key: cord-0035024-42e1w2cv
authors: Maley, Jason H.; Stevens, Jennifer P.
title: Ventilator-Associated Pneumonia
date: 2019-07-24
journal: Evidence-Based Critical Care
DOI: 10.1007/978-3-030-26710-0_29
sha: c62fbe0e64a41d3a5bea6d9e5655112f0074204a
doc_id: 35024
cord_uid: 42e1w2cv

Ventilator-associated pneumonia occurs in patients who have been intubated for at least 2–3 days with significant exposure to hospital-acquired organisms. Treatment should be initiated rapidly and cover Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, and methicillin-resistant Staphylococcus aureus(MRSA). Within 72 h or with the availability of culture results, antibiotics should be narrowed. Active research is on-going to identify patients at risk for ventilator-associated complications and to minimize the likelihood of infection in these patients.

on the ventilator. While early treatment is essential, rapid de-escalation of antibiotics in the face of negative culture results is also important. Sampling of the respiratory tract is necessary to further guide management; samples may be obtained either through tracheobronchial aspiration, bronchoalveolar lavage (BAL), mini-BAL, or protected specimen brush (PSB). Careful observation of individual hospitals' bacterial antibiogram is essential to provide treatment targeted to the resistance profile of each institution. The most common MDR pathogens include P. aeruginosa, Escheriochia coli, Klebsiella pneumonia, and Acinetobacter species as well as methicillin-resistant S. aureus [1] .

A high suspicion for VAP followed by rapid diagnosis and treatment is critically important. Zilberberg and colleagues found that among nearly 400 patients alive at 48 h with hospital-acquired pneumonia, inappropriate empiric antibiotic therapy was associated with a significant increase in mortality (30% vs. 18 .3%, p = 0.013; OR 2.88 95% CI 1. 46-5.67 in multivariable logistic regression). Treatment escalation did not change the risk of death in this single-center study [2] . Unfortunately, treatment is often delayed. In one study among 107 patients, 30.7% of patients had their therapy for VAP inappropriately delayed, defined as ≥24 h passing between VAP onset and providing the appropriate antimicrobial treatment. A delay in writing the antibiotic orders was the primary reason for delay in therapy in 75% of cases [3] . Endotracheal aspirate is the preferred means of sampling, prior to or at the time of antibiotic initiation, as multiple studies have demonstrated that this technique is equivalent to bronchoscopy with regards to patient outcomes and antibiotic exposure [4, 5] .

Patients with VAP should be universally initiated on therapy for (1) MRSA (for example, with vancomycin or linezolid) and (2) resistant gram-negative bacteria, such as Pseudomonas aeruginosa, Klebsiella pneumoniase, and Acinetobacter species. Treatment options for gram negative organisms include: antipseudomonal cephalosporins (cefepime or ceftazidime), antipseudomonal carbapenems (imipenem or meropenem), β-Lactam/β-lactamase inhibitor (piperacillin-tazobactam). When combination therapy for gram-negative bacteria is considered (see Evidence Contour below), addition of an antipseudomonal fluoroquinolone or an aminoglycoside should be considered. The dominant pathogens in one's local ICU should also contribute to decision making for appropriate choices of therapy but should be guided by the overall principles of the ATS/IDSA guidelines, as demonstrated by the IMPACT HAP collaboration [6, 7] .

In addition to MDR risk factors, appropriate antimicrobial therapy should consider the patient's risk factors for: (1) extended-spectrum beta-lactamase-producing (ESBL) Enterobacteriaceae; (2) Legionella; and (3) anaerobes. If ESBL Enterobactereiaceae is suspected, a carbapenem should be used. Concerns about Legionella should prompt use of a macrolide or fluoroquinolone over an aminoglycoside. Some providers would treat patients with recent aspiration events for anaerobes, using clindamycin, β-Lactam/β-lactamase inhibitors, or a carbapenem.

For all other patients for whom the suspicion of VAP is low, appropriate therapy should be guided by the patient's risk factors for multidrug resistant organisms. In the absence of risk factors for MDR organisms, the ATS/IDSA guidelines recommend antibiotic therapy that targets Streptococcus pneumonia, Haemophilus influenza, Methicillin-sensitive Staphylococcus aureus, and antibiotic-sensitive enteric gram negatives: ceftriaxone, fluoroquinolone, or ampicillin/sulbactam [8] . While not all patients with HCAP have MDR organisms, distinguishing between the two may be difficult with recent residence in a nursing home or hospitalization for more than 48 h in the past 3 months appearing to increase the patient's risk the most [9, 10] .

Patients with ventilator-associated pneumonia should have the duration of antimicrobial therapy guided by type of organism. In a study of 401 patients using a randomized controlled design, there was no difference in mortality in the arm treated for 8 days vs. 15 days, although patients with Pseudomonas spp. had higher rates of recurrence [11] . A subsequent meta-analysis demonstrated patients with lactose non-fermenting gram-negative bacilli had nearly a two-fold increased odds of recurrence with shorter therapy courses [12] . In the absence of identification of lactose non-fermenting gram-negative bacilli (i.e. Pseudomonas, stenotrophomonas, and Acinetobacter), durations of 7-8 days should be used.

It is critical to de-escalate antimicrobial therapy when a specific pathogen has been identified, or when cultures are negative at 48-72 h. This helps prevent over-use of antibiotics and the development of resistance. Observational data provide a strong safety signal. In a study of surgical patients, neither mortality (34% vs. 42%) nor recurrent pneumonias (27% vs. 35%) dif-fered between patients with VAP who underwent de-escalation vs. those who did not [13] . Among 398 patients with VAP, in a study by Kollef and colleagues, de-escalation of therapy occurred for 22% of patients. These patients had a lower mortality rate (17%) than those patients who underwent escalation (43%) or who had no change to their regimens (24%) [14] .

Serum biomarkers, particularly C-reactive protein and procalcitonin (PCT), have been examined as guides for both the initiation and discontinuation of antibiotics. While the data are inconsistent regarding the clinical utility of these biomarkers [15] , procalcitonin levels may help inform decisions to de-escalate antibiotic therapy. In subgroup analyses of the PRORATA trial, investigators found that patients with ventilator-associated pneumonia assigned to the study arm (where antibiotics were discontinued after PCT levels reached <0.5 μg) had 3.1 fewer days (95% CI 0.7 days-5.6 days) of antibiotics than those patients assigned to the control arm, without a difference in mortality [16] . In contrast, a multicenter randomized control trial of 1656 patients cared for initially in the emergency department for pneumonia had no difference in duration of antibiotic use when treatment decisions were guided by PCT, although under half of patients were hospitalized in this population [17] . Other studies that have looked at procalcitonin to guide therapy for undifferentiated septic shock or in broader settings have replicated that mortality does not appear to be affected when procalcitonin is used to guide therapy, although the findings on duration of antibiotics is more heterogeneous [18, 19] .

Not all fevers are pneumonia, even in ICU patients with radiographic infiltrates. If patients are not improving at 48-72 h, and respiratory cultures taken before antibiotics are negative, be vigilant for other causes of fever (such as central line infections, intraabdominal process, etc.) and for complications of pneumonia (such as abscess and empyema). This scenario should also prompt reconsideration of the potential presence of resistant pathogens, and may warrant consultation with infectious diseases specialists.

In all patients with suspected VAP, obtain an endotracheal aspirate for culture at minimum. Whether to pursue bronchoscopic sampling (or other invasive techniques) is more controversial. Endotracheal aspirates are very sensitive-a negative result is quite helpful because it has a high negative predictive value. Positive results can be harder to interpret. In one study of 52 episodes of pneumonia, endotracheal aspirate was found to have a sensitivity of 97.7% and specificity of 50% as compared with protected brush specimen [20] . Other studies have employed the Clinical Pulmonary Infection Score (CPIS) with a cut-off of 6 as a noninvasive method of identifying patients with VAP, using autopsy findings of pneumonia as the gold standard (Table 29 .1) [21] . Fabregas et al. found a score of greater than 6 had a sensitivity of 77% but a specificity of 42% [22] . Conversely, bronchoscopic sampling may be less sensitive but is more specific for pneumonia. Randomized controlled trials are mixed. An RCT of 413 patients found no benefit to invasive sampling in unadjusted analyses, but did after adjustment for baseline factors [23] . A more recent RCT of 740 patients found no benefit to bronchoalveolar lavage over endotracheal aspirate [5] . Our practice is to perform immediate endotracheal aspirate in all patients with suspected VAP, but to reserve bronchoalveolar lavage or protected brush for selected cases, consistent with the IDSA/ATS guidelines but in contrast to the European Respiratory Society guidelines [1, 24] .

The current recommendation from the ATS/IDSA is for coverage with either (1) 15 mg/kg of vancomycin every 8-12 h with a target serum trough between 15 and 20 mg/kg OR (2) 600 mg of linezolid every 12 h. One prospective trial of 1184 patients suggested that linezolid may be superior to vancomycin. In this study, 46% of patients treated with vancomycin had cul- The score may be calculated as a noninvasive method of determining whether a patient is a low-risk for pneumonia. A score of more than 6 has a 77% sensitivity and 42% specificity to identify VAP [22] tures persistently positive for MRSA, while only 17% of patients treated with linezolid did. At 60 days, however, there was no difference in mortality rates, although nephrotoxicity did occur at greater rates with vancomycin [25] . As research in this space continues to evolve, linezolid may be a particularly good option among patients with renal failure.

Coverage with a second agent for gram-negative bacilli may be warranted based on local microbiologic patterns. For example, for patients with P. aeruginosa VAP who remain in shock or high-risk of death when antibiotic susceptibilities are known, the ATS/IDSA guidelines recommend combination therapy rather than monotherapy [1] . However, it is worth noting that synergy of medications has only been demonstrated in vitro and in neutropenic or bacteremic patients and randomized controlled trials have not demonstrate differences in clinical outcomes between monotherapy and combination therapy groups [7, 26, 27 ]. An observational cohort study in Lancet suggested combination therapy may be harmful, as the cohort of patients with ATS/IDSAcompliant antimicrobial therapy had a higher risk of death at 28 days than the noncompliant group [28] . This remains controversial, whether these individuals were at higher risk of death from the medications, the infections, or misidentification of them as at higher risk for MDR infection.

While clinical suspicion and identification of ventilatorassociated pneumonia should remain high, significant controversy has revolved around establishing a reliable epidemiological surveillance definition. Prior to January 2013, the Centers for Disease Control's surveillance reporting definition the included several subjective components, including the change in the "character of sputum" and in radiographs [29] [30] [31] [32] [33] . As a result, several studies identified little agreement either across infection control experts at a single institution [34] or across multiple institutions [35] . Other definitions that sought to identify episodes of VAP either through greater invasive strategies or through other scoring mechanisms fared equally poorly [36] .

In response, an effort of many professional societies and the CDC generated an alternative approach with the creation of the entity Ventilator Associated Event (VAE) [37] . Intended to cast a broader net, this newly-defined condition is intended to identify the majority of iatrogenic harm from mechanical ventilation, including but not limited to pneumonia [38, 39] . Further, it is designed to be reliable as it is solely based on any changes made to the ventilator that would indicate worsening oxygenation after a period of stability and at least 3 days into the course of mechanical ventilation. Review of radiology has been removed from the definition. There are subsequent subcategories of harm, including probably or possible pneumonia, which are based on antibiotic changes and evidence of positive qualitative or quantitative cultures (Table 29. 2) [37] .

While several studies have shown that this definition does lead to a reliable identification of individuals at higher risk of in-hospital mortality, it remains unclear the breadth of true disease states captured by definition [40, 41] . Lilly and colleagues found that the new VAE definition captured neither pneumonias nor hospital-acquired complications 93% of the time [42] . In contrast, Boudma and colleagues found ventilator-associated condition to be reasonably sensitive at identifying episodes of VAP (0.92) but not specific (0.28) [43] . Further, Adult [42, 44] . The first major intervention study to date designed to attempt to reduce rates of VAE demonstrated found spontaneous awakening trials and spontaneous breathing trials to be effective [45] . However, this remains a significant area of evolving science.

Data suggest that the rate of VAP remains stable, despite efforts at prevention, affecting around 10% of ventilated patients [46] . Modifiable risk factors for patients with VAP should be considered, in an effort to minimize the likelihood of developing VAP at the outset. These were described in a recent update on preventing ventilator associated pneumonia by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Disease Society of America (IDSA) and are summarized in Table 29 .3 [39] . Recommendation Level of recommendation Minimizing sedation and assessing readiness to extubate daily through pairing spontaneous breathing trials and spontaneous awakening trials, which have been shown in two randomized control trials and one meta-analysis to reduce length of stay and duration of mechanical ventilation [47] [48] [49] [50] High Instituting early mobilization and physical therapy, which has been shown to decrease length of stay and improve earlier return to independent function [51] Moderate Implementing strategies to reduce pooling of secretions above the endotracheal tube cuff, such as using endotracheal tubes with subglottic suctioning for patients requiring mechanical ventilation of 48 h or more [52] [53] [54] . A metaanalysis demonstrated reduction in VAP rates and length of mechanical ventilation [55] Moderate Changing ventilator circuits only when needed rather than on a schedule, which does little to decrease VAPs but does reduce costs [56] High Making use of noninvasive positive pressure ventilation (NIPPV) whenever possible, but only in the populations which have been shown to have some benefit (e.g. in chronic obstructive pulmonary disease or cardiogenic pulmonary edema) [57] . This recommendation, however, cautions use of NIPPV that may delay intubation, such as profound hypoxemia, acute respiratory distress syndrome or impaired consciousness [58] High Keeping the head of the bed elevated to at least 30°, which has only been shown to decrease VAP rates in one of three randomized control trials, but has little downside [59] [60] [61] Low

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