key: cord-0849841-4p2qweym authors: Gautret, Philippe; Houhamdi, Linda; Nguyen, Nhu Ngog; Hoang, Van Thuan; Giraud-Gatineau, Audrey; Raoult, Didier title: Does SARS-CoV-2 re-infection depends on virus variant? date: 2021-06-28 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2021.06.029 sha: e99474da4b3565c265cd219a9e56ef34b9e1808b doc_id: 849841 cord_uid: 4p2qweym nan Knowledge about the degree of protection against re-infection with SARS-CoV-2 is limited. 17 A large observational study conducted among more than 500,000 people, in Denmark 18 addressing infection rates during the last four months of 2020 showed that 0.7% of individuals 19 who tested positive by PCR in early 2020, tested positive again in late 2020, while 3.3% of 20 those who tested negative in early 2020, tested positive in late 2020. Protection rate against 21 repeat infection was thus 80.5% [1] . In Marseille, France where large-scale SARS-CoV-2 22 PCR testing was proposed to the population since the early beginning of the epidemic we France. The M1V reached a very weak peak of incidence but accounted for up to 100% of 31 infections during part of July 2020, then disappeared after 1.5 month [2], while incidence of 32 the M4V that appeared in July 2020 showed an atypical wave shape and continued to account Assessment of 83 protection against reinfection with SARS-CoV-2 among 4 million PCR-tested 84 individuals in Denmark in 2020: a population-level observational study Introduction 87 into the Marseille geographical area of a mild SARS-CoV-2 variant originating from 88 sub-Saharan Africa: An investigational study Emergence and outcomes of the SARS-CoV-2 'Marseille-4' variant CoV-2 re-infection depends on virus variant? SARS-CoV-2 variants, spike mutations and immune escape 2 0 2 0 -5 2 0 2 0 -7 2 0 2 0 -9 2 0 2 0 -1 1 2 0 2 0 -1 3 2 0 2 0 -1 5 2 0 2 0 -1 7 2 0 2 0 -1 9 2 0 2 0 -2 1 2 0 2 0 -2 3 2 0 2 0 -2 5 2 0 2 0 -2 7 2 0 2 0 -2 9 2 0 2 0 -3 1 2 0 2 0 -3 3 2 0 2 0 -3 5 2 0 2 0 -3 7 2 0 2 0 -3 9 2 0 2 0 -4 1 2 0 2 0 -4 3 2 0 2 0 -4 5 2 0 2 0 -4 7 2 0 2 0 -4 9 2 0 2 0 -5 1 2 0 2 0 -5 3 2 0 2 1 -2 2 0 2 1 -4 2 0 2 1 -6 2 0 2 1 -8 2 0 2 1 -1 0 2 0 2 1 -1 2 2 0 2 1 -1 4 2 0 2 1 -1 6 2 0 2 1 -1 8 Time (Year-Week)Number of patients with a second SARS-CoV-2 infection Number of positive-SARS-CoV-2 patients Patients positive to SARS-CoV-2 Reinfection following an initial infection that took place during the 1st wave Reinfection following an initial infection that took place during the 2nd wave