key: cord-0842653-308aolf8
authors: Bineshfar, Niloufar; Mirahmadi, Alireza; Karbasian, Fereshteh; Pourbakhtyaran, Elham; Karimi, Abdollah; Sarafi, Mehdi
title: Acute Pancreatitis as a Possible Unusual Manifestation of COVID-19 in Children
date: 2021-02-02
journal: Case Rep Pediatr
DOI: 10.1155/2021/6616211
sha: 4def7dbff4526f7a7cce0c161ff4530ce14c3182
doc_id: 842653
cord_uid: 308aolf8

Coronavirus disease-2019 (COVID-19) which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread throughout the world causing problems for millions of people. Symptoms of COVID-19 in pediatric patients include both respiratory and gastrointestinal symptoms. The most common symptoms are fever, cough, and fatigue. In this report, we describe a case of a previously well 14-year-old boy, who presented to our emergency department with a complaint of abdominal pain, nausea, and vomiting without fever or respiratory symptoms. He was diagnosed with acute pancreatitis based on an abnormal amylase level and abdomen computed tomography (CT) and later found to be infected by SARS-CoV-2, by a positive reverse transcriptase-polymerase chain reaction (RT-PCR) test.

In December 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease-2019 (COVID-19), was discovered in Wuhan, China [1] .

COVID-19 in children presented mostly with mild upper respiratory symptoms. e most common symptoms are fever, cough, and fatigue; however, gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain were also reported [2, 3] .

Acute pancreatitis (AP) which is caused by medications, trauma, gallstones, and less prevalently viral infections in pediatric patients is the sudden inflammation of the pancreas [4, 5] . We report a case of a COVID-19associated pancreatitis presenting in a 14-year-old boy. A 14- year-old boy presented to our emergency department with abdominal pain in the epigastric region associated with anorexia, nausea, and vomiting for 24 hours. e patient had no fever or respiratory symptoms. ere was no underlying disease. He mentioned a history of contact with his aunt who was suspected of COVID-19. On physical examination, the patient was not ill or toxic and vital signs were normal: RR: 20, PR: 98, BP: 100/65, and T: 36.9°C. e abdomen was soft, nondistended with right lower quadrant and epigastric tenderness.

Laboratory tests revealed elevated amylase (1914, normal <100 μ/l) and lymphopenia, and other blood test results were within normal limits (Table 1) . Later, a nasopharyngeal swab specimen was collected which tested positive for SARS-CoV-2 on reverse transcriptase-polymerase chain reaction (RT-PCR).

Due to the positive SARS-CoV-2 RT-PCR, a chest X-ray ( Figure 1 ) and computed tomography (CT) ( Figure 2 ) were obtained. Abdomen CT was suggestive of pancreatitis ( Figure 3 ). e patient was treated with bowel rest, intravenous crystalloid fluid resuscitation, and ondansetron, pantoprazole, and empiric antibiotics including ceftriaxone and metronidazole. e symptoms were resolved gradually within 3 days, and the patient was discharged with decreasing amylase level.

AP in pediatric patients is most commonly caused by drugs, trauma, and gallstones [4, 5] . Less common causes of AP have been reported as infections. e relation between AP and some viruses such as CMV, HIV, HSV, EBV, VZV, mumps virus, coxsackievirus, and some others has been proven [4] [5] [6] [7] . Based on the Revised Atlanta Classification System for AP Diagnosis, at least two of the three following criteria should be found: (1) abdominal pain (defined as acute onset, persistent, severe epigastric pain often radiating to the patients' back), (2) increased serum lipase or amylase levels to greater than 3 times the upper limit of normal value, and (3) characteristic findings of AP on contrast-enhanced CT [8] . AP was diagnosed in our patient based on the Atlanta criteria. In the search for etiology, none of the common causes of AP was found and the only significant finding was a positive SARS-CoV-2 PCR test. Recent studies have shown gastrointestinal symptoms are fairly common in COVID-19 but the relation between COVID-19 and AP has not been described [9] [10] [11] . However, a case series of 52 COVID-19 patients reported pancreas injury in 9 patients (17% of patients) [12] . e clear pathogenesis of AP in COVID-19 patients is unknown, but the mechanism of AP following viral infections is different and depends on the type of the virus involved [5] . Currently, there is some evidence showing SARS-CoV-2 enters cells in the lungs and gastrointestinal system by binding to the angiotensin-converting enzyme 2 (ACE2) (and transmembrane protease, serine 2 (TMPRSS2) receptors), as another study by using immunostaining has shown ACE2 is highly expressed in the pancreas; thus, AP in COVID-19 patients could occur due to the direct cytopathic effect of local virus replication [12, 13] . e endothelial location of the ACE2 receptors and response to SARS-CoV-2 infection may cause increased thrombophilia in pancreas vessels in COVID-19 patients, and this vascular thrombosis may lead to AP [14] . Also, AP may be caused by the indirect effect of the harmful systemic immune response induced by SARS-CoV-2 infection [12] . A certain association between COVID-19 and AP has not been proved yet so we recommend further research to be conducted to evaluate any possible relation. A study reported serum lipase level rising in COVID-19 patients without AP symptoms [15] . erefore, we suggest that AP diagnosis should be based on Atlanta criteria and not only on the serum lipase level. In addition, the serum lipase level may not be specific and can rise in other diseases and conditions including increased gut permeability (diarrhea) with SARS-CoV-2 infection [16, 17] . 

Considering the possible association between COVID-19 and AP, we suggest full personal protective equipment (PPE) in contact with patients with AP symptoms and also in COVID-19 recognition test if possible.

Severe acute respiratory syndrome coronavirus-2 COVID-19: Coronavirus disease-2019.

No written consent has been obtained from the patient as there are no patient identifiable data included in this case report.

e authors declare no conflicts of interest. Case Reports in Pediatrics 3

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