key: cord-0684490-ipo5zgus
authors: Mahmud, Ehtisham; Dauerman, Harold L.; Welt, Frederick GP.; Messenger, John C.; Rao, Sunil V.; Grines, Cindy; Mattu, Amal; Kirtane, Ajay J.; Jauhar, Rajiv; Meraj, Perwaiz; Rokos, Ivan C.; Rumsfeld, John S.; Henry, Timothy D.
title: Management of Acute Myocardial Infarction During the COVID-19 Pandemic
date: 2020-04-21
journal: Journal of the American College of Cardiology
DOI: 10.1016/j.jacc.2020.04.039
sha: 5d9706bd214b03044febca929d4d448ce4b5472a
doc_id: 684490
cord_uid: ipo5zgus

Abstract The worldwide pandemic caused by the novel acute respiratory syndrome coronavirus 2 (SARS-CoV2) has resulted in a new and lethal disease termed coronavirus disease 2019 (COVID-19). Although there is an association between cardiovascular disease and COVID-19, the majority of patients who need cardiovascular care for the management of ischemic heart disease may not be infected with COVID-19. The objective of this document is to provide recommendations for a systematic approach for the care of patients with an acute myocardial infarction (AMI) during the COVID-19 pandemic. There is a recognition of two major challenges in providing recommendations for AMI care in the COVID-19 era. Cardiovascular manifestations of COVID-19 are complex with patients presenting with AMI, myocarditis simulating a ST-elevation MI presentation, stress cardiomyopathy, non-ischemic cardiomyopathy, coronary spasm, or nonspecific myocardial injury and the prevalence of COVID-19 disease in the US population remains unknown with risk of asymptomatic spread. This document addresses the care of these patients focusing on 1) the varied clinical presentations; 2) appropriate personal protection equipment (PPE) for health care workers; 3) role of the Emergency Department, Emergency Medical System and the Cardiac Catheterization Laboratory; and 4) Regional STEMI systems of care. During the COVID-19 pandemic, primary PCI remains the standard of care for STEMI patients at PCI capable hospitals when it can be provided in a timely fashion, with an expert team outfitted with PPE in a dedicated CCL room. A fibrinolysis-based strategy may be entertained at non-PCI capable referral hospitals or in specific situations where primary PCI cannot be executed or is not deemed the best option.

The worldwide pandemic caused by the novel acute respiratory syndrome coronavirus 2 (SARS-CoV2) has resulted in a new and lethal disease termed coronavirus disease 2019 . Given the exponential growth of the disease, patients with COVID-19 may overwhelm the emergency department (ED), medical floors, intensive care unit resources, personal protective equipment (PPE) supplies, and medical staff. Thus, healthcare systems are reducing elective procedures and surgeries to prepare for, and manage, infected patients. The United States now has the highest number of documented COVID-19 patients in the world, and it is likely that we will be managing patients with this disease over at least the next 12-18 months.

Patients with cardiovascular disease who develop COVID-19 have a higher risk of mortality [1] [2] [3] [4] [5] [6] . However, it is important to emphasize that the majority of patients who need cardiovascular care for the management of ischemic heart disease, peripheral vascular or structural heart disease may not be infected with COVID-19. Further, as we prepare for the care of patients with COVID-19 related illness, we also need to ensure that the overall patient population continues to benefit from the tremendous advancements in cardiovascular care made over the past 3 decades. 7, 8 The objective of this document is to provide recommendations for a systematic approach for the care of patients with an acute myocardial infarction (AMI) during the COVID-19 pandemic. It is critical to: 1) inform the public that we can minimize exposure to the coronavirus so they continue to call the Emergency Medical System (EMS) for acute ischemic heart disease symptoms and therefore get the appropriate level of cardiac care that their presentation warrants;

2) target the use of primary percutaneous coronary intervention (PCI) or fibrinolysis (at referral or non-PCI capable hospitals) in patients with ST-elevation myocardial infarction (STEMI) and aim to avoid reperfusion therapy for those with other causes of ST-segment elevation on the electrocardiogram (ECG); and

3) maximize the safety of medical personnel by appropriate masking of patients and the use of personal protection equipment (PPE).

The writing group for this statement has been organized to ensure diversity of perspectives and demographics, multi-stakeholder representation, and appropriate balance of relationships with industry (RWI). Policies from all three participating societies require that writing group members with a current financial interest are recused from participating in discussions or voting on relevant recommendations. The work of the writing group was supported exclusively by the Society for Cardiovascular Angiography and Interventions (SCAI) and the American College of Cardiology (ACC), nonprofit medical specialty societies, without commercial support.

The American College of Cardiology, the American College of Emergency Physicians, and the Society for Cardiovascular Angiography and Interventions endorsed the statement as official society guidance in April 2020. Consensus statements are primarily intended to help clinicians make decisions about treatment alternatives; clinicians also must consider the clinical presentation, setting, and preferences of individual patients to make judgements about the optimal approach.

There is a paucity of data to provide uniform recommendations. Observational studies from China and Europe have provided some guidance regarding the management of AMI in patients with COVID-19. [1] [2] [3] [4] [5] [6] This writing group has been convened to provide clinical guidance for AMI patients during the COVID-19 pandemic, taking into account the United States (US) healthcare system. There is a recognition of two major challenges in providing recommendations for AMI care in the COVID-19 era: 1) Cardiovascular manifestations in the COVID-19 patient are complex: patients may present with AMI, myocarditis simulating a STEMI presentation, stress cardiomyopathy, non-ischemic cardiomyopathy, coronary spasm, or myocardial injury without a documented Type I or Type II AMI. [1] [2] [3] [4] [5] [6] ; and

2) The prevalence of COVID-19 disease in the US population remains unknown. In certain regions, community spread of SARS-CoV2 is prevalent, and the sensitivity of testing is imperfect. Further, patients testing positive for COVID-19 can be asymptomatic despite significant abnormalities noted on chest computed tomography (CT) scan and there appears to be significant risk of asymptomatic transmission of the disease. [9] [10] Therefore, a balance must be struck in identifying appropriate patients for invasive approaches to AMI regardless of their COVID-19 status, and maintaining the safety of healthcare workers who might be exposed to the disease as well as minimizing contamination of cardiac catheterization laboratory (CCL) facilities. The need for additional patient evaluation might translate into some delays in reperfusion. A small study from Hong Kong examining the care of STEMI patients during the COVID-19 outbreak demonstrated a delay in symptom onset to medical contact times suggesting that there may also be patient and/or or systems-related delays in medical care during this pandemic. 6 In addition, there has been a reduction in STEMI activations, reflecting a reluctance to seek medical attention or misdiagnoses given the focus on respiratory issues. 11 Given this complexity, a reassessment of the current strategies for efficient and effective management of AMI during the COVID-19 pandemic is required. This is addressed with a focus on 1) clinical presentation including STEMI, cardiogenic shock, out-of-hospital cardiac arrest (OHCA), and non-STEMI; 2) PPE for health care workers; 3) role of the ED, EMS and CCL; and 4) Regional STEMI systems of care. We conclude with recommendations that balance the benefits and risks of invasive management of ischemic heart disease, as well as health care team protections, anticipating these recommendations to be relevant during the entire period of the US coronavirus pandemic.

Primary percutaneous coronary intervention (PCI) is the standard of care for patients presenting to PCI centers (within 90 minutes of first medical contact). 7 This should remain the standard of care for STEMI patients during the COVID-19 pandemic with some important caveats (Table 1) (Figures 1 and 2 ). Until we can firmly establish the prevalence of the disease in the general population of the country, all patients presenting with a suspected STEMI should be considered COVID-19 possible. With a primary PCI strategy, ED stays should be focused and patients should be transferred to the CCL as expeditiously as possible. Yet, additional time to establish an AMI diagnosis may be indicated (e.g. in some cases, echocardiography to assess for wall motion), and/or for COVID-19 status assessment and potential treatment (e.g. respiratory support).

In certain circumstances, a more detailed and confirmatory evaluation in the ED might be required prior to transfer to the CCL. Thus, during the COVID-19 pandemic, there may be longer door-to balloon (D2B) times. D2B times should still be tracked, but we may expect more patient and/or system-related delays documented as appropriate reasons for delay in the ACC National Cardiovascular Data Registry (NCDR) programs (Chest Pain-MI and/or CathPCI). These programs are also working to support direct COVID-19 status documentation to further inform patient risk and local quality of care assessments.

Two point-of-care assays have recently received Food and Drug Administration (FDA) approval for rapidly making the diagnosis of COVID-19. 12 As these tests become widely available, they should be routinely implemented in all STEMI patients to better characterize patient diagnosis and risk, optimize the treatment plan for a given patient (for AMI +/-COVID- 19) , and guide appropriate placement within the hospital, including a dedicated CCL and postprocedure unit.

It is important to emphasize that primary PCI should remain the standard of care, including for COVID-19 confirmed or probable patients. Once primary PCI is performed on the infarct related artery, if clinically safe and indicated, any high grade disease in a non-infarct related artery should also be treated during the index procedure to minimize further exposure of the CCL staff during a staged procedure. Primary PCI is superior for establishing normal (TIMI grade 3) coronary flow compared to an initial fibrinolysis strategy and has a significantly lower risk of fatal and nonfatal bleeding complications 7 . Furthermore, after a fibrinolysis-based strategy, just over 50% of patients reperfuse resulting in a high proportion of patients requiring rescue PCI. 7 This can result in prolonged ICU hospitalization with attendant exposure to multiple healthcare providers and limiting access of ICU beds for COVID-19 patients.

In addition, some of these patients may have a "STEMI-mimicker" such as focal myocarditis or stress cardiomyopathy known to be associated with COVID-19 13, 14 . Fibrinolysis of these patients would provide no benefit to the patient, but still incur bleeding risk and eventual invasive diagnostic catheterization given that the ST-elevation is unlikely to resolve. Each primary PCI center will need to monitor the ability to provide timely primary PCI based on staff and PPE availability, need for additional testing, as well as a designated CCL which will require terminal cleaning after each procedure. In the absence of these resources, a fibrinolysis first approach should be considered.

For patients who have an unclear, or equivocal, diagnosis of STEMI due to atypical symptoms, diffuse ST-segment elevation or atypical ECG findings, or a delayed presentation, additional noninvasive evaluation in the ED is recommended (Figure 1 ). The focus of this evaluation is two-fold: 1) further risk stratification for COVID-19 status and 2) further evaluation of the diagnosis specifically assessing the potential for coronary thrombotic occlusion versus other pathologies. Either a point of care ultrasound (POCUS) of the heart or a traditional transthoracic echocardiographic evaluation to assess for wall motion abnormality consistent with the electrocardiographic change may provide valuable information. Available clinical, ECG, laboratory and imaging data can inform a decision between the ED physician and interventional cardiologist regarding CCL activation. Coronary CT angiography may be considered in cases where the findings of ST elevation and transthoracic echocardiography are divergent. One clear advantage of an invasive approach to STEMI in the current era is the ability to diagnose a thrombotic coronary occlusion (as opposed to stress cardiomyopathy or myocarditis) before embarking on an early reperfusion approach. Regardless, patients with hemodynamic instability might still require an invasive evaluation in the CCL to make a definitive diagnosis and provide necessary hemodynamic assessment and support.

We note that not all COVID-19 patients with ST elevation with/without an acute coronary occlusion will benefit from any reperfusion strategy or advanced mechanical support. In COVID-19 confirmed patients with severe pulmonary decompensation (adult respiratory distress syndrome) or pneumonia who are intubated in the ICU and felt to have an excessively high mortality, consideration for compassionate medical care may be appropriate. This decision is best made by each local healthcare team based on individual patient prognosis, patient and family wishes, as well as the resources available at their specific healthcare system.

Primary PCI is the standard of care for patients transferred rapidly from non-PCI centers (within 120 minutes of first medical contact at Referral Hospital). 7 For patients in whom rapid reperfusion with primary PCI is not feasible, a pharmacoinvasive approach is recommended with initial fibrinolysis followed by consideration of transfer to a PCI center ( Figure 3 ). 15, 16 Transfer to a PCI center following fibrinolysis in the pre-COVID-19 period was generally considered routine and should remain the standard of care. However, patients with STEMI at a referral hospital with established COVID-19 infection should be discussed prior to transfer to a PCI center. Fibrinolysis within 30 minutes of STEMI diagnosis, and transfer for rescue PCI when necessary, may be preferable for all COVID-19 positive STEMI patients who are at a referral hospital provided the diagnosis of a true STEMI is highly likely.

While fibrinolysis first as a therapeutic strategy has been proposed for COVID-19 STEMI patients based on the experience from Sichuan hospital in China, 17 this might be more applicable in regions with limited primary PCI centers. In the United States, we propose that an initial fibrinolysis therapy be used in non-PCI capable hospitals if the first medical contact to reperfusion is felt to be >120 minutes. In the era of COVID-19, each regional STEMI system will need to closely monitor transfer processes and times with active adjustment to a fibrinolysis first approach if delays ensue that might not have been present prior to the pandemic. As outlined above, in the presence of an equivocal diagnosis of a STEMI in a COVID-19 positive or probable patient, additional noninvasive imaging should help determine if the patient is likely to have ST-elevation associated with an occluded coronary artery, and therefore might benefit from a fibrinolysis reperfusion approach.

Patients with resuscitated out-of-hospital cardiac arrest (OHCA) and/or cardiogenic shock will continue to be the highest risk subgroup of AMI patients. These patients will also be the highest risk for droplet-based spread of COVID-19. Patients with resuscitated OHCA should be selectively considered for CCL activation in the presence of persistent ST-elevation on their electrocardiogram, and a concomitant wall motion abnormality on echocardiographic evaluation. We recommend that OHCA patients without ST-elevation not receive a routine early invasive approach unless hemodynamic instability ensues, an acute coronary occlusion remains high on the differential diagnosis, and a multidisciplinary team concurs. 18, 19 Appropriate PPE for the healthcare team in the emergency department and the CCL are required regardless of COVID-19 status since history may be limited in these patients. Consideration of revascularization and potential mechanical circulatory support (MCS) for patients in cardiogenic shock should proceed with PPE and special precautions for high droplet components of the procedure (i.e. intubation and extubation in negative pressure room by anesthesia if possible; intubation prior to arrival in the CCL).

For known COVID-19 positive or probable patient, while MCS might be considered for a cardiomyopathy and cardiogenic shock, venous-venous (V-V) extracorporeal membrane oxygenation (ECMO) should be considered for severe pulmonary decompensation and failure to oxygenate. When feasible, bedside placement of MCS or ECMO might decrease the risk of exposure to the CCL or cardiothoracic surgical team. The approach is dependent on local resources and the COVID-19 disease burden in the community. Finally, there are not enough data at this time to state whether advanced support devices for COVID-19 associated cardiovascular pathology will positively impact mortality rates and thus individual patient risk assessment is required. In contrast, patients admitted with an acute coronary syndrome who are felt to be COVID-19 possible, should continue to get standard medical therapy with an early invasive approach as clinically indicated. As rapid testing for COVID-19 becomes more easily available, it should be performed as soon as possible to establish diagnosis, inform risk assessment, and guide placement within the hospital. As the prevalence of COVID-19 remains unknown, we recommend that all medical staff taking care of AMI patients (regardless of COVID-19 positive, probable or possible) should have PPE in place during cardiovascular procedures, regardless of specific location (e.g. ED, CCL, ICU/CCU, hospital ward).

Ensuring adequate protection of all healthcare workers in the EMS, transfer hospitals, PCI Center ED and the CCL team is critical. Cardiovascular teams in China developed policies and procedures for performing interventional cardiovascular procedures in the safest possible environment to optimize clinical outcomes and minimize the risk of infection of CCL teams, but these involved access to rapid testing protocols for the diagnosis of COVID-19. 17 Given the current delays in testing for COVID-19 in the US, it is not feasible to await results of testing for STEMI, shock or OHCA patients as has been proposed in protocols used in China. 17 Therefore, all patients requiring emergent activation of the CCL should be treated as COVID-19 possible.

Since the start of the COVID-19 outbreak, the World Health Organization maintains the recommendation of using medical masks for regular care of COVID-19 patients in the context of droplet and contact precautions, and respirators (N95, FFP2 or FFP3) for circumstances and settings where aerosol generation can occur. 21, 22 The latter include patients on bi-level or continuous positive pressure ventilation, those requiring intubation/extubation, defibrillation with need for CPR, and airway suctioning-all of these high risk situations can be encountered during primary PCI for STEMI and OHCA. 23 We note that intubation and extubation are both considered high risk for aerosol generation and whenever possible, a Powered Air Purifying Respirator (PAPR) should be used with endotracheal intubation. In addition, the minimum number of personnel should be in the room at the time of intubation/extubation. Given the potential risk of aerosol generation during all emergency AMI procedures, this writing group recommends PPE with aerosolization protection for the entire CCL staff during PCI for all STEMI patients during this COVID-19 pandemic as per the previously published ACC/SCAI guidelines for managing CCL patients during the COVID-19 epidemic 24 . Finally, we note that teams should consider minimization of the number of physician and staff potentially exposed during invasive cardiovascular procedures; this may include limiting the involvement of trainees in high risk procedures and patients.

The ED is the place of initial medical contact for the majority of patients with STEMI in the United States. For the past two decades, the priority in emergency medicine in caring for these patients has been to rapidly diagnose STEMI and aim for urgent reperfusion. However, as mentioned previously, the electrocardiographic diagnosis of STEMI is more difficult in the presence of COVID-19. It is important to emphasize that liberal use of the electrocardiogram in both the prehospital setting and the ED is still encouraged. Respiratory viral infections are known to increase the incidence of true STEMI (i.e. acute coronary occlusion) 25 , but myocarditis has been reported in cases of COVID-19 2, 13 . As the electrocardiographic distinction between a true STEMI versus COVID-19 associated myocarditis can be challenging, additional noninvasive testing in consultation with cardiologist may be warranted.

Prehospital care providers who respond to calls for cardiac complaints will typically have no forewarning that a patient with a potential AMI may also have symptoms of COVID-19.

Therefore, we recommend that prehospital care providers have a low threshold of wearing appropriate protective equipment whenever responding to patients with a primary cardiac complaint. In the setting of cardiac arrest, the use of PPE is even more critical for the reasons stated earlier.

Certain Emergency Medical System (EMS) STEMI protocols around the United States allow the prehospital care providers to activate their local hospital CCL when diagnosing STEMI in the field and directly transport the patient from the ambulance to the CCL ("ED Bypass"). This has contributed to reductions in first medical contact-to-balloon time and improved patient care. However, due to the logistical issues and time delays secondary to diagnostic uncertainty of STEMI with COVID-19, direct transport of the patient to the CCL is not felt to be prudent at this time. Therefore, we recommend initial assessment of all STEMI patients in the ED during the COVID-19 pandemic to ensure the correct diagnosis and care plan (Figure 2) . The attending interventional cardiologist should be notified, but without activation of the entire STEMI team until the plan for CCL activation is confirmed.

Regional systems of care for patients with STEMI have emphasized efficiency and simplicity 8, 26 . A fundamental strength of regional STEMI systems has been the ability to standardize protocols and provide quality improvement for a wide range of non-PCI hospitals, including community hospitals without on-site PCI 8 . The COVID-19 epidemic has quickly altered the landscape for regional STEMI care and systems and interventional cardiology teams are now faced with a new set of circumstances in which modified recommendations for care are expected and warranted. Regional systems of care for STEMI require close integration of EMS, ED providers, and STEMI referral hospitals in conjunction with the PCI center team. Each component of the regional STEMI system has its own inherent risk of COVID-19 infection/spread, as well as its own potential for delay in reperfusion for patients with STEMI.

Based on early experience in China and Europe, key challenges include the availability of ICU beds, ventilators, ECMO, and the risk to HCW (including EMS personnel, ED staff and specialized diagnostic and treatment units like the CCL). As the US experience with COVID-19 is rapidly evolving, definitive best practices are clearly challenging and require flexibility for a complex regional care system. Based upon these new operational risks and patient comorbidities, it is imperative to consider immediate adjustments that maximize treatment options for patients with acute cardiovascular emergencies while protecting the safety of patients and providers. We propose the following guiding principles for Transfer STEMI Regional Systems of Care in the era of coronavirus (Table II) (Figure 3) . These recommendations will need to be adapted to each regional system's PCI Center, STEMI referral hospitals, and EMS system and need to be communicated clearly between cardiology and emergency medicine providers within each hospital. As the COVID-19 pandemic grows or recedes, this algorithm will need to be updated and adapted but will eventually return to the principles of simplicity and efficiency previously outlined in the STEMI Accelerator program and the ACC/AHA Guidelines 7, 8, 26 . For now, each system must recognize the competing and equally important principles of (A) timely reperfusion of STEMI patients, B) safe regional transport and treatment of potentially high-risk patients and C) additional emphasis on protection and safety of all health care personnel.

During the COVID-19 pandemic, primary PCI remains the standard of care for STEMI patients at PCI capable hospitals when it can be provided in a timely fashion, with an expert team outfitted with PPE in a dedicated CCL room. A fibrinolysis-based strategy may be entertained at non-PCI capable referral hospitals or in specific situations where primary PCI cannot be executed or is not deemed the best option. Clinicians should recognize that patients with COVID-19 are inherently complex: a broad differential diagnosis for ST elevations (including COVID-associated myocarditis) should be considered in the ED prior to choosing a reperfusion strategy. In the absence of hemodynamic instability or ongoing ischemic symptoms, NSTEMI patients who are COVID-19 positive or probable are optimally managed with an initial medical stabilization strategy. It is imperative that health care workers use appropriate PPE for all invasive procedures during this pandemic, and that new rapid COVID-19 testing be expeditiously disseminated to all hospitals involved in the care of patients with AMI.

Finally, we believe that each regional STEMI care network needs to revise their suggested algorithm for its local environment and ensure that EMS and referral hospital teams are facile with a balanced and standardized approach towards STEMI care during the COVID-19 pandemic. Table I .

• All STEMI patients should initially undergo evaluation in the Emergency Department.

• Patients should be evaluated in the ED prior to CCL activation to ensure appropriate risks are assessed. • All patients require the placement of a face mask to prevent droplet contamination of the CCL and environment prior to transport • CCL staff and physicians should have appropriate PPE for safe performance of the procedure, including gowns, gloves, full face mask and an N95 respiratory mask. If N95 masks are to be re-used between cases by a single HCW, then an additional surgical mask should be worn on top of this mask. The number of HCW present during the procedure should be limited to only those essential for patient care and procedure support.

• Patients with respiratory compromise should be intubated prior to arrival in the CCL if possible.

• If intubation is required in the CCL, all personnel should have complete PPE and exposures should be minimized to essential team members only. • For all procedures at high risk of aerosolization, PAPRs should be considered.

• Proper PPE training should be provided and practiced by physicians and CCL staff involved in all cases and extra consideration should be given to the protection of trainees in high risk patients and procedures.

• Primary PCI should remain the default strategy in patients with clear evidence of a STEMI; if a Primary PCI approach is not feasible, a pharmacoinvasive approach may be considered.

• During the COVID-19 period, there may be delays in D2B times that result from evaluation and/or management of COVID-19 patients. This can be documented in the medical record and coded in the NCDR CathPCI Version 5 as follows:

• If primary PCI for STEMI, code "Yes" for Seq. #7850 (Patient Centered Reason for Delay in PCI) and selecting "Other" in Seq. #7851 (Delay Reason). • If primary thrombolytic therapy for STEMI, code "Yes" for Seq. #14208 (Patient Reason for Delay in Thrombolytic). • Within the CCL, a single negative pressure procedure room with essential supplies only is preferable for the care of known COVID-19 positive or probable patients with a terminal clean after the procedure.

• To preserve ICU beds, all hemodynamically stable STEMI patients following PCI should be admitted to an intermediate care telemetry unit with plan for early (<48 hours) discharge 25 . • Each regional STEMI system should update their system of care immediately to maximize patient and provider safety including adequate PPE during transport and procedures for STEMI patients who are COVID-19 positive or probable.

• First medical contact to reperfusion time remains of paramount importance and should not substantially delay primary PCI for STEMI patients. Additional time at the Primary PCI center ED or ICU may be a necessary delay required for confirmation of COVID-19 and STEMI status prior to transfer to the CCL.

• STEMI patients with cardiogenic shock and/or resuscitated cardiac arrest should still be prioritized for a primary PCI approach. If timely PCI is not possible or team/room/PPE not available, a pharmacoinvasive strategy may be considered.

• It is critical to ensure PPE and rapid sterilization procedures are prioritized throughout the entire system of care and that communication occur among transfer hospital, EMS, ED and CCL providers regarding COVID-19 status.

• EMS should include a brief assessment of COVID-19 status (positive, probable or possible) in their report to the PCI center for an incoming STEMI patient. If a patient is COVID-19 positive or probable, EMS should follow CDC guidelines regarding droplet precautions during and immediately after transfer.

• All transfer STEMI patients should be re-evaluated at the Primary PCI center ED or ICU for COVID-19 status and the concept of ED Bypass should not be utilized during the pandemic.

• Patients with STEMI at a Referral hospital with established COVID-19 infection should be discussed prior to transfer to a PCI center. Fibrinolysis within 30 minutes of STEMI diagnosis, and transfer for rescue PCI when necessary, may be preferable for all COVID-19 positive STEMI patients who are at a Referral hospital provided the diagnosis of a true STEMI is highly likely. Center) . The decision to proceed with an initial fibrinolysis or direct transfer to a percutaneous coronary intervention (PCI) center is multifactorial, and will likely vary in different regions. The treatment decision also depends on whether the patient is COVID-19 positive or probable and should be made between the referral hospital physician and PCI center physician.

On transfer of a patient with a STEMI from a referral hospital to a PCI center, the patient should be reevaluated for the COVID-19 status and STEMI diagnosis. The patient can then be taken for primary PCI, pharmacoinvasive PCI or rescue PCI, as indicated. 

Clinical features of patients infected with 2019 novel coronavirus in Wuhan

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-infected Pneumonia in Wuhan, China

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol

Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19)

Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on ST-Segment-Elevation Myocardial Infarction Care in Hong Kong

ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

From concept to reality: a decade of progress in regional STelevation myocardial infarction systems

Chest CT Findings in Cases from the Cruise Ship "Diamond Princess"with Coronavirus Disease 2019 (COVID-19). Radiology: Cardiothoracic Imaging

Presumed asymptomatic carrier transmission of COVID-19

Reduction in ST-Segment elevation cardiac catheterization laboratory activations in the United States during COVID-19 pandemic

FDA approval of rapid COVID-19 testing. Accessed google search

The variety of cardiovascular manifestations of COVID-19. Circulation

Synergistic treatment of ST-segment elevation myocardial infarction with pharmacoinvasive recanalization

Safety and efficacy of a pharmacoinvasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to long-distance transfers

How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People's Hospital

Cardiac arrest: a treatment algorithm for emergent cardiac procedures in the resuscitated comatose patient

Coronary angiography after cardiac arrest without ST-segment elevation

Early versus delayed invasive intervention in acute coronary syndromes

COVID-19) Situation Report-66

WHO Infection Prevention and Control Guidance for COVID-19 available at

Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review

Catheterizatiion laboratory considerations during the coronavirus (COVID-19) pandemic. From ACC's Interventional Council and SCAI

Acute myocardial infarction after laboratory-confirmed influenza infection

Regional Systems of Care Demonstration Project: American Heart Association Mission: Lifeline STEMI Systems Accelerator

Value-Based ST-Segment-Elevation Myocardial Infarction Care Using Risk-Guided Triage and Early Discharge

The authors acknowledge Lawrence Ang, MD, FACC, FSCAI for his assistance in the drafting of the figures.