key: cord-0715536-sbuwquvm
authors: Workman, Joseph
title: Proportion of COVID-19 Cases that Are Asymptomatic in South Korea: Comment on Nishiura et al
date: 2020-05-14
journal: Int J Infect Dis
DOI: 10.1016/j.ijid.2020.05.037
sha: 5446a0b124efe2822a417216f0bfe55d07d1177a
doc_id: 715536
cord_uid: sbuwquvm

• The Korean Centers for Disease Control & Prevention reports the asymptomatic case proportion for COVID-19 is 33.3%. • The asymptomatic case proportion in South Korea closely approximates the rate of 30.8% reported by Nishiura et al. (2020) among Japanese nationals returning from abroad. • The asymptomatic case proportion in South Korea is higher (56.1%) among those who re-test positive for COVID-19.

Abstract: A structured abstract of 150 to 200 words must be provided as part of each manuscript, except correspondence Keywords: COVID-19; Asymptomatic; Korea Proportion of COVID-19 Cases that Are Asymptomatic in South Korea: Comment on Nishiura et al.

In a recent paper, Nishiura et al. (2020) estimated the asymptomatic rate of COVID-19 cases among Japanese nationals who were tested upon returning to Japan from abroad. The authors estimated the proportion of positive COVID-19 cases that were asymptomatic to be 30.8% (95% confidence interval: 7.7%, 53.8%). In an April 6 Press Release, the Korean CDC Division of Risk Assessment and International Cooperation reported, "asymptomatic case proportion is 33.3% based on the presence or absence of symptoms at the time of confirmation. Further analysis is underway based on clinical progress." Unfortunately, the press release did not provide details on 1) what proportion of cases were pre-symptomatic and eventually exhibited symptoms and 2) how many positive cases the 33.3% asymptomatic rate was based upon, which would be required for J o u r n a l P r e -p r o o f calculating a confidence interval of the asymptomatic case rate. The same press release from April 6 stated the overall prevalence of COVID-19 in South Korea at the time as, "As of 0:00, 6

April 2020, a total of 10,284 cases (including 769 imported cases) have been confirmed."

One concerning trend is that the Korean CDC has found cases where individuals test positive for COVID-19 a second time after initially recovering from the disease. This raises the possibility that anti-bodies do not provide long term immunity from COVID-19. The asymptomatic case rate appears higher for those who test positive for COVID-19 a second time.

In an April 17 press release the Division of Risk Assessment and International Cooperation stated, "of the 137 retested-positive cases with reported clinical and epidemiological information, 61 (43.9%) cases were symptomatic. All of the 61 symptomatic cases had mild symptoms." This would indicate 56.1% of re-tested positive cases were asymptomatic (author's own calculation of 95% confidence interval: 48.8%, 64.4%).

Both the Korean CDC and Nishuara et al. (2020) found the asymptomatic case rate for COVID-19 was approximately 30% of cases. The numbers presented in this comment from South Korea help put Nishiura et al.'s (2020) findings from the Japanese nationals returning from abroad in a broader context. This comment also emphasizes that the asymptomatic rate may be higher among those who re-test positive for COVID-19.

The author received no funding in support of the manuscript and has no conflicts of interest to declare.

J o u r n a l P r e -p r o o f

assessment and International cooperation. 2020. The updates on COVID-19 in Korea as of 17 April

2020. The updates on COVID-19 in Korea as of 6 April

Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19)