key: cord-0064763-0pylhu82 authors: Rattka, Manuel; Dreyhaupt, Jens; Winsauer, Claudia; Stuhler, Lina; Baumhardt, Michael; Rottbauer, Wolfgang; Imhof, Armin title: Effekt der COVID-19-Pandemie und des Lockdowns auf die Inzidenz von Herzinfarktpatienten in Deutschland – Ergebnisse einer Metaanalyse date: 2021-06-21 journal: Kardiologe DOI: 10.1007/s12181-021-00479-4 sha: 95d09435e65872596c55a59f28143d016051f8c4 doc_id: 64763 cord_uid: 0pylhu82 BACKGROUND: Since the beginning of the COVID-19 pandemic there have been observations from around the world reporting on the phenomenon of a reduction in numbers of patients with myocardial infarction. In this meta-analysis the incidences of STEMI and NSTEMI patient admissions in Germany during and before the COVID-19 pandemic were analyzed. METHODS: A comprehensive literature search was performed through PubMed, Embase and Web of Science using combinations of the keywords “COVID”, and “myocardial infarction”, or “STEMI”, or “NSTEMI”, and “Germany”. RESULTS: Based on our search strategy out of 40 identified studies 5 were included in the meta-analysis. The hospital admission rates of patients with acute myocardial infarction in Germany significantly declined during the pandemic (incidence rate ratio, IRR = 0.849, 95% confidence interval 0.827–0.872). This was the same for patients with STEMI (IRR = 0.875, 95% confidence interval 0.837–0.914) and NSTEMI (IRR = 0.760, 95% confidence interval 0.633–0.911). DISCUSSION: In this meta-analysis we could show that in Germany the frequency of hospital admissions of patients with myocardial infarction significantly declined during the COVID-19 pandemic. Consequently, during the ongoing pandemic it is crucial to continue informing and educating the public on the symptoms of a heart attack and the necessity of timely medical care to avoid potential endangerment of patients with myocardial infarction. Seit Beginn des SARS-CoV-2(Schweresakutes-Atemwegssyndrom-Coronavirus Typ 2 [severe acute respiratory syndrome coronavirus type 2])-Ausbruches mehren sich die Hinweise, dass die Pandemie das Gesundheitsverhalten und die medizinische Versorgung der Bevölkerung negativ beeinflusst [3, 8] . So wurde gezeigt, dass in Deutschland die Fallzahlen für diverse Bereiche der Krankenhausversorgung zu Beginn der Pandemie rückläufig waren [4] . Mutmaßlich lässt sich dies auf die notwendige Erhöhung der Kapazitäten der Kliniken zur Versorgung von COVID- Es erfolgte eine selektive Literatursuche in PubMed, Web of Science und Embase mit den Suchbegriffen "COVID" und "myocardial infarction" oder "STEMI" oder "NSTEMI" und "Germany". Eine ausführlichere Darstellung der Vorgehensweise und Methoden sowie die Limitationen befinden sich im ergänzenden Material. Background. Since the beginning of the COVID-19 pandemic there have been observations from around the world reporting on the phenomenon of a reduction in numbers of patients with myocardial infarction. In this meta-analysis the incidences of STEMI and NSTEMI patient admissions in Germany during and before the COVID-19 pandemic were analyzed. Methods. A comprehensive literature search was performed through PubMed, Embase and Web of Science using combinations of the keywords "COVID", and "myocardial infarction", or "STEMI", or "NSTEMI", and "Germany". Results. Based on our search strategy out of 40 identified studies 5 were included in the meta-analysis. The hospital admission rates of patients with acute myocardial infarction in Germany significantly declined during the pandemic (incidence rate ratio, IRR = 0.849, 95% confidence interval 0.827-0.872). This was the same for patients with STEMI (IRR = 0.875, 95% confidence interval 0.837-0.914) and NSTEMI (IRR = 0.760, 95% confidence interval 0.633-0.911). Discussion. In this meta-analysis we could show that in Germany the frequency of hospital admissions of patients with myocardial infarction significantly declined during the COVID-19 pandemic. Consequently, during the ongoing pandemic it is crucial to continue informing and educating the public on the symptoms of a heart attack and the necessity of timely medical care to avoid potential endangerment of patients with myocardial infarction. Strecken-Hebungsinfarkt (STEMI) und/ oder Nicht-ST-Strecken-Hebungsinfarkt (NSTEMI) extrahieren. Diese wurden in die Metaanalyse inkludiert [1, 5, [9] [10] [11] . Eine Übersicht der eingeschlossenen Studien ist der . Tab. 1 zu entnehmen. In der vorliegenden Metaanalyse konnten wir zeigen, dass die Inzidenz der Zuweisungen von Patienten mit akutem Herzinfarkt in Deutschland während der COVID-19-Pandemie signifikant sank. Sowohl die Inzidenz für Patienten mit STEMI als auch NSTEMI zeigte sich signifikant reduziert. Bereits kurz nach Auftreten der ersten SARS-CoV-2-Infektionen wurde über einen potenziellen ungünstigen Ef- Acute myocardial infarction admissions in Berlin during the COVID-19 pandemic ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation The invisible hand-medical care during the pandemic The effects of the COVID-19 pandemic and lockdown on routine hospital care for other illnesses 31 days of COVID-19-cardiac events during restriction of public life-a comparative study Effect of the COVID-19 pandemic on mortality of patientswithSTEMI: asystematicreviewandmetaanalysis Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era The untold toll-the pandemic's effects on patients without Covid-19 Impact of COVID-19 outbreak on regional STEMI care in Germany Decline of emergency admissions for cardiovascular and cerebrovascular events after the outbreak of COVID-19 Temporal trends in the presentation of cardiovascular and cerebrovascular emergencies during the COVID-19 pandemic in Germany: an analysis of health insurance claims ZhangWetal(2020)Management and outcomes of patients with STEMI during the COVID-19 pandemic in China