key: cord-0781998-ayuwwzva
authors: Swancutt, Mark; Chorba, Terence
title: SARS-CoV-2, Mannerism, Marten, Mink, and Man
date: 2021-07-03
journal: Emerg Infect Dis
DOI: 10.3201/eid2707.ac2707
sha: 271e9e459fe9d4551956a847077863f1cdaec4b2
doc_id: 781998
cord_uid: ayuwwzva

Among the many mustelids are wolverines, weasels (including ermines), otter, badgers, marten (including sables), ferrets, and mink. Since the early Middle Ages, the quest for furs of these animals has played a role in European national expansion into areas where fur-bearing mustelids were populous, including Russia’s expansion into Siberia and France and England’s expansion into North America. Recent experimental research has shown that many mammals can be infected with the virus, including cats, dogs, bank voles, deer mice, fruit bats, ferrets, hamsters, mink, skunks, pigs, rabbits, raccoon dogs, tree shrews, white-tailed deer, rhesus macaques, and cynomolgus macaques. In January 2021, a combined report of the Food and Agriculture Organization of the United Nations, the World Organisation for Animal Health (OIE), and the World Health Organization presented data from OIE and other sources from 36 countries with mink farming industries and documented widespread virus transmission, in both Europe and North America. Because of concerns that mink farm populations could serve as a reservoir for ongoing coronaviruses transmission and result in development of mutations that would undermine the effectiveness of SARS-CoV-2 vaccines, large-scale culling of these animals has been pursued by Denmark, the Netherlands, and Spain. [...]it appears that in addition to all the human-to-human contact prevention measures needed to control and eliminate SARS-CoV-2 transmission, interventions that reduce contact of humans or domestic (or farmed) animals with bats or other susceptible wild animals will be needed to avert future spillover with pandemic potential.

Mannerism is characterized by realist but decorous art in which there is subtle, unsettling elongation of figures with stylized features and poses.

Among Parmigianino's more renowned works is a portrait painting from 1531-1534 of a young woman, Antea, which appears on this month's cover. It is unknown whether the painting is an image of a specific person or a stylized composition. We behold a beautiful young woman facing forward, with elongated bodily proportions, as is characteristic of Mannerist works. With a small oval head set upon a large torso and wide shoulders, her arms and hands appear exaggerated in size, as if the parts of her body were proportioned for different paintings. Yet despite these physical disproportions, the viewer has an impression of great beauty, a testimony to the subtlety and success of this Mannerist portrait. Contributing to the incongruousness of the image of this young lady, she is clad in the garments of an older woman, or a woman of an age with which we more commonly associate wealth; Antea is bejeweled, fingering a gold chain with her left hand, and dressed luxuriously. Among her layers of garments are a gold blouse with a fine white apron, a detailed gold satin dress, leather gloves, and a marten fur stole complete with the animal's head, on which the nose is pierced with a ring still attached to a chain.

For millennia, people have worn animal furs, first for survival and protection and later for fashion. In European populations, the wearing of furs of Mustelidae, a family of carnivorous mammals, has been popular. Among the many mustelids are wolverines, weasels (including ermines), otter, badgers, marten (including sables), ferrets, and mink. Since the early Middle Ages, the quest for furs of these animals has played a role in European national expansion into areas where fur-bearing mustelids were populous, including Russia's expansion into Siberia and France and England's expansion into North America. More recently, as with animals of many other species, mustelid fur farming, principally of mink, has become widely practiced in North America and Europe.

We are currently in the midst of a global pandemic caused by SARS-CoV-2, a Betacoronavirus related to coronaviruses found in horseshoe bats. SARS-CoV-2 infection spilled over as a zoonosis, perhaps through an intermediate animal, into humans in Hubei, China, a circumstance that was first identified in December 2019. As of May 25, 2021, approximately 168 million cases of SARS-CoV-2 infection and 3.5 million deaths in humans had been reported worldwide. SARS-CoV-2 infection has also naturally spread as a zoonosis from humans to dogs, domestic cats, captive felids (cats) in zoos and sanctuaries, gorillas in zoos, farmed mink, and recently, to pet ferrets. Recent experimental research has shown that many mammals can be infected with the virus, including cats, dogs, bank voles, deer mice, fruit bats, ferrets, hamsters, mink, skunks, pigs, rabbits, raccoon dogs, tree shrews, white-tailed deer, rhesus macaques, and cynomolgus macaques.

Extensive spillback of SARS-CoV-2 from humans to mink on mink farms was first reported in April 2020 in the Netherlands. Mink-to-human transmission has been documented in the Netherlands, Denmark, and Poland and is suspected to have occurred in the United States. In January 2021, a combined report of the Food and Agriculture Organization of the United Nations, the World Organisation for Animal Health (OIE), and the World Health Organization presented data from OIE and other sources from 36 countries with mink farming industries and documented widespread virus transmission, in both Europe and North America. Because of concerns that mink farm populations could serve as a reservoir for ongoing coronaviruses transmission and result in development of mutations that would undermine the effectiveness of SARS-CoV-2 vaccines, large-scale culling of these animals has been pursued by Denmark, the Netherlands, and Spain. Coronavirus variants have been identified in mink farms, including one with three amino-acid changes and two deletions in the spike protein. The escape of mink from farms into the wild is quite common; in one region of Denmark, 79% of wild mink have been found to be escapees. Presence of phylogenetically related SARS-CoV-2 in farmed mink and in free-ranging mink was first reported in Utah, USA, in December 2020. As with any zoonotic pathogen, the transmission of SARS-CoV-2 between animals and people emphasizes the importance of the One Health concept in the global approach to diseases that affect people and animals living in our shared environment.

Just as aspects of the figures in Mannerist paintings often need explanation that can be complicated, difficult, and anxiety provoking, the issues surrounding fur farming for fashion, potential exchange of SARS-CoV-2 between human populations and various animal species, and the massive culling of the commercial mink population are also complex and controversial. However, it appears that in addition to all the human-to-human contact prevention measures needed to control and eliminate SARS-CoV-2 transmission, interventions that reduce contact of humans or domestic (or farmed) animals with bats or other susceptible wild animals will be needed to avert future spillover with pandemic potential. Like the rat-borne Black Plague of the mid-14th century that ravaged the Italian states where Parmigianino executed his magnificent portrayal of Antea with her luxurious mustelid stole a century and a half later, the current coronavirus pandemic underscores again how we share pathogens with other species. With more than 1 million deaths and 1 billion infections attributed annually to zoonotic infections before the SARS-CoV-2 pandemic, we are challenged to assess and mitigate the potential risks of coronavirus transmission posed by fur farms, to both humans and other animals. These are but two facets of the multifaceted public health goal of One Health, noted by CDC, "of achieving optimal health outcomes recognizing the interconnection between people, animals, plants, and their shared environment."

COVID-19 and animals: mink and SARS-CoV-19

Assessing the risks of SARS-CoV-2 in wildlife

Animal reservoirs and hosts for emerging alphacoronaviruses and betacoronaviruses

SARS-CoV-2 seroprevalence in household domestic ferrets (Mustela putorius furo). Animals (Basel)

Art and illusion: a study in the psychology of pictorial representation

SARS-CoV-2 transmission between mink (Neovison vison) and humans

Ecology of zoonoses: natural and unnatural histories

US confirms world's first SARS-CoV-2 cases in gorillas

Parmigianino's Antea: a beautiful artifice

Methods for the identification of farm escapees in feral mink (Neovison vison) populations

COVID-19 update (319): Spain (AR) animal, farmed mink, 1st rep

Reverse zoonosis of COVID-19: lessons from the 2009 influenza pandemic

SARS-CoV-2 in animals used for fur farming

SARS-CoV-2 spillover events