key: cord-0780467-xxr4p114 authors: Kahn, Sandra; Ehrlich, Paul; Feldman, Marcus; Sapolsky, Robert; Wong, Simon title: The Jaw Epidemic: Recognition, Origins, Cures, and Prevention date: 2020-07-22 journal: Bioscience DOI: 10.1093/biosci/biaa073 sha: aaf8c4297795b331ce7981afc62ccc5a6e0b5e12 doc_id: 780467 cord_uid: xxr4p114 Contemporary humans are living very different lives from those of their ancestors, and some of the changes have had serious consequences for health. Multiple chronic “diseases of civilization,” such as cardiovascular problems, cancers, ADHD, and dementias are prevalent, increasing morbidity rates. Stress, including the disruption of traditional sleep patterns by modern lifestyles, plays a prominent role in the etiology of these diseases, including obstructive sleep apnea. Surprisingly, jaw shrinkage since the agricultural revolution, leading to an epidemic of crooked teeth, a lack of adequate space for the last molars (wisdom teeth), and constricted airways, is a major cause of sleep-related stress. Despite claims that the cause of this jaw epidemic is somehow genetic, the speed with which human jaws have changed, especially in the last few centuries, is much too fast to be evolutionary. Correlation in time and space strongly suggests the symptoms are phenotypic responses to a vast natural experiment—rapid and dramatic modifications of human physical and cultural environments. The agricultural and industrial revolutions have produced smaller jaws and less-toned muscles of the face and oropharynx, which contribute to the serious health problems mentioned above. The mechanism of change, research and clinical trials suggest, lies in orofacial posture, the way people now hold their jaws when not voluntarily moving them in speaking or eating and especially when sleeping. The critical resting oral posture has been disrupted in societies no longer hunting and gathering. Virtually all aspects of how modern people function and rest are radically different from those of our ancestors. We also briefly discuss treatment of jaw symptoms and possible clinical cures for individuals, as well as changes in society that might lead to better care and, ultimately, prevention. " What are the causes and consequences of the growing prevalence of crooked teeth?" is a muchneglected question in public health. The much-neglected answer is the same as for other "diseases of civilization": that industrialized humanity has developed an unprecedented lifestyle. Among many other things, that lifestyle has dramatically changed the environments in which human beings develop and has led to serious health problems (Ehrlich and Blumstein 2018) , including the largely hidden ones connected with human jaws. One branch of dentistry, orthodontics, has become big business, and many children are now wearing braces and then retainers to manage malocclusion. The prevalence of orthodontic treatment, largely for cosmetic reasons, during a lifetime may be reaching 20% in the United States with the "need" much higher (Brunelle et al. 1996 , Christopherson et al. 2009 ). Furthermore, increasing numbers of people are suffering facial pain connected to their jaws, specifically where they join the rest of the skull at the temporomandibular joint (Sessle 2015) . In some populations, up to 10% of people are sufferers (LeResche 1997) , and a branch of medicine has developed that specializes in treating craniofacial pain. Unhappily, rampant malocclusion and facial pain are actually only the tip of the iceberg-symptoms of a more serious underlying pandemic. Children are increasingly walking around and sleeping with their mouths open, snoring, and, along with adults, suffering obstructive sleep apnea and upper airway resistance syndrome (UARS). The increase in these problems can be only roughly estimated because of various forms of detection bias. Nonetheless, unbiased sampling of skulls of industrialized and hunter-gatherer populations shows unambiguously that the former suffer a higher incidence of jaw problems. " Obstructive sleep apnea refers to having repeated stressful episodes of interrupted sleep from a temporary cessation of breathing, tracing often to jaws too small to house the tongue adequately. UARS is sleep fragmentation, often accompanied by snoring, without apnea, often traceable to narrowed jaws (Guilleminault and De Los Reyes 2011) The prevalence of obstructive sleep apnea appears to be perhaps 2%-7% or more in children (Lumeng and Chervin 2008) , about 5%-20% in adults in general (Finkel et al. 2009 ), and over 80% in some elderly populations (Senaratna et al. 2017) . The available data have many shortcomings, but a reasonably conservative estimate is that obstructive sleep apnea afflicts at least 1 in 20 people worldwide (Punjabi 2008) , which is one indicator of the global extent of the jaw epidemic. We have found no data on the frequency of UARS, but it seems reasonable to assume that it is higher than the frequency of obstructive sleep apnea. In children of normal weight, obstructive sleep apnea "is a disorder of oral-facial growth" (Huang and Guilleminault 2013, Stupak and Park 2018) . The stress caused by obstructive sleep apnea or lesser degrees of sleep disturbance, such as UARS, is associated with a wide range of diseases including heart disease (e.g., Peker et al. 2006 , Gottlieb et al. 2010 , Taylor et al. 2017 , Lopes et al. 2018 , cancer (Campos-Rodriguez et al. 2013) , ADHD (Montgomery and Wiggs 2015) , and possibly Alzheimers disease (Walker 2017a , Fultz et al. 2019 , as well as with deaths from errors caused by fatigue on the highway (Tregear et al. 2009 ) and in hospitals, where interns often get inadequate sleep (Walker 2017b) . One of the potentially nasty consequences for individuals with obstructive sleep apnea is that the stress of disturbed sleep results in more or less constant sympathetic arousal. Virend Somers and his colleagues at the Cardiovascular Center at the University of Iowa College of Medicine concluded "that patients with obstructive sleep apnea have high sympathetic activity when awake, with further increases in blood pressure and sympathetic activity during sleep" (Somers et al. 1995 , Usui et al. 2005 , Abboud and Kumar 2014 . Men with obstructive sleep apnea, if they also have insomnia that involves high sympathetic activity (Nunn et al. 2016) , are also at greater risk for depression or hypertension than those with either condition alone (Gupta and Knapp 2014, Lang et al. 2017) . Moreover, the disruption of sleep that is a typical consequence of obstructive sleep apnea increases the risk of cardiovascular disease (Palma et al. 2013 , most probably arising at least in part from the increased sympathetic tone (Bisogni et al. 2016) . Complicating the whole picture is that stress itself is a cause of disturbed sleep, a dangerous positive feedback system (Han et al. 2012) . During the 2009 swine flu "epidemic, " about 0.5%-2% of Americans developed flu symptoms (Reed et al. 2009 ). It therefore seems reasonable to call the array of orofacial (and related airway) problems now afflicting people in the industrialized world a jaw epidemic, of which malocclusion is but one symptom. The oral and facial alignment and developmental issues in the childhood population can be traced specifically to poorly developed jaws. Nonetheless shrunken jaws are not being viewed as a medical issue of major consequence but rather as one of cosmetic concern. Origins: Evolutionary and environmental causes of the epidemic The root causes of our jaw problems go back several hundred thousand years as the crania of archaic hominids evolved into those of modern Homo sapiens. Major features of that transition included moving to a more globular brain case with a shrunken face tucked under it, dramatic shortening of the human jaw, and backward movement of the tongue. These may have been accompanied by a tendency for mouth breathing as our ancestors moved onto savannahs and needed greater airflow to lungs to increase endurance for pursuit hunting. If endurance running was important (Bortz II 1985 , Bramble and Lieberman 2004 , Lieberman DE et al. 2009 ), the shrinkage of the face may have helped to stabilize the head (Lieberman DE 2008) . "Human distance runners are obligatory mouth breathers (but not panting). " Significantly lower levels of general fitness in modern societies may reveal why so many people are overbreathing (hyperventilation) orally, becauase relatively nonstrenuous tasks are provoking mouth breathing because of reduced respiratory efficiency (Tomkinson et al. 2012 (Tomkinson et al. , 2019 . Oral overbreathing alters oral rest posture, thereby the developmental growth of the jaws. Dentists are familiar with what they call "long face syndrome" or "hyperdivergent growth"; it results from hanging the mouth open and produces a face with augmented downward facial development and restricted airway development. The cause is changes in habitual posture related to narrowed airways and weak chewing muscles. It leads to overeruption-the teeth becoming too long (Buschang et al. 2013) . Keeping the teeth apart at rest alters jaw structure, causing, among other things, a downward and backward rotation of the mandible. Together with increased malocclusion and other changes that accompany recent jaw shrinkage, this has made the airway more susceptible to blockage or collapse and children more susceptible to choking if they try to talk and eat (swallow) simultaneously. But preceding evolutionary changes toward smaller jaws also (Harari et al. 2010) provided presumed advantages, such as allowing the evolution of speech with syntax. As all the structures shortened and descended, the physical structure for such speech became possible (Lieberman P 2007) . The selection pressures causing these changes as archaic Homo sapiens genomes evolved into modern Homo sapiens genomes over thousands of generations have been speculated on (Lieberman DE 2008) but not identified with any certainty. The original reduction in jaw size that occurred millions of years ago as hominins evolved from ape-like ancestors has resumed over the last tens of generations, moving much too rapidly to be attributed to genetic evolution. Comparisons of Medieval and modern skulls demonstrate this dramatically, with tooth crowding considerably less frequent in the Middle Ages (Moore et al. 1968 , Helm and Prydsö 1979 , Luther 1993 , and there has been rapid change in jaw morphology in that brief period (Goose 1981) . With very rare exceptions, hunter-gatherers had roomy jaws. Malocclusion and noneruption of third molars (wisdom teeth) and crowding of the tongue were close to nonexistent; preindustrial jaws were simply roomier than those of people exposed to modern lifestyles (e.g., Price 1939 , Proffit 1975 , Helm and Prydsö 1979 , Gibson and Calcagno 1993 , Luther 1993 , Kaifu 1997 , Evensen and Øgaard 2007 , Rose and Roblee 2009 , Lieberman DE 2013 , Kahn and Ehrlich 2018 . The jaw epidemic is therefore a recent phenomenon and temporal and geographic correlation strongly suggests that it can be traced to changes in environmental factors due to agriculture and industrialization, but exactly what those factors are and how they operate remain uncertain. Indeed, environmental influences on skeletal growth are largely ignored by the orthodontic profession, which often accepts jaw skeletal development as genetic in nature, although the teeth themselves are recognized as subject to environmental influences (Proffit 1978 , Tulloch et al. 1998 , 2004 , Dolce et al. 2007 , Siara-Olds et al. 2010 , Ehsani et al. 2015 . The strong correlations in time and space with the course of the jaw epidemic and the agricultural and industrial revolutions has naturally called attention to softening diets and a reduction in the amount of chewing required for adequate nutrition , Buschang et al. 2013 , Kahn and Ehrlich 2018 . In the course of dealing with the genetic explanation of the epidemic, we now think too much emphasis has been put on the chewing function and not enough on oral posture. Current evidence suggests that alteration of oral postural influences on skeletal growth is the main cause of malocclusion. It results from changes in the persistent but gentle forces that appear to influence phenotypic skeletal development-soft tissue positioning molding bone shape and size (Sankey et al. 2000 , Mew 2004 , 2015a , Buschang et al. 2013 , Buschang and Jacob 2014 , Pisani et al. 2016 . Bones grow (and change shape) under light but persistent pressures. Those created by oral posture-the positions of the jaws and tongue in relation to each other when a child is not eating or speaking-constitute signals that, among other signals, guide the growth of the jaws. What Mew (2004) postulated and more recently Engelke and his colleagues (Engelke et al. 2011 , Knösel et al. 2016 ) have demonstrated as "correct" oral posture is holding the teeth lightly together, with the tongue positioned against the palate; clinical studies show that this posture results in an adequately roomy jaw (Wong 2018) . The Engelke team began to elucidate experimentally the details of pressure differences within functional "compartments" (formed by the positions of the lips tongue and soft palate) of the closed mouth, especially the way that, at the end of a proper swallow, there remains a self-sustaining negative pressure in the key compartment. They concluded (Engelke et al. 2011 ) that subjects (largely free of malocclusion) who swallow using the actions of fully closing their mouths prior to an upward tongue pump generate a negative intraoral pressure system. This, in turn, is shown to develop a natural biomechanical equilibrium of forces surrounding the dental arches as well as to reduce the upper airway resistance to nasal breathing. Importantly, once this negative pressure is created, little if any further muscular input is required to sustain this closed posture, thereby providing what could well be the biologically optimal therapeutic rest position. This basically says actions just before and after swallowing caused by environmental changes produced aberrant swallowing that may hold the keys to the etiology of the jaw epidemic. The problem is not a function of chewing itself but, rather, of maintaining the necessary negative pressure for long periods after a swallow, which is only possible in a closed compartment with that correct oral posture. The critical area seems to be the rear of the tongue, which is parasympathetically innervated, meaning the posture can be sustained without voluntary muscle action through passive light suction. In any case, the importance of muscle posture and function in skeletal morphogenesis is well established (Henderson and Carter 2002) , although full understanding of the complex mechanical and biochemical processes influencing how bones develop remains elusive (Ornitz and Marie 2015, Wu et al. 2016) . The preponderance of evidence suggests the epidemic is caused by environmental modification of the pattern of gentle and persistent pressures that signal the normal development of the bones of the maxilla and the mandiblethe upper and lower jaws (Woodside et al. 1983) . That is seen in animal studies (such as blocking a monkey's nose or using a device to change the pressures its tongue applies to its palate; Harvold 1968) where changing the environment disrupts normal jaw development. Also, when the teeth are not kept in contact during rest, the tongue spills out over the teeth (as it does when the jaw is hung open) so the whole pressure system fails. Jaws shrink, but the tongue does not; indeed, it may grow larger in an obese individual (Nashi et al. 2007 ). The tongue may flow back into the throat, especially when an overweight individual is supine, partially blocking the airway (channel for air in the throat) and contributing to snoring or, if blockage is complete, obstructive sleep apnea. Reshaping of bones by persistent gentle pressures is also demonstrated by the fate of toe bones in Chinese women subjected to foot binding (Zhang et al. 2014 ) and changes in skull shape from head binding (Bridges et al. 2002 ; see also https: //bit.ly/2LRiBwN). The most obvious results of disruption of normal information flow between developing soft tissues and developing jawbones in modern people have been the shrinkage of the human jaws, their backward movement accompanied by crowding and misalignment of teeth. That leads to a reduction of space for the tongue, mouth breathing, and loss of tone in orofacial muscles (Harari et al. 2010) , as well as other changes in facial morphology (Bresolin et al. 1983) . A big requirement in understanding the epidemic and treating its victims is to uncover exactly which of a number of possible factors disrupt correct oral posture and by how much? One obvious candidate that has received much attention is the effects on jaw musculature on switching to a diet that requires less chewing (Sakashita et al. 1996 , Hall 2010 , Limme 2010 , Le Révérend et al. 2014 , Sella-Tunis et al. 2018 ). That environmental transition had an "impact on the human speech apparatus (and) spoken language" (Blasi et al. 2019) ; that is, our occlusion changed from edge-to-edge to overbite and overjet over the last 6000-8000 years. That switch also appears to foster an incorrect (or reverse) swallow. Incorrect swallowing can result in open compartment resting postures, which, in turn, distorts the developing jaw shape, whereas correct adult swallowing results in the necessary physiological posture held by negative pressure and that can be maintained during sleep when maximum growth occurs. Hunter-gatherers usually did not gorge on massive soft meals or on calorie-laden, nutrition-free liquids, like soft drinks. We suspect cultural traditions of thorough mastication, deliberate complete swallows, and pauses developed in circumstances where food was not normally superabundant ("chew your food thirty times, kids"). A connection of muscle use and mouth breathing to jaw development (Surtel et al. 2015) has been shown by animal experiments. It appears that a transition to softer diets disrupts the signaling system that determines appropriate orofacial structure. The negative impact on jaw development of that transition has been demonstrated in people and other mammals (Beecher and Corruccini 1981 , Hinton 1993 , Pirttiniemi et al. 2004 , Bonin et al. 2007 , Kingsmill et al. 2010 ). Nonhuman animals that had their oral posture disrupted by nose blockage or a dietary manipulation (Harvold 1968 ) showed changes in their jaws analogous to what is happening to children in industrialized societies today (Grippaudo et al. 2016, Kahn and . Furthermore, studies of jaw size in relation to toughness and abundance of food and clinical studies in which treatment focused on muscle exercise and oral posture (how the jaws are held when not functioning) alters development of the maxilla and mandible (Wong 2018) support the environmental explanation of the jaw epidemic. It seems that swallowing properly and chewing thoroughly, which are helpful in keeping the resting tongue and jaws in correct posture, prevented hunter-gatherers from developing long-face syndrome (Buschang et al. 2013) . The spread of that syndrome may have started early in industrialization with reduction of duration of breastfeeding (Amaral et al. 2017 ) and weaning to liquid or near-liquid baby foods. There is evidence that extended breastfeeding reduces the chances of children having some types of malocclusion (Peres et al. 2015 , Boronat-Catalá et al. 2017 , Doğramacı et al. 2017 or suffering obstructive sleep apnea. This suggests that the early complex muscle use associated with breast (as opposed to bottle) feeding may be one factor in achieving the muscle tone (Huang and Guilleminault 2013) and pressures that are critical to proper oral posture and development of the maxilla and mandible. It was not until agriculture and then, especially, industrialized food processing created the environment in which correct oral posture was often compromised that many human jaws underwent rapid shrinkage (Goose and Parry 1974 , Frake and Goose 1977 , Kaifu 1997 , Rock et al. 2006 , Rose and Roblee 2009 ). Agriculture and industrialization encouraged a more sedentary lifestyle, moving indoors, where ventilation rates are low and allergens are concentrated (Bornehag et al. 2005) . Subsequent sending offspring to viral sinks, such as daycare centers, and other factors in civilization resulted in developed countries having 20%-25% of children under 5 suffer blockage of the nasal airway in early life (Jesenak et al. 2011) . A stuffy nose automatically leads to mouth breathing and reverse swallowing, altering the shape of the jaws and face during development (Jefferson 2010) . Aberrant breathing and swallowing as a consequence of infection (bacterial or viral), gastroesophageal reflux, adenoid hypertrophy (Niu et al. 2018) , smoke (Bugova et al. 2018) , asthma (Nava et al. 2007 ) and allergens (Jesenak et al. 2011 , Marseglia et al. 2011 , Niu et al. 2018 in early childhood affect adult jaw structure. The prevalence of pollution-emitting motor vehicles has also contributed to the worldwide increase in the frequency of allergic rhinitis (Janssen et al. 2003 ) and mouth breathing, as have changes to more processed and readily available foods in the human diet (Hoff et al. 2005 , De Batlle et al. 2008 . Another possible contributor to the epidemic is premature spoon (utensil) feeding before a child's normal developmental system is ready for transition to adult swallowing. Spoons, forks, and chopsticks may not be iPhones, but they are technology and are being used to change the way children are raised (Brace 1986 ). In most industrialized societies, spoon feeding starts at around 6 months. Weaning is critical to transition from the immature or baby swallow to the adult swallow, and the method of food delivery is important in swallowing (Aytekin et al. 2014 , Hernandez et al. 2019 ). The practice of force feeding children with spoons before they are ready likely disrupts the normal sequence of development. The only way to eat from a spoon is to slurp from it. Spoon feeding too early does not lead to the proper transition to mature swallowing; it teaches a child to suck and swallow. This is not an infantile or adult swallow; instead, it is an aberration. This is why most of the food ends up on the face when spoon feeding a 6-month-old. It seems likely that spoon feeding became common during industrialization, when mothers had to hurry and get back to work and spoon feeding was quick and easy. Even societies that traditionally use chopsticks start children on spoons (Visser 2015) . What other factors might change the way people hold their tongues and jaws at rest? The main time our jaws are at rest is when we are sleeping. If the posture hypothesis is right, function (exercise) will change the shape of the jaw, but only posture will allow for coordinated growth. In theory, a child can have balanced growth with weak muscles if it sleeps with its mouth fully closed. It can have strong muscles and also an undersized jaw if it does lots of hard chewing and breastfeeds for years (function) and if it does not sleep with its mouth fully closed. So a key change in the environment of a world settling down to practice agriculture and then industrializing may have been how people sleep, very differently from the way our primate relatives and hunter-gatherers slept-mostly on the ground (not in beds), on their sides, and without pillows. That had many postural advantages, including encouraging keeping the mouth shut (Tetley 2000) . This hypothesis surely deserves more investigation, because human sleep patterns are unique among primates and are thought to have been critical to the development of human beings' extraordinary cognitive abilities (Nunn et al. 2016 ). An interesting issue is the different perceptions of nighttime safety between hunter-gatherers and sedentary peoples (Musharbash 2013) and their possible impacts on sleep quality and, therefore, on jaw development. Sadly, we lack the data to say how blame should be apportioned for the epidemic among the factors discussed above and listed in table 1. But environmentally instigated bad oral posture, we emphasize, appears to disrupt the muscular-postural guidance of facial development, leading to the jaw epidemic as first agriculture (Katz et al. 2017 ) and sedentariness and then industrialization spread over the world. Eating, not surprisingly, has a great impact on jaw form, as has been long recognized (Ferris 1909) . The effect of loading bone with heavier mastication appears directly to affect the density and size of the structures (Lieberman DE et al. 2004, Zink and Lieberman 2016) . "Both human and animal studies have reported the effect of food consistency on orofacial development, suggesting that a diet with harder textures enhances bone and muscle growth, which could indirectly lead to better mastication efficiency and potentially reduce the need for orthodontic treatment" (Le Révérend et al. 2014 ). However, without considering the effect of posture, it is difficult to determine the influence of chewing on the form and balance between the jaws (Kaifu 1997) . In summary, here are hypothetical evolutionary and then environmental steps to explain the origins of the jaw epidemic: a shift from sleeping in chimp-like tree nests to ground sleeping and a change of sleep posture; mouth breathing for endurance running when hunting on the savanna; a switch to a hunter diet, with reduced chewing and altered swallowing; smoke-induced respiratory distress from the use of fire; a change in mouth resting posture; a change in facial development and a reduction of jaw size; the development of speech; and postagriculture changes in living environment. See table 1. The overall failure of the dental community to understand the jaw epidemic is partly because "most of the theories accept genetic changes as the main or underlying cause" (Knösel et al. 2016 ). This persistent error can be seen in this quote on malocclusion in the respected WebMD (www. webmd.com/oral-health/guide/crooked-teeth-misaligned-bites#1): "Most often crooked teeth, overbites, and underbites are inherited traits just as the color of your eyes or size of your hands. " The US-government-approved MedlinePlus chimes in with roughly the same view (https: //medlineplus.gov/ency/ article/001058.htm): "Malocclusion is most often hereditary. This means it is passed down through families. " Orthodontics is a big and successful business, and, in an era of genetic determinism, it is convenient to blame malocclusion on genetics, avoiding the complexities of prevention. As a result, orthodontic techniques tend toward symptom management with temporary relief of aesthetic concernsteeth straightening for teenagers, with lifelong management strategies (retainers) usually required for permanent success (Little 1999) . Some scholars, although they accept all or some of our narrative, still assert that part of the problem must be genetic or hereditary. They apparently do not realize that, because every attribute of all living organisms must to some degree be traceable to their DNA (or RNA), the statement is nonsensical. Nonetheless, some scientists continue to push partial blame for the epidemic toward genetic evolution (Punjabi 2008 ) while ignoring the etiology of jaw shrinkage Long breast feeding, specialized muscle use Insufficient nursing to develop posture or to hold muscle tone and distortion (Powell 2009 ). The success of some clinical techniques to normalize jaw growth in young children (Kahn and Wong 2016 , Kahn and Ehrlich 2018 , Wong 2018 and abundant evidence that jaw shrinkage is a factor in both obstructive sleep apnea and the advancement of maxilla and mandible are key treatments, in addition to other surgical techniques (Sunitha and Kumar 2010, Olszewska et al. 2012) . This further makes clear the largely environmental cause of the epidemic. This confusion over etiology is a possible result of the genetic determinism (Feldman 2014 ) that is characteristic of much of popular science. For instance, recent genome-wide association studies (GWAS) studies aimed at orofacial issues have been focused on possible genetic factors involved in the variation in the eruption of third molars (wisdom teeth). But they in no way suggest that selection and widespread genomic evolution explain the rarity of impacted third molars in hunter-gatherers compared with their common occurrence in settled or industrialized human populations (Sullivan et al. 2016 , Crittenden et al. 2017 , Vukelic et al. 2017 ; see also box 1). Similar problems occur when "racial" differences in the occurrence of jaw-related disease are discussed. For instance, Weinstock and colleagues (2014) found that African-American children were about 20% more susceptible to pediatric obstructive sleep apnea than children of other ethnic groups. But, unhappily, possible key environmental variables such as allergen concentrations at home or the length of nursing were ignored, as were different head shapes in different human groups that could make some more susceptible to the impacts of environmental change. In short, despite the great attention paid to a possible genetic evolutionary cause of the jaw epidemic, precious little evidence of genomic change being a significant factor has been uncovered (e.g., Cruz et al. 2008 , Xue et al. 2010 , Mossey 2014a , 2014b , Moreno Uribe and Miller 2015 , Patel and Ifzah 2016 . Suffice it to say that if there were selection pressures against big jaws, the limited number of generations (as few as 15) in which shrinkage has been observed in population samples (Luther 1993 , Larsen 1995 , 2006 would not be long enough for a genetic-evolutionary explanation. Anecdotally, shrinkage has been observed in one generation (Waugh 1937) or within a single individual (see figures 1 and 2). There is also discussion of the possibility that genetic drift is involved in jaw morphology. But drift is random changes in the frequency of structural genes in small populationshardly an explanation for a unidirectional global trend in populations of millions exposed to similar environmental changes. Prevention is the ideal solution for parents of children with jaw development problems. The best course is probably to seek help from an orthodontist or other practitioner who works with the postural factors and have her help them to change their child's jaw resting posture. The aim is to redirect the trend in growth from the age of 3 or 4 so the jaws remain balanced by fostering a correct swallowing or resting environment. To date, there are almost no treatment approaches that aim for the prevention of jaw development problems. There are no definitive evidence-based interceptive approaches. No early intervention approaches have been proven to change skeletal growth patterns to any clinically significant degree. The focus on functional appliances (devices that attempt to change the shape of the mandible) and the correction of dysfunction have not been successful means to correct skeletal malocclusion. Schulz and colleagues (2005) and Siara-Olds and colleagues (2010) revealed that these methodologies provided a predominance of only dentoalveolar changes (altering the parts of the maxilla and mandible that evolved to hold teeth), whereas Tulloch and colleagues (1998, 2004) , Box 1. Some genetic detail. Recent attempts to find genetic contributions to craniofacial phenotypes have also used GWAS. For example, an analysis of 2329 people of European ancestry using more than 9 million single nucleotide polymorphisms (SNPs) found that 1821 SNPs across 15 genetic loci were associated with quantitatively defined aspects of facial shape (Claes et al. 2018) . They found that most of these genes were active in CNCCs, a group of embryonic cells that arise at 3-6 weeks of gestation and are important in formation of the facial plan. Many of the SNPs involved were regulatory variants. It is not unreasonable that such regulatory elements can be profoundly affected by environmental conditions during development. The type of chewing or breathing could well constitute environmental effects on CNCCs that may contribute to phenotypes of the jaw (Askary et al. 2017) . It is still the case, however, that the sample sizes of genetic studies of jaw morphology are underpowered relative to corresponding GWAS of such phenotypes as height and body mass index, where sample sizes of half a million are now routine. Genetic studies of malocclusion etiology have identified 4 deleterious mutations in genes, DUSP6, ARHGAP21, FGF23, and ADAMTS1 in familial class III cases. . Although some of these variants may have large impacts on class III phenotypic expression, their low frequency (less than 1%) makes them unlikely to explain most class III malocclusions that can be as high as 18% of malocclusion in Chinese population for example (Hardy et al. 2012 ). This research also may seem to some to confirm the theory that the basic cause of widespread malocclusion lies in "genetic etiology" when, in fact, it cannot. To the contrary it is becoming increasingly clear from studies of height, mental illness, body mass index and most other complex human traits (likely including jaw configuration) that the heritable component is due to hundreds or thousands of genes each with very small effect. That militates against a sudden, near global, genetic change causing a rapid shrinkage of human mandibles and maxillae. Major (2006a, 2006b) , O'Brien and colleagues (2009), and Batista and colleagues (2018) have confirmed the elusiveness of any form of definitive methods for modification of the basal bone. However, almost none is not the same as none. Sankey and colleagues (2000) and Mew (2004 Mew ( , 2015a Mew ( , 2015b showed treatment effects of clinically significant growth direction changes of basal bone. Addressing oral posture is the common thread for each of these studies and a sound reason to direct attention and funding to testing and developing postural approaches (rather than the historical and current attention to functional approaches) for the correction of malocclusion and sleep disordered breathing. But as we have said, for patients already suffering the stress that accompanies this epidemic through sleep disruption (of which the worst is obstructive sleep apnea), symptomatic treatments include oral appliances, the use of CPAP (continuous positive airway pressure) machines, and surgery (Liu et al. 2016 (Liu et al. , 2019 . As the role of poor oral posture as a cultural-etiological factor for malocclusion and sleep disordered breathing, is confirmed, programs such as Forwardontics and GOPex (short for good oral posture exercise; Ehrlich and Levin 2005) specifically designed to restore norms (such as table manners and linguistic patterns; MacLarnon and Hewitt 1999) that provide a natural oral environment and cure or significantly improve aberrant swallowing and other ailments can be employed in treatment of individuals (Ehrlich and Levin 2005, Ehrlich 2009 ). These protocols encourage closed mouth resting posture by creating a new jaw architecture (expansion) as well as the correct breathing and, especially, swallowing patterns. The exercises focus on changing the start and end of the swallowing routine to produce the proper pressures during long rest periods. This should accompany the array of therapies being implemented to address the symptoms of the jaw epidemic. The results of treatment and posture training can be seen in figures 3 and 4. Poor sleep quantity or quality is stressful, and indices of activation of the physiological stress response can be induced by truncated sleep, disrupted sleep, and even the anticipation when going to sleep that it would be unpredictably disrupted (Born et al. 1999) . Consonant with that, obstructive sleep apnea is fairly consistently associated with increased tone of the sympathetic nervous system (SNS; arising from increased stimulation of the SNS or decreased renal clearance of circulating catecholamines), and well as activation of the adrenocortical axis (for a review, see Meerlo et al. 2008 , Bisogni et al. 2016 . Moreover, the bulk of studies show that when obstructive sleep apnea is significantly countered by CPAP treatment, there are decreases in circulating catecholamine levels, blood pressure, and heart rate (for a review, see Bisogni et al. 2016) . These findings constitute further evidence of the adverse downstream health consequences of the jaw epidemic. Problems such as the impact of premature spoon feeding on jaw development would best be dealt with by trying to change social norms. Feeding practices need to change. Utensil use needs to be timed with proper development. Spoons and pureed baby food, should not be used at 6 months when the child's first teeth are erupting but delayed to 12-18 months, when its molars come in. That time also coincides with the beginning of speech. It should become the norm to respect that timeline, and the dental community should be at the frontlines of promoting it. Other social strategies that could help reduce the impact of the jaw epidemic would be to train health professionals to reemphasize posture and table manners, encourage children not to talk while they are eating-mealtime discussions should be an important source of education. But only encourage discussion after they are 6 years old and in an appropriate place. It's been done in the past; perhaps it could be done in the future. Promoting good eating and speaking manners may be a social animal's antidote to bad jaw growth and development. But as clinical studies show, that requires discipline to counter the social pressures of industrial society. Sadly, the cure may continue to elude society if people continue to ignore adult responsibility in this and related areas (Kahn and Wong 2016, Lustig 2017) . Until such extensive social change can be entrained, there is a possible chain of action for both the avoidance of jaw shrinkage as well as mitigation of the consequences when it has occurred. Sadly, the latter may involve surgical correction of poorly developed skeletal structures. Permanent solutions invariably necessitate the modification or elimination of the habits, postural and functional, that resulted in less than optimal size and configuration for orofacial structures. The jaws, tongue, all the 32 adult teeth, including the third (wisdom) molars, and the airway develop in coordination and need to be treated as an integrated complex (as in a sense, should the entire body, including the mind) if modern environments are to be prevented from causing serious noncommunicable diseases. Early intervention (starting, ideally, in infancy) with targeted growth programs has was shown in limited clinical trials that jaw shrinkage can be avoided (Wong 2018) . This brings us to a social-institutional question: How do we increase the supply or availability of orthodontists and other practitioners who fully understand the jaw epidemic? Orthodontic professionals are the clinical facial growth experts, basing their practical techniques on the ideas of pioneers such as Angle (1907) , Moss (1997) , and Enlow and Hans (1996) . The need to move orthodontics from symptomatic treatment of misaligned jaws and teeth to prevention has long been recognized, but nonetheless, the emphasis has remained on the symptoms rather than the etiology of disrupted oral posture, especially causes in early childhood. A sign of this misplaced emphasis is the widespread opinion among orthodontists that early treatment does not work, when their view of "early" is starting around 7 years old-about at the end of a key growth period of the human face (Scott 1954) . "As the technology of tooth movement has improved, the smaller has been the interest in the developmental aspects of the malocclusions" (Varrela and Alanen 1995) . Indeed, Varrela and dental anthropologist Robert Corruccini (1984) correctly stated, "From the clinical point of view the most important element of the new perspective is that most of the malocclusions orthodontists are treating today are environmentally induced and, at least in theory, preventable. Prevention can therefore be considered as a potential alternative for active treatment. " In practice, the only "prevention" done (functional orthopedics; Fränkel and Fränkel 1983) is to use appliances in attempts to correct jaw shrinkage in 7-8-year-old children, when we believe it is already too late. We, in contrast, suggest guiding jaw growth in children as young as 2 years old, Now is surely the time for a broad revision of dental and orthodontic training. The orthodontic profession is in trouble. As orthodontist Bill Hang quoted, "Smile Direct within 5 years will do more orthodontics than all the orthodontists in the United States combined.… Every practice will be devastated (https://vimeo.com/295502729). " Smile Direct Club is a commercial enterprise that, using techniques developed by Align Technology for straightening teeth with a series of plastic disposable devices, straightens teeth with no direct contact with a dental professional involved (https:// bit.ly/2BPKKzH). One danger of this is that just moving teeth around and then necessarily holding them in place with a plastic or wire retainer may not solve problems of airway restriction that a forwardontist (an orthodontist with enhanced training when needed) could correct. Indeed, they may disguise the malocclusion symptoms of the much more serious consequences of jaw shrinkage that, as we've noted, include heart attacks, malignancies, learning difficulties, dementia, and death on the highway or in hospitals. During a pandemic, less active treatments, changing habits early, and the use of remote online consultations will lower the risks to families and healthcare personal. This involves using removable appliances and minimizing personal contact and aerosol production to help to prevent contamination within the orthodontic settings. Prioritizing treatments that retrain nasal breathing and resting with mouth fully closed will very likely enhance the antiviral response against SARS-CoV-2 by engaging the filtering effect of the nose and by increasing antiviral NO levels in the airways (Martel et al. 2020) . One of the basic educational problems the jaw epidemic highlights is the lack of training in evolutionary theory, not just in medical schools but in elementary, secondary school, and college education. Not only does this lead to absurdities such as that crooked teeth are caused by genetics and the resultant expense and suffering but, more dramatically, in the miserable societal response to pesticide and antibiotic resistance. Added to this is the isolation of dentistry (at least in the United States) from medicine in general. One consequence of this isolation is the lack of orofacial data; that is, there is no equivalent of the Framingham studies (e.g., Meigs et al. 2003) , and too few studies that were focused on prevention (e.g., of malocclusion incidence, braces use, sleeping positions, table manners and use of utensils in eating, environmental allergen exposure, overall posture, in relation to oral posture). We see the future of dentistry as a respected and integral healthcare profession becoming tied to medicine and science based. Efforts must be made to increase substantive training experience in general internal medicine and biological sciences (especially evolutionary theory) for dental students. Eventually, they should play key roles in orthorhinopediatric teams that will help guard the health of young Homo sapiens. Humanity is facing a series of gigantic environmental problems (Ehrlich and Ehrlich 2013) , but this is one where people can do something significant individually-in particular, to help protect their children. Not enough attention is paid to the mismatch (Ehrlich and Blumstein 2018) between human genetic endowments and modern environments. Unfortunately, stunningly little attention is paid in the medical community to cause, cure, and prevention. Updating orthodontic training and dealing clinically more effectively with the jaw epidemic could be an ideal place to start changing that. 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