key: cord-0872217-nr4v7vyq
authors: Khezri, Mohammad Rafi
title: PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19
date: 2021-01-11
journal: Hum Cell
DOI: 10.1007/s13577-021-00484-5
sha: 1c206691fab9b75d75956a0f9a8867eec3147304
doc_id: 872217
cord_uid: nr4v7vyq

nan

Ang II induces different organs' fibrosis [5] . These effects seen from Ang II can be related to the PI3K/AKT signaling pathway, since binding of Ang II to its receptor, angiotensin II receptor type 1 (AT1R), causes activation of this pathway [6] . On the other hand, activation of the PI3K/AKT signaling pathway has been linked to the induction of lung tissue fibrosis, which has been detected in patients with COVID-19 [5, 7] . Regarding the role of this pathway in inducing inflammation, we can mention the activation of factors such as activated protein-1 (AP-1) and nuclear factor kappa B (NF-κB) [8] . Various studies have shown that suppression of the PI3K/AKT signaling pathway inhibits NF-κB and AP-1 and ultimately reduces the expression of inflammatory cytokines such as IL-6 and TNF-α [9] . Based on this evidence, the use of drugs, such as azithromycin, which have been shown to inhibit PI3K/AKT signaling pathway and ultimately suppress inflammation [10] , along with antiviral drugs to combat COVID-19 can be considered.

A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19

Loss of proprotein convertase furin in mammary gland impairs proIGF1R and proIR processing and suppresses tumorigenesis in triple negative breast cancer

SARS-CoV-2 infectivity and neurological targets in the brain

Cell entry of bovine ephemeral fever virus requires activation of S rc-JNK-AP 1 and PI 3 K-A kt-NF-κ B pathways as well as C ox-2-mediated PGE 2/EP receptor signalling to enhance clathrin-mediated virus endocytosis

Pathological role of angiotensin II in severe COVID-19

Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling

PI3K/Akt signaling is involved in the pathogenesis of bleomycin-induced pulmonary fibrosis via regulation of epithelial-mesenchymal transition

Inflammatory signalings involved in airway and pulmonary diseases

O-methylbulbocapnine and dicentrine suppress LPS-induced inflammatory response by blocking NF-κB and AP-1 activation through inhibiting MAPKs and Akt signaling in RAW264.7 macrophages

PI3K/Akt-Nrf2 and anti-inflammation effect of macrolides in chronic obstructive pulmonary disease