key: cord-0734623-5e0meli6 authors: HU, Deying; KONG, Yue; LI, Wengang; HAN, Qiuying; ZHANG, Xin; ZHU, Li Xia; WAN, Su Wei; LIU, Zuofeng; SHEN, Qu; YANG, Jingqiu; HE, Hong-Gu; ZHU, Jiemin title: Frontline nurses’ burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study date: 2020-06-27 journal: EClinicalMedicine DOI: 10.1016/j.eclinm.2020.100424 sha: 5adc2c8ac232f23c4cda2e79bd7d25879241d8e8 doc_id: 734623 cord_uid: 5e0meli6 BACKGROUND: During the Coronavirus Disease 2019 (COVID-19) pandemic, frontline nurses face enormous mental health challenges. Epidemiological data on the mental health statuses of frontline nurses are still limited. The aim of this study was to examine mental health (burnout, anxiety, depression, and fear) and their associated factors among frontline nurses who were caring for COVID-19 patients in Wuhan, China. METHODS: A large-scale cross-sectional, descriptive, correlational study design was used. A total of 2,014 eligible frontline nurses from two hospitals in Wuhan, China, participated in the study. Besides sociodemographic and background data, a set of valid and reliable instruments were used to measure outcomes of burnout, anxiety, depression, fear, skin lesion, self-efficacy, resilience, and social support via the online survey in February 2020. FINDINGS: On average, the participants had a moderate level of burnout and a high level of fear. About half of the nurses reported moderate and high work burnout, as shown in emotional exhaustion (n = 1,218, 60.5%), depersonalization (n = 853, 42.3%), and personal accomplishment (n = 1,219, 60.6%). The findings showed that 288 (14.3%), 217 (10.7%), and 1,837 (91.2%) nurses reported moderate and high levels of anxiety, depression, and fear, respectively. The majority of the nurses (n = 1,910, 94.8%) had one or more skin lesions, and 1,950 (96.8%) nurses expressed their frontline work willingness. Mental health outcomes were statistically positively correlated with skin lesion and negatively correlated with self-efficacy, resilience, social support, and frontline work willingness. INTERPRETATION: The frontline nurses experienced a variety of mental health challenges, especially burnout and fear, which warrant attention and support from policymakers. Future interventions at the national and organisational levels are needed to improve mental health during this pandemic by preventing and managing skin lesions, building self-efficacy and resilience, providing sufficient social support, and ensuring frontline work willingness. The pandemic of Coronavirus Disease 2019 (COVID-19) is currently a major global public health emergency [1] . By 27 March 2020, there were 465,915 confirmed cases in 199 countries, and 21,031 people had lost their lives [2] . The outbreak of COVID-19 put global and national healthcare systems to test, which when overwhelmed, can severely compromise the well-being of frontline healthcare workers (HCWs) [3] . Since the first COVID-19 case was reported in December 2019 in Wuhan [4] , approximately 42,000 HCWs, including 28,600 nurses all over China, were sent to Hubei Province to assist local healthcare teams to care for COVID-19 patients [5] . A study revealed that HCWs who were working in Wuhan often felt stress, depression, and anxiety, but this study didn't target specially at frontline nurses [6] . HCWs, especially nurses, who come close in contact with these patients when providing care are often left stricken with inadequate protections from contamination, high risks of infection, working burnout, fear, anxiety, and depression [7, 8] . Nurses constitute the largest part of the healthcare workforce in an epidemic [9] , and they undertake most of the tasks related to infectious disease containment [10] . To date, epidemiological data on the mental health of frontline nurses who are caring for COVID-19 patients and its associated factors are still limited. Such evidencebased knowledge is crucial for HCWs and the government to prepare for health responses to pandemics such as COVID- 19 . The aim of this study was to examine mental health (burnout, anxiety, depression, and fear) and its associated factors among frontline nurses who were caring for COVID-19 patients in Wuhan, China. The research questions were: (a) What are the levels of burnout, anxiety, depression, fear, skin lesion, self-efficacy, resilience, and social support among frontline nurses? (b) What are the differences in burnout, anxiety, depression, and fear between nurses' various sociodemographic and other COVID-related background subgroups? (c) What are the relationships between burnout, anxiety, depression, fear, and other aforementioned variables? This was a large-scale cross-sectional, descriptive, correlational study. This study was conducted in two hospitals in Wuhan, China. One hospital, which consists of three divisions that were located in different places, was originally a public tertiary hospital in Wuhan, and two out of the three divisions were converted to venues that only received COVID-19 patients after 13 January 2020 and 13 February 2020, respectively. These two divisions had 1860 beds in total, with approximately 2000 nurses who were caring for COVID-19 patients. The other hospital was newly established and operated specially for COVID-19 patients since 3 February 2020, with 1000 beds and 600 nurses. All frontline nurses who were caring for COVID-19 patients in the participating hospitals were invited to participate in this study. Nurses who were diagnosed with any prior mental disorders and/or who had the COVID-19 were excluded from the study. Sociodemographic and other COVID-9 related background data were collected using a self-developed questionnaire. Sociodemographic data consisted of gender, age, marital status, child-rearing, monthly household income, education, professional title, clinical experience, working duration as a frontline nurse, average working hours per shift, whether Wuhan is the original working place, way to be dispatched to Wuhan for those nurses from other cities, position in the hospital, whether the working ward has changed, prior training or experience of caring similar patients, their confidence in caring for patients with COVID-19 infection, self-protection, and working safety. Their belief in their families, colleagues, and hospital readiness to cope with this COVID-19 outbreak was also collected. Willingness and reasons to participate in frontline work during the COVID-19 outbreak were also included. Suggestions to improve frontline work were also explored. Nurses' burnout was measured by the Chinese version of the Maslach Burnout Inventory: Human Services Survey (MBI-HSS) for Medical Personnel (MP) [11] , which contains 22 items with three dimensions: emotional exhaustion (EE, 9 items), depersonalization (DP, 5 items), and personal accomplishment (PA, 8 items). Each item Evidence before this study The outbreak of COVID-19 put global and national healthcare systems to test, which when overwhelmed, can severely compromise the well-being of frontline healthcare workers (HCWs). We searched electronic databases, including CINAHL, PubMed, Google Scholar, and the China National Knowledge Infrastructure, for articles that were published in either English or Chinese from 1 January 2003 to 12 February 2020, using the following keywords: disease outbreak, pandemic, medical crises, quality of life, self-efficacy, resilience, social support, fatigue, anxiety, depression, fear, nurses, healthcare workers, and healthcare professionals. The selection criteria included: (i) non-interventional studies on any pandemic outbreaks, (ii) studies that focused on the impact of any pandemic outbreaks on the health of healthcare workers, and (iii) studies that identified various contributing factors of the experiences described by healthcare workers during any pandemic outbreaks. Articles that were excluded were those that: (i) focused heavily on clarifying transmission routes and improving surveillance systems, (ii) emphasized on how the outbreak led to the development of a particular phenomenon or transition in nursing practice, and (iii) were conducted on humanitarian aid workers. A total of 31 full-text journal articles were reviewed. The physical and psychological well-being of frontline HCWs was compromised across all pandemic outbreaks. Many researches evaluated only the psychological impacts of pandemic outbreaks on frontline HCWs without considerations of other possible influencing factors. None reported the mental health statuses of frontline nurses in particular during the COVID-19 outbreak. In the absence of epidemiological data on the mental health of frontline nurses who are caring for COVID-19 patients and its associated factors, our study recruited 2014 frontline nurses with diverse demographic backgrounds and explored their mental health statuses during the COVID-19 outbreak. There was a total of 1324 nurses who were originally working in Wuhan and 690 nurses who were supporting Wuhan from other provinces in China, making our results a good representative of the mental health statuses of the Chinese frontlines nurses woring in Wuhan during the pandemic. We found that frontline nurses experienced a variety of mental health challenges, especially burnout and fear. The prevalence of anxiety, depression, and skin lesion was high. The majority of the nurses expressed their willingness to participate in frontline work. Mental health outcomes were positively correlated with skin lesion and negatively correlated with self-efficacy, resilience, social support, and frontline work willingness. Future interventions at the organisational and national levels are needed to improve frontline nurses' mental health during the pandemic by addressing its associated factors. Similar research and support may be extended to include other frontline healthcare workers. was measured by a seven-point Likert scale. For the EE and DP dimensions, higher scores meant more severe burnout, while for the PA dimension, lower scores meant more severe burnout. Scores of 19À26 or 27 on EE, 6À9 or 10 on DP, and 34À39 or 33 on PA were indicative of moderate or high burnout for the respective dimensions [11] . The Cronbach's alpha value of the MBI-HSS for MP was 0.86 in this study. Nurses' anxiety was measured by the Chinese version of Zung's Self-Rating Anxiety Scale (SAS) [12] . The SAS contains 20 items that examine emotional and physical symptoms of anxiety. Each item was measured by a four-point Likert scale. The total scores ranged from 25 to 100 (20 £ 1 £ 1.25 to 20 £ 4 £ 1.25), with 50À59, 60À69, and 70 indicating mild, moderate, and severe anxiety, respectively [13] . The Cronbach's alpha value of the SAS was 0.87 in this study. Nurses' depression was measured by the Chinese version of Zung's Self-Rating Depression Scale (SDS) [14] . The SDS has 20 items that assess emotional, physiological, psychomotor, and psychological imbalance. Each item was measured by a four-point Likert scale. The total scores ranged from 25 to 100 (20 £ 1 £ 1.25 to 20 £ 4 £ 1.25), with 53À62, 63À72, and 73 indicating mild, moderate, and severe depression, respectively [13] . The Cronbach's alpha value of the SDS was 0.88 in this study. Nurses' fear was measured by the Fear Scale for Healthcare Professionals (FS-HPs), which was developed by the research team. The FS-HPs has eight items that assess nurses' fear of infection and death as well as nosocomial spreading to their loved ones during COVID-19 outbreak. Each item was measured by a five-point Likert scale. The total score ranged from 8 to 40, with 19, 20À29, and 30À40 indicating no or mild fear, moderate, and severe fear, respectively. Ten experts were invited to evaluate its content validity, giving it a total Content Validity Index (CVI) of 1.0. The Cronbach's alpha value of the FS-HPs was 0.80 in this study. Skin lesion was measured using a self-developed scale named the Skin Lesion Scale (SLS) based on the book "Epidemic Prevention Medical Protective Equipment related Skin Lesion and Management". [15] The scale has 11 items that examine various common skin lesions related to personal protective equipment (PPE) among HCWs, including facial flushing, blistering of the mouth, skin erosions, skin soaking, skin allergies, skin chapping, skin indentation marks, cutaneous lichen, red spots with clear boundaries, blisters, and isolated pyoderma. For each type of skin lesion, we asked whether each nurse had such a condition (Each "yes" response was given a score 1 and each "no" response was given a score of 0, giving a total score of 0À11). For nurses who had skin lesions but could not manage them, such questions were asked: (1) not sure how to manage them, (2) no medicine available during the period, and (3) the root cause for the skin lesions cannot be changed. A group of ten experts were invited to evaluate the content validity, resulting a total CVI of 1.0. The Cronbach's alpha value of the SLS was 0.73 in this study. Nurses' self-efficacy was measured by the Chinese version of the General Self-efficacy Scale (GSS) [16] . It consists of ten items and each was measured by a five-point Likert scale. The total score of the scale ranged from 10 to 40. The higher the score, the better the selfefficacy. The Cronbach's alpha value of the GSS was 0.93 in this study. Nurses' resilience was measured by the Chinese version of the Connor-Davidson Resilience Scale-10 (CD-RISC-10) [17] . It contains ten items with a five-point Likert scale. The total score of the scale ranged from 0 to 40. The higher the score, the better the resilience. The Cronbach's alpha value of the CD-RISC-10 was 0.96 in this study. Social support was measured using the Chinese version of the Multidimensional Scale of Perceived Social Support (MSPSS) [18] . The scale consists of 12 items and uses a seven-point Likert scale. It has two subscales: intra-family social support and extra-family social support. The higher the mean score, the better the social support. The Cronbach's alpha value of the MSPSS was 0.96 in this study. The online questionnaire survey was developed using an online platform called "Questionnaire Star". After obtaining ethical approval from the two participating hospitals, the directors of nursing and the head nurses were informed about the inclusion and exclusion criteria. The head nurses distributed the online survey to the WeChat group of frontline nurses who were caring for COVID-19 patients on 13 February 2020. Those who had interest in the survey then filled in the survey on the "Questionnaire Star" platform, which had a feature that only when all questions were answered, the online questionnaire could be submitted. A token of appreciation of 50 RMB (equivalent to 7 USD) was provided to each participant via the WeChat red packet on the completion of the online survey. Data collection was completed on 24 February 2020. The study protocol has been published on the last author's institutional website. Ethical approval was obtained from the participating hospitals' ethical review boards as well as the last author's university. All nurses provided consent by ticking the "yes" box to indicate their willingness to participate in the online survey. Voluntary participation and data confidentiality were emphasized. Data were analysed using IBM SPSS version 25.0 for Windows [19] . Descriptive statistics were used to summarize nurses' sociodemographic and other COVID-related background variable subgroups (such as working duration as the frontline nurses, reasons for being dispatched to Wuhan, confidence in self-protection, and so on) and all continuous outcome variables (including burnout, fear, anxiety, depression, fear, skin lesion, self-efficacy, resilience, and social support). An independent two-sample t-test was used to examine the differences in mental health outcomes between sociodemographic and other COVID-related background variable subgroups. Pearson product-moment correlation coefficient was used to examine the relationships between burnout, fear, anxiety, and depression and all other continuous outcome variables. P values of less than 0.05 were considered statistically significant. The funding bodies had no role in study design, data collection, analysis, and interpretation, the manuscript writing, or submission decision. The corresponding authors had full access to all the data and had final responsibility for the decision to submit for publication. Of the 2110 nurses who opened the survey link, nine (0.4%) ticked the "no" box to indicate their unwillingness to participate in the study and withdrew from the survey. Among the rest of 2101 nurses who completed and submitted the survey, 68 (3.2%) nurses reported that the number of days working at the frontline was zero indicating they had not begun their duties as frontline nurses, and 19 (0.9%) spent less than five minutes to complete the survey with several scales ticking the same answers consecutively (Fig. 1) . Thus, these nurses were excluded, leaving a total of 2014 frontline nurses who were included in this study. patients, self-protection, and work safety. The majority of the frontline nurses believed that their family, colleagues, and hospitals were ready to cope with the COVID-19 outbreak. The majority of the participants (n = 1950, 96.8%) indicated their willingness to participate in frontline work with the following reasons: responsibility and mission as a nurse, prior experiences during the SARS outbreak, patriotism, dedication, helping others, extra welfare, hospital assignment, and the mission as a communist party member. Some participants (n = 64, 3.2%) indicated their unwillingness because of safety concerns, family caring needs such as breastfeeding, fear, work stress, and personal health problems. The participants put forward some suggestions to support frontline nurses' work: (1) improve the welfare and social statuses of frontline nurses, (2) strengthen training regarding self-protection and provide adequate PPE, (3) enhance manpower and resource allocations, (4) improve the conditions of accommodation, food, and environments for frontline nurses, and (5) offer more psychosocial support to frontline nurses. The majority of the participants (n = 1910, 94.8%) had one or more skin lesion(s) caused by PPE. Among nurses who did not manage their skin lesions (n = 1703, 84.6%), 316 nurses (15.7%) indicated that they were not sure about the management, 518 nurses (25.7%) indicated that no medicine was available during the period, and 718 nurses (35.7%) said that the root causes were not changeable. Besides the 11 skin lesions that we included in our self-developed scale, some nurses mentioned other skin lesions such as conjunctivitis, ear tenderness, decrustation, beriberi, and needle stick injuries. Table 3 shows the differences in the burnout, anxiety, depression, and fear levels between various sociodemographic and other characteristic subgroups. It was typical for one mental health variable to have significant differences for some, but not all sociodemographic and other characteristic subgroups. However, statistically significant differences in the levels of burnout, anxiety, depression, and fear were found between subgroups of the following variables: professional title (p<0.05), whether Wuhan was the original working place (p<0.05), whether working wards had changed (p<0.05), confidence in caring for COVID-19 patients (p<0.001), confidence in self-protection (p<0.001), evaluations of work safety (p<0.001), belief in family's or colleagues' or hospitals' readiness to cope with the COVID-19 outbreak (p<0.001), and willingness to participate frontline work (p<0.01) . Table 4 showed the relationships among mental health and other health outcomes for frontline nurses. EE was positively correlated with skin lesion (r = 0.182) and negatively correlated with self-efficacy (r=À0.193), resilience (r=À0.325), intra-family social support (r=À0.170), and extra-family social support (r=À0.234). DP was negatively correlated with resilience (r=À0.208), intra-family social support (r=À0.221), and extra-family social support (r=À0.216). PA was positively correlated with self-efficacy (r = 0.376), resilience (r = 0.436), intra-family social support (r = 0.348), and extra-family social support (r = 0.363). Anxiety was positively correlated with skin lesion (r = 0.265) and negatively correlated with self-efficacy (r=À0.262), resilience (r=À0.427), intra-family social support (r=À0.274), and extra-family social support (r=À0.333). Similarly, depression was positively correlated with skin lesion (r = 0.224) and negatively correlated with self-efficacy(r=À0.409), resilience (r=À0.554), intra-family social support (r=À0.384), and extra-family social support (r=À0.455). Fear was negatively correlated with resilience (r=À0.121). including "1=Very unconfident", "2=Unconfident", and "3=Somewhat confident", and Confident, including "4=Confident" and "5=Very confident". b Measured by a 5-point scale and regrouped into two categories: Unsafe, including "1=Very unsafe", "2=Unsafe", and "3=Somewhat Safe", and Safe, including "4=Safe" and "5=Very safe". This is the first study that examined frontline nurses' mental health and its associated factors during the COVID-19 outbreak using a large-scale cross-sectional design. The strengths of this study included the multi-centered sampling and the big sample size. We conducted our survey in a local hospital and a newly built hospital specially for COVID-19 patients. Among all participants, 1324 were originally working in Wuhan, whereas 690 nurses were originally from other provinces who were supporting Wuhan's healthcare system. The diversity of nurses' geographic background make our sample a relatively good representative of nurses from China.This study found that the prevalence of burnout, anxiety, depression, and fear was high in frontline nurses. Skin lesions were very common for frontline nurses wearing PPE. Although frontline nurses were suffering from the aforementioned physical and mental health symptoms, they still expressed their willingness to participate in frontline work during the COVID-19 outbreak. We also found that frontline nurses' mental health was positively correlated with skin lesion and negatively correlated with self-efficacy, resilience, social support, and frontline work willingness. In this study, frontline nurses reported moderate levels of burnout. Moreover, 60.5%, 42.3%, and 60.6% of the frontline nurses had moderate/high EE, DP, and PA, respectively, which all indicated a high prevalence of burnout among frontlines nurses. The COVID-19 outbreak has led to a sharp increase in admissions and presentations to hospitals and consequently impacts the workload of nurses. A previous study indicated that each additional patient added to a nurse's workload was associated with a 23% increase in the likelihood of burnout [20] . In a study of nurses during the Middle East Respiratory Syndrome outbreak, nurses started to sink into a state of burnout after a prolonged and sustained period of exposure to the deteriorating situation with no end in sight [21] . This study showed that 40% to 45% of the frontline nurses experienced anxiety or depression, with 11% to 14% having moderate to severe anxiety or depression. Similar to the SARS outbreak in 2003, due to the life-threatening nature of the disease and the increasing workload, frontline nurses were at high risks of anxiety and depression [22] . Compared to the previous report on 5062 HCWs (3240 from non-isolation wards, 1607 from isolation wards, 215 off work or in self-isolation), including 3417 nurses, 1004 doctors and 641 medical technicians, regardless of whether they were working at frontline during COVID-19 outbreak in Wuhan [6] , the incidence of anxiety and depression of frontline nurses in our study was relatively higher. This study showed that the frontline nurses suffered from fears of infection and death as well as nosocomial spreading to their loved ones. As the numbers of infection and mortality cases surge, the COVID-19 outbreak in China has caused public panic and distress [7] . HCWs caring for COVID-19 patients were also found to be scared [7] . As of 27 February 2020, 3387 healthcare professionals have been diagnosed with COVID-19 in China [23] . As of 1 March 2020, 25 healthcare workers died not only because of being infected with COVID-19 but also because of cardiac arrest or other ailments due to fatigue and overwork during the COVID-19 outbreak [24] . Thus, for frontline nurses, their colleagues getting infected or dying might aggravate their fears. The frontline nurses' burnout, anxiety, and depression were weakly positively correlated with skin lesion, which means that the worse the skin lesion, the higher the burnout, anxiety, and depression levels. Currently, in the context of a lack of definite and effective treatment for COVID-19, wearing PPE is the most effective way to prevent infections, especially in HCWs [25] . However, it is very uncomfortable and inconvenient to wear PPE, especially when they were wearing the same PPE throughout the shift for a few hours, and 94.8% of the frontline nurses reported one or more skin lesion in our study. Moreover, a large number of nurses did not manage and treat their skin lesions due to a lack of related knowledge or no medicine available at hand. Appropriate training on skin lesion prevention and adequate medicine to manage skin lesion should be guaranteed to protect frontline nurses, thus promoting their mental health. Our findings showed that frontline nurses' burnout, anxiety, and depression were moderately negatively correlated with self-efficacy and resilience, which means that when nurses have better self-efficacy and resilience, they may experience less mental health problems. Higher self-efficacy is beneficial for disaster preparedness [26] . Resilience can mitigate the negative impact of work related stress and prevent poor psychological health outcomes among nurse [27] . Individual attributes and organisational resources should be addressed to build self-efficacy and resilience, thus achieving improvement in the mental health of nurses [28] . The frontline nurses' burnout, anxiety, depression, and fear were moderately negatively correlated with social support. A systematic review indicated that a lack of social support was one of important risk factors for developing negative psychological outcomes in HCWs across all types of disasters [29] . The availability of psychological interventions, including the establishment of response, social support, medical, and assistance hotline teams, was beneficial and helpful for frontline nurses' mental health [6] . Although the prevalence of burnout, anxiety, depression, fear, and skin lesion was high, 1950 (96.8%) nurses still expressed their willingness to participate in frontline work. Moreover, the frontline nurses' mental health was strongly negatively correlated with frontline work willingness based on the t-test results. Nursing willingness or intention, voluntary and active caring for patients during any newly emerging infectious diseases [30] , is important in mitigating nurses' burnout, anxiety, depression, and fear. Thus, suggestions from the frontline nurses to improve their working conditions, such as enhancing of manpower and resource allocation, as well as to improve welfare and living conditions, should be addressed to support nurses' willingness in caring for COVID-19 patients. This survey was conducted from 13 to 24 February 2020. The confirmed cases of COVID-19 in Wuhan reached the peak on 13 February 2020 and decreased gradually. Confirmed cases were still reported after the completion of data collection [2] . The timing of the survey may limit the generalization to all frontline nurses who were working in other period and in other parts of China where the pandemic situation was not that severe. Moreover, the frontline nurses might expressed less burnout, anxiety, depression and fear than real condition due to social desirability. Because of the time limit and COVID-19 urgency, we developed the fear scale for health care professionals and generated the thresholds based on our experiences. A future study is needed to test and better decide the thresholds of the fear scale. Moreover, the cross-sectional design provided information at one time point only. The correlation shown in this study does not imply causation. The lack of follow-up data of frontline nurses' mental health made it impossible to know their mental health statuses over time. Longitudinal studies are recommended for future studies to capture more in-depth information about the mental health statuses of frontline nurses, both in China and other parts of the world. Frontline nurses experienced a variety of mental health challenges, especially burnout and fear, which warrants more attention and support from policymakers. Future interventions at the organisational and national levels are needed to improve frontline nurses' mental health during the pandemic by considering preventing and managing skin lesions, building self-efficacy and resilience, providing sufficient social support, and ensuring frontline work willingness. Similar research and support may be extended to include other frontline healthcare workers. We declare no competing interests. This study was funded by the 2020 COVID-19 Emergency Response Special Fund from Xiamen University (20720200025) and Huazhong University of Science and Technology (2020kfyXGYJ001) in China. Table 4 Relationships among mental health variables and other health variables for the frontline nurses (n = 2014). Burnout-EE a Burnout: DP b Burnout: PA c Anxiety Depression Fear Burnout: EE a À Burnout: DP b 0.401*** À Burnout: PA c À0.041* À0.138*** À Anxiety 0.637*** 0.417*** À0.242 *** À Depression 0.569 *** 0.406*** À0.378 *** 0.768 *** À Fear 0.413*** 0.095*** 0.073 ** 0.268*** 0.178 *** À Skin lesion 0.182*** À0.097*** À0.019 0.265 *** 0.224*** 0.078*** Self-efficacy À0.193*** 0.096*** 0.376 *** À0.262*** À0.409 *** À0.063 ** Resilience À0.325*** À0.208*** 0.436 *** À0.427*** À0.554*** À0.121 *** Intra-family social support À0.170*** À0.221*** 0.348 *** À0.274*** À0.384*** 0.090 *** Extra-family social support À0.234*** À0.216 *** 0.363*** À0.333*** À0.455*** 0.038* a EE=emotional exhaustion. b DP=depersonalization. c PA=personal accomplishment. * 0.01p<0.05. ** 0.001p<0.01. *** p<0.001. World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 -11 World Health Organization. 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