key: cord-0688135-v8xkv3ec
authors: Decio, Alice; Mazza, Angelo; Quadri, Vera; Ronconi, Monica Silvia; Brusadelli, Claudia; Ruggeri, Maurizio; D’Antiga, Lorenzo
title: Neurological Manifestations of COVID-19 in Children: A Case of Facial Nerve Palsy
date: 2020-12-17
journal: Pediatr Neurol
DOI: 10.1016/j.pediatrneurol.2020.12.006
sha: 05cb186cc1c134ac68b393497f9a069fbdab4852
doc_id: 688135
cord_uid: v8xkv3ec

nan

Neurological Manifestations of COVID-19 in Children: A Case of Facial Nerve Palsy Kaur and colleagues 1 presented a child with an unusual neurological presentation (longitudinally extensive transverse myelitis) following SARS-CoV-2 infection. Unlike acute presentations due to direct SARS-CoV-2 invasion of the central nervous system (i.e. encephalitis 2 ), immune-mediated neurological symptoms may occur when the patient has already cleared the virus and has developed antibodies against it.

Facial nerve palsy has been reported as a possible complication of COVID-19. 3 Its incidence increased during the pandemia both in adult 4 and pediatric 5 emergency departments; in affected patients, nasopharyngeal swabs tested negative for SARS-CoV-2, but serology has not been obtained.

We describe a 15-month-old girl with right peripheral facial nerve palsy without any other neurological signs. Serological tests for common infectious etiologies (herpes simplex virus 1, herpes simplex virus 2, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, Mycoplasma pneumoniae, Borrelia burgdorferi) were negative. Magnetic resonance imaging showed enhancement of the intra-auricular tract of the right facial nerve.

Nasopharyngeal polymerase chain reaction for SARS-CoV-2 was negative, but serological testing revealed positive IgG antibodies. Remarkably, the patient and her family had earlier experienced mild respiratory symptoms, fever, anosmia, and ageusia, all of which recovered spontaneously. Our patient underwent a course of prednisone (1 mg\kg\day for six days followed by tapering) and subsequently achieved clinical resolution.

Along with other well-established infections that trigger facial nerve palsy, we propose to carry out both SARS-CoV-2 swab and serology testing because facila palsy could represent an immune-mediated neurological complication of COVID-19, similar to transverse myelitis and Guillain-Barr e syndrome.

Transverse myelitis in a child with COVID-19

Encephalitis associated with COVID-19 infection in an 11-year-old child

Neurological manifestations of patients infected with the SARS-CoV-2: a systematic review of the literature

A rise in facial nerve palsies during the coronavirus disease 2019 pandemic

Increased childhood peripheral facial palsy in the emergency department during COVID-19 pandemic