key: cord-0020583-2yxxmdhj authors: Vahdatpour, Cyrus A.; Ryan, John J.; Zimmerman, Joshua M.; MacCormick, Samuel J.; Palevsky, Harold I.; Alnuaimat, Hassan; Ataya, Ali title: Advanced airway management and respiratory care in decompensated pulmonary hypertension date: 2021-09-02 journal: Heart Fail Rev DOI: 10.1007/s10741-021-10168-9 sha: 4775c8bbf7dbe49e0ff785afe6882ad5c31a9cf4 doc_id: 20583 cord_uid: 2yxxmdhj Meticulous risk stratification is essential when considering intubation of a patient with decompensated pulmonary hypertension (dPH). It is paramount to understand both the pathophysiology of dPH (and associated right ventricular failure) and the complications related to a high-risk intubation before attempting the procedure. There are few recommendations in this area and the literature, guiding these recommendations, is limited to expert opinion and very few case reports/case series. This review will discuss the complex pathophysiology of dPH, the complications associated with intubation, the debates surrounding induction agents, and the available options for the intubation procedure, with specific emphasis on the emerging role for awake fiberoptic intubation. All patients should be evaluated for candidacy for veno-arterial extracorporeal membrane oxygen as a bridge to recovery, lung transplantation, or pulmonary endarterectomy prior to intubation. Only an experienced proceduralist who is both comfortable with high-risk intubations and the pathophysiology of dPH should perform these intubations. Pulmonary hypertension (PH) is characterized by progressive pulmonary vascular remodeling resulting in increased pulmonary vascular resistance (PVR). This results in increased right ventricular (RV) afterload, which stimulates adaptive RV remodeling and may progress to RV failure. PH is diagnosed by a mean pulmonary arterial pressure (mPAP) of > 20 mmHg on right heart catheterization [1] . Pre-capillary PH is defined with a PVR of ≥ 3 wood units and a pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg. For the purposes of this paper, we will discuss PH in the context of pre-capillary PH. There is no formal hemodynamic definition of acutely decompensated PH (dPH) although it is commonly described by association with hemodynamic instability and with the use of inotropic agents and vasopressors. However, a descriptive definition characterizes dPH as a constellation of signs and symptoms that suggest inadequate cardiac output (CO) and/or increased central venous pressure (CVP) secondary to increased RV afterload [2, 3] . In order to determine best practice, dPH would benefit from a more formalized definition, similar to what is used in cardiogenic shock. Cardiogenic shock uses a combination of the following: (a) systolic blood pressure (SBP) < 90 mmHg for > 30 min or vasopressor support to maintain a SBP > 90 mmHg, (b) clinical evidence of end-organ damage (i.e., decreased urine output, altered mental status, cool extremities, jugular venous distention, serum lactic acid > 2 mmol/L, elevated serum creatinine, transaminitis), and (c) the use of hemodynamic criteria (i.e., cardiac index < 2.2 L/min/m 2 or PCWP > 15 mmHg) [4] . Additional hemodynamic criteria for RV failure (RVF) should be considered that includes a right atrial pressure/PCWP ratio > 0.5 [5] . A proposed definition for dPH is represented in Table 1 and emphasizes markers of RVF. Currently, dPH primarily remains a clinical diagnosis and exists as a continuum of pre-shock physiology to refractory hemodynamic instability. Acute respiratory failure (ARF), as defined by a new onset of respiratory insufficiency with evidence of hypoxia and/or hypercapnia, is a common finding amongst dPH patients. When emergent endotracheal intubation (ETI) is necessary, it is associated with a high risk of hemodynamic deterioration and death ( Fig. 1 ) [6] . PH patients with ARF commonly experience systemic hypotension and hypoxia due to a combination of their underlying acute and chronic pathophysiology often within 1 h of intubation [7] . These are often worsened during intubation, possibly from a combination of the following: (a) the effects of sedatives administered for intubation, (b) peri-intubation attempts at lung recruitment via noninvasive positive pressure ventilation (NIPPV), and (c) during the transition from spontaneous to positive pressure ventilation after intubation. As an effort at lung recruitment, NIPPV may increase PVR through hyperinflation, and the positive intrathoracic pressure in turn have effects on venous return and RV afterload. ARF requiring ETI is associated with increased risk of cardiovascular collapse [8] . ETI is associated with increased mortality in hypotensive patients without RV failure [9] and increased risk for cardiac arrest in [8, 10, 11] . The critically ill cohort is subject to technical difficulty requiring repeat attempts in roughly one-third of patients undergoing ETI [12] . Complicating the situation, delaying ETI with noninvasive ventilation (NIV) trials is associated with increased mortality [8, 13, 14] . There is a paucity of evidence specifically dedicated to dPH and emergent ETI. It is commonly recommended to avoid intubation, if possible, in dPH patients [15, 16] , but this is based primarily on anecdotal experience. This review aims to elucidate the concerns surrounding ETI in dPH patients and emphasizes that intubation in this population should be performed by an experienced proceduralist. Chronic RV failure in PH is related to the inability of the RV to adapt to a progressively increased afterload developing as a consequence of progressive pulmonary vascular remodeling. Chronic increase in RV afterload causes RV wall stress that propagates adaptive myocardial remodeling through concentric hypertrophy. As RV tension increases, RV wall hypertrophy develops and progresses. Eccentric RV hypertrophy eventually occurs in order to reduce RV wall tension [3] . This is maladaptive and correlates with clinical manifestations, such as progressive exertional dyspnea or syncope, and the predisposition towards acute RV failure/ dPH. Right ventriculo-arterial (VA) coupling describes a state of energy transfer from the RV to the pulmonary vasculature. In PH, VA coupling is generally preserved in the early stages of RV remodeling. VA coupling correlates with pulmonary artery compliance, as a compliant pulmonary artery preserves RV function and a poorly compliant pulmonary artery promotes RV failure [17] . As PH progresses, RV function eventually becomes maladaptive-adversely impacting the pulmonary vascular load such that energy transfer becomes less efficient. This process is called right VA uncoupling and is described by decreased RV End-Systolic Elastance (E es )/ Aterial Elastance (E a ). This ratio is used to assess how RV contractility is adapted to afterload. Normal value of this ratio is considered to be 1.5 to 2.0. A ratio of < 0.8 is considered to reflect substantial RV maladaptation and a RV ejection fraction less than 35% [18] . VA uncoupling correlates with impending RV failure, increasing RV volume and mass, and distensibility/capacitance of the pulmonary arteries [18, 19] . Measurements of right VA coupling on right heart catheterization, cardiac magnetic resonance imaging, and echocardiography are a current area of investigation for intervention and prognostication. Over time, most patients with PH become increasingly susceptible to decompensate, which is commonly caused by disease progression, pulmonary embolism, infection, volume overload, arrhythmias, anemia, hypercarbia, or acid-base disturbances. These processes are associated with an acute increase in RV afterload, which increases RV myocardial oxygen demand, disrupts systolic and diastolic RV coronary perfusion, promotes septal displacement into the left ventricle (ventricular interdependence), and increases right atrial pressures causing venous congestion of vital organs. Clinically, this is characterized by peripheral edema, jugular venous distension, hypotension, tachycardia, and respiratory distress. These clinical findings are accompanied by evidence of multisystem organ failure-commonly involving the kidneys, liver, and gastrointestinal tract [15] . PH is associated with an increased risk of hemodynamic instability during and shortly after ETI [6, [20] [21] [22] [23] . Atelectasis, hypoxemia, and hypercapnia are complications that increase PVR as a consequence of deep sedation and supine positioning for direct laryngoscopy (DL). It is inferred that placing the patient in the supine position during intubation may increase RV preload, increase RV distention, reduce RV output, and exacerbate systemic hypotension [24] [25] [26] [27] . Therefore, positioning the patient at an incline during DL or video laryngoscopy (VAL) for intubation should be considered. Induction with anesthetic agents lead to systemic vasodilation which can decrease coronary artery perfusion. The combination of increased myocardial oxygen demand and decreased coronary perfusion induce right ventricular ischemia, which can trigger hemodynamic collapse during intubation [7] . Consideration of conscious sedation as opposed to rapid sequence intubation (RSI) or not using any sedation should be considered prior to intubation. Atelectasis causes impaired oxygenation and reduced pulmonary compliance [28] . Both can increase PVR and RV afterload by promoting hypoxic vasoconstriction and increasing pressures within the pulmonary circuit. Prior to intubation, physicians often attempt to reduce atelectasis by upright positioning of the patient and NIPPV trials. Upright positioning will reduce RV preload and allow gravity to expand the lungs. NIPPV provides positive end-expiratory pressure (PEEP), which recruits compressed alveoli to participate in oxygenation at the expense of increasing intra-thoracic pressures. NIPPV has been correlated with a reduction in SBP, mPAP, and CO in a small study of 33 stable patients with either precapillary or post capillary PH [29] . This suggests cautious NIPPV use in dPH patients. Larger studies are needed to validate the safety of NIPPV in ARF of dPH and use with vasodilator and vasopressor therapies. Hypoxemia and hypercapnia are causes of regional perfusion redistribution within the lung and can trigger local vasoconstriction of the lung. This leads to an increase in RV afterload, which increases RV oxygen demand and potentiates ischemia in patients with dPH. Prior to intubation, these patients are often trialed with high flow nasal cannula (HFNC) and/or NIPPV for optimization with variable success. RSI is a form of an advanced airway management commonly used in critically ill patients that uses a combination of medications to cause immediate unresponsiveness and muscular relaxation. Not every dPH requires RSI to perform ETI and some patients can undergo ETI with less sedation. A brief overview of commonly available induction agents is provided in Table 2 . A critical challenge during RSI is avoiding exacerbation of hemodynamic instability [16, 30] . Induction with a two medication combination of propofol with high dose opioids or benzodiazepines should be avoided in this cohort due to their compounding negative effects on sympathetic tone and on cardiac contractility, preload, and afterload [30] . While expert opinion and limited studies make suggestions for or against certain agents, mortality in dPH patients is more likely due to the proceduralist's misunderstanding of the following: (1) the pathophysiology in dPH; (2) the anesthetic and hemodynamic goals of the intubation procedure; and (3) the pharmacology of the various drug options and how these medications relate to the hemodynamic goals. Propofol is associated with systemic hypotension by decreasing systemic vascular resistance, mean arterial pressure, and cardiac output. Additionally, it reduces the baroreceptor reflex, poses negative inotropic effects, and acts as a direct myocardial depressant [31, 32] . Generally, it is recommended to avoid propofol in dPH patients due to its vasodilator and cardiac depressive properties which can trigger hemodynamic instability. Ketamine is both a direct myocardial depressant as well as a sympathomimetic and as such may maintain or raise preinduction blood pressure. The contrasting properties may in part explain why ketamine has been shown to have more peri-intubation-related hypotensive events in comparison to etomidate in one observational study [33] . However, ketamine has also been shown to a reasonable alternative to maintain stable hemodynamics in one randomized controlled trial [34] . Ketamine is a reasonable option in dPH patients to minimize hypotension during RSI and improve coronary artery and end organ perfusion. Ketamine, in combination midazolam and rocuronium, have been utilized successfully with vasopressors for intubation in stable preoperative PH patients [35] . Etomidate has been demonstrated to have less hemodynamic effects compared to propofol in rodent models with PH [36] . Etomidate is associated with adrenal suppression which can result in delayed hypotension and hemodynamic collapse [34, 37] . Etomidate and ketamine have been shown to be comparable sedative options for endotracheal intubation in septic patients [34] . One small retrospective study has compared outcomes in 33 peri-operative patients with PH secondary to Eisenmenger syndrome or other similar cardiac defects [38] . While hypotension and hypoxia were common complications in stable perioperative PH patients, propofol was more commonly associated with hypotension than etomidate. However, this finding was not statistically significant and was limited by a small sample size, being conducted in a single center, and the nonrandomization of induction agent selection. The decision to intubate a dPH patient should be tailored to the condition of the individual patient and the experience of the proceduralist. Common indications for intubation in dPH include progressive respiratory failure (hypoxic and/or hypercapnic), impaired consciousness with Glasgow Coma Scale less than or equal to 8, worsening airway obstruction, and impending hemodynamic arrest. When preparing for ETI in a dPH patient, consideration of ECMO and lung transplantation or pulmonary endarterectomy candidacy is warranted. Cardiothoracic surgery should be engaged prior to intubation should the patient be considered as a candidate for any of these surgical interventions, and in case the patient decompensates despite maximum medical therapy post ETI. Figure 2 provides a checklist for the approach to intubation in dPH [39] . When possible and prior to intubation, a discussion should be held which reviews the potential benefits and risks associated with this specific cohort. Due to its high risks, patients and their legal surrogate(s) should understand that periprocedural mortality is high. If the patient is not a candidate for ECMO or lung transplantation, then clarifying realistic expectations is critical if the patient does not improve with optimized medical care. Anand et al. [40] found that palliative care services (PCS) were utilized in 2.2% of all PH patients and were significantly associated with longer hospital stays, higher hospitalization costs, and higher inhospital mortality. This likely reflects providers involving PCS in sicker patients and/or late in the hospital course, although the later was not well defined given that the study was performed using the National Inpatient Sample. When preparing to institute respiratory support, the patient should have at the bedside a system for pre-oxygenation, a bag valve mask, a range of ET tubes, rescue devices, airway adjuncts (bougie, stylet), suction devices, laryngoscope, end tidal CO2 monitoring, ventilator, inhaled pulmonary vasodilators, vasopressors, inotropes, induction medications, and paralytics. Table 3 describes common assessment to predict difficulty with ET intubation. Table 4 provides an overview for the types of tracheal intubation. Continuous telemetry, noninvasive blood pressure monitoring, and pulse oximetry are standard in critical care. An arterial line should be in place prior to the procedure for accurate blood pressure monitoring and for titration of vasoactive agents. If ECMO support is considered, a femoral arterial line is preferred. All dPH patients should have central access and at least two peripheral intravenous lines prior to intubation. If a pulmonary arterial (PA) catheter is unavailable, the central line should be used for central venous pressure monitoring and to measure mixed central venous saturation. PA catheterization should not delay emergent intubation. Intensivists may elect to use minimally invasive hemodynamic monitoring such as the FloTrac device, which uses arterial wave form analysis to provide hemodynamic information. In dPH patients, FloTrac device has been demonstrated in one small study and commentary to be inferior to the PA catheter in patients with a CI < 2.2 in determining accurate hemodynamic information using echocardiography in both groups [41, 42] . The agent to use as first-line vasopressor in dPH is controversial and varies between institutions [43] . Expert opinion suggests that norepinephrine or vasopressin should be considered as first-line vasopressor in dPH patients [15] . Phenylephrine should not be used in this cohort as it may cause pulmonary arterial vasoconstriction and an increase in right ventricular afterload in an already failing and vulnerable RV [44] . Dobutamine and milrinone are inotropic agents that may be used to stabilize dPH patients and, if on, should be continued throughout the peri-intubation period. [45] [46] [47] . Inhaled milrinone, by itself or in combination with inhaled prostacyclin, has been shown to be a promising as they improve mean pulmonary artery pressures and cardiac index, while having minimal to no effect on the systemic circulation [48] [49] [50] . Patients should be pre-oxygenated judiciously to balance timing of the procedure and the levels of oxygen saturation. Preoxygenation increases patients' oxygen reserve to prevent or postpone arterial oxygen desaturation during apnea after RSI [51] . HFNC may be preferable to NIPPV to correct for hypoxia and avoid the negative effects of PEEP on the RV. The use of HFNC in combination with inhaled vasodilator may also improve hypercarbia. This occurs via (1) effects on reducing RV afterload through pulmonary vasodilation and (2) preferential vasodilation in better oxygenated areas of the lung which improves efficiency of gas exchange. Nasal cannula or HFNC may be continued during apnea and the peri-procedural process as a technique to minimize arterial oxygen desaturation [51] . All chronic PAH-specific therapies should be continued throughout the intubation process to avoid rebound increases in PVR which can acutely worsen RV failure. Patients already on intravenous PH therapy medications (usually a prostacyclin) most often have an already preestablished central venous access catheter to receive therapy. This therapy should not be interrupted, nor should any other medications be mixed with this dedicated intravenous prostacyclin therapy access [52] . If continuous intravenous prostacyclin therapy has been initiated earlier in the ICU course, it should be maintained at the existing dose for hemodynamic stability. Likewise, if inhaled prostacyclin or nitric oxide is initiated prior to intubation, it would be recommended to continue this therapy during the peri-intubation process. Both these agents can be administered via HFNC or NIPPV, as well as via a mechanical ventilator. Impending circulatory failure in PH patients during intubation has been associated with decrease in MAP by 35% from baseline [20] . This acute decrease in MAP results in a reduction in RV perfusion potentially causing RV ischemia, depressed myocardial contractility, and impaired cardiac output. Vasopressors should be used post-intubation and through initiation of mechanical ventilation to maintain a MAP goal of > 65 mmHg. Arrhythmias are common in patients with PH and restoration of sinus rhythm is desirable [53] . Antiarrhythmic agents such as amiodarone may be required and electrical cardioversion of unstable arrhythmias should be performed to rapidly restore sinus rhythm. Positive pressure ventilation from mechanical ventilation causes increased intrathoracic pressure leading to increased RV afterload [54] . To reduce RV stress and myocardial oxygen demand, ventilator settings should adopt low PEEP and low tidal volume strategies in efforts to reduce plateau pressures. Permissive hypercarbia should be avoided as this can increase PVR and RV afterload [55] . Trending of central venous pressure, mixed venous saturations, arterial blood pressures, and oxygenation saturations are critical to monitor patients post-intubation to titrate vasopressors, vasodilators, inotropes, and mechanical ventilator settings. Awake flexible fiberoptic intubation (FOI) is considered the gold standard in the management of suspected difficult ETI. One multicenter randomized control trial compared 43 awake FOI patients and 41 awake VAL intubated patients using the McGrath Series 5 video laryngoscope. They found no difference in time to ETI between FOI and VAL [56] . Patients were intubated by a proceduralist trained in both techniques and most were successfully intubated on first attempt. This study is limited by the lack of blinding and the fact that the intubations were all performed during elective procedures. dPH patients are difficult airways in an emergent setting and would not be represented by this patient selection. One study showed that emergency department providers are less likely to rely on FOI during difficult intubations [57] . While this study did not include awake patients during difficult airway management, it is reasonable to infer that operators would still be uncomfortable using FOI in awake difficult airways. The modality selection in acute settings is likely dependent on proceduralist familiarity and device availability. Such that, an emergency department provider may feel natural with VAL or DL intubation [57] compared to a pulmonary trained intensivist who feels comfortable trialing FOI [58] . A case report described successful awake fiberoptic intubation of a critically ill patient with severe PH requiring emergent abdominal surgery [59] . Four percent lidocaine was used to anesthetize the posterior oropharynx, and 2% lidocaine was used to anesthetize the bilateral superior larynx and trachea. Multiple vasopressors, inotropes, and nitric oxide were started before intubation and were continued during the procedure. The patient was then sedated with midazolam and ketamine before diagnostic peritoneal lavage and ultimately died peri-procedurally from gross fecal peritonitis secondary to necrotic appendicitis and massive intraventricular thrombus. A case series of nine patients demonstrated the feasibility of awake bronchoscopic intubation with NIPPV [7] . All patients had confirmed PAH and were experiencing acute hypoxic respiratory failure requiring emergent ETI. Patients were pre-oxygenated for a minimum of 15 min with either NIPPV or HFNC prior to ETI in the semi-recumbent position. Systemic hypotension with a new or increased vasopressor requirement was the most common complication post-intubation. Awake FOI is a potential option in dPH patients and is limited by proceduralist familiarity and equipment availability. Awake FOI or VAL may be desirable in dPH due to the avoidance of RSI and its resulting hemodynamic risks. More studies are needed to clarify their safety and efficacy in dPH patients. Intubation of dPH patients remains a clinical challenge for the intensivist. The approach to intubation of these patients is based on expert opinion and extrapolated from airway management of the general critically ill and left-sided heart failure populations. Any necessary procedure should be performed by an experienced proceduralist who understands the pathophysiology of dPH, who is familiar with the various vasoactive and anesthetic agents, and who is comfortable with both DL or VAL and FOI. Ketamine and etomidate are the primary sedatives recommended during RSI within this cohort, despite limited evidence specifically within the dPH cohort. More studies are needed on the role of awake FOI in dPH patients. 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All authors read and approved the final manuscript. Ethics approval and consent to participate Not Applicable. Consent for publication Not Applicable. The authors declare no competing interests.