key: cord-0702986-g7s0xbo8
authors: Sauza-Sosa, Julio C.; Mendoza-Ramirez, Jorge; Velazquez-Gutierrez, Carlos N.; De la Cruz-Reyna, Erika L.; Fernandez-Tapia, Jorge
title: Echocardiographic signs of successful thrombolysis in a pulmonary embolism and COVID-19 pneumonia
date: 2021-02-18
journal: J Echocardiogr
DOI: 10.1007/s12574-021-00517-w
sha: c0128d72dfe15b9a5b170047fba61731482771e7
doc_id: 702986
cord_uid: g7s0xbo8

nan

A 78-year-old woman presented to the emergency department with two weeks of weakness, cough and progressive dyspnea. Her past medical history included diabetes mellitus. On presentation, she reported increasing levels of dyspnea in the previous 48 h. Upon presentation, the patient had a temperature of 97.7℉ (36.5℃), heart rate of 105 beats/ minute, respiratory rate of 24 beats/minute, and blood pressure of 117/65 mmHg, her arterial oxygen saturation was 64%. Physical examination demonstrated crackles in bilateral lower lung fields. Admission blood work showed leukocytes 14 270/µL, creatinine 1.51 mg/dL, pH 7.43, pCO 2 25.1 mm Hg, pO 2 84.8 mm Hg, HCO 3 17 mmol/L, lactate 4.52 mmol/L, C-reactive protein of 29.3 mg/L, D-dimer level of 39,805.62 ng/mL, NT pro-BNP 15,171 pg/mL, hs-Troponine I 295.7 ng/mL, ferritin 2990 ng/mL and positive RT-PCR test for coronavirus disease 2019 (COVID-19). The electrocardiogram showed sinus tachycardia, right axis deviation and systolic overload of the right ventricle. Transthoracic echocardiogram showed dilation of right cavities and right ventricle dysfunction (Fig. 1a , Video 2), severe tricuspid regurgitation and normal left ventricular function (Ejection Fraction 66%). Computed tomography of the chest revealed a bilateral extensive crazy paving pattern consistent with an infectious or inflammatory process and pulmonary embolism (PE) with extension into bilateral pulmonary arteries (Fig. 1b) .

Management involved initial airway stabilization with supplementary oxygen, fractional heparin for anticoagulation and intravenous levosimendan for acute right ventricle failure. However, according to the high risk of deterioration conditioned by organ dysfunction (acute kidney failure), ICU admission, high O 2 requirement, hypoperfusion and RVOT VTI < 9.5 cm, intermediate or half-dose systemic fibrinolysis consisting of intravenous alteplase 10 mg bolus followed by 40 mg over two hours. The patient experienced less supplemental oxygen requirements in the next hours. During the following 24 h she presented gastrointestinal bleeding requiring transfusion of two blood packs. At 48 h of fibrinolysis her right ventricular size and function normalized (Fig. 1c , Video 2) with tricuspid regurgitation. Due to the poor economic situation, the patient was transferred to another hospital after determining her being in better conditions and able to be moved. Unfortunately, the patient died after the transfer to the other hospital secondary to septic shock.

In patients with pneumonia secondary to COVID-19 the principal etiology of hypoxemia is acute respiratory distress syndrome. However, when present PE plays a significant role, adding an extra point of complexity to the management of the hypoxic state. Correct selection of patients undergoing fibrinolysis therapy may therefore be the key to success or failure in the therapy of patients with COVID-19.

We evaluated the risk of decompensation based on several clinical, laboratory and echocardiographic markers to make the decision of starting fibrinolytic therapy, as has been done in other hospitalization centers [1] [2] [3] . Half-dose systemic thrombolysis in intermediate-high risk PE has shown lower mortality rate, lower bleeding rate and less required vasopressor therapy and invasive ventilation [4, 5] that has recently been used in other patients with COVID-19 [3] .

Half-dose systemic thrombolysis should be considered as a therapeutic treatment in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) complicated with PE. Thrombolytic therapeutic interventions can improve right-sided heart failure, hypoxemia and the supplemental oxygen requirements in patients with SARS-CoV-2.

The online version contains supplementary material available at https ://doi.org/10.1007/s1257 4-021-00517 -w.

Funding None.

Conflict of Interest Sauza-Sosa JC, Mendoza-Ramirez J, Velazquez-Gutierrez CN, de la Cruz-Reyna EL and Fernandez-Tapia J declare that they have no conflict of interest.

Human rights statements and informed consent All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later revisions. Informed consent was obtained from all patients for being included in the study.

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