key: cord-0766948-yz0n1yxb
authors: Bertran Recasens, B.; Martinez‐Llorens, J. M.; Rodriguez‐Sevilla, J. J.; Rubio, M. A.
title: Lack of dyspnea in patients with Covid‐19: another neurological conundrum?
date: 2020-05-12
journal: Eur J Neurol
DOI: 10.1111/ene.14265
sha: ee77bfee7d9c6d2e09afa71f4ef438d912d7d3f4
doc_id: 766948
cord_uid: yz0n1yxb

One relevant feature of the Covid-19 disease is the absence of dyspnea, described as 'shortness of breath' or 'an unpleasant urge to breathe'. The lack of dyspnea is observed even in the most severe cases, in which subjects present tachypnea and tachycardia. In the Wuhan cohort, 62.4% of severe cases and 46.3% of those who ended up intubated, ventilated or dead did not present dyspnea[1,2].

One relevant feature of the Covid-19 disease is the absence of dyspnea, described as 'shortness of breath' or 'an unpleasant urge to breathe'. The lack of dyspnea is observed even in the most severe cases, in which subjects present tachypnea and tachycardia. In the Wuhan cohort, 62.4% of severe cases and 46.3% of those who ended up intubated, ventilated or dead did not present dyspnea [1, 2] .

Similar findings have been reported in the severe acute respiratory syndrome coronavirus (SARS-CoV) infection where only 34.8% of critical patients reported dyspnea. These data differ significantly from other viral pulmonary infections where the presence of dyspnea is much more frequent, i.e. 69% in Severe acute respiratory syndrome-middle East respiratory syndrome, 95% in respiratory syncytial virus and 82% in influenza [3] .

Dyspnea is a multidimensional cognitive construct of respiratory sensation, resulting from peripheral afferences and processed through the brainstem to subcortical and supratentorial structures. Peripheral afferent fibers are located in the lungs and airways; they respond to chemical and mechanical stimuli and drive physiological responses such as cough, tachypnea and dyspnea. The afferent fibers that appear to play the most relevant role in dyspnea are the pulmonary C-fibers, which are predominantly located below the alveolar membrane. The chemical activation of these C-fibers (histamine, adenosine, prostaglandine E2 or lobeline) causes dyspnea or intensifies it and their inhibition (inhaled furosemide) suppresses it.

Although local changes in viral pneumonia could stimulate C-pulmonary fibers, the cytokine storm syndrome (which is rather characteristic of Covid-19) could damage these neurons and therefore explain a total or partial loss of their function. However, this hypothesis collides with the fact that some viral respiratory infections induce an upregulation of receptors from these afferent sensory fibers [4] .

For many viruses, the olfactory bulb is the gateway to the central nervous system. In particular, hyposmia has been observed in patients with Covid-19 [5] . Furthermore, experimental findings show that SARS-CoV enters the central nervous system via the olfactory bulb. It rapidly spreads to other regions, causing neuronal death and affecting the nucleus of the solitary tract (where pulmonary Cfibers are projected) on the fourth day since the onset of the infection [6] . It is important to point out that there are other structures that participate in the sensory perception of dyspnea that are affected before the involvement of the nucleus of the solitary tract (i.e. thalamus, insula and limbic system).

However, whereas other neurological manifestations of the central nervous system [5] have been described, such as dizziness, we must be cautious in attributing those symptoms to a direct neurotoxic effect of the virus rather than a systemic response in the infectious context.

The emerging situation of a global epidemic of Covid-19 has presented many challenges in a wide variety of disciplines from science to the economy. Neurologists should not ignore the questions raised by this novel coronavirus and we must be prepared to answer them. This is why now, more than ever, what Gandalf once (almost) said remains valid: "A neurologist is never late, nor is he early, he arrives precisely when he means to."

Clinical characteristics of coronavirus disease 2019 in China

The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients

Influenza and viral pneumonia

Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells

COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of metaanalysis

Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2

The authors declare no financial or other conflicts of interest.