key: cord-0781999-7xdzrsyz
authors: Gupta, H.; Gupta, M.; Bhargava, S.
title: Potential use of Turmeric in COVID‐19
date: 2020-07-01
journal: Clin Exp Dermatol
DOI: 10.1111/ced.14357
sha: 643fb978f9a151699a690f4d29d435673a934145
doc_id: 781999
cord_uid: 7xdzrsyz

Turmeric (Curcuma longa L.) is an integral part of Asian culture which has been used in traditional medicine systems like Ayurveda, Unani and Siddha owing to its wide array of medicinal properties since centuries. Curcumin, the predominant curcumoid in turmeric, influences multiple signaling pathways and been found to possess anti‐inflammatory, anti‐oxidant, antimicrobial, hypoglycemic, wound healing, chemopreventive, chemosensitising and radiosensitising properties.(1) To enhance the bioavailability of curcumin, newer technologies such as adjuvant, nanoparticles, liposomes, micelles and phospholipid complexes are evaluated in the process of drug development. It is documented to be most efficacious in high doses at around 6‐7 gm per day which is well tolerated orally.(1) It has been widely used as a common household remedy for cough, sore throat and respiratory ailments in Asia.

Turmeric (Curcuma longa L.) is an integral part of Asian culture which has been used in traditional medicine systems like Ayurveda, Unani and Siddha owing to its wide array of medicinal properties since centuries. Curcumin, the predominant curcumoid in turmeric, influences multiple signaling pathways and been found to possess anti-inflammatory, anti-oxidant, antimicrobial, hypoglycemic, wound healing, chemopreventive, chemosensitising and radiosensitising properties. 1 To enhance the bioavailability of curcumin, newer technologies such as adjuvant, nanoparticles, liposomes, micelles and phospholipid complexes are evaluated in the process of drug development. It is documented to be most efficacious in high doses at around 6-7 gm per day which is well tolerated orally. 1 It has been widely used as a common household remedy for cough, sore throat and respiratory ailments in Asia. 3 Curcumin is found to be beneficial in other viral disorders like AIDS due to its inhibitory activity over HIV protease and integrase along with synergistic action on other therapeutic drugs. 4 Other viruses include hepatitis B, hepatitis C, zika, chikungunya, dengue etc also have inhibitory effect due to curcumin.Respiratory distress syndrome with fulminant hypercytokinemia and multiorgan failure is the leading cause of mortality with COVID-19. Curcumin has been found to

This article is protected by copyright. All rights reserved attenuate Influenza A virus induced lung tissue injury by blocking the NF-κB signaling and inhibiting the production of inflammatory cytokines. Curcumin is a natural ligand of PPAR-γ, which represses the inflammatory process by reducing cytokine production, thereby it may play a role in protecting lung injury associated with COVID. 5 Turmeric has been used for centuries with a good safety profile. Owing to its promising efficacy in Influenza A viral infections mediated by regulating immune response to prevent injury to pulmonary tissue, well defined randomized studies can be taken up by researchers to evaluate the efficacy of turmeric derivatives against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to overcome this draconian pandemic.

Turmeric: A condiment, cosmetic and cure

3D-quantitative structure-activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase

Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection

Curcumin and its analogues: a potential natural compound against HIV infection and AIDS

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease

Accepted Article