key: cord-0858766-kuh2ym7s authors: Harbuwono, Dante S.; Handayani, Dwi O.T.L.; Wahyuningsih, Endang S.; Supraptowati, Novita; Ananda; Kurniawan, Farid; Wafa, Syahidatul; Kristanti, Melly; Pantoro, Nico I.; Sinto, Robert; Kurniawan, Heri; Rebekka; Tahapary, Dicky L. title: Impact of diabetes mellitus on COVID-19 clinical symptoms and mortality: Jakarta’s COVID-19 epidemiological registry date: 2021-11-12 journal: Prim Care Diabetes DOI: 10.1016/j.pcd.2021.11.002 sha: 10e709c9ae66483d0ed2a31c88c05023096f9e6c doc_id: 858766 cord_uid: kuh2ym7s BACKGROUND AND AIMS: While the higher prevalence of diabetes mellitus (DM) at younger age in Indonesia might contribute to the relatively higher COVID-19 mortality rate in Indonesia, there were currently no available evidence nor specific policy in terms of COVID-19 prevention and management among DM patients. We aimed to find out the association between diagnosed diabetes mellitus (DM) with COVID-19 mortality in Indonesia. METHODS: We performed a retrospective cohort study using Jakarta Province’s COVID-19 epidemiological registry within the first 6 months of the pandemic. All COVID-19 confirmed patients, aged >15 years with known DM status were included. Patients were assessed for their clinical symptoms and mortality outcome based on their DM status. A Multivariate Cox-regression test was performed to obtain the relative risk (RR) of COVID-19 mortality in the diagnosed DM group. RESULTS: Of 20,481 patients with COVID-19, 705 (3.4%) had DM. COVID-19 mortality rate in DM group was 21.28%, significantly higher compared to 2.77% mortality in the non-DM group [adjusted RR 1.98 (CI 95% 1.57-2.51), p < 0.001]. In addition, COVID-19 patients with DM generally developed more symptoms. CONCLUSIONS: DM is associated not only with development of more COVID-19 clinical symptoms, but also with a higher risk of COVID-19 mortality. This finding may provide a basis for future policy regarding COVID-19 prevention and management among diabetes patients in Indonesia. Indonesia, as the fourth most populous country in the world, has struggled with a huge number of COVID-19 cases during the more-than-one-year pandemic. The total cases have so far reached more than 1.5 million as of April 2021,[1] placing Indonesia as one of the Asian countries with the highest number of COVID-19 cases. [1] [2] [3] The mortality rate of COVID- 19 in Indonesia has been reported to be slightly higher than the worldwide estimate,[1] despite the relatively younger J o u r n a l P r e -p r o o f population structure. This, in part, might be contributed by the relatively higher prevalence of cardiometabolic diseases, including diabetes mellitus (DM), at younger age group. [4] [5] [6] [7] [8] Previous studies highlighted that those with cardiometabolic risk factors such as diabetes mellitus (DM) have been associated with the worse clinical manifestation and higher mortality in COVID-19. [9] [10] [11] The chronic low-grade inflammation state in people with DM set the stage for further elevations of inflammatory cytokines in COVID-19. Furthermore, immune dysregulation in DM impairs the host's ability to combat the disease, providing these populations with poorer infection outcomes. [12, 13] However, despite overwhelming evidence on the association between DM and worse COVID-19 outcomes, evidence from Asian countries outside China, especially Indonesia is lacking. [14, 15] This lack of evidence itself might as well contribute to the lack of initiatives to provide prioritization of COVID-19 prevention and care among those with DM in Indonesia. Therefore, our study aims to describe the association between diagnosed DM with COVID-19 mortality from the Jakarta area, the capital city of Indonesia, during the first 6 months of the COVID-19 pandemic. In addition, we also compare the clinical symptoms between those with and without DM. Evidence reported in our study will not only enrich the available evidence on the association between DM and COVID-19 mortality in Asian and low to middle income countries, but may also set a reasonable basis for future policy in the terms of COVID-19 prevention strategies, including vaccination, while also providing insights on the difference on clinical symptoms for COVID-19 early detection and care among DM patient. Our study was a retrospective cohort study which included all confirmed case of COVID-19 from the Jakarta province area from 2 nd March 2020, the first COVID- 19 before COVID-19 diagnosis. All patients not meeting these criteria were included in the non-DM group. Other comorbidities such as hypertension, heart disease, chronic kidney disease, and chronic liver disease were diagnosed based on the history profile and/or any treatment for each respective disease given before COVID-19 diagnosis. The primary endpoint was all-cause mortality. All death that occurred after the diagnosis of COVID-19 was considered the consequence of the COVID-19 infection. Comparison between two groups was analyzed using Chi-Square test for categorical data and unpaired T-test for numerical data. As age, sex, and other comorbidities were reported to affect COVID-19 mortality in many previous studies, they were considered as confounding variables in this study. Thus, a multivariate Cox-regression test was performed to obtain the relative risk (RR) of diagnosed DM with COVID-19 mortality and was adjusted for age, sex, and other comorbidities. All data analysis was performed using SPSS version 25. A total of 27,863 COVID-19 patients were registered during the study period. After exclusion of subjects < 15 years old and missing diabetes diagnosis status, 20,481 subjects were included for analysis. (Fig 1) . J o u r n a l P r e -p r o o f 5 The baseline characteristics of our study subjects are summarized in Table 1 . Diabetes diagnosis was observed in 705 (3.44%) patients. They were generally older and with more comorbidities than the non-DM group. Moreover, COVID-DM patients were also more likely to have symptoms than the non-DM group, notably fever, cough, dyspnea, nausea/vomitus, and pneumonia. While the mortality rate for COVID-19 in the overall population of this study was 3.41%, for those with DM it was 21.28%. The presence of DM was significantly associated with increased mortality in COVID-19 patients [unadjusted RR and 95% confidence interval (CI): 7.67 (6.51-9.04)] ( Table 2 ). In addition, after adjustment for age, sex, and other comorbidities, DM was associated with almost twice times higher mortality in COVID-19 patients compared to non-DM. (Table 3 ). Our study confirmed previous reports that DM was independently associated with a significantly higher COVID-19 mortality. In addition, clinical symptoms of COVID-19 were consistently more observed in those with DM. The increased mortality risk in COVID-DM patients by two fold observed in our study was similar to the data shown by previous meta-analysis. [11] There are several mechanisms on how DM could increase mortality risk in COVID-19 patients. As it is shown in this study, the majority of DM patients in Indonesia has chronic diabetic complications and cardiometabolic comorbidities, which in part is due to the higher proportion of DM patients diagnosed at a late stage. [6] [7] [8] However, despite the strong attenuation after the adjustment for important cardiometabolic comorbidities , the association between DM and COVID-19 mortality was still significant, suggesting other pathways might play a role. Several pathways have been reported to play a role: increased expression of angiotensin-converting enzyme-2 (ACE-2) receptor, aging cells, a higher pro-inflammatory condition, and impaired T-cell function and antibody production. [11] It is important to note that our study also observed that patients with DM were more likely to present with clinical symptoms compared to non-DM patients. These findings were in line with previous study which shown that DM increases the risk for severe COVID-19 infection. [9, 11, 16, 17] However, our findings were in contrast with previous study reported similar symptoms of COVID-19 with pneumonia for both DM and non-DM group. [18] This difference might be related with the J o u r n a l P r e -p r o o f difference in the study population. Our study analyzed the data from a centralized COVID-19 registry, integrating data from contact tracing at community, primary health care facilities, and hospital. It also included asymptomatic individuals and may thus better represent the COVID-19 cases as a whole. Our study could not provide a direct answer whether DM was associated with a higher risk to contract COVID-19 infection. If anything, the prevalence of DM diagnosis among COVID-19 patients (3.4%) observed in our study was slightly higher compared to the DM prevalence in general population of the Jakarta province area (2.6%). [5] Other registry based studies from China and United States (US) showed a DM prevalence in COVID-19 patients of 5.3% and 10.9%, respectively. [19] This prevalence in China is lower than the general population, meanwhile in the US, the prevalence is similar to the general population. However, the relatively lower or similar proportion of DM among COVID-19 infected subjects in comparison to those observed in general population might also be contributed by the widely available health information on the risk of COVID-19 on DM patients and that all DM patients should protect themselves more. Despite having a relatively younger age of population, the mortality rate for COVID-19 in our study was higher in comparison to worldwide mortality rate. In our study, the mortality rate of COVID-19 patients in Jakarta was 3.41%. This number is comparable with India, another highlypopulated low-to middle-income country (LMIC), which reported a case fatality rate of COVID-19 as 3.17-3.88% in June 2020. [20, 21] However, other LMIC in South East Asia, such as Myanmar, show a significantly lower mortality rate with only 0.6% thanks to an overall better management strategy for COVID-19 prevention and management. [22] Nit et al. [23] stated only 302 confirmed cases of COVID-19 with no death in Cambodia, another LMIC country in South East Asia with limited health resources. In part, the presence of DM and other cardiometabolic risk factors at a younger age might play a role. [7, 8] In addition, a significant portion of subjects with cardiometabolic risk factors in Indonesia were undiagnosed cases, including the case with DM of which more than 70% of DM cases were undiagnosed. [8] Moreover, majority of DM patients in Indonesia failed to reach their glycemic target. [6] These findings might further contribute to the increase mortality rate due to COVID-19 [24] [25] [26] by their influence on immune dysfunction[27] and thromboembolic risks. [28] It is also important to mention that other factors, such as the limited experience during early J o u r n a l P r e -p r o o f pandemic and limited healthcare resources might also contribute to the increased mortality. [4] These findings may also suggest that the management of COVID-19 in Indonesia still has room for improvement. Our study is the first study that showed the impact of DM on COVID-19 mortality in Indonesia, a fourth most populous country in the world. The large number of subjects and data of other comorbidities were strong points for this study. Nonetheless, there are some limitations . The COVID-19 epidemiological registry collected from the ES form is the only data currently available to be analyzed. However, as the majority of resources had been allocated for the care of COVID-19 patients, the completeness of the data was lacking. In such, we have no data on whether DM was well or poorly controlled, and no information on the laboratory parameter such as blood glucose, or data on diabetes medication. Important data related with metabolic disorders such as body mass index or obesity was also lacking. In conclusion, our study not only confirmed previous report that DM is independently associated with a higher risk of COVID-19 mortality, but also evidence that COVID-DM patients were also more likely to have clinical symptoms. This result may be used as a basis for setting a policy regarding COVID-19 prevention among DM patient, including the priority of COVID-19 vaccines. In addition, development of acute infection symptoms among DM patients might warrant early and priority access to COVID-19 test and care. Further study is warranted to understand more the inter-relationship between these two double pandemics, especially its short and long-term health and economic impact. Coronavirus Cases COVID-19 and Indonesia The impact of COVID-19 and strategies for mitigation and suppression in low -And middle-income countries. 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