key: cord-0774943-pt5wyzab authors: Poon, Liona C.; Yang, Huixia; Kapur, Anil; Melamed, Nir; Dao, Blami; Divakar, Hema; McIntyre, H. David; Kihara, Anne B.; Ayres‐de‐Campos, Diogo; Ferrazzi, Enrico M.; Di Renzo, Gian Carlo; Hod, Moshe title: Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals date: 2020-04-28 journal: Int J Gynaecol Obstet DOI: 10.1002/ijgo.13156 sha: 295df8eb863e8b06f7940e66b1cd284ca6132846 doc_id: 774943 cord_uid: pt5wyzab In response to the World Health Organization (WHO) statements and international concerns regarding the coronavirus disease 2019 (COVID‐19) outbreak, FIGO has issued comprehensive guidance for the management of pregnant women. Coronaviruses are enveloped, nonsegmented, positive-sense ribonucleic acid (RNA) viruses belonging to the family Coronaviridae, order Nidovirales. 1 The epidemics of the two notable β-coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), have caused more than 10 000 cumulative cases in the past two decades, with mortality rates of 10% for SARS-CoV and 37% for MERS-CoV. 2 A meta-analysis 15 of eight studies, including 46 248 infected patients, has shown that the most prevalent clinical symptom is fever (91% ± 3; 95% CI, 86-97), followed by cough (67% ± 7; 95% CI, 59-76), fatigue (51% ± 0; 95% CI, , and dyspnea (30% ± 4; 95% CI, [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] . The most prevalent comorbidities are hypertension (17% ± 7; 95% CI, [14] [15] [16] [17] [18] [19] [20] [21] [22] and diabetes (8% ± 6; 95% CI, 6-11), followed by cardiovascular diseases (5% ± 4; 95% CI, 4-7) and respiratory system disease (2% ± 0; 95% CI, 1-3). The hallmark of treatment of patients with COVID-19 infection is supportive care. Recent studies have suggested possible benefit of hydroxychloroquine and azithromycin, 16 while no benefit has been seen with the combination of lopinavir and ritonavir in hospitalized adult patients with severe COVID-19 infection. 17 However, these findings should be further investigated in larger trials. Pregnancy is a physiological state that predisposes women to viral respiratory infection. Due to the physiological changes in the immune and cardiopulmonary systems, pregnant women are more likely to develop severe illness after infection with respiratory viruses. In 2009, pregnant women accounted for 1% of patients infected with influenza A subtype H1N1 virus, but they accounted for 5% of all H1N1-related deaths. 18 In addition, SARS-CoV and MERS-CoV are both known to be responsible for severe complications during pregnancy, including the need for endotracheal intubation, admission to an intensive care unit (ICU), renal failure, and death. 6, 19 The case fatality rate of SARS-CoV infection among pregnant women is up to 25%. 6 Currently, however, there is no evidence that pregnant women are more susceptible to COVID-19 infection or that those with COVID-19 infection are more prone to developing severe pneumonia. Pregnancy may also modify the clinical manifestation, for example lymphocytopenia may be even more marked. To date, summarized data from five small series including 56 pregnant women diagnosed with COVID-19 during the second and third trimester demonstrated that the most common symptoms at presentation were fever and cough; two-thirds of patients had lymphopenia and increased C-reactive protein, and 83% of cases had chest CT scan showing multiple patches of ground-glass opacity in the lungs. [20] [21] [22] [23] [24] Over and above the impact of COVID-19 infection on a pregnant woman, there are concerns relating to the potential effect on fetal and neonatal outcome; therefore, pregnant women require special attention in relation to prevention, diagnosis, and management. Fever is common in COVID-19-infected patients. Previous data have demonstrated that maternal fever in early pregnancy can cause congenital structural abnormalities involving the neural tube, heart, kidneys, and other organs. [25] [26] [27] However, a recent study including 80 321 pregnant women reported that the rate of fever in early pregnancy was 10%, while the incidence of fetal malformation in this group was 3.7%. 28 Among the 77 344 viable pregnancies with data collected at 16-29 weeks of pregnancy, in the 8321 pregnant women with a reported temperature above 38°C lasting 1-4 days in early pregnancy, compared with those without a fever in early pregnancy, the overall risk of fetal malformation was not increased (odds ratio [OR]=0.99 (95% CI, 0.88-1.12). 28 It has been reported that viral pneumonia in pregnant women is associated with an increased risk of preterm birth, fetal growth restriction (FGR), and perinatal mortality. 29 Based on nationwide populationbased data it was demonstrated that pregnant women with other viral pneumonias (n=1462) had an increased risk of preterm birth, FGR, and having a newborn with low birth weight and an Apgar score of less than 7 at 5 minutes, compared with those without pneumonia (n=7310). Given the higher risk of infection and poorer outcomes, including very high mortality, among the elderly population and those with comorbidities (in particular diabetes, hypertension, etc. as noted by Yang et al. 15 ), it is important to consider the potential impact of pre-existing hyperglycemia and hypertension on the outcome of COVID-19 in pregnant women. There are at present no studies to guide us on this aspect, but based on evidence from nonpregnant women it would be logical to assume that the risk of acquiring and presenting with more severe clinical manifestations in pregnant women with these comorbidities, hyperglycemia in particular, will be higher. The higher risk of acquiring SARS-CoV-2 in pregnant women with hyperglycemia may also be partly related to greater risk of exposure due to more frequent visits to healthcare facilities for follow-up. The stress of infection, accompanied by severe anxiety and use of high doses of corticosteroids, is likely to worsen glycemic control and enhance the risk of secondary infections and thus requires careful consideration in management. Similarly, women with pre-existing or pregnancy hypertension may have a higher risk of manifesting pre-eclampsia and its consequences. There is currently no evidence to guide on these aspects; however, it is important to highlight that one in seven pregnancies is impacted by hyperglycemia and one in 10 is impacted by hypertension. These issues must be kept in mind in the clinical management, along with the importance of noting the presence of these conditions to enable collection of more data that would guide informed decisions. At this point, the clinical management of these conditions must follow established protocols, including screening for pre-eclampsia and initiation of aspirin prophylaxis. 32 Women with hyperglycemia should preferably receive insulin in case medical therapy is required. Based on the limited information available currently and our knowledge of other similar viral pulmonary infections, the following expert opinions are offered to guide clinical management. Case definitions are those included in the WHO's interim guidance, "Global surveillance for COVID-19 caused by human infection with COVID-19 virus". 33 A suspected case for whom laboratory testing for COVID-19 is inconclusive. A person with laboratory confirmation of COVID-19 infection, irrespective of clinical signs and symptoms. Any suspected case should be tested for COVID-19 infection using available molecular tests, such as qRT-PCR. Lower respiratory tract specimens likely have a higher diagnostic value compared with upper respiratory tract specimens for detecting COVID-19 infection. WHO recommends that, if possible, lower respiratory tract specimens, such as sputum, endotracheal aspirate, or bronchoalveolar lavage be collected for COVID-19 testing. If patients do not have signs or symptoms of lower respiratory tract disease or specimen collection for lower respiratory tract disease is clinically indicated but collection is not possible, upper respiratory tract specimens of combined nasopharyngeal and oropharyngeal swabs should be collected. If initial testing is negative in a patient who is strongly suspected of having COVID-19 infection, the patient should be resampled, with a sampling time interval of at least 1 day and specimens collected from multiple respiratory tract sites (nose, sputum, endotracheal aspirate). Additional specimens, such as blood, urine, and stool may be collected to monitor the presence of virus and the shedding of virus from different body compartments. When qRT-PCR analysis is negative for two consecutive tests, COVID-19 infection can be ruled out. A contact is a person involved in any of the following: • Providing direct care for COVID-19 patients without using proper personal protective equipment (PPE). • Being in the same close environment as a COVID-19 patient (including sharing workplace, classroom, or household, or attending the same gathering). • Traveling in close proximity (within 2 meters or 6 feet) to a COVID-19 patient in any kind of conveyance. In order to ensure access to specialized care, pregnant women who are symptomatic may need to be prioritized for testing. 33 WHO has provided guidance on the rational use of PPE for COVID-19. When conducting aerosol-generating procedures (e.g. tracheal intubation, noninvasive ventilation, cardiopulmonary resuscitation, manual ventilation before intubation), healthcare workers are advised to use respirators (e.g. N95, FFP2 or equivalent standard) with their PPE. 34 The Centers for Disease Control and Prevention (CDC) additionally considers procedures that are likely to induce coughing (e.g. sputum induction, collection of nasopharyngeal swabs, suctioning) as aerosol-generating procedures. 35 Chest imaging, especially CT scan, is essential for evaluation of the clinical condition of a pregnant woman with COVID-19 infection. [36] [37] [38] FGR, microcephaly, and intellectual disability are the most common adverse effects from high-dose (>610 mGy) radiation exposure. [39] [40] [41] According to data from the American College of Radiology and the American College of Obstetricians and Gynecologists, when a pregnant woman undergoes a single chest X-ray examination, the radiation dose to the fetus is 0.0005-0.01 mGy, which is negligible, while the radiation dose to the fetus is 0.01-0.66 mGy from a single chest CT or CT pulmonary angiogram. [42] [43] [44] Chest CT scanning has high sensitivity for diagnosis of COVID-19. 38 In a pregnant woman with suspected COVID-19 infection, a chest CT scan may be considered as a primary tool for the detection of COVID-19 in epidemic areas. 38 Informed consent should be obtained and a radiation shield applied over the gravid uterus. Suspected, probable, and confirmed cases of COVID-19 infection should be managed initially by designated tertiary hospitals with effective isolation facilities and protection equipment. Suspected/probable cases should be treated in isolation and confirmed cases should be managed in a negative pressure isolation room, although it is recognized that these may be unavailable in many units. In general, critically ill confirmed cases should be admitted to a negative pressure isolation room in an ICU. 45 However, we are all aware that this capacity can be rapidly filled. Ideally, designated hospitals should set up a dedicated negative pressure operating room and a neonatal isolation ward. All attending medical staff should wear appropriate PPE (respirator, goggles, faceprotective shield, water-resistant surgical gown, gloves) when providing care for suspected/probable/confirmed cases of COVID-19 infection. 46 In areas with widespread local transmission of the disease, healthcare services in both high-and low-income countries may be unable to provide such levels of care to all suspected/probable/confirmed cases. Pregnant women with a mild clinical presentation may not initially require hospital admission, and home confinement can be considered provided that this is possible logistically and that monitoring of the woman's condition can be ensured without compromising the safety of her family. 47 If negative pressure isolation rooms are not available, patients should be isolated in single rooms or grouped together once COVID-19 infection has been confirmed. For transfer of confirmed cases, the attending medical team should wear appropriate PPE and keep themselves and their patient a minimum distance of 2 meters or 6 feet from any individuals without PPE. • Fetal surveillance: undertake CTG for FHR monitoring when gestational age is beyond the limit of viability based on local practice (23-28 weeks). Based on these observations, there is consideration for the use of low molecular weight heparin in severe cases; however, its efficacy in improving the outcomes of severe COVID-19 pneumonia requires further investigation before formal recommendation. • Fetal surveillance: if appropriate, CTG for FHR monitoring should be undertaken when gestational age is beyond the limit of viability based on local practice (23-28 weeks). • Medically indicated preterm delivery should be considered by the multidisciplinary team on a case-by-case basis. For women with severe disease who are at less than 32 weeks of pregnancy (but are beyond the threshold of viability), a transfer to a center with a level 2 or level 3 neonatal ICU should be considered (if this service is not available at the local center) due to the increased risk for indicated preterm birth. Special attention should be given to women with associated comorbidities like hyperglycemia and hypertension and existing management protocols must be followed, with the exception that women with COVID-19 pneumonia and associated hyperglycemia in pregnancy requiring medical therapy should preferably be shifted to insulin therapy. Several precautions should be taken to minimize the risk of transmission between pregnant women, healthcare providers, and other patients in the hospital. The number of clinic visits in low-risk women with uncomplicated pregnancy can be decreased and replaced by virtual visits using phone or video calls. Women may be advised to check their blood pressure at home if possible, with appropriate advice given regarding when to seek medical assistance. A suggestion for a modified schedule is illustrated in Algorithm 1 ( Fig. 1) and has also been recommended by others. 56 In addition, it is useful to contact women prior to clinic visit to request that they arrive without a companion, as well as to screen them for symptoms or exposure relevant to COVID-19. In cases of positive screen, the visit should be deferred by 14 days unless the visit is urgent for maternal and/or fetal reasons, in which case the healthcare providers should be made aware and they should use proper personal protection procedures. It is also advised that all patients undergo screening at the entrance to the clinic or medical center. In cases of positive screen, the patient should be asked to wear a mask. The patient should be identified as screen positive to ensure that the team takes the necessary precautions and to ensure that the patient is seen with high priority to mini- When a patient presents to the obstetrical triage or emergency depart- Women with mild symptoms with no risk factors for severe disease may be discharged home after being advised to monitor symptoms and to seek care in case the symptoms worsen ( Fig. 2 60 Cesarean delivery should be performed ideally in an operating room with negative pressure. • For the protection of the medical team, the use of birthing pools in hospital should be avoided, given evidence of virus in feces and the inability to use adequate protection equipment for healthcare workers during water birth. • Both regional anesthesia and general anesthesia can be considered, depending on the clinical condition of the patient and after consultation with the obstetric anesthetist, in accordance with recommendations of obstetric anesthesia societies. 61 Regional anesthesia is preferable given the risk to the staff. Staff should consider extending PPE to cover aerosols in case of aerosol-producing procedures such as intubation (Fig. 3: Algorithm 3). This is why most units around the world are trying to avoid cesarean delivery under general anesthesia where at all possible. F I G U R E 3 Algorithm 3: Intrapartum and postpartum management. • For preterm cases requiring delivery, we urge caution regarding the use of antenatal corticosteroids for fetal lung maturation in a critically ill patient, because this can potentially worsen the clinical condition 62 and the administration of antenatal steroids would delay the delivery that is necessary for management of the patient. The use of antenatal steroids should be considered in discussion with infectious disease specialists, maternal-fetal medicine subspecialists, and neonatologists. 56, 63 In the case of an infected woman presenting with spontaneous preterm labor, tocolysis should not be used in an attempt to delay delivery to administer antenatal steroids. • Miscarried embryos/fetuses and placentae of COVID-19-infected pregnant women should be treated as infectious tissues and they should be disposed of appropriately; if possible, testing of these tissues for SARS-CoV-2 by qRT-PCR should be undertaken. • Regarding neonatal management of suspected, probable, and confirmed cases of maternal COVID-19 infection, the umbilical cord should be clamped promptly and the neonate should be transferred to the resuscitation area for assessment by the attending pediatric team. There is insufficient evidence regarding whether delayed cord clamping increases the risk of infection to the newborn via direct contact. 59 In units in which delayed cord clamping is recommended, clinicians should consider carefully whether this practice should be continued. • The contact precautions and use of PPE should be maintained during the postpartum period, until the mother tests negative for COVID-19. • There is currently insufficient evidence regarding the safety of breastfeeding and the need for mother/baby separation. 20, 21, 64 If the mother is severely or critically ill, separation appears to be the best option, with attempts to express breastmilk to maintain milk production. There should be a dedicated breast pump and after each pumping, the device must be thoroughly washed according to manufacturer's recommendations. 64 If the patient is asymptomatic or mildly affected, breastfeeding and colocation (also called rooming-in) can be considered by the mother in coordination with healthcare providers, or may be necessary if facility limitations prevent mother/baby separation. Since the main concern is that the virus may be transmitted by respiratory droplets rather than breastmilk, breastfeeding mothers should ensure that they wash their hands and wear a three-ply surgical mask before touching the baby. When rooming-in, the baby's cot should be kept at least 2 meters or 6 feet from the mother's bed, and a physical barrier such as a curtain may be used (Fig. 4: Algorithm 4) . 65, 66 The mother could be asked to express breastmilk while someone else feeds the baby. • The majority of postpartum visits may be conducted remotely as long as the patient does not have specific concerns that require inperson examination. Certain concerns (breast, abdominal scar) may be assessed over video or photos. Decreasing the number of visits may be also valuable in the event of shortage of healthcare providers as it is possible that a considerable proportion of healthcare workers will need to be isolated due to unexpected exposure to COVID-19. • Pregnant women are at an increased risk for anxiety and depression; once they have been defined with suspected/probable/confirmed COVID-19 infection they may exhibit varying degrees of psychiatric symptoms that are detrimental to maternal and fetal health. 67 • Mother/baby separation may impede early bonding as well as establishment of lactation. 68 These factors will inevitably cause additional stress for mothers in the postpartum period. • Healthcare providers should pay attention to a patient's mental health, including promptly assessing her sleep patterns and sources of anxiety, depression, and even suicidal ideation. A perinatal psychiatrist should be consulted when necessary. Currently, there are no effective drugs or vaccines to prevent COVID-19. Therefore, personal protection should be considered to minimize the risk of contracting the virus. 69 • Maintain good personal hygiene: consciously avoid close contact with others during the COVID-19 pandemic period; reduce participation in any gathering in which a distance of at least 2 meters or 6 feet between individuals cannot be maintained; pay attention to hand washing and use hand sanitizer (60%-95% alcohol concentration) frequently. 70 • Wearing a three-ply surgical mask when visiting a hospital or other high-risk area is recommended. • Seek medical assistance promptly for timely diagnosis and treatment when experiencing symptoms such as fever and cough. • Medical staff who have been exposed unexpectedly without appropriate PPE to a COVID-19-infected pregnant patient should be quarantined or self-isolate for 14 days. • Pregnant healthcare professionals should follow risk-assessment and infection-control guidelines following exposure to patients with suspected/probable/confirmed COVID-19. Preventive measures associated with biohazardous exposures include 71-73 : • Use of single patient disposal supplies and equipment. • Needleless systems. • Standard and special transmission precautions. • Red biohazardous waste containers and bags. • Appropriate use of PPE. • Use of a neutral zone in surgical areas and other areas where invasive procedures are performed. • Safe disposal of sharps not only in healthcare facilities but also in a woman's home and their community. 2 • Protocols that address non-sharp biohazardous material management with waste segregation and storage in clearly labeled, leak proof, puncture-resistant secondary containers, followed by collection that provides sterilization by autoclaving, incineration, interment, disinfection/encapsulation methods, energy-based technologies, or collection by an emergency environmental and biosafety service. • Pregnant women with confirmed COVID-19 infection should be managed by designated tertiary hospitals and should be counseled on the risk of adverse pregnancy outcome. • Negative pressure isolation rooms should be set up for safe labor and delivery and neonatal care. This may not be possible in many low-resource settings but all possible attempts should be made for isolation and infection control. • During the COVID-19 pandemic period, a detailed history regarding exposure relevant to COVID-19 and clinical manifestations should be acquired routinely from all pregnant women attending for routine care. • Chest CT scan should be included in the work-up of pregnant women with suspected/probable/confirmed COVID-19 infection. • Suspected/probable cases should be treated in isolation and confirmed cases should be managed in a negative pressure isolation room. A woman with confirmed infection who is critically ill should be admitted to a negative pressure isolation room in the ICU. • Antenatal examination and delivery of pregnant women infected with COVID-19 should be carried out in a negative pressure isolation room on the labor ward. Human traffic around this room should be limited when it is occupied by an infected patient. • All medical staff involved in management of infected women should wear appropriate PPE as required. • Management of COVID-19-infected pregnant women should be undertaken by a multidisciplinary team (obstetricians, maternal-fetal medicine subspecialists, intensivists, obstetric anesthetists, internal medicine or respiratory physicians, midwives, virologists, microbiologists, neonatologists, infectious disease specialists). • Timing and mode of delivery should be individualized, dependent mainly on the clinical status of the patient, gestational age, and fetal condition. • At present, limited data suggest that there is no evidence of vertical mother-to-baby transmission in women who develop COVID-19 infection in late pregnancy. • There is currently insufficient evidence regarding the safety of breastfeeding and the need for mother/baby separation. If the mother is severely or critically ill, separation appears the best option, with attempts to express breastmilk to maintain milk production. If the patient is asymptomatic or mildly affected, breastfeeding and colocation (rooming-in) can be considered by the mother in coordination with healthcare providers. • Healthcare professionals engaged in obstetric care should be trained and fitted appropriately for respirators. Epidemiology, genetic recombination, and pathogenesis of coronaviruses A novel coronavirus associated with severe acute respiratory syndrome Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia World Health Organization. Summary of probable SARS cases with onset of illness from 1 Middle East respiratory syndrome coronavirus (MERS-CoV) Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1 Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan Clinical characteristics of coronavirus disease 2019 in China Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: A systematic review and meta-analysis Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label nonrandomized clinical trial A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Pandemic H1N1 Influenza in Pregnancy Working Group. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records Clinical analysis of 10 neonates born to mothers with 2019-nCov pneumonia Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province Clinical characteristics of pregnancy with the 2019 novel coronavirus disease (COVID-19) infection Maternal illness, including fever and medication use as risk factors for neural tube defects Associations between maternal fever and influenza and congenital heart defects Maternal febrile illnesses, medication use, and the risk of congenital renal anomalies Fever in pregnancy and the risk of congenital malformations: A cohort study Pneumonia during pregnancy: Has modern technology improved maternal and fetal outcome? Pneumonia and pregnancy outcomes: A nationwide population-based study An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention Global surveillance for COVID-19 caused by human infection with COVID-19 virus. Interim guidance Rational use of protective equipment for coronavirus disease 2019 (COVID-19). Interim guidance Centers for Disease Control and Prevention. Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease Coronavirus disease 2019 (COVID-19): Role of chest CT in diagnosis and management Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: A multicenter study Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: A report of 1014 cases Imaging the pregnant patient for nonobstetric conditions: Algorithms and radiation dose considerations Drugs and Lactation Database (LactMed Discussion: Severe mental retardation and cancer among atomic bomb survivors exposed in utero Committee Opinion No. 723: Guidelines for diagnostic imaging during pregnancy and lactation ACR-SPR practice parameter for imaging pregnant or potentially pregnant adolescents and women with ionizing radiation Quality initiatives: Guidelines for use of medical imaging during pregnancy and lactation Emerging understandings of 2019-nCoV No 225-Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19 China trials anti-HIV drug on coronavirus patients. The Guardian National Institutes of Health. NIH clinical trial of remdesivir to treat COVID-19 begins Diagnosis and treatment of adults with community-acquired pneumonia. An Official Clinical Practice Guideline of the Coronavirus disease 2019 (COVID-19) and pregnancy: What obstetricians need to know Circulating high sensitivity troponin T in severe sepsis and septic shock: Distribution, associated factors, and relation to outcome Acute respiratory failure and mechanical ventilation in pregnant patient: A narrative review of literature cal-manag ement-of-severeacute-respi ratory-infec tion-when-novel-coron avirus-(ncov)-infec tion-is-suspe cted MFM guidance for COVID-19 Infants born to mothers with severe acute respiratory syndrome Obstetric considerations on delivery issues for pregnant women with COVID-19 infection Novel coronavirus infection and pregnancy Guidelines for pregnant women with suspected SARS-CoV-2 infection Society for Obstetric Anesthesia and Perinatology. Interim Considerations for Obstetric Anesthesia Care Related to Covid-19 Corticosteroids as adjunctive therapy in the treatment of influenza Coronavirus in pregnancy and delivery: Rapid review Coronavirus disease (COVID-19) and breastfeeding Interim Considerations for Infection Prevention and Control of Coronavirus Disease 2019 (COVID-19) in Inpatient Obstetric Healthcare Settings Clini cal-Guida nce-and-Publi catio ns/Practi ce-Advis ories/ Pract ice-Advis ory-Novel-Coron aviru s2019 ?IsMob ileSe t=false Insomnia and depressive symptoms in late pregnancy: A population-based study From the frontlines of COVID-19 -How prepared are we as obstetricians: A commentary Chinese Medical Association; Society of Perinatal Medicine, Chinese Medical Association; Editorial Board of Chinese Journal of Perinatal Medicine. Proposed management of COVID-19 during pregnancy and puerperium Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected. Interim guidance Registered Nursing. Handling hazardous and infectious materials: NCLEX-RN Biohazardous waste: segregation, collection and disposal guide Infection Control. 3. Management of regulated medical waste in health-care facilities The authors thank Mary Ann Lumsden, FIGO Chief Executive, Jeanne Conry, FIGO President Elect, and Hani Fawzi, FIGO Director of Projects, for their comments and advice on this paper.