key: cord-0867459-oa1imjop authors: Bakhshi, Hooman; Gattani, Raghav; Ekanem, Emmanuel; Singh, Ramesh; Desai, Mehul; Speir, Alan M.; Sinha, Shashank S.; Sherwood, Matthew W.; Tehrani, Behnam; Batchelor, Wayne title: Ventricular Septal Rupture and Cardiogenic Shock Complicating STEMI during COVID-19 Pandemic: An Old Foe Re-Emerges date: 2020-12-23 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.12.013 sha: 947d0f36e0383a058ebf1235d462beea9c5cc875 doc_id: 867459 cord_uid: oa1imjop The COVID 19 pandemic resulted in a total reduction in the number of hospitalizations for acute coronary syndromes. A consequence of the delay in coronary revascularization has been the resurgence of structural complications of myocardial infarctions. Ventricular septal rupture (VSR) complicating late presenting acute myocardial infarction (AMI) is associated with high mortality despite advances in both surgical repair and perioperative management. Current data suggests a declining mortality with delay in VSR repair; however, these patients may develop cardiogenic shock while waiting for surgery. Available options are limited for patients with VSR who develop right ventricular failure and cardiogenic shock. The survival rate is very low in patients with cardiogenic shock undergoing surgical or percutaneous VSR repair. In this study we present two late presenting ST elevation MI patients who were complicated by rapidly declining hemodynamics and impending organ failure. Both patients were bridged with venoarterial extracorporeal membrane oxygenation (ECMO) to cardiac transplant. acute coronary syndromes. A consequence of the delay in coronary revascularization has been the resurgence of structural complications of myocardial infarctions. Ventricular septal rupture (VSR) complicating late presenting acute myocardial infarction (AMI) is associated with high mortality despite advances in both surgical repair and perioperative management. Current data suggests a declining mortality with delay in VSR repair; however, these patients may develop cardiogenic shock while waiting for surgery. Available options are limited for patients with VSR who develop right ventricular failure and cardiogenic shock. The survival rate is very low in patients with cardiogenic shock undergoing surgical or percutaneous VSR repair. In this study we present two late presenting ST elevation MI patients who were complicated by rapidly declining hemodynamics and impending organ failure. Both patients were bridged with venoarterial extracorporeal membrane oxygenation (ECMO) to cardiac transplant. Key words: STEMI, ventricular septal rupture, mechanical circulatory support, VA-ECMO, heart transplant, COVID-19, The incidence of mechanical complications secondary to acute myocardial infarction (AMI) has declined significantly in the past few decades due to advances in early reperfusion with primary percutaneous intervention (PCI) strategy. 1 Despite a decline in the number of hospitalizations for acute coronary syndromes in the early months of the COVID-19 pandemic 2 , the incidence of mechanical complications has risen. 3 This is most likely due to delay in revascularization, which is an established risk factor for development of mechanical complications following AMI. 1 Parikh et al reported two patients with late presenting AMI complicated by VSR. 4 One patient expired due to multi-organ failure despite mechanical circulatory support. Second patient underwent surgical repair after a failed percutaneous VSR closure. Similar to the reports from other centers, we have been encountering mechanical complications of late presenting AMI with higher frequency during COVID-19 pandemic compared to the pre-pandemic era. In this report we describe the clinical course of two patients with VSR secondary to late presenting AMI who eventually underwent orthotropic heart transplant at our tertiary medical center. A 56-year-old man presented to the emergency room with 5 days of exertional angina and shortness of An intra-aortic balloon pump (IABP) was placed for afterload reduction and to temporize his hemodynamic instability. Structural heart and cardiothoracic surgery teams were consulted to determine potential VSR closure options. Due to the apical location of the VSR and presence of LV thrombus he was deemed not to be a suitable candidate for percutaneous closure of the defect. Thus, it was felt that surgical closure with concurrent bypass of the RCA was most appropriate clinically. While awaiting surgical repair, the patient developed worsening cardiogenic shock with elevation in biventricular filling pressures ( Table 1 ). The presence of an LV thrombus precluded the use of Impella. He was referred for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with placement of an atrial septal drainage cannula for LV venting as a bridge to cardiac replacement therapy given the profound irreversible nature of his hemodynamic compromise. The patient was evaluated by the advanced heart failure service and he was listed for a heart transplant. Six days later, he underwent uncomplicated orthotopic heart transplantation, and he was discharged on postoperative day 25 with intact end organ function. A 53-year-old man presented to an outside hospital with 7 days of progressive exertional chest pain. The multidisciplinary cardiogenic shock team was convened, and the patient was transferred to our center for further management. Upon arrival, mechanical circulatory support was escalated to VA-ECMO for cardiopulmonary support with placement of an atrial septal drainage cannula for LV venting, as a bridge to definitive therapy. Structural heart and cardiothoracic surgery teams were consulted to determine potential VSR closure options. Given the large size of the VSR, a surgical approach was favored. While awaiting surgery, serial echocardiograms demonstrated progressive RV failure. The advanced heart failure service evaluated the patient and he was listed for heart transplant. He remained on VA-ECMO for 16 days prior to undergoing successful, uncomplicated heart transplantation. On postoperative day 4, the patient was noted to have ischemic changes of bilateral toes and an arterial ultrasound demonstrated bilateral digital disease consistent with distal thrombo-embolization, a complication of ECMO necessitating amputation of his toes. On postoperative day 25, patient was discharged home and continues to do well. In the absence of surgical repair, the in-hospital mortality rates associated with mechanical complications following AMI exceed 90%. 5 Historically, surgical repair is the treatment of choice for VSR complicating AMI. Despite the advances in surgical techniques and perioperative care the mortality rate after surgical repair remains high. 6 In a recently published meta-analysis of 41 studies, Matteucci et al reported an operative mortality of 38.2% (2430 death out of 6,361 patients). 7 Reoperation was performed for residual or recurrent VSR in 7.4% of patients. The post-operative mortality is even higher in patients with RV dysfunction and patients with cardiogenic shock. 7, 8 In recent years percutaneous repair has been proposed as an alternative option in selected patients with high surgical risk and simple rupture amenable to percutaneous repair. 1 Schlotter et al in a meta-analysis of 13 studies showed a 30-day mortality of 32% (14-75%) in patients who underwent percutaneous repair. 9 Serious procedural complications were device embolization, arrhythmia and left ventricular rupture. Similar to surgical repair, post percutaneous repair survival rate in the presence of cardiogenic shock is extremely poor. 8, 10 In one study, 30-day mortality rate after percutaneous repair was significantly higher in patients with cardiogenic shock (88%) compared to non-shock patients (38%). 10 Given the acuity of illness in these patients, timing of surgery remains controversial. 1 There is a significant survival rate improvement with delay in VSR repair 11 database demonstrated the highest mortality in patients who underwent repair in the first 24 hours. 12 Surgical repair in the first 7 days was associated with higher mortality (54.1%) compared with intervention after 1 week (18.4%). 12 Mechanical circulatory support (MCS) has emerged as a potentially suitable temporizing measure for hemodynamic stabilization prior to definitive treatment, as demonstrated in case series. 13 VA-ECMO has been used successfully in patients with cardiogenic shock complicating AMI-VSR. 5 Timely initiation of VA-ECMO optimizes tissue perfusion and prevents irreversible end organ failure. 13 Despite full cardiopulmonary support, VA-ECMO increases LV afterload resulting in enhanced left to right shunting, and progressive RV dysfunction. 14 Strategies to vent the LV (i.e. IABP, Impella, arterial septostomy or transatrial drainage cannula) may mitigate these unfavorable hemodynamic effects. 14 Both of our patients stabilized hemodynamically with VA-ECMO but showed deteriorating RV function. Since RV dysfunction is associated with higher mortality and poor outcomes post AMI-VSR surgical repair 15 , they were listed for heart transplantation. In the era of COVID-19, heightened public awareness about the potentially fatal consequences of delay in clinical presentation for symptoms suggestive of AMI is imperative. In the case of VSR complicating AMI, VA-ECMO with tailored LV venting may be a viable strategy for hemodynamic stabilization and bridging to surgical repair or cardiac replacement therapy. 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Transthoracic echocardiogram showing the ventricular septal rupture (orange arrow) in subcostal view Transthoracic echocardiogram showing the ventricular septal rupture (orange arrow) in subcostal view