key: cord-0869135-l93zev26
authors: Hasan, Syed Shahzad; Capstick, Toby; Razi Zaidi, Syed Tabish; Kow, Chia Siang; Merchant, Hamid A.
title: Use of corticosteroids in asthma and COPD patients with or without COVID-19
date: 2020-05-26
journal: Respir Med
DOI: 10.1016/j.rmed.2020.106045
sha: d9197446bb4d3f2e991d10dd7ff20512ddd698fa
doc_id: 869135
cord_uid: l93zev26

The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions. A recent warning from WHO on systemic corticosteroid use amid COVID-19 raised suspicion among public and healthcare professionals regarding the safety of steroid use during the SARS-CoV-2 pandemic. The corticosteroids (inhaled and oral) are commonly prescribed in the management of asthma and COPD patients and any unsolicited changes in medications use may lead to potentially severe exacerbations and risk patient lives. This article provides a critical review of clinical evidence and offers a detailed discussion on the safety and efficacy of corticosteroids in asthma and COPD patients, both with and without COVID-19.

The World Health Organisation (WHO) recently on 13 th March 2020 recommended against the routine use of systemic corticosteroids in the clinical management of severe viral pneumonia if coronavirus disease 2019 (COVID-19) is suspected [1] . This is due to the lack of effectiveness of routine treatment with corticosteroids and the risk of potential harm as reported in previous literature for viral pneumonia outbreak, including Severe Acute Respiratory Syndrome (SARS) [1, 2] . In fact, the SARS-Coronavirus-2 (SARS-CoV-2) causing COVID-19 is closely related to SARS-CoV-1 that caused the previous SARS outbreak [3] .

Since patients with asthma and chronic obstructive pulmonary disease (COPD) represent a group where the inhaled corticosteroid (ICS) or oral corticosteroid (OCS) are commonly prescribed, therefore the risk-benefit of corticosteroid use in this group of patients with or without COVID-19 diagnosis is needed. The discussion that follows, segregated into two different groups of patients with regards to the use of corticosteroids amid current COVID-19 outbreak: (i) asthma and COPD patients who do not have COVID-19 as yet, and (ii) asthma and COPD patients who have COVID-19, is based on clinical evidence and risk-benefit assessment amid COVID-19 pandemic.

Due to the recent warning from WHO on systemic corticosteroid use in COVID-19 associated viral pneumonia and the potentially detrimental effects of steroids on the immune system to combat viruses, there has been a general fear on inhaled and oral corticosteroids (ICS and OCS, respectively) use among patients with asthma and COPD who have yet to acquire COVID-19. The use of ICS has been associated with a respiratory infection. A (Cochrane) systematic review of 43 randomised controlled trials of inhaled fluticasone (n=21,247) and budesonide (n=10,150) among COPD patients reported that ICS may increase the risk of non-fatal serious adverse pneumonia events (requiring hospital admission) by 62 (OR 1.62, 95% CI: 1.00 -2.62) to 78% (OR 1.78, 95% CI: 1.50 -2.12) compared to control but without an increase in mortality, and this appears to be a drug-specific phenomenon or the class effect [4] .

More recently, there has also been a suggestion of an increased risk of upper respiratory tract infections (URTI) associated with ICS use in asthma. In a 2019 systematic review of 17 randomized controlled trials in asthmatic patients (n = 15,336), the risk of URTI was increased with ICS use compared to no ICS use (odds ratio 1.24; 95% confidence interval 1.08 to 1.42) reported [5] . However, the meta-analysis showing an increased risk for respiratory infection associated with ICS use, are comparatively small in asthmatic patients and includes pooled estimates with wide confidence intervals in COPD patients, and therefore the association is relatively weak. In addition, pneumonia is common in people in COPD, with risk factors including older age, lower body mass index, more severe airflow limitation, greater COPD exacerbation rates, and low eosinophil counts [6] .

The increased risk of respiratory infection with ICS may be due to impairment in antiviral innate immune responses with a reduction in neutrophil recruitment [7, 8] and a delay in viral clearance in COPD patients [9] . Nonetheless, impairment in antiviral immune response was not replicated in a recent study among asthmatic patients on ICS [10] . It is, however, possible that the effect of ICS may vary depending on the type of respiratory infection and patient factors such as the severity of their respiratory condition as well as the physicochemical properties of ICS. Fluticasone has been observed to reside for a longer duration in airway lumen and mucus due to its poor solubility and permeability across the airway mucosa [11] . Conversely, budesonide with greater solubility traversed quickly through the airways [11] . The prolonged presence of fluticasone has been observed to maintain longer glucocorticoid receptor occupancy and thus sustains its anti-inflammatory and immunosuppressive action in the airways, which explains its higher potency and extended local immunosuppression relative to budesonide [12] . Indeed, a meta-analysis of seventeen trials [13] with 15,336 asthmatic subjects revealed an increased risk of upper respiratory tract infection with fluticasone (Peto odds ratio: 1.18; 95% confidence interval 1.02-1.38) but not budesonide. Similarly, a meta-analysis of 25 randomised controlled trials involving 49,982 COPD subjects [14] demonstrated an increased risk of pneumonia with fluticasone (relative risk: 1.84, 95% confidence interval 1.47-2.30) but not budesonide The data related to the overall or differential effects of ICS on COVID-19 is still lacking though a recent in vitro study (preprint) [15] suggests not only their safety but also a preventive effect from COVID-19. The study found ciclesonide and mometasone blocked the replication of SARS-CoV-2 by targeting viral non-structural protein 15 . Similarly, another in vitro study [16] other conditions such as rheumatoid arthritis, inflammatory bowel disease, polymyalgia rheumatica/giant cell arteritis, connective tissue disease, and cancer) [17] . The study reviewed an anonymised electronic medical data of more than 275,000 patients retrieved from The Health Improvement Network and found that overall, the patients receiving OCS were at five times greater risk of developing lower respiratory tract infection than control (hazard ratio 5.84; 95% confidence interval 5.61-6.08). However, the retrospective study covering such disparate medical conditions may subject to confounding, since for instance, asthma or COPD itself was associated with an increased risk of serious respiratory infections. A 2017 Cochrane review found that corticosteroids reduced the mortality and morbidity in adults with severe pneumonia (bacterial and/ or viral) and significantly improved clinical outcomes [18] .

While we do not find any studies on the association between the use of ICS/OCS and the acquisition of COVID-19, some hints can be found from emerging epidemiological studies that reported an association between asthma/COPD and COVID-19. We anticipate that patients with asthma or COPD would be at increased risk of COVID-19 and experienced a more severe course of infection due to limited pulmonary reserves. Nevertheless, to our contrary, an under-representation of patients with asthma/COPD in COVID-19 is seen (about 1.5% reported in Chinese studies) [19, 20] when compared to the estimates of asthma and COPD prevalence (estimated 6.9% in China) [21] . A similar trend in patients was observed with SARS [22, 23] and the Middle East respiratory syndrome [24] . Therefore, the possible inhibitory effect of ICS on the replication of SARS-CoV-2 and other coronaviruses that may subsequently prevent ICS users from acquiring COVID-19 cannot be ruled out. Besides, the use of ICS may limit or improve symptoms of the disease where ICS users may not be symptomatic to seek testing or treatment. A case report from Japan [25] suggested a possible improvement in the course of disease with the use of ICS ciclesonide. It was shown that three COVID-19 patients requiring oxygen therapy were recovered after administration of inhaled ciclesonide, though it may be argued that patients may have improved even without inhaled ciclesonide due to the absence of a control group in the case report.

For asthma and COPD patients who do not have COVID-19 as yet, it is important to maintain good symptom control with usual therapy. This is to minimise the risk of an exacerbation and the associated need for hospital intervention, which could potentially increase the exposure to acquiring COVID-19.

Furthermore, poorly controlled asthma may lead to a more complicated disease course for those with COVID-19 infection. A 2013 systematic review and meta-analysis of seven randomised controlled trials found that discontinuing ICS (preventer) in people with stable asthma more than doubled the risk of asthma exacerbation (relative risk 2.35; 95% confidence interval 1.88 to 2.92) [26] . Therefore, the benefit of continuing ICS therapy based on the respective guideline outweighs the suspected risk of respiratory infection.

Some asthmatic patients may, however, benefit from add-on non-steroidal preventer/controller inhalers which may potentially reduce the steroid load (corticosteroid-sparing effect), such as longacting beta2-adrenoceptor agonists (LABAs), mast-cell stabilisers (cromoglycates) or non-steroidal anti-inflammatory agents (nedocromil). The efficacy of chronic LABAs as corticosteroid-sparing agents was examined in a (Cochrane) systematic review of 10 randomised trials comparing high-dose ICS versus combined low-dose ICS plus LABA in which the addition of a chronic LABA permitted 37 to 60% reduction of the ICS dose without deterioration of asthma control [27] . In another study in poorly controlled severe steroid dependant asthmatic patients (1600ug/day inhaled beclomethasone dipropionate and ≥5 mg/day oral prednisolone), the inhaled sodium cromoglycate (16 mg/day) resulted in a mean reduction of 3.68 mg/day oral corticosteroids (95% CI 1.35, 5.95) plus a significant improvement in the lung function demonstrated by peak expiratory flow measurements [28] . Another older study reported an addition of nedocromil among patients on high doses of ICS (beclomethasone 1000 or 2000 µg a day) resulted in a minor reduction in the dosage of corticosteroids compared with placebo [29] . This approach requires careful supervision and close monitoring by experienced clinicians in asthma management, and albeit the use of cromoglycates may not be a cost-effective strategy in the clinical practice of asthma, it may potentially help to reduce the uncertain risk of ICS amid COVID-19 pandemic [30] .

In contrast to asthma, the benefits of ICS in COPD patients are less clear and therefore should be avoided unless the patients are very symptomatic and are frequent exacerbators. Dual long-acting bronchodilator therapy inhalers achieve greater reductions in exacerbation frequency compared to ICS plus long-acting beta2-agonist combination inhalers, with a lower risk of pneumonia [31] . There have been equivocal results regarding the consequences of withdrawing ICS in COPD patients. A metaanalysis in 2007 [32] investigated the impact of ICS withdrawal in COPD patients and reported no significant increase in the overall rate of exacerbation but a clinically important increased risk of severity in the observed exacerbations. Besides, the time to the first exacerbation was significantly shorter among COPD patients who discontinued ICS. In addition, the lung function (-30 ml of forced expiratory volume in one second) and the quality of life was significantly impaired after ICS withdrawal. A recent study examined the effect of ICS withdrawal in the context of dual bronchodilator therapy found that the deterioration in lung function and an increase in exacerbation frequency was greatest among COPD patients with a blood eosinophil count ≥ 300 cells/μL at baseline, which suggests that a subset of COPD patients are likely to benefit from ICS therapy [33] .

On the other hand, the minority of patients with severe allergic asthma who are receiving maintenance OCS should be titrated to the lowest possible dose sufficient to maintain symptoms. These patients should be supported with the corticosteroid-sparing effects of the biological drug, omalizumab [34] , which could reduce the risk of adverse events from OCS use including increased risk of respiratory infection and thus a potential reduction in healthcare costs. Similarly, other biologicals such as mepolizumab [35] and benralizumab [36] have a corticosteroid-sparing effect and may be considered in patients with severe eosinophilic asthma receiving maintenance OCS. A trial of withdrawal of OCS may be considered after patients have been asymptomatic or stable for several months on OCS. Since OCS have no role in the daily treatment of COPD due to a lack of benefit, tapering should be considered for COPD patients receiving OCS. Other potential COPD therapies such as phosphodiesterase-4 inhibitors (roflumilast) or macrolide antibiotics (azithromycin) in former smokers, should be considered in cases where symptoms of COPD are poorly controlled [37] .

The benefits of continuing ICS (or OCS) treatment, therefore, outweigh the uncertain risks in the context of COVID-19 pandemic, and hence major respiratory and health societies recommended against discontinuation of ICS (or OCS) in asthmatic patients [38] [39] [40] [41] [42] [43] [44] [45] . For COPD patients, they have also urged to maintain their regular therapy which may include ICS, to maintain good control of symptoms and prevents exacerbations ( Table 1) . Table 1 : Recommendation on the use of inhaled and oral corticosteroids by major respiratory and health societies.

Recommendation Reference Global Initiative for 'People with asthma should continue all of their inhaled medication, including inhaled corticosteroids, as prescribed by their doctor.' [38] Asthma (GINA) 'In acute asthma attacks, patients should take a short course of oral corticosteroids if instructed in their asthma action plan or by their healthcare provider, to prevent serious consequences.' 'In rare cases, patients with severe asthma might require long-term treatment with oral corticosteroids (OCS) on top of their inhaled medication(s). This treatment should be continued in the lowest possible dose in these patients at risk of severe attacks/exacerbations.' Global Initiative for Obstructive Lung Disease (GOLD) 'GOLD is not aware of any scientific evidence to support that inhaled (or oral) corticosteroids should be avoided in patients with COPD during the COVID-19 epidemic.' 'COPD patients should maintain their regular therapy.' [39] European Lung Foundation 'Patients with asthma should never stop taking their preventer inhaler unless asked to do so by a medical professional. Stopping your steroid inhaler could put you at higher risk of complications with COVID-19 due to making your asthma worse.' [40] American Lung Association 'If you use inhaled corticosteroids or intranasal steroids, there's probably not a risk to developing a weakened immune system. If you use oral corticosteroids, there's a slight increase of a suppressed immune system. If you're in an asthma flare, your healthcare provider can help you decide which medications are the right choice to help you breathe. Do not stop or avoid taking your medication without discussing it with your healthcare provider.' [41] British Thoracic Society 'There is no evidence that inhaled steroids increase the risk of getting COVID-19 so please advise your patients to continue with all of their inhalers, including ICS and ICS/LABA combination inhalers.' 'If your patient develops symptoms and signs of an asthma exacerbation then they should follow their personalised asthma action plan and start a course of steroids if clinically indicated.' 'For patients on maintenance oral corticosteroids, they should continue to take them at their prescribed dose as stopping steroids suddenly can be harmful. It is worth reiterating the "sick day rules" and reminding patients that if they become unwell (for any other reason) they need to increase their steroid dose appropriately (usually doubled).' [42] The Primary Care Respiratory Society 'People with asthma must continue their preventive ICS according to current guidelines.' 'Oral corticosteroids should be used in people with asthma attacks according to current UK guidelines. There is no evidence to suggest appropriate use of OCS in asthma attacks will cause a worse outcome if COVID 19 or similar viruses are suspected to be the trigger.' [43] Asthma and Allergy Foundation of America 'Steroids are not a risk for people with asthma, so continue to take your medications as prescribed.' [44] National

'Recommends that patients should continue taking their regular inhaled and oral medicines, including corticosteroids, in line with their individualized self-management plan. This includes those with COVID-19 or suspected of having it.' 'If they develop symptoms of COVID-19, the guidance advises that patients should not start a short course of oral corticosteroids and/ or antibiotics.' 'Patients using non-invasive ventilation at home should be advised that, because these are potentially infectious aerosol-generating procedures, they should take appropriate precautions such as using equipment in a well-ventilated room and using it way from other family members if possible.' [45] 

Viral respiratory infections have been one of the most common exacerbation triggers in asthma and COPD patients [46, 47] . This can be explained by their ability to induce proinflammatory cytokines, such as IL-1, IL-6, and IL-11, within airway epithelial cells [48] . While it is still not known if COViD-19 may trigger an exacerbation in asthmatic and COPD patients, the similar induction of proinflammatory cytokines (including IL-1 and IL-6) and subsequent lung inflammation in suggests that an exacerbation is likely in patients with asthma/COPD [49] . Therefore, the main goal of therapy in asthma and COPD patients with COVID-19 is to decrease the risk of exacerbation that could further compromise pulmonary reserve. In COVID-19 asthmatic patients, the ICS dose may be up-titrated up to 4x baseline if asthma worsens (as indicated by peak expiratory flow monitoring). This is particularly important in poorly adherent patients on low dose ICS, as this may prevent severe exacerbations, and reduce the need for rescue OCS courses [50] . An alternative option for patients who use a combination of ICS/LABA (long-acting β-agonists such as formoterol) inhaler as single maintenance and reliever therapy (SMART) is to increase the as-needed dose when symptoms flare, which has found to reduce the risk of severe exacerbations requiring OCS by two-thirds compared with those receiving only inhaled short-acting bronchodilator (SABA) [51] .

For COPD patients, more frequent use of SABA (short-acting β-agonists) is warranted when symptoms flare and titrated to response [37] . If an acute exacerbation of asthma and COPD in the context of COVID-19 does occur, there is no reason to believe that a different than usual approach should be adopted in home/clinic/inpatient management, and patients/clinicians should follow individualised asthma/COPD self-management plan which may include the use of short course of OCS, as delaying therapy may increase the risk of a life-threatening exacerbation [52] . Short-term use of OCS in both asthma [53, 54] and COPD [55, 56] exacerbations accelerates the resolution of exacerbations, prevents disease progression, early relapse after emergency treatment, and reduces morbidity. The OCS therapy can be stopped abruptly as soon as symptoms have subsided, and lung function has been improved. However, patients should be reminded that a short course of OCS should not be self-initiated in the presence of COVID-19 symptoms such as fever, dry cough, or myalgia [45] . The approach detailed above, including the management of exacerbations, is also applicable for the severely/critically ill COVID-19 patients with asthma and COPD patients receiving emergency care in the hospital.

In a response to COVID-19 outbreak, the consultant endocrinologists/diabetologists advised considering a physiological stress dose of systemic corticosteroids (hydrocortisone 50-100 mg intravenously thrice daily) in hospitalised asthma and COPD patients (without exacerbation as yet)

with chronic ICS/OCS use of longer than 3 months due to possible adrenal insufficiency [57] . Albeit, the use of systemic corticosteroids in the treatment of COVID-19 is discouraged by the WHO [1] , we suggest that its use can be considered based on COVID-19 severity in COVID-19 patients with concomitant asthma or COPD. The use of systemic corticosteroids may not be justified for mild-to-moderate COVID-19 patients. In patients with severe/critical disease, especially those with septic shock or ARDS, where cytokine storm is increasingly being recognised, a systemic corticosteroid may play an important role. There are some retrospective studies [58, 59] to support this at the moment, nevertheless, this will be confirmed soon from clinical trials and clinical experience from hospitalised COVID-19 patients in the current COVID-19 pandemic.

Inhaled corticosteroids are usually administered via an inhaler (such as a metered-dose inhaler or dry powder inhaler), but nebuliser solutions of corticosteroids are occasionally used in a clinical setting.

Whilst joint guidance issued by The Department of Health, UK advised that administration of medication via nebulisation is not a viral droplet generating procedure, and so is not considered to represent a significant infectious risk [60] , there are concerns from other sectors that this may not be the case. The World Health Organization, the Global Initiative for Asthma, and the UK's National Institute for Health and Care Excellence (NICE) have all advised that nebulised treatment can potentially increase the risk of virus transmission to healthcare personnel and other patients due to aerosolisation of SARS-CoV-2 [61, 62] . Therefore, metered-dose inhalers with spacer devices should be preferred over nebulisers to deliver drugs wherever possible [61] . If nebulisation is inevitable, an airborne infection isolation room must be used for nebulisation with appropriate personal protective equipment and adequate contact and airborne precautions in place.

The main goal of therapy for asthma/COPD patients with or without COVID-19 is to minimise the risk of an exacerbation: for patients without COVID-19, an exacerbation associated hospitalisation could potentially increase the exposure to acquiring COVID-19; and for patients with COVID-19, an exacerbation could further decrease pulmonary reserve. With this in mind, the clinicians should always consider the lowest possible ICS/OCS dose to maintain symptom control in patients with asthma to avoid the detrimental effects of corticosteroid therapy. Nevertheless, the use of ICS in patients with COPD is controversial, and for COPD patients on ICS who developed a frequent respiratory infection or are not responding to therapy, a reconsideration of management strategy is recommended on a case to case basis [7] .

The management of an exacerbation of asthma and COPD in the context of COVID-19 pandemic should follow the usual approach, including the use of short courses of rescue OCS, while consideration for avoiding the use of nebulised drug administration should be made due to concerns about the transmission of COVID-19 in hospitalised patients unless nebulised in an airborne isolation room with necessary precautions. Studies are, however, lacking on the association between the use of ICS/OCS and the acquisition or severity of COVID-19. Future studies should, therefore, aim to collect data on the use of ICS/OCS in COVID-19 patients to ascertain the potential benefits or harms of ICS/OCS in COVID-19.

clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected (Accessed on

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease

Inhaled corticosteroids and risk of upper respiratory tract infection in patients with asthma: a meta-analysis

The natural history of community-acquired pneumonia in COPD patients: a population database analysis

Budesonide and formoterol reduce early innate anti-viral immune responses in vitro

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Increased type 2 inflammation post rhinovirus infection in patients with moderate asthma

Differences in the efficacy and safety among inhaled corticosteroids (ICS)/long-acting beta2-agonists (LABA) combinations in the treatment of chronic obstructive pulmonary disease (COPD): Role of ICS

Inhaled corticosteroids dose regimens: therapeutic relevance of lipophilicity, solubility, dissolution and absorption from the lung

Inhaled corticosteroids and risk of upper respiratory tract infection in patients with asthma: a meta-analysis

Inhaled corticosteroids and risk of pneumonia in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials

The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral

Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells

Common infections in patients prescribed systemic glucocorticoids in primary care: a population-based cohort study

Corticosteroids for pneumonia. Cochrane Database Syst Rev

Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis

Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis

Chronic Respiratory Risk Factors Collaborators; GBD 2016 occupational chronic respiratory risk factors collaborators. Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study

Clinical features and outcomes of severe acute respiratory syndrome and predictive factors for acute respiratory distress syndrome

Severe acute respiratory syndrome: prognostic implications of chest radiographic findings in 52 patients

Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study

Three cases of the early to midstages of COVID-19 pneumonia improved by inhalation of ciclesonide

The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials

Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children

Comparison of three treatment regimens of inhaled sodium cromoglycate in the management of adult patients with severe, steroid-dependent asthma

Steroid sparing effect of nedocromil sodium in asthmatic patients on high doses of inhaled steroids

Comparison of the cost-effectiveness of budesonide and sodium cromoglycate in the management of childhood asthma in everyday clinical practice

Long-acting muscarinic antagonist (LAMA) plus long-acting betaagonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev

Withdrawal of inhaled corticosteroids in COPD: A meta-analysis

Long-term triple therapy de-escalation to indacaterol/glycopyrronium in patients with chronic obstructive pulmonary disease (sunset): a randomized, double-blind, triple-dummy clinical trial

Omalizumab for Severe Allergic Asthma Treatment in Italy: A Cost-Effectiveness Analysis from PROXIMA Study

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease

Recommendations for inhaled asthma controller medications

Global Initiative for Chronic Obstructive Lung Disease (GOLD). GOLD CoViD-19 guidance

Covid-19 -Your Questions Answered by A Respiratory Expert

American Lung Association. Asthma & COPD: CoViD-19 Myth Busting with Dr

Advice for Healthcare Professionals Treating People with Asthma (adults) in relation to CoViD-19

PCRS Pragmatic Guidance: Diagnosing and managing asthma attacks and people with COPD presenting in crisis during the UK Covid 19 epidemic

Asthma and Allergy Foundation of America. Coronavirus (CoViD-19): What People With Asthma Need to Know

COVID-19 rapid guideline: community-based care of patients with chronic obstructive pulmonary disease (COPD)

The role of viruses in acute exacerbations of asthma

Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: a systematic review

Role of viral infections in asthma and chronic obstructive pulmonary disease

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies

Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations

Inhaled combined budesonide-formoterol as needed in mild asthma

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma

Effect of a short course of prednisone in the prevention of early relapse after the emergency room treatment of acute asthma

Corticosteroids for preventing relapse following acute exacerbations of asthma

Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group

Efficacy of corticosteroid therapy in patients with an acute exacerbation of chronic obstructive pulmonary disease receiving ventilatory support

Our response to COVID-19 as endocrinologists and diabetologists

Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, china

A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia

Public Health Agency (PHA) Northern Ireland, Health Protection Scotland (HPS) and Public Health England. COVID-19: Guidance for infection prevention and control in healthcare settings. as official guidance

COVID-19: GINA answers to frequently asked questions on asthma management

Modes of transmission of virus causing coid-19

Inhaled corticosteroids dose regimens: therapeutic relevance of lipophilicity, solubility, dissolution and absorption from the lung

• Asthma/COPD patients should avoid potential hospitalisation due to exacerbation • Any hospitalisation increases the risk to acquire COVID-19• The benefits of continuing corticosteroid outweigh the risks amid COVID-19 pandemic• Asthma/COPD patients should continue regular medicines including corticosteroids• Inhalers should be preferred over nebulisers to avoid COVID-19 transmission Declarations of interest: none