key: cord-0839078-2rjqu3eb
authors: Salem, Aliasger K.; Nguyen, Juliane; Ainslie, Kristy M.
title: The AAPS Journal Theme Issue: Rising Stars in Drug Delivery and Novel Carriers
date: 2022-04-05
journal: AAPS J
DOI: 10.1208/s12248-022-00700-6
sha: 3a880cb855c547c02ff2b88033bf5ce7dfff1ad6
doc_id: 839078
cord_uid: 2rjqu3eb

nan

mouse model of traumatic brain injury (TBI). This study showed that after intravenous administration in a TBI mouse model, positively charged peptide-modified nanoparticles accumulated more in off-target organs, including the heart, lung, and kidneys, than zwitterionic, neutral, or negatively charged peptide-modified nanoparticles [2] . Dr. Brenner presents a review on how complement achieves its blockade of nanomedicine, which nanocarrier material properties best avoid complement, and current and future strategies to control complement to unleash nanomedicine's potential [3] . Dr. Chung provides a review that summarizes the current understanding of exosome biogenesis and uptake and discusses atherogenic and atheroprotective functions of exosomes secreted from vascular endothelial cells, vascular smooth muscle cells, immune cells, and platelets [4] . Dr.

McHugh presents a review that discusses recent advances in the development of TLR7/8 agonist delivery systems and provides a perspective on promising future directions [5] . Dr. Gallego-Perez describes several nanotechnology-based cell therapies in regenerative medicine [6] . Dr. Fiegel reports on zwitterionic polymer coatings that enhance gold nanoparticle stability and uptake in various biological environments. This study showed that differences in the composition of the fluids result in differing impacts on particle fate [7] . Dr. Manickam reports on the optimization of lipidoid nanoparticles for delivery of therapeutic siRNAs to neural cells [8] . Finally, Dr. Pearson reports on a controlled and reproducible method for the formulation of nanoparticles using microfluidics and their formulation-dependent inherent antiinflammatory immunomodulatory properties [9] . Overall, the webinar series as well as the research works published in this special theme issue highlight the bright future of drug delivery and novel carriers.

Modulating oral delivery and gastrointestinal kinetics of recombinant proteins via engineered fungi

Pharmacokinetic analysis of peptide-modified nanoparticles with engineered physicochemical properties in a mouse model of traumatic brain injury

The nano-war against complement proteins

Exosomes in atherosclerosis, a double-edged sword: their role in disease pathogenesis and their potential as novel therapeutics

Employing drug delivery strategies to overcome challenges using TLR7/8 agonists for cancer immunotherapy

Nanotechnology-driven cell-based therapies in regenerative medicine

Zwitterionic polymer coatings enhance gold nanoparticle stability and uptake in various biological environments

Development of lipidoid nanoparticles for siRNA delivery to neural cells

Microfluidic-generated immunomodulatory nanoparticles and formulation-dependent effects on lipopolysaccharide-induced macrophage inflammation

Guest Editors: Aliasger Salem, Juliane Nguyen and Kristy Ainslie