key: cord-0804280-1jmdd4ky authors: Boccalini, Sara; Bechini, Angela title: Is it time to reconsider measles, mumps, and rubella immunisation strategies? date: 2020-09-01 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(20)30519-3 sha: c6e4df51d01515d84a4ba5474d5c8bbb3b11aeb0 doc_id: 804280 cord_uid: 1jmdd4ky nan Since the late 1990s, measles has continued to be a public health problem, and so WHO launched a global plan for measles and congenital rubella elimination in 1997. Despite the rele vant efforts, the goals of elimination have not yet been achieved, and the deadline to reach them has been post poned many times. Moreover, even in areas where high immunisation coverage has been registered, epidemics of measles have occurred in the past 10 years worldwide. 1-4 What can be done to eliminate this disease? Increased immunisation coverage in children and suscep tible individuals continues to be the most important way to reach the elimination objectives. However, it is now evident that vaccination uptake should be encouraged in any suitable way. For example, some countries have adopted effective mandatory vacci na tion, in order to increase coverage. 5 In addition, it is also necessary to better understand potential problems of immunogenicity (primary vaccine failure) and the waning protection over time (secondary vaccine failure) of the measles-mumps-rubella (MMR) vaccine. In The Lancet Infectious Diseases, Julie Schenk and colleagues 6 did an accurate meta-analysis, which is-to our knowledge-the first of its kind, on the overall data related to the immuno genicity and antibody persistence after immunisa tion with trivalent MMR vaccines. Their results show that antibody levels are high (>91%) soon after immunisation, but they decline over time. These data could be very use ful for the future assessment of MMR immunisation strate gies and their effectiveness. Thus, continuing to vaccinate is imperative, but we must keep in mind that primary and secondary vaccine failure can sometimes occur. As reported by the authors, their results are also valuable to build more truthful mathematical models representing transmission of infectious diseases. These models will allow us to identify the most relevant susceptible groups in society and, consequently, the most suitable vaccination strategies to achieve the elimination of measles. However, it will also be crucial to recognise that the circulation of wild-type viruses decreases and natural boosters disappear when universal immunisation is implemented. The reduction of natural boosters could have a further relevant impact on the rate of waning of immunity. This issue in particular must be included in any future consideration of strategies for the prevention of measles. The authors analysed humoral immunity only, which is a proxy in the estimation of protection, and could therefore underestimate the real level of protection, as cellular immunity was not included. In this sense, low antibody concentrations do not necessarily correspond to a lack of protection. However, these are the best data available so far and, if correctly used, could be very useful in the assessment of future public health decisions. Meanwhile, we are waiting for new scientific evidence on the degree of protection via cellular immunity, in people without detectable antibodies. Data retrieved in this systematic review are from healthy individuals. Thus, it is reasonable to suppose a lower response (such as lower immunogenicity and shorter duration of protection) in individuals with underlying health conditions. Therefore, attention should be paid to identify and protect these target groups. Standardisation of serological tests for immunity is also desirable. The definition of a gold-stan dard cutoff level of seropositivity for protection against measles, mumps, and rubella will allow results that are com parable between laboratories and countries to be obtained, and reliable sero-epidemiological profiles of the population to be established, 7 to identify suscep tible individuals to whom prevention activities should be addressed. In the past 10 years, vaccine hesitancy has led to a decrease in the uptake of the MMR vaccine. At present, a further issue to consider is the impact of the current COVID-19 pandemic on vaccina tion. During this emergency, a general reduction of immunisa tion coverage is expected worldwide, as shown by preliminary data registered in the USA. 8 In the near future, if these negative trends are confirmed, we can foresee an increase in vaccine-preventable infec tious diseases. This concern should be kept in mind when planning future catchup campaigns to immu nise individuals who missed vaccinations during the COVID-19 pandemic. Because of the aforementioned issues, effective organisa tion of public health initiatives becomes much more important in each country, to protect susceptible individuals and difficult-to-reach populations. In particular, health-care workers should ensure that they correctly communicate the effectiveness of the MMR vaccine to the general population. 9 Therefore, in the future, we must reconsider the current MMR immunisation strategies, on the basis of the relevant data on primary and secondary vaccine failure, as reported by Schenk and colleagues. We declare no competing interests. Department of Health Sciences, University of Florence, Florence 50134, Italy (SB, AB) Ongoing measles outbreak in southern Bavaria Measles outbreaks in Italy: a paradigm of the re-emergence of vaccine-preventable diseases in developed countries Spotlight on measles 2010: ongoing measles outbreak in Northern Ireland following an imported case Pan American Health Organization. Region of the Americas is declared free of measles Childhood vaccination coverage in Europe: impact of different public health policies Immunogenicity and persistence of trivalent measles, mumps, and rubella vaccines: a systematic review and meta-analysis Progress in the elimination of measles and congenital rubella in central Italy Decline in child vaccination coverage during the COVID-19 pandemic -Michigan Care Improvement Registry Attitude toward immunization and risk perception of measles, rubella, mumps, varicella, and pertussis in health care workers working in 6 hospitals of