key: cord-0747229-rdfdy90o
authors: Bostan, Ecem; Elmas, Leyla; Yel, Beril; Yalici‐Armagan, Basak
title: Exacerbation of plaque psoriasis after inactivated and BNT162b2 mRNA COVID‐19 vaccines: A report of two cases
date: 2021-08-30
journal: Dermatol Ther
DOI: 10.1111/dth.15110
sha: 8a3ab4199e200b5ea1ad1598e1275cb22331bdcd
doc_id: 747229
cord_uid: rdfdy90o

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It is thought that vaccines may trigger autoimmune or inflammatory diseases through the cellular and humoral immune mechanisms they use to generate vaccine-induced immune protection. 8, 9 Although we cannot identify a direct pathological link between SARS-CoV-2 vaccines and psoriasis exacerbation, the lack of any other triggering factors and exacerbation of the lesions after the second dose of vaccines may suggest an immunological relationship in the current cases.

Since patients with psoriasis are more likely to have multiple comorbidities or using immunosuppresive drugs for treatment of psoriasis which may lead to severe COVID-19 infection; vaccination against SARS-CoV-2 is strongly recommended for them. However, it should be kept in mind that vaccines against SARS-CoV-2 may exacerbate psoriasis and patients need to be followed-up closely. Further controlled studies based on larger cohort are needed to identify the exact relationship between SARS-CoV-2 vaccines and psoriasis exacerbation.

The authors declare that there is no conflict of interest. Basak Yalici-Armagan: conceptualization; data curation; supervision; writing review and editing.

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

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