key: cord-0888301-ozp2hpti authors: Davido, Benjamin; Davido, Guillaume; Annane, Djillali title: No further delays in offering booster doses in countries experiencing a major resurgence of COVID-19 date: 2021-11-30 journal: J Travel Med DOI: 10.1093/jtm/taab187 sha: 4cee1f79c49fa6e08a9454408fe7da0a5db3506b doc_id: 888301 cord_uid: ozp2hpti Covid booster shots should be proposed and recommended to all fully vaccinated individuals, considering antibody levels are waning over time and that the risk of being infected typically reappears after 6 months. Covid booster shots should be proposed and recommended to all fully vaccinated individuals, considering antibody levels are waning over time and that the risk of being infected typically reappears after 6 months. While most countries around the world genuinely believed that the pandemic could The main concern is that every country is applying its own strategy, delayed over time, especially because WHO unfortunately cannot deliver a universal and unique Indeed, the vaccine booster is legitimate since, a recent work in Israel 6 showed that the third dose allows to recover a gain in neutralizing antibodies in fully vaccinated individuals aged over 60 years-old and reduces by 10-fold the risk of confirmed infection due to the Delta variant and by 19-fold the risk of hospital admission. Those findings are supported by another study by Barda et al. 7 in Israel that confirmed that the booster shot was effective for preventing severe outcomes in a large scale population of 1 million of individuals aged over 30 years-old. Thus extending booster shot should prevent many deaths in older people as the epidemics resurges in numerous countries. In addition, the United-Kingdom booster programme using the BNT162b2 mRNA vaccine since September 2021 in people aged over 50 or with comorbidities, confirmed a significant increased protection from the booster shot against symptomatic disease, irrespective of which primary course vaccine was received 8 . So, a third dose for everyone? Yes, but the reality is that we must prioritize vaccination. The most fragile and those who are the most at risk of developing a severe form requiring hospital admission must be vaccinated first. Healthcare professionals and caregivers should also be prioritizedin countries such as France and Italy, the age is actually not a criterion to access boosters in this population. Because of their increased risk of occupational exposure to SARS-CoV-2 and the In this context it should be borne in mind that on the one hand, success in controlling the subsequent waves of COVID-19 is based on the effectiveness of the third dose campaign which is a marathon and the hardest part will be to pass the winter 2021 milestone. On the other hand, a high coverage with primary series (2 doses) must be achieved to prevent deaths, particularly in low-and middle-income countries where the population remains insufficiently vaccinated (<10%) for many reasons (conflicts, 11. World Health Organization. Framework Goals and Principles at a Glance. 2020. Waning Immunity after the BNT162b2 Vaccine in Israel Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase Duration of Effectiveness of Vaccines Against SARS-CoV-2 Infection and COVID-19 Disease: Results of a Systematic Review and Meta-Regression Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis Myocarditis with COVID-19 mRNA Vaccines Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study Effectiveness of BNT162b2 (Comirnaty, Pfizer-BioNTech) COVID-19 booster vaccine against covid-19 related symptoms in England: test negative case-control study Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and Funding sources: none. Authors' Contributions: BD, GD and DA conceptualized and designed the manuscript, coordinated, drafted the initial manuscript, and reviewed the manuscript.All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.