key: cord-0019097-83dea86j
authors: Dienstmann, Guilherme; Barbosa dos Santos, Vitor; Comar, Samuel Ricardo
title: Mushroom-shaped red blood cells (pincer cells): a brief update
date: 2021-07-09
journal: Hematol Transfus Cell Ther
DOI: 10.1016/j.htct.2021.05.009
sha: 654da152d49634bda9a5d9fcfe1e959854e119e0
doc_id: 19097
cord_uid: 83dea86j

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Red cells with cytoplasmic projections, resembling pincerlike cells, also known as mushroom-shaped red blood cells, as Figures 1 and 2 , are usually associated with erythrocyte disorders, such as congenital dyserthropoietic anemias, hereditary spherocytosis associated with Banda-3 protein deficiency, disseminated intravascular coagulation, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura, kidney disease, microangiopathic hemolytic anemia, erythroleukemia and, more rarely, oxidative drug-induced hemolysis. However, a recent study have demonstrated a relationship between these cells and infection caused by Sars-CoV-2 in a pathophysiologic mechanism that possibly involves the occurrence of oxidative stress, which triggers progressive cascade of inflammation, known as citokines storm, that leads to red blood cell damage. 1−3 Figure 1 -Pincer cells in a patient with chronic kidney disease and diagnosed with COVID-19.

Are mushroomshaped erythrocytes an indicator of COVID-19?

Mushroom-shaped red blood cells in protein band-3 deficiency

Congenital dyserythropoietic anaemia type II (HEMPAS): a family study