key: cord-0684466-7jd4jhxw
authors: Giannotta, Juri Alessandro; Fattizzo, Bruno; Bortolotti, Marta; Girmenia, Corrado; Ielo, Claudia; Metafuni, Elisabetta; Visentin, Adele; Apolito, Vincenzo; Lucchesi, Alessandro; Giai, Valentina; Beggiato, Eloise; Di Bona, Eros; Giglio, Fabio; Sica, Simona; Iori, Anna Paola; Barcellini, Wilma
title: SARS‐CoV‐2 vaccination in patients with paroxysmal nocturnal hemoglobinuria: An Italian multicenter survey
date: 2022-03-26
journal: Am J Hematol
DOI: 10.1002/ajh.26545
sha: e15c94a1838325d097a1065ff769b4522df6c7b5
doc_id: 684466
cord_uid: 7jd4jhxw

nan

To the Editor: SARS-CoV-2 infection and vaccination have raised concern in paroxysmal nocturnal hemoglobinuria (PNH). 1 In fact, PNH patients carry an increased infectious risk secondary to therapy with complement inhibitors or to underlying bone marrow failure (BMF), and therefore, may benefit from preventive strategies such as vaccinations. On the other hand, vaccines may potentially trigger a hemolytic flare or a breakthrough hemolysis (BTH) by amplifying complement activation, as described for meningococcal serogroup B vaccine. 2 So far, isolated reports of hemolytic exacerbations following SARS-CoV-2 vaccines have been reported in PNH [3] [4] [5] and other complement-mediated disorders, such as cold agglutinin disease and atypical hemolytic uremic syndrome. 5 

COVID-19 infection in patients on anticomplement therapy: the Leeds National Paroxysmal Nocturnal Haemoglobinuria service experience

How we treat paroxysmal nocturnal hemoglobinuria: a consensus statement of the Canadian PNH network and review of the national registry

Autoimmune-and complement-mediated hematologic condition recrudescence following SARS-CoV-2 vaccination

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

Complement mediated hemolytic anemias in the COVID-19 era: case series and review of the literature

Thrombotic events with Neisseria Meningitidis vaccination in patients with paroxysmal nocturnal hemoglobinuria, UK experience

COVID-19 in patients with paroxysmal nocturnal haemoglobinuria: an Italian multicentre survey

The authors declare no competing financial interests.

Juri Alessandro Giannotta, Bruno Fattizzo and Wilma Barcellini conceived the study and wrote the paper. All authors followed the patients, collected data, and revised the paper for intellectual content.

The data supporting the findings of this study are available from the