key: cord-0831311-h4ft0k03
authors: Friedensohn, Limor; Zur, Meital; Timofeyev, Maxim; Burshtein, Saar; Ben Michael, Yossi; Fink, Noam; Glassberg, Elon
title: Sub-cutaneous Pfizer/BioNTech COVID-19 vaccine administration results in seroconversion among young adults
date: 2021-08-05
journal: Vaccine
DOI: 10.1016/j.vaccine.2021.07.096
sha: f25bca4fa77b08231b81ae046197a97982b292ef
doc_id: 831311
cord_uid: h4ft0k03

Route of vaccine administration plays a role in extent and quality of immunogenicity. 790 military personnel accidentally received the first of two doses of Pfizer/BioNTech mRNA anti Covid-19 vaccine using a needle intended for subcutaneous administration. A serological blood test (on day 21, prior to the second intramuscular dose) was performed, analyzing whether immunological response was elicited. 98.2% demonstrated seroconversion. IgG titers were negatively correlated with age and did not correlate with BMI. Our results could help reassure providers confronted with a similar mistake and may even imply a possibly new and effective administration route.

None of the authors have published or submitted any related papers from the same study.

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Seroconversion was defined as IgG levels above 50 Au/ml. Consent to a 5 ml blood draw was 32 requested from all participants. 

The amount of subcutaneous fat, as implied by BMI, did not play a role in the seroconversion 63 rates. Females had higher IgG titers. Whether this is unique to the route of administration is yet 64 to be discovered. Additionally, in correlation with previous publications (8,9) we found that recovered Covid-19 patients had a 10 fold higher immune response following a single Acknowledges 88 We thank IDFMC northern and central medical command for their assistance in blood collection 89 and transportation for laboratory analysis. 

Safety and 94 efficacy of the BNT162b2 mRNA Covid-19 vaccine

Public Assessment Report Authorization for Temporary Supply COVID-19 mRNA 97

Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection. Department 98 of Health and Social Care (DHSC) Pfizer Limited & BioNTech Manufacturing GmbH

What role does the route of immunization play in the generation 101 of protective immunity against mucosal pathogens?

Administration routes affect the quality of immune responses: a cross-sectional 105 evaluation of particulate antigen-delivery systems

Solid Lipid Nanoparticles as Carriers for Delivery of Hepatitis B Surface Antigen for 109

Vaccination Using Subcutaneous Route

A 111 subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic 112 humoral immunity in mice

This research did not receive any specific grant from funding agencies in the public, commercial, 85 or not-for-profit sectors. 86