key: cord-0813414-g4h83139
authors: Holm, Mette; Hartling, Ulla Birgitte; Schmidt, Lisbeth Samsø; Glenthøj, Jonathan Peter; Kruse, Alexandra; Rytter, Maren Heilskov; Lindhard, Morten Søndergaard; Lawaetz, Marie Cecilie; Zaharov, Tatjana; Petersen, Jens Jakob; Andersen, Rikke Moeller; Lemvik, Grethe; Marcinski, Pawel; Thaarup, Jesper; Jensen, Lise Heilmann; Borch, Luise; Nielsen, Allan Bybeck; Vissing, Nadja Hawwa; Schmiegelow, Kjeld; Nygaard, Ulrikka
title: Multisystem inflammatory syndrome in children occurred in one of four thousand children with severe acute respiratory syndrome coronavirus 2
date: 2021-06-28
journal: Acta Paediatr
DOI: 10.1111/apa.15985
sha: 4f64e271a75210d81a5bb354b44c8acf79d88ae3
doc_id: 813414
cord_uid: g4h83139

Multisystem inflammatory syndrome in children (MIS-C) is a novel disease that is associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1 . Until now, only one study has attempted to estimate the incidence of MIS-C among SARS-CoV-2 infected children and adolescents2 . This study from the New York State has reported an incidence of MIS-C of 2 per 100,000 persons younger than 21 years of age between 1 March 1 and 10 May 2020.

Multisystem inflammatory syndrome in children (MIS-C) is a novel disease that is associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 1 Until now, only one study has attempted to estimate the incidence of MIS-C among SARS-CoV-2infected children and adolescents. 2 This study from the New York State has reported an incidence of MIS-C of 2 per 100,000 persons younger than 21 years of age between 1 March and 10 May 2020.

In the same period and population, the incidence of laboratoryconfirmed SARS-CoV-2 infection was 322 per 100,000, equivalent to an incidence of MIS-C of one in 161 of SARS-CoV-2-infected individuals. 2 However, at this very early stage during the pandemic, access to SARS-CoV-2 PCR testing was very limited, particularly among asymptomatic children and adolescents. Thus, the estimated incidence from the New York State may have been overestimated. We found that 13/23 (57%) had hypotension, five (22%) received vasopressor support, 12 (52%) were admitted to intensive care units. 

Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic

Multisystem inflammatory syndrome in children in New York State

Prevalence of SARS-CoV-Antibodies in Danish Children and Adults

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study

The need for hospitalization due to SARS-CoV-2 in children: a population-based estimate

The authors have no conflicts of interest to declare.