key: cord-0714536-jfyzwedr
authors: Papa‐Gobbi, Rodrigo; Bueno, Alba; Serradilla, Javier; Talayero, Paloma; Stringa, Pablo; Pascual‐Miguel, Bárbara; Alcolea‐Sánchez, Alida; González‐Sacristan, Rocío; Andrés, Ane M.; López‐Santamaría, Manuel; Rumbo, Martín; Ramos‐Boluda, Esther; Hernández‐Oliveros, Francisco
title: Novel coronavirus (SARS‐CoV‐2) infection in a patient with multivisceral transplant
date: 2020-08-08
journal: Transpl Infect Dis
DOI: 10.1111/tid.13430
sha: 2b7199a478835b493713fd88d8fbdda2205be0ea
doc_id: 714536
cord_uid: jfyzwedr

Coronavirus disease 2019 (COVID-19) pandemic has become one of the most challenging episodes in the history of modern public health, with particular emphasis in high risk population. However, the evidence regarding their response to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2), the agent responsible for COVID-19 is scant 2 . Herein we present the clinical and therapeutic course of a SARS-CoV-2 infection in a patient with multivisceral transplant and a recent tuberculosis infection.

To the Editor, Coronavirus disease 2019 (COVID-19) pandemic has become one of the most challenging episodes in the history of modern public health, with particular emphasis in high-risk population. 1 However, the evidence regarding their response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for COVID-19 is scant. 2 Herein, we present the clinical and therapeutic course of a SARS-CoV-2 infection in a patient with multivisceral transplant and a recent tuberculosis infection. Table 1 . Pharyngeal adenovirus infection was diagnosed, with C-reactive-protein (CRP) and white blood cells (WBC) above normal range. On March 13, abdominal pain got worse and blood in stool appeared; therefore, he was admitted for hospital monitoring. Vital signs were between normal ranges during the whole hospitalization period. RT-PCR testing was negative for both adenovirus (pharyngeal smear and peripheral blood) and SARS-CoV-2 (nasopharyngeal swab). As seen in the previous laboratory test, WBC, platelets, and CRP values were above normal range. Sirolimus (ng/mL) 6-8 10.3

Note:: Values unbold were above reference range. Flow cytometry experiments: lymphocytes were gated according to their forward and side characteristics. CD4 and CD8 cells were previously defined as CD3 + CD45RA -7AAD -.

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CRP, C-reactive protein; eGFP, estimated glomerular filtration rate (based on CKD-EPI creatinine); LDH, lactate dehydrogenase; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; Scr, serum creatinine; WBC, white blood cells.

The trinity of COVID-19: immunity, inflammation and intervention

Global Transplantation COVID Report

Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission

Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome

Hydroxychloroquine or chloroquine for treatment or prophylaxis of COVID-19: A living systematic review

Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation?

Novel coronavirus (SARS-CoV-2) infection in a patient with multivisceral transplant