key: cord-0821548-qws7j38g authors: Schatzman, Austin; Vandenheuvel, Julia; Villalobos, Tibisay; Rooney, Kris title: Transient leukopenia, thrombocytopenia, and severe neutropenia associated with acute SARS‐CoV‐2 infection date: 2021-06-20 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.29105 sha: 89395946886de99f9099904e750d701cfa9e3f7b doc_id: 821548 cord_uid: qws7j38g nan To the Editor: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported to cause a myriad of manifesta- in GATA 1 are well recognized in trisomy 21 to cause megakaryocyte and erythroid abnormalities but not myeloid. 13 Thus, the presence of leukopenia, thrombocytopenia, and severe neutropenia in our patient remain novel findings. Rapid bone marrow response occurred without SARS-CoV-2 infection in two pediatric patients with immune cytopenias: a single institution experience during the pandemic COVID-19-associated pancytopenia can be self-limiting and does not necessarily warrant bone marrow biopsy for the purposes of SARS-CoV-2 diagnostics Mechanism of thrombocytopenia in COVID-19 patients Hematological manifestations of SARS-CoV-2 in children Severe neutropenia in infants with severe acute respiratory syndrome caused by the novel coronavirus 2019 infection Can COVID-19 cause severe neutropenia? Post-COVID-19 severe neutropenia Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors Neutropenia in pediatric practice Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells Pathologic features of down syndrome myelodysplastic syndrome and acute myeloid leukemia: a report from the Children's Oncology Group Protocol AAML0431