key: cord-0810109-zwx6xxc0
authors: Qiu, Shizheng; Zhang, Yu; Wang, Donghua; Hu, Yang
title: The high expression of SARS-CoV-2 cell receptors might lead to higher COVID-19 infection rates in cancer patients
date: 2021-09-02
journal: J Infect
DOI: 10.1016/j.jinf.2021.08.045
sha: e815613e7d1dcc358aa283cc850404ec929e4d2a
doc_id: 810109
cord_uid: zwx6xxc0

nan

In this study, we investigated the impact of all known potential SARS-COV-2 receptors in the four clinically observed tumor types most susceptible to COVID-19, including lung cancer, esophageal carcinoma, B-cell lymphoma and leukemia (6) . NRP1, the ACE2-dependent co-receptor, and TMEM106B, a proviral host factor for SARS-CoV-2 were differentially expressed in all the four tumors (4, 5) . Among the three potential SARS-COV-2 receptors identified by Zhu et al, LDLRAD3 was significantly up-regulated in lung cancer, esophageal carcinoma and B-cell lymphoma, CLEC4G was significantly up-regulated in leukemia, and TMEM30A was significantly up-regulated in esophageal carcinoma, B-cell lymphoma and leukemia (4) . Interestingly, whether in normal tissues or tumor tissues, the level of ACE2 expression was quite low. We believed that the SARS-COV-2 receptor that made cancer patients more susceptible to infection was unlikely to be ACE2.

In summary, we explained the potential reasons why patients with four malignant tumors were more susceptible to COVID-19, namely the upregulation of SARS-COV-2 receptors in tumor tissues made individuals more likely to be infected by SARS-COV-2. We suggested NRP1, TMEM106B, LDLRAD3, TMEM30A and CLEC4G as a potential genetic shared genes for tumors and COVID-19, but ACE2 might not be included.

Shizheng Qiu, Yu Zhang and Donghua Wang have contributed equally to this work. 

Which cancer type has the highest risk of COVID-19 infection?

Promedior and Roche; grants and personal fees from Pliant; non-financial support from Redx and NuMedii; and is trustee for Action for Pulmonary Fibrosis, outside the submitted work. Conflict of interest: K. Mossman has nothing to disclose

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. Sci China Life Sci

Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2

COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges