key: cord-0072002-bpzk9yrq authors: Kravitz, Max S.; Dagan, Alon S. title: Man With Hoarse Voice and Dyspnea on Exertion date: 2021-12-20 journal: Ann Emerg Med DOI: 10.1016/j.annemergmed.2021.07.109 sha: 233853c05b158f42a4100c87cc34a5b2ac50e608 doc_id: 72002 cord_uid: bpzk9yrq nan [Ann Emerg Med. 2022;79: 18.] A 39-year-old otherwise healthy man presented to the emergency department (ED) with a 2-month history of hoarse voice and progressive dyspnea on exertion. He reported a preceding flu-like illness with negative COVID-19 testing at the time. Physical examination was notable for a pulse rate of 113 beats/min and a hoarse voice. Bedside nasopharyngoscopy by the ED team demonstrated left vocal cord paresis (Figure 1 , Video E1 [available at http://www.annemergmed.com]). Chest radiography showed marked cardiomegaly (Figure 2 ). Laboratory studies were notable for a pro b-type natriuretic peptide of 2,444 pg/mL. The patient was admitted to the cardiology service with a diagnosis of acute systolic heart failure. Cardiac catheterization demonstrated severe global systolic dysfunction without angiographically apparent coronary artery disease. COVID-19 antibody testing returned positive. For the diagnosis and teaching points, see page 30. To view the entire collection of Images in Emergency Medicine, visit www.annemergmed.com. Solution Set Oversight Committee Cofact (human prothrombin complex) product monograph human prothrombin complex) product monograph Nederlandse Internisten Vereniging Fixed versus variable dose of prothrombin complex concentrate for counteracting vitamin K antagonist therapy An observational, prospective, two-cohort comparison of a fixed versus variable dosing strategy of prothrombin complex concentrate to counteract vitamin K antagonists in 240 bleeding emergencies Evaluation of fixed dose 4-factor prothrombin complex concentrate for emergent warfarin reversal Fixed versus variable dosing of prothrombin complex concentrate in vitamin K antagonistrelated intracranial hemorrhage: a retrospective analysis Randomised controlled trial protocol to evaluate a fixed dose prothrombin complex concentrate against the variable dose in vitamin K antagonist related bleeding (PROPER3) Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study Understanding noninferiority trials The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition Management of warfarin-associated bleeding or supratherapeutic INR French clinical practice guidelines on the management of patients on vitamin K antagonists in at-risk situations (overdose, risk of bleeding, and active bleeding) Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and meta-analysis ACC/AHA Guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology Fixed dose 4-factor prothrombin complex concentrate for the emergent reversal of warfarin: a retrospective analysis