of Escherichia-Coll O157 by Commercial Latex Agglutination Tests Screening for Cystic Fibrosis: use of AFS08 Mutation Step Procedure for Early Diagnosis of Polycystlc Kidney Disease with Polymorphic DNA Markers on Both Sides of the Gene Turnout Imaging with Labelled Ltposomes Rapid Diagnosis of Tuberculosis by Amplification of Mycobacterial DNA in clinical Samples Detection of Sickle Cell Anaemia Mutation by Colour DNA Amplification Invivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein Specificity of Helmtitis C Antibody ELISA in Patients with ELaemophtlla Accurate Assays for Antt-HIV in Urine Glycoprotein GB of Herpes Simplex Virus Expresses Type-common and Type-specific Antigenic Determinants in Vtvo EBELING FETAL: Recombinant Immunoblot Assay for Hepatitis C Virus Antibody as Predictor of Infectivity Current Concepts --the Polymerase Chain Reaction: a New Method of Using Molecular Genetics for Medical Diagnosis Antibodies to Transforming Growth Factor-~2 Peptides: Specific Detection of TGF-~2 in Immunonssays Detection of Residual ber/ab/ Translocation by Polymerase Chain Reaction in Chronic Myeluld Leukaemia Patients after Bonemarrow Transplantation Ttypsinogen Activation Peptides Assay in the Early Prediction of Severity of Acute Pancreatitis KrlZIS A Detection of Minority point Mutations by Modified PCR Technique: a New Appro~tch for a Sensitive Diagnosis of Tumor-progression Markers ~tal Diagnosis of Friedrelch Ataxla The Detection of Normal Hidden Stem Cells During the Development of Lenkemia --Assays with PGK Isozyme. EoqO Hemato11990 HIV Antibodies in Whole Saliva Detected by ELlSA and Western Blot Assays. JMed Viro11990 False-positlve Results with PCR to Detect Leukaemia Establishment of Human Monorlonal Antibody Recognizing a New Tumor-Associated Anti8en from a Patient with Small Cell Lung Carcinoma. Hybr/dot~ Antilmdy to Supero~ide Dismuta~, Autuimmnne Hepatitis, and Antibody Tests for Helmtitis C Virus Absence of mv Infection in Blood Donors with Indeterminate Western Blot Tests for Antibody to HIV-1 Identification of a UK Outbreak Strain of Netsserta Meningittdd* with a DNA Probe Antibody 624H12, Which Detects Lung Cancer at Early Stages, Recognizes a Sugar Sequence in the Glycosphingolipid DtfucosyIneolactonorhexaosylceramide (V31~lcllI31~lcnI~6Ccr) Defining DNA Diagnostic Tests Appropriate or Standard clinical Care Tyrosine Hydroxylase Polymorphtsms Associated with Manicdepressive illness PAL-E~ Monoclonal Antibody with lmmunoreacthrlty for Endothelium Specific to Brain Tumours polymerase Chain Reaction Testing of HIV-I Seronegative At-risk Individuals Mutation Analysis for Heterozygote Detection and the Prenatal Diagnosis of Cystic Fibrosis Prenatal Sex Determination by DNA Amplification from Maternal peripheral Blood Antiphospholipid Antibodies --More Than Just a Disease Marker Looking for HPV Type 16 by PCR ~ RNA Probes Detect Nucleotide Sequence Homology Between Members of Two Different Nairovtrus Serogroups Amplification of a [3-11aemoglobin Sequence in Individual Human Oocytes and Polar Bodies Automated Polymerase Chain Reaction for Paplllomavirus Screening of Cervicovaglnal Lavages -Comparison with Dot-Blot Hybridization in a Sexually Transmitted Diseases Clinic Population Detection of Human Coronavirus 229E in Nasal Washings Using RNA:RNA Hybridisatinn Amplification Refractory Mutation System for Prenatal Diagnosis and Carrier Assessment In Cystic Fibrosis Detection of AFt08 Deletion by Amplification Refractory Mutation System Cloning and Sequencing of the Gene (Tsg56) Encodin 8 a Type-Specific Antigen from Rickettsia-Tsutsugalaloshi Rapid Detection and Prenatal Diagnosis of ~-thalassaemia: Studies in Indian and Cypriot Populations in the UK Microbial DNA Diagnostic Technology Polymerase Chain Reaction for Studies of Mother to Child Transmission of HIV1 in Africa Improved Test to Identify HeterozygoteS for Congenital Adrenal Hyperplasla Without Index Case Examination CERIANI RI2 Biochemical and Histological Characterization of Antigens Preferentially Expressed on the Surface and Cytoplasm of Breast Carcinoma Cells Identified by Monoclonal Antibodies Against the Human Milk Fat Globule Prospects for Genetic Diagnosis of Inherited Predisposition to Cancer Production and Characterization of Human Moneclonal Antibodies Against Core Protein P25 and Transmembrane Glyeoprotein Gp41 of HIV-1 Production of a Monorlonal Antibody (K-931) to a Sqnamons Cell Carcinoma Associated Antigen Identified as the 17-1A Antl8en Use of Urine for HIV-1 Antibody Screeuln 8 [letter USe of HIV-1 pulGene Precursor to Detect HIV-1 and HIV-2 [letter Association Between Poor Prognosis in Earlystage Invaalve Cervical Carcinomas and Nondetection of HPV DNA Rapid Detection of Herpes-simplex-virus DNA in Cerebrospinal Fluid of Patients with Herpes Simplex Encephalitis Rapid Detection of Polymorphism Near Gene for Adult Polycystic Kidney Disease Detection of Hepatitis B viral DNA by Polymerase Chain Reaction in Patients with Hepatitis B surface Antigen SI~DMORE S: Recombinant lmmunobiot Assay for Hepatitis C Antibody Cytofluorometrtc Analysis of Thymlc Interdlgltating Cells from CS7BL/6 Mice Prior and after Leukemogenic X-irradiation Blo~kittg-ELISA for Detection of Specific Antibodies to the Glycoproteins of the Human Immunodeficiency Virus Type I (HIV-1). JMed Viro11990 The Molecular Basis of Rem-Thalassemia in Thailand -Application to Prenatal Diagnosis Use of Anticontamtnation Primers in the Polymerase Chain Reaction for the Detection of Human Papilloma Virus Genotypes in Cervical Scrapes and Biopsies HUFF Pc Early Diagnosis of HIV Infection in Infants by Detection of Ig& HIV Antibodies Potential Value of Serology for Diagnosis of Extrapulmonary Tuberculosis Antibody Avidity Test for Recent Infection with Hepatitis C Virus Molecular Genetic Basis of the Histo-blood Group ABO System Amplification and Direct Neucleotide Sequencing of CDNA from the Lysate of Low Numbers of Diploid Human Cells A 5-HT 3 Antagonists arid Ligands for Dopamine D 1 and Autorecepturs Offer New Leads for Antipsychotic Drugs All Agonist that is Selective for Adenylate Cyclase-coupled Muscarinic Receptors Synthesis and Characterization of ~t-conoto~in ilia ~ty Imbeling of ~t Opluld Receptors by Sulf~ydryl Alkylattng Derivatives of Morphine and Morphinone ZERBAN Pc A New Vaccine Against Tick-borne Encephalitis: Initial Trial in Man Including a dose-response Study Snake Neurotoxin Generated by Chemical Cleavage of a Hybrid Protein Recovers Full Biological Properties Processin 8 of Alzhelmer Beta-A4 Amylold Precursor Protein -Modulation by Agents that Regulate Protein Phosphorylatlon Interactions Between Glutamater8ie and Monoaminergic Systems Within the Basal Ganglia -Implications for Schizophrenia and Parkibsons Disease A Second Molecular Form of D 2 DopamIne Receptor in Rat and Bavine Caudate Nucleus Molecular Pathogenesis of Neural Lesions Induced by Pollovtrus Type 1 EAA PHARMACOLOGY: Excitatory Amino Acid Receptors In Epilepsy Role of Extraceilular Disulfide-bonded Cystetnes in the Ligand Binding Function of the ~2-adrenergtc Receptor BLOOM SPc The Distribution, Purification, and pharmacological Action of an Amphibian Neuromedtn U Direct Measurement of Agonist Binding to Genetically Engineered Peptides of the Acetylchollne Receptor by Selective T 1 NMR Relaxation Interactloos Between Immune Activation Cascades and Biosynthesis of Neurutransmitters Selective Expression of Purkinje-Cell Antigens In Tumor Tissue from Patleuts with Pacaneoplastic Cerebellar Degeneration Excitatory Amino Acid Antagonists and Parkinsons Disease Alternative Splicing Directs the Expression of Two D 2 Dopamine Receptor Isoforms SPIEGEL l~ Mus4~rhtic Agontsts for Senile Dementia.. Past Experience and Future Trends Cloning and Expressioo of a Rat Brain GABA Transporter Platelet and Erythrocyte Membrane Changes In Alzheimers Disease Vaccination Against Experimental Aller~c Encephalomyelitis with T Cell Receptor Peptldes The Cannabinoid Receptor -Biochemical, Anatomical and Behavioral Characterization Emerging Approaches In the Molecular Design of Receptor-Selective Peptide Hgands --Conformatinnal, Topographical and Dynamic Considerations Antibodies to a Phosphollpase-A2 from Vipera-Russelli Selectively Neutralize Venom Neurotoxiclty The use of Molecular Techniques in Studying viral Pathogenesis in the Nervous System Structure, Expression and Function of a Schwannomaderived Growth Factor Enzyme Specificity of Proteinase Inhibitor Region in Amyloid Precursor ProteIn of Alzheimer's Disease: Different Properties Compared with Protease Nexin I Excitatory Amino Acid Antagonists and Parkinsons Disease -Reply Inhibition of Experimental Autolmmune Encephalomyelitis Induction in Sjl/J Mice by Using a Peptide with High Affinity for LSS Molecules Tyrosine Hydroxylase Polymorphtsms Associated with Manicdepressive Illness Acute Myelofibrosis --Response to Recombinant Human Interferon Alpha-2A Alzheimers Pathology Explored Identification of a Brain Acetylcholine Receptor/alpha-Subuuit Able to ifitld Alpha-Bungarotoxtn A Model for the Interaction of Muscarinic Receptors, Antgonists, and Two Distinct Effector Substances SIELEY DPc Multiple D 2 Dopamine Receptors Produced by Alternative RNA Splicing Calcium/calmodulin-dependent Protein Kinase H Increases Glutamate and Noradrenaline Release from Synaptosomes Limited Heterogeneity of Rearranged T-ceil Receptor Vet Transcripts in Brains of Multiple Sclerosis Patients FIAF~R Db= T-Cell Recogltition of an Immunodominant Myelin Basic Protein Epitope in Multiple Sclerosis Two Adjacent MyoDl-binding Sites Regulate Expression of the Acetylehollne Receptor ~x-subunit Gene Inhibition of Transmitter Release by Botullnum Neurotoxin a --Contribution of Various Fcasments to the Intoxication Process Thymopoietin, a Thymic Polypeptide, Regulates Nicotinic ¢-bunsarotoxin Sites in Chromalnn Cells in Culture. Mol Pbarmaco11990 Nerve and Epidermal Growth Factors Induce the Release of the Alzhehner Amylold Precursor from PC12 Ceil Cultures The Noncompetitive Blocker IH-3~Chlorpromazine Labels 3 Amino Acids of the Acetylchofine Receptor Gamma-Subunit --Implications for the Alpha-Helical Organization of Regions-Mii and for the Structure of the Ion Channel Flunartzine protects Neurons from Death after Axotomy or NGF Deprivation A Monoclonal Anti-imlpramine Antibody with Antidepressant Binding properties Similar to the Muscarinic Receptor Messenger Molecules In the Cerebeilum The Design of Full Agonists for the Cortical Muscartntc Receptor Brain 5-HT1A Receptor Agonism: a Novel Mechanism for Antthyp~rtenslve Action Reconstitutiou of Solubllized Delta-Opiate Receptor Binding Sites in Lipid Vesicles Excitatory Amino Acid Antagonists and Parktnsons Disease -Reply Molecular Cloning and Expression of the CDNA for a Novel ¢l-adrenergic Receptor Subtype The Protease Inhibitory Properties of the Alzheimers Beta-Amyloid Precursor Protein Evidence that Beta-amyloid Protein in Alzheimers Disease is not Derived by Normal Processing Molecular Cloning and Characterization of a novel Dopamine Receptor (D3) as a Target for Neuroleptics Cloning and Sequence Analysis of the V H and V L Regions of an Anti-myelin/DNA Antibody from a Patient with Peripheral Neuropathy and Chronic Lymphocytic Leukemia Identification of Glycoino6itol Phosphollpid Linked and Truncated Forms of the Serapie Prion Protein Neuroscience: a Finger on Brain Receptors Aspects of the Structure of the D2 Dopamine Receptor Secapte Priori proteins Accumulate in the Cytoplasm of Persistently Infected Cultured Cells Atuyloid protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (in Dutch) protease Nexin-II (amyloifi B-protein Precursor): a Platelet u-granule Protein. Science Molecular Determinants of the Benzodiazepine Receptor Affinities and Anticonvuisant Activities. Mol Pharmaco11989 Monoclonal Antibody to Theilers Murine Encephalomyelitis virus Defines a Determinant on Myelin and Ollgodeudrocytes, and Augments Demyellnation in Experimental Allergic Encephalomyelitis High-dose Intravenous Immunoglobufin for Multiple Sclerosis Neural Differentiation Increases Expression of Alzheimer Amylold ProteIn precursor Gene in Murine Embryonal Carcinoma Cells. B/ocbem Cloning and Expression of Human and Rat D1 Dopamine Receptors & Identification of Residues in the Insulin Molecule Important for Binding to insulin-Degrading Enzyme Insulin Receptor internalization Defect in an Insulinresistant Mouse Melanoma Cell Line 64000 Mr Autoantibodles as Predictors of insulin-dependent Diabetes GHERZl Pc Glucose Starvation and Glyeosylation hlhtbltors Reduce Insulin Receptor Gene Expression --Characterization and Potential Mechanism in Human Cells Insulin Regulation of the 2 Glucose Transporters in 3T3-L1 Adipocytes Molecular Pathology of Type-1 Diabetes NOTIGNS AI2 Frequency of B Cells Committed to the Production of Antibodies to Insulin in Newly Diagnosed Patients with Insulin-dependent Diabetes Mellitus and Generation of High Affinity Human Monoclonal lgG to Insulin Oral Delivery of Insulin Kidney Sialidase and Sizlytransferas¢ Activities in Spontaneously Experimentally Diabetic Rats. Influence of Insulin and Sothinll Treatments Diabetes Induced in Male Transgenic Mice by Expression of Human H-ras Oncoprotein in Pancreatic ~-celis Oral Insulin [letter Usage by Murine lgG Antibodies that Bind Autologoos Insulin Pervanadate [peroxide(s) of Vanadate] Mimics Insulin Action in Rat Adipocytes Via Activation of the Insulin Receptor Tyrosine glnase Iusulin-ilke Effects of Epidermal Growth Factor and Insulin-like Growth Factur-I on [3H]2-deoxygiucose Uptake, Dlacylgiycerol Generation and Protein Kinase C Activation in BC3H-1 Myocytes Non-Tolerance and Differential Susceptibility to Diabetes in Transgeoic Mice Expressing Major Histocompatlbllity Class.lI Genes on Pancreatic Beta-Cells Insuiln-Hke Growth Factor-I and Factor-ll Acute Effect of Thyroid Hormone on Insulin Secretion in Rats. B/ochem Pharmaco11990 Prevention of Diabetes in Nonobese Diabetic Mice by Tumor Necrosis Factor (TNF) --Similarities Between TNF-alpha and Interleukin-1 Comparison of Insulin Analogue B9AspB27GIu and Soluble Human Insulin in Insulin-treated Diabetes Insulin Gene I~nhaneer Binding Protein Isl-1 is a member of a Novel Class of Proteins Containing Both a Home~ and a Cys-His Domain JUS3aCE RM Jm Complete Sequenee-specific IH NMR Assignments for Human Insulin The Role of Amylin in the Insulin Resistance of Non-Insulin-Dependent Diabetes-Mellitus Thyroid Hormone Analogue 8KF-L-94901 -Effects on Amino Acid and Carbohydrate Metabolism in Rat Skeletal Muscle Invitro Prevention of Insulin-Dependent Diabetes Meliltus in Non-Obese Diabetic Mice by Transgenes Encoding ModLfed I-A ~ or Normal I-E Or-Chain Dissection of the Growth versus Metabolic Effects of Insulin and Insulin-like Growth Factor-I in Transfected Cells Expressing Ktnase-defective Human Insulin Receptors MESSIELA JI~ Insulins Regulation of GFos Gene Transcription in Hepatoma Cells A Family of Polypeptide Substrates and Inhibitors of Insulin Receptor Kinase Identification of Soybean Protein Components that Modulate the Action of Insulin Invitro A Naturally Occurring Mutation of Insulin Receptor Alanine-1134 Impairs Tyrosine Kinase Function and is Associated with Dominantly Inherited Insulin Resistance Islet Amyloid Polypeptide, a Novel Pancreatic Peptide, is a Circulating Hormone Secreted Under Glucose Stimulation Prevention of Diabetes in BB/Wor Rats Treated with Monoclonal Antibodies to Interferon-Gamma Insulin-like Growth Factur-H Matmose 6-phosphate Receptor is Incapable of Activating GTP-binding Proteins in Response to Mannose 6-phosphate, But Capable in Response to Insulinlike Growth Factor-lI Identification of Epitopes on the Human Insulin Receptor Reacting with Rabbit Polyclonal Anttsera and Mouse Monoclonal Antibodies Insulin Stimulates the Activity of a Protamine Klnase in Isolated Rat Hepatocytes T-Ceil Clones from a Type-1 Diabetes Patient Respond to Insulin Secretory Granule Proteins Inhibition of Type-1 Diabetes in BB Rats with Recombinant Human Tumor N~is Factor-Alpha. flmmuno11990 Insulin Down-regulates Insulin Receptor Number and Up-regulates Insulin Receptor Affinity in Cells Expressing a Tyrosine Ktnase~lefective Insulin Receptor Immune Responses to Insulin and Lymphocyte Subclasses at Diagnosis of Insulin-Dependent Diabetes and One Year Later Prevention of Diabetes in Non-Obese Diabetic I-A k Transgenic Mice Cloning and Expression of Human Insulinlike Growth Factor Binding Protein 3 Conformational Studies of Peptides Corresponding to the Coeliac-Activating Regions of Wheat Alpha-Gliadin A Domain of the Insulin Receptor Required for Endocytnsis in Rat Fibroblasts Autocrine Regulation of Human Tumor Ceil Proliferation by Insulin-Like Growth Factor-II --an Invitro Model insulin Alters the Target Size of the Peripheral Cyclic AMP Phosphodiesterase But not the Integral Cyclic GMP-StImuiated Cyclic AMP Phosphodiesterase in Liver Plasma Membranes STRE~ Pc Identification of a Pancreatic ~-cell Insulin Gene Transcription Factor that Binds to and Appears to Activate Ceil-type-specific Expression --Its Possible Relationship to Other Cellular Factors that Bind to a Common Insulin Gene Sequence Prostaglandtns Regulate Surfactant Protein-A (Sp-A) Gene Expression in Human Fetal Lung invitro Research Paper Analysis --can Antibodies to IgE Act as Anti-allergics Nonsteroidal Anti-Inflammatory Dt~lgs Inhibit Gastric Peroxtdase Activity Regulation of Hepatic Acute Phase Plasma Protein Genes by Hepatocyte Stimulating Factors and Other Mediators of Inflammation Antilnflamq0tatOry Peptides (aOtiflamminS) Inhibit Synthesis of Piatelet-activating Factor, Neutrophil Aggregation and Chemotaxts, and Intradermal Inflammatory Reactions PORTA Pc An Anti-Inflammatory Protein Secreted from the Rat Seminal Vesicle Epithelium Inhibits the Synthesis of Platelet-Activating Factor and the Release of Arachidonic Acid and Prostacyclin Monoclonal Antibodies Specific for Human IgE-producing B Cells --a Potential Therapeutic for IgE-medlated Allergic Diseases Regulation of Human IgE Synthesis.1. Human IgE Synthesis Invitro is Determined by the Reciprocal Antagonistic Effects of Interleukin-4 and Interferon-oamma~ Modulation of Mediator Release from Human Basophlls and Pulmonary Mast Ceils and Macrophages by Auranofin. Bi~ Pharmaco11990 The Neutropifil-activating PepUde NAF/NAP-1 Induces Histamine and Leukotriene Release by Interleukin 3-primed Basophlls Studies on the Homing of Mycobacterinm-Sensitized Lymphocytes-T to the Synovinm During Passive Adjuvant Arthritis. Cell lmmuno11990 Enhanced Endogenous Leukotriene Biosynthesis in Patients Treated with Granulocyt e-macrophage Clonoy-stimuiating Factor CAIS MJ: Effects of Human Recombinant ILl-Beta on Rheumatoid and Non-Rheumatoid Hnman Synovtal Cell Growth MAre Pc Quantitative Analysis of Cytokine Gene Expression in Rheumatoid Arthritis Anaphylatoxin Binding and Degradation by Rat Peritoneal Mast Cells -Mechanisms of Degranulation and Control. f Immuno11990 More Selective Hgands at Elcosanoid Receptor Subtypes Improve Prospects in Inflammatory and Cardiovascular Research T-Cell Ftbronectin -an Unexpected Inflammatory Lymphokine Evening Primrose Oil and Atoplc Eczema Vaccination A o-ain.t Experimental Allergic Encephalomyelitis with T Ceil Receptor Peptides Successful Treatment of Atopic Dermatitis with Complexes of Allergen and Specific Antibodies Antitumor Promotion and Pharmaceutical applications Blood -Miscellaneous Antiinflammation-Down-Modulation of Ap-1 (Fos Jtm) Activity by Glucocorticnid Hormone utilization of Vitamin-A in Rats with Inflammation Conformatlonal Stability of B Cell Epitopes on Group I and Group lI/k, rmatophago/des Spp. Allergens: Effect of Thermal and Chemical Denaturation on the Binding of Murine ISG and Human IgE Antibodies Dlscoordinate Expression of Stromelysin, Collagenase, and Tissue Inhibitor of Metalloproteinases-1 in Rheumatoid Human Synovial Flbroblasts -Synergistic Effects of Interleukin-1 and Tumor Necrosis Factor-Alpha on Stromelystn Expression Modulation of Mast Cell Responses to Adenosine by Agents that Alter Protein ~-C Activity Characterization of a Nonglycusylated Single Chain Urinary Plasminogen Activator Secreted from Yeast Allergen Presentation by Epidermal Iangerhans Cells from Patients with Atoplc Dermatitis is Mediated by lgE Interleukln-1 and Tumor Necrosis Factor Potentiate Anglotensin-II-Stimulated, and Calcium Ionophore-Stimulated Prostaglandin E2 Synthesis in Rat Renal Mesanglal Ceils Hlrudin-Ba~d Peptides Block the Inflammatory Effects of ThrombIn on Endothelial Cells Pol~eA'tc Analogues of N-Formyl Peptldes ace Potent Activators of Degranulatinn and Superoxide Production by Human Neutrophtls Cytoklnes and Growth Regulation of Synoviocytes from Patients with Rheumatoid Arthritis and Rats with Streptococcal Cell Wall Arthritis Regulation and Deregulation of Human lgE Synthesis Tumor Necrosis Factor Inhibitor --Purification, NH2-Termlnal Amino Acid Sequence and Evidence for Anti-lnflammatory and lmmtmomodulatory Activities Suppression of Auaphylactic Shock in Sensitized Guinea Pigs by Structural Requirement for Autoreactivity on Human Pyruvate Dehydrogenase-E2, the Major Autoanflgen of Primary Bifiacy cirrhosis --Implication for a Conf~rmatinnal Autoepitope ll-4 Induces Allergic-Like Inflammatory Disease and Alters T-Cell Development in Transgenic Mice Cloning and Sequencing of a CDNA Expressing a recombinant House Dust Mite Protein that Binds Human IgE and Corresponds to an Important Low Molecular Weight Allergen The Effect of New Potent Selective Inhibitors of Protein Klnase-C ou the Neutrophil Respiratory Burst. B'~chem Biophys Res Commun Mechanism of Hypersensitivity Reactions: Proposed Involvement of Reactive Metabolites Generated by Activated Leukocytes Effects of Non-steriodal Anti-inllalnlmttory Drugs on Huamn Neutrophll NADPH Oxidase in Both Whole Cell and Cell-free Systems. Blochem Pharmaco11990 Regulation of Manganese Superoxide Dismutase by Llpopolysacchartde, Interlenkin-1, and Tumor Necrosis Factor --Role in the Acute Inflammatory Response Local Production of Tumor Necrosis Factor ct, Interleukin 1, and Interleukln 6 in Meningococcal Meningitis. Relation to the Inflammatory Response ELLINGSWORTH LPC Antagonistic and Agontstie Effects of Transforming Growth Factor-Beta and il-1 in Rheumatoid Synovium Differential Inhibition of Histamine Release from Mast Cells bY Protein Klna~-C lnhibttors -Staurosporine and K-252A Comparison of Diversity and Function of House Dust Mite-Specific Lymphocyte-T Clones from Atopie and Non-Atopic Donors Monoclonal Antibody to Thellers Murine Encephalomyelitis Virus Defines a Determinant on Myelin and oligodendrocytes, and Augments Demyelination in Experimental Allergic Encephalomyelitis A Human H-l-Alpha Derivative Which Lacks Prostaglandin-E2 Inducing Activity and Inhibits the Activity of 11-1 Through Receptor Competition Suppression of Adjuvant Arthritis in Lewis Rats by Oral Administration of Type-lI Collagen Human Recombinant Factor-XIII from Saccharomyces-Cerevisiae -Crystallization and Preliminary X-Ray Dam Dry IBstant Blood Typing Plate for Bedside Use Specificity of Hepatitis C Antibody ELISA in Patients with HaemophUia Disruption of a C/EBP Binding Site in the Factor IX Promoter is Associated with llaemophllia B [letter] FISCHL METAL: Recombinant Human Erythroprotein for Patients with AIDS Treated with Zidovudine Effects of Recombinant Interferons on Human Megakaryocyte Growth. Exp Hemato11990 A Phase I/I1 Trial Recombinant Granulocyte-macrophage Clony-stimulating Factor for children with Aplastir Anemia Inhibition by Aprotinin of TPAmediated Fibrtnolysts During Orthotopic Liver Transplantation Expression and Characterization of Recombinant Human Factor-V and a Mutant Lacking a Major Portion of the Connecting Region New Effectors of Human Hemoglobin --Structure and Function Lack of Inhibitor to Monoclonal-antifiody Purified Factor VIII Concentrate Pharmacokinetics and Effects of Recombinant Human Erythropoietin after Intravenous and Subcutaneous Injections in Healtyh Volunteers The Biology of Hematopoletic Growth Factors -Studies Invitro Under Serum-Deprived Conditions Interferon-Gamm,'t Modulates Fetal Hemoglobin Synthesis in Sickle Cell Anemia and Thah~seraia Lack of Inhibitor to Monoclonal-Antibody Purified Fviti Concentrate ~etter Amplification of a ~-haemoglobin Sequence in Individual Human Ooeytes and Polar Bodies. Lamer Rapid Detection and Prenatal Diagnosis of ~-thalassaemia: studies in Indian and Cypriot Populations in the UK SCHULTEHERMANN Pc Hemoregulatory Peptide Pglu-Glu-AsP-Cys-Lys -a New Synthetic Derivative for Avoiding Dlmertzatinn and Loss of Inhibitory Activity. Mol Pharmaco11990 Invivo Effects of Human Recombinant Interleukin-6 on Hemopoiette Stem and Progenitor Cells and Circulating Blood Cells in Normal Mice Nucleation and Growth of Fibres and Gel Formation in Sickle Cell Haemoglobin Suppression of HIV Antigenaemia by AL721 The Ability of Mouse Monoclonal Antibodies to Direct the Cytotoxic Function of Cytoklne-Activated Human Eosinophlls Complete Amino Acid Sequence of Tenebrosin-C, a Cardiac Stimulatory and ILaemolytic Protein from the Sea Anemone Actinia-Tenebrosa Effects of Recombinant Human Granniocyte Coinny-stimulating Factor on the Hematologic Recovery and Survival of Irradiated Mice Clearance of Rh D-positive Red Coils with Monoclonal Anti-D. Lancet Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects WINS~ PPc Haemophllla B Caused by Mutation of a Potential Thrombin Cleavage Site in Factor IX Erythropoietin, Alumininm, and Anaemia In Patients on Haemodialysis Antibacterial Activity of Phosphono Dipeptides Based on 1-Amtno-l-Methylethanephosphmttc Acid ~ ~ BPc Restoration of Spermatogeuesis by Exogenously Administered Testosterone in Rats Made Azoospermic by Hypophysectomy or withdrawal of Luteinizlng Hormone Alone TOMATIS Pc New Features of the Delta-Opinid Receptor --Conformational Properties of Deltorphin-I Analogues. B/0chem Autologous Bone Marrow Transplantation for Acute Myelnid Leukemia Using Monoclonal Antibody-put, ged Bone Marrow Chondrocyte Activation by Interleukin-1: Analysis of the Synergistic Properties of Fibroblast Growth Factor and Phorbol Myristate Acetate. Arch B/0chem B/ophys 1989 Leukotriene A 4 Hydrolase Activity of Human Airway Epithelial Cells GM-CSF incubation Prior to Treatment with Cytaraiflne or Doxorubicin Enhances Drug Activity A oain~t AML Ceils Invitro -a Model for Leukemia Chemotherapy Protective Effect of Polyclonal and Monoclonal Antibodies Against Abortion in Mice Infected by Chlamydla-Psittaci Modulation of Mediator Release from Human Basophils and Pulmonary Mast Cells and Macrophages by Auranofin pilot Phase I Study Using gidovudine in Association with a lO-day Course of Anti-CD4 Monoclonal Antibody in Seven AIDS Patients P53 Functions as a Cell Cycle Control Protein in Osteosarcomas The Effects of Recombinant Human interleukin-l-beta on Cellular Proliferation and the Production of pgotBtaol~nd[n.E2, Plasminogen Activator, Osteocalcin and Alkaline Phosphatase by Osteoblast-like Cells Derived from Human Bone The Human Growth Hormone Receptor. Secretion from Est~erichia Coli and Disulfide Bonding Pattern of the Extracellular Binding Domain Replacement of a Labile Aspartyl Residue lncre~es the Stability of Human Epidermal Growth Factor Evaluation of Kemptide, a Synthetic Serine-containing Heptapeptide, as a Phosphate Acceptor for the Estimation of Cyclic AMP-dependent Protein Ktnase Activity in Respiratory Tissues Growth Hormone for Short Children The Role of Haemopoietic Growth Factors in Bone Marrow Transplantation Expression of Immunoglobulin-T-cell Receptor Chimeric Molecules as Functional Receptors with Antibody-type Specificity ROSE Rb~ Effect of Zldovudtne and Granuiocyte-macrophage Colony-stimulating Factor on Human Immunodeficiency Virus Replication in Alveolar Macrophages Synthetic Peptides Containin S T-Cell and B-Celi Epitopes from Human lmmtmodeliciency Virus Envelope Gpl20 induce Anti-lilY Proliferative Responses and High Titers of Neutralizing/mtibodies in Rhesus Monkeys Use of Bone Marrow Somatic Cell Hybrid Lines to Generate Monoclonal Antibodies Specifically Reactive with Rare Marrow Cells lmmtmoreactive Growth Hormone (GH) Secretion by Human Lymphocytes Effects of Retinotc Acid, 1,25-dihydroxyvitamin D3, Cytosine Arabinoside and ~-interferon on Bone Marrow Cells from Patients with Myelodysplastic Symlromes H: FK409, a novel Vasodllator Isolated from the Acid-treated Fermentation Broth of Streptomyces G~ I.Taxonomy, Fermentation, Isolation, and Physico-chemical and Biological Characteristics Growth Inhibition of Human Flbroblasts by Epidermal Growth Factor in the Presence of Arachidonic Acid Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides The Complete Amino Acid Sequence of the Shorter Form of Human Basic Flbroblast Growth Factor Receptor Deduced from Its CDNA Relationship Between T Epitupes and Immunogenicity Bovine Growth Hormone: Human Food Safety Evaluation Enzymatic Synthesis of the Precursor of Leu-enkephalin in Waterimmiscible Organic Solvent Systems Biochemical Characterization of the Cholecystoklntn Receptor on Chp212 Human Neuroblastoma Cells. Mol Pharmaco11990 Synergistic Effects of Vinblastine and Recombinant Interferon-Beta on Renal Tumor Cell Lines HLA-DR Peptide Inhibits HIV-induced Regulation of Growth Hormone (GH) Bloactivity by a Recombinant Hnman GH-Binding ProteIn Enhanced Immunogenicity of Recombinant Peptide Pusimm Containing Multiple Copies of a Heterologous T-Helper Epitope Long-term Cardiorespiratory Effects of Amelioration of Renal Anaemia by Erythropoietin Molecular Cloning of a Novel Bone-forming Compound: Osteoinductive Factor Comparison of Antineoplastic Activity of Cytosine Aesbinoside and 5-Aza-2'-Deoxycytidine A=o~ln~t Human Leukemic Cells of Different Phenotype Antisense RNA of the Latent Feriod Gene (MerS) Inhibits the Differentiation of Murine Erythroleukemia CeLls Effect of GM-CSF on Circulating Granulocyte-monocyte Progenitors in Autologous BMT APPELBAUM FP~ Use of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Graft Failure after Bone Marrow Transplantation Structure and Activity of Artificial Mutant Variants of Human Growth Hormone An HIV-1 and HIV-2 Cross-Reactive Cytotoxtc T-Cell Epitope Inhibitory Effects of the Bone-Derived Growth Factors Osteoinductive Factor and Transforming Growth Factor-Beta on Isolated Osteoclasts Chimeric Peptides --Transport Through the Blood-brain Barrier in Vim and Cleavage of Disulfide Linkage by Brain Protection Against Mucoid Pseudomonas-Aeruglnosa in Rodent Models of Endobronchlal Infections Requirement of Tumoor Necrosis Factor for Development of silica-induced Pulmonary Fibrosis Characterizing T-cell Epitopes in Vaccine Candidates Subcutaneous Recombinant Granulocyte-Macrophage Colony-stimulating Factor used as a Single Agent and in an Alternating Regimen with Azldothymidine in Leukopenic Patients with Severe Human Immunodeficiency Virus Infection The Influence of Interferon Mpha and G~tmma, Singly or in Combination on Human Natural Cell Mediated Cytotoxicity Human Growth Hormone-variant Demonstrates a receptor Binding Profile Distinct from that of Normal Pituitary Growth Hormone Effects of Human Growth Hormone in Men Over 60 Years Old The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency Synthetic Analogs of Growth Hormone-releasing Factor with Antagonistic Activity in V~ro~ Echtstatin is a Potent Inhibitor of Bone Resorption in Culture Allogeneic Bone Marrow Transplantation for Leukemia with Marrow Grafts Depleted of Lymphocytes by Counterllow Centrifngatton GI/DFF C• Inhibtion of Simian Varicella Virus Infection of Monkeys by l-(20Deoxy-2-Fluoro-l-~-D-Arabinofuranosyl)-5-Ethyluracll (FEAU) and Synergistic Effects of Combination with Human Recombinant inteferon-~ incorporation of T and B Epitopes of the Cirumsporozoite Protein in a Chemically Defined Synthetic Vaccine Against Malaria Functional Role of Respiratory Tract Haemagglutinin-Specillc IgA Antibodies in Protection A~tnst Influenza Isolation and Characterization of Opioid Antagonist Peptides Derived from Homan Lactoferrin Grafting Ovarian Cells to Combat Sterility (in French) Synergistic Antttumor Activity of Etoposide and Human Interleukin-la~Against Human Melanoma Cells Bone Marrow Graft Engineering by Counterflow Centrifugal Elutriatinn --Results of a Phase-I-I1 Clinical Trial Recombinant Human Bone Morphogenetic Protein induces Bone Formation Biochemical Characterization Studies on a Leukocyte Alloantigen Expressed with High Frequency in Leukaemia Patients Contraceptive Efficacy of Testosterone-induced Azoospermia in Normal Men