key: cord-0825858-34v0slpq
authors: Baddal, Buket; Cakir, Nedim
title: Co-infection of MERS-CoV and SARS-CoV-2 in the same host: a silent threat
date: 2020-06-22
journal: J Infect Public Health
DOI: 10.1016/j.jiph.2020.06.017
sha: ac1e73de0b0e1e61a828dbdb44dcdf864fb6b7db
doc_id: 825858
cord_uid: 34v0slpq

nan

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CoVs have in the past demonstrated a marked capacity to employ homologous recombination, a process by which viruses exchange genetic material in the context of a coinfection. Indeed, studies have generated substantial evidence that SARS-CoV genome exhibited signs of a mosaic ancestry, and showed that there are at least seven potential regions of recombination in the SARS-CoV genome in the replicase-and spike-coding regions [3] . Further investigation of SARS-CoV origin suggested that SARS-CoV emerged following a recombination event of bat SARS-related coronaviruses (SARSr-CoVs) [4] . Similarly, the epidemic MERS-CoV experienced recombination events between the different lineages, which occurred in dromedary camels in Saudi Arabia [5] .

Unsurprisingly, SARS-CoV-2 was also shown to use recombination as a crucial strategy in different genomic regions including the envelope, membrane, nucleocapsid, and spike glycoproteins to become a novel infectious agent, impacting virus reproductive adaptability, allowing for genotype adjustment [6] . Single-nucleotide variation analysis of 84 SARS-CoV-2 genomes have revealed that SARS-CoV-2 has been undergoing active recombination [7] .

Moreover, latest reports on SARS-CoV-2 evolution provide compelling evidence that SARS-CoV-2's entire receptor binding motif (RBM) was introduced through recombination with CoVs from pangolins [8] . 

World Health Organization a. Coronavirus disease (COVID-19) Situation Report -133

Genetic Recombination, and Pathogenesis of Coronaviruses

Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2

novel coronavirus is undergoing active recombination

Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection

Middle East respiratory syndrome coronavirus (MERS-CoV) -The Kingdom of Saudi Arabia.Disease Outbreak News: Update 24

World Health Organization c. Middle East respiratory syndrome coronavirus (MERS-CoV) -Saudi Arabia. Disease Outbreak News: Update 5

The authors declare that they have no competing interests

Not Applicable