key: cord-0891574-fa5colwk
authors: Ko, J. Y.; Danielson, M. L.; Town, M.; Derado, G.; Greenland, K. J.; Daily Kirley, P.; Alden, N. B.; Yousey-Hindes, K.; Anderson, E. J.; Ryan, P. A.; Kim, S.; Lynfield, R.; Torres, S. M.; Barney, G. R.; Bennett, N. M.; Sutton, M.; Talbot, H. K.; Hill, M.; Hall, A. J.; Fry, A. M.; Garg, S.; Kim, L.; Group, COVID-NET Investigation
title: Risk Factors for COVID-19-associated hospitalization: COVID-19-Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System
date: 2020-07-29
journal: nan
DOI: 10.1101/2020.07.27.20161810
sha: c2ef4e00f2102cf79a052ff90e988ce653e29139
doc_id: 891574
cord_uid: fa5colwk

Background: Identification of risk factors for COVID-19-associated hospitalization is needed to guide prevention and clinical care. Objective: To examine if age, sex, race/ethnicity, and underlying medical conditions is independently associated with COVID-19-associated hospitalizations. Design: Cross-sectional. Setting: 70 counties within 12 states participating in the Coronavirus Disease 2019-Associated Hospitalization Surveillance Network (COVID-NET) and a population-based sample of non-hospitalized adults residing in the COVID-NET catchment area from the Behavioral Risk Factor Surveillance System. Participants: U.S. community-dwelling adults ([≥]18 years) with laboratory-confirmed COVID-19-associated hospitalizations, March 1- June 23, 2020. Measurements: Adjusted rate ratios (aRR) of hospitalization by age, sex, race/ethnicity and underlying medical conditions (hypertension, coronary artery disease, history of stroke, diabetes, obesity [BMI [≥]30 kg/m2], severe obesity [BMI[≥]40 kg/m2], chronic kidney disease, asthma, and chronic obstructive pulmonary disease). Results: Our sample included 5,416 adults with COVID-19-associated hospitalizations. Adults with (versus without) severe obesity (aRR:4.4; 95%CI: 3.4, 5.7), chronic kidney disease (aRR:4.0; 95%CI: 3.0, 5.2), diabetes (aRR:3.2; 95%CI: 2.5, 4.1), obesity (aRR:2.9; 95%CI: 2.3, 3.5), hypertension (aRR:2.8; 95%CI: 2.3, 3.4), and asthma (aRR:1.4; 95%CI: 1.1, 1.7) had higher rates of hospitalization, after adjusting for age, sex, and race/ethnicity. In models adjusting for the presence of an individual underlying medical condition, higher hospitalization rates were observed for adults [≥]65 years, 45-64 years (versus 18-44 years), males (versus females), and non-Hispanic black and other race/ethnicities (versus non-Hispanic whites). Limitations: Interim analysis limited to hospitalizations with underlying medical condition data. Conclusion: Our findings elucidate groups with higher hospitalization risk that may benefit from targeted preventive and therapeutic interventions.

As of June 26, 2020, over 9 million cases of Coronavirus Disease 2019 , the disease caused by SARS-CoV-2, have been reported worldwide (1); over 2 million cases, including >120,000 deaths, have been reported in the United States (2) . Older age and underlying medical conditions are prevalent among cases (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13) . Based on preliminary estimates, approximately 30% of U.S. laboratory-confirmed COVID-19 cases were among adults aged ≥65 years (7, 8) and about one third had underlying medical conditions (9) .

Among U.S. hospitalized cases, diabetes mellitus (8, 9, 10, 11, 12, 13, 14) , hypertension (10, 11, 12, 13, 14) , cardiovascular disease (8, 9, 10, 14) obesity (10, 11, 13, 14) , and chronic lung disease (8, 9, 10) were common. However, the risk of hospitalization imparted by underlying medical conditions is not clear; many of these conditions, e.g., obesity (15) , hypertension (16), and diabetes (17) , are also prevalent in the general U.S. population.

Similarly, the risk of hospitalization related to sex and race/ethnicity is unclear. An estimated 60% of New York patients hospitalized for COVID-19 were male (11) ; however, other studies have found the male-female distribution among COVID-19 hospitalizations to be similar to the general U.S. population (50%) (10, 18) . Non-Hispanic black adults comprised a greater proportion of hospitalized COVID-19 cases compared to the community population in 14 states (10) and to overall hospitalizations in Georgia (18).

Two studies of communities served by single health care systems in Louisiana (19) and in New York City and Long Island (20) assessed the independent risk for hospitalization among adults who tested positive for SARS-CoV-2 (19, 20) ; however these studies did not account for the underlying distribution of age, sex, race/ethnicity and underlying medical conditions in these communities.

To better understand the independent association of age, sex, race/ethnicity, and underlying medical conditions with COVID-19-associated hospitalization relative to the non-for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

hospitalized community-dwelling population, we calculated rate ratios for adults with and without select underlying medical conditions, adjusted for age, sex, and race/ethnicity, using data from the Coronavirus Disease 2019-Associated Hospitalization Surveillance Network (COVID-NET) and the Behavioral Risk Factor Surveillance System (BRFSS), two large multi-state surveillance systems.

COVID-NET is an all age population-based surveillance system of laboratory-confirmed COVID-19-associated hospitalizations. To be included as a case, patients must have a positive SARS-CoV-2 test no more than 14 days before admission or during hospitalization; be a resident of the pre-identified surveillance catchment area; and be admitted to a hospital where residents of the surveillance catchment area receive care. Medical chart abstractions using a standard case report form are performed by trained surveillance officers to collect additional data such as patient demographics, underlying medical conditions, clinical course, and outcomes data.

Additional COVID-NET details are described elsewhere (10, 21) . This study includes 70 counties in 12 participating states (California, Colorado, Connecticut, Georgia, Maryland, Michigan, Minnesota, New Mexico, New York, Oregon, Tennessee, and Utah).

The BRFSS is a nationwide cross-sectional telephone survey that collects state-based data on health-related risk behaviors, chronic health conditions, and use of preventive services from more than 400,000 community-dwelling adults (≥18 years) each year (22). The BRFSS was used to provide estimates of the non-hospitalized population in the 70 COVID-NET counties included in this study, herein referred to as the COVID-NET catchment area. The percentage of adults with the select underlying medical conditions of interest by demographic subgroup (sex, age group, race/ethnicity group) were calculated from BRFSS respondents residing in the for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . COVID-NET catchment area. These responses were then weighted to the total population at risk for hospitalization residing in the catchment area using an iterative proportional fitting method, which includes categories of age by gender, race and ethnicity groups, education levels, marital status, regions within states, gender by race and ethnicity, telephone source, renter or owner status, and age groups by race and ethnicity to improve the degree and extent to which the BRFSS sample properly reflects the sociodemographic make-up of our geographic area of interest (22). Weights also accounted for survey design, probability of selection, nonresponse bias, and non-coverage error (22). To understand if the prevalence of underlying medical conditions in the COVID-NET catchment area was different from national estimates, nationwide BRFSS data were used. All weighted population estimates were calculated using 2018 BRFSS data for each characteristic and underlying medical condition except hypertension; 2017 was the most recent year of available BRFSS data that included hypertension questions.

To match the population captured by BRFSS, this analysis was restricted to communitydwelling adults (≥ 18 years) residing in the 70 COVID-NET counties in 12 states with available data on underlying medical conditions ( Figure 1 ). As of June 23, 2020, there were a total of 5,715 adult COVID-19-associated hospitalizations eligible for inclusion in our analysis; 5,416 adults had underlying medical condition data and composed the analytic population for this study.

In COVID-NET, the presence of underlying medical conditions was ascertained if the condition (hypertension; history of myocardial infarction, coronary artery disease, coronary artery bypass grafting; stroke; diabetes mellitus; chronic kidney disease; asthma; chronic obstructive pulmonary disease [COPD] ) was present in the patient's medical chart that detailed their COVID-19-associated hospitalization. In BRFSS, underlying medical conditions were for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . based on self-report to the question: "Has a doctor, nurse, or other health professional ever told you that you had… " (high blood pressure; heart attack also called myocardial infarction, angina or coronary heart disease; stroke; diabetes, chronic kidney disease; asthma; COPD, emphysema, or chronic bronchitis).

Histories of myocardial infarction, coronary artery disease, and coronary artery bypass grafting (only available in COVID-NET) were categorized as coronary artery disease. In BRFSS, adults who self-reported having high blood pressure and answered "yes" to the subsequent question "are you currently taking medication for your high blood pressure?" were categorized as having hypertension. In COVID-NET data, body mass index (BMI) was calculated using height and weight listed in medical charts; if these data were not available, recorded BMI was used. In BRFSS, self-reported height and weight were used to calculate BMI. BMI was then categorized as obese (≥30 kg/m 2 ) or severely obese (≥40 kg/m 2 ).

For both COVID-NET and BRFSS data, we created an "any condition" variable (which included presence of history of coronary artery disease; stroke; diabetes; obesity; severe obesity; chronic kidney disease; asthma; COPD) and "number of conditions" variable (0; 1; 2; 3+).

Hypertension was not included in the "any condition" or "number of conditions" variables because COVID-NET catchment estimates for hypertension were derived from 2017 BRFSS estimates and could not be integrated with the other 2018 estimates of underlying medical conditions. Although hypertension is not included in these composite variables, in 2017, 14% of adults with treated hypertension also had at least one other underlying medical condition examined in this analysis. Additional details are available in Supplemental Table 1 . The following categories were defined for age (18-44; 45-64; ≥65 years), sex (male; female), and race/ethnicity (non-Hispanic white; non-Hispanic black; other). Other races and ethnicities besides non-Hispanic white and non-Hispanic were aggregated due to small cell sizes from the for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . COVID-NET catchment area once these data were stratified by age, sex and underlying medical conditions.

Demographic characteristics were tabulated among hospitalized COVID-19 cases overall and by underlying medical condition. The prevalence of select underlying medical conditions was calculated among COVID-19-associated hospitalizations, the COVID-NET catchment area, and nationwide. Unadjusted rate ratios were calculated to compare the relative rates of hospitalization by demographic subgroup or presence of each underlying medical condition. The numerator for each rate was the number of hospitalized adults in each demographic subgroup with or without each underlying medical condition estimated from COVID-NET. The denominator for each rate was the number of adults in each demographic subgroup with or without each underlying medical condition derived from BRFSS estimates for the COVID-NET catchment area. Generalized Poisson regression models with a scaled deviance term to account for overdispersion were used to calculate unadjusted and adjusted rate ratios and 95% confidence intervals (CIs) associated with hospitalization. Multivariable models included an individual underlying medical condition, age, sex, and race/ethnicity. Model goodness of fit was assessed by evaluating standardized deviance residual plots. Rate ratios with 95% CIs that excluded 1 were considered statistically significant. We also assessed the prevalence of co-occurring conditions in hospitalized cases (Supplemental Table 2 ); however, due to the analytic design of this study and small cell counts of BRFSS estimates from the COVID-NET catchment area, we were unable to account for combinations of underlying medical conditions in our adjusted models. Weighted population estimates from BRFSS were calculated using SAS-callable SUDAAN. All other analyses were performed using SAS v.9.4 (SAS Institute, Cary, NC).

No personal identifiers were included in either COVID-NET or BRFSS data submitted to CDC. This analysis was exempt from CDC's Institutional Review Board, as it was considered for use under a CC0 license.

This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . part of public health surveillance and emergency response. Participating sites obtained approval for the COVID-NET surveillance protocol from their respective state and local IRBs, as required.

Of 5,416 community-dwelling adults with COVID-19-associated hospitalization, 30%

were aged 18-44 years, 40% were aged 45-64 years and 31% were aged 65+ years; 53% were male; 34% were non-Hispanic White, 32% were non-Hispanic Black and 34% were of other races/ethnicities (Table 1) . Overall, 55% had obesity, 49% had hypertension, 33% had diabetes, 16% had severe obesity, 13% had asthma, 12% had chronic kidney disease, 9% had a history of coronary artery disease, 6% had COPD, and 4% had a history of stroke. Excluding hypertension, 73% of hospitalized cases had at least one underlying medical condition. Co-occurring underlying medical conditions were common among hospitalized cases (e.g., most adults with coronary artery disease, stroke, diabetes, chronic kidney disease, or COPD also had hypertension) (Supplemental Table 2 ).

Among hospitalized cases, the prevalence of underlying medical conditions was greatest among adults aged 65+ years except for obesity, severe obesity, and asthma (Table 1 ). The prevalence of obesity (63%) and severe obesity (25%) was greatest among adults aged 18-44 years. The prevalence of asthma was similar across all age groups. Males and females had similar prevalences of history of stroke, diabetes, and COPD. The prevalence of underlying medical conditions was highest among non-Hispanic black adults, except for coronary artery disease and COPD.

The overall prevalence of selected underlying medical conditions was greater among hospitalized cases compared to the COVID-NET catchment area population ( Figure 2 ). COVID-NET catchment area estimates were similar or slightly lower than nationwide estimates:

for use under a CC0 license.

This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . hypertension (21% vs. 25%), coronary artery disease (5% vs. 7% ), history of stroke (3% vs. 3%), diabetes (9% vs. 11%), obesity (28% vs. 31%), severe obesity (4% vs 5%), chronic kidney disease (2% vs. 3%), asthma (10% vs. 9%), and COPD (5% vs. 7%).

Unadjusted rate ratios for COVID-19-associated hospitalizations of adults 45-64 years of age and 65 years and older, versus 18-44 years, were 2.0 (95%CI: 1.8, 2.1) and 2.7 (95%CI: 2.5, 2.9), respectively ( Table 2 ). The unadjusted rate ratio for hospitalization comparing males to females was 1.2 (95%CI: 1.1, 1.3) and for non-Hispanic black to non-Hispanic white adults was 3.9 (95%CI: 3.7, 4.2). Adults with, versus without, specified underlying medical conditions had higher rates of hospitalization; unadjusted rate ratios ranged from 1.2 (95%CI: 0.4, 3.8) for COPD to 5.3 (95%CI: 2.4, 12.1) for chronic kidney disease.

The rate ratios for underlying medical conditions attenuated after adjustment for age, sex, and race/ethnicity; except for the rate ratios for severe obesity and asthma which remained stable ( Figure 3 ). After adjustment for age, sex, and race/ethnicity, rate ratios for hospitalization increased with the number of conditions (versus no conditions), with the greatest rate ratio for adults with 3+ conditions (aRR: 5.0; 95%CI:3.9, 6.3) (Supplemental Table 3 ).

Across individual underlying medical condition models, the adjusted rate ratio of hospitalization was significantly higher for adults ≥65 years and 45-64 years (versus 18-44 years), males (versus females), and non-Hispanic black and other race/ethnicities (versus non-Hispanic whites) ( Table 2) . For example, in the severe obesity model, adults ≥65 years (aRR:

for use under a CC0 license.

This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . 4.6; 95%CI: 3.6, 5.9), 45-64 years (aRR: 2.7; 95%CI 2.1, 3.4) versus18-44 years; males versus females (aRR: 1.4; 95%CI: 1.1, 1.7); and non-Hispanic blacks (aRR: 4.7; 95%CI: 3.8, 5.9) and other race/ethnicities (aRR: 3.5; 95%: 2.8, 4.3) versus non-Hispanic whites had higher hospitalization rates. These associations were similar in models adjusting for any condition ( Table 2 ) and number of conditions (Supplemental Table 3 ).

In this study utilizing two large multi-state surveillance systems to compare hospitalized cases with the community at risk, we found that increasing age, male sex, non-Hispanic black race/ethnicity, other race/ethnicities, and select underlying medical conditions were associated with a significantly greater risk for COVID-19-associated hospitalization relative to the nonhospitalized community-dwelling adult population. Among the underlying medical conditions studied, the magnitude of risk was greatest for severe obesity, chronic kidney disease, diabetes, obesity, and hypertension; each of these conditions was independently associated with approximately 3 or more times the risk of hospitalization after accounting for age, sex, and race/ethnicity. Among adults who tested positive for SARS-CoV-2 and sought care at health systems in Louisiana (19) and in New York City and Long Island (20) , chronic kidney disease (20) , obesity (19, 20) , diabetes (20) , and hypertension (20) were also found to be associated with increased odds of hospitalization (adjusted odds ratios ranging from 1.4 to 2.4) after accounting for age, sex, race/ethnicity (19, 20) , and either the Charlson comorbidity index (19) or other select medical conditions (20) . Our study extends the literature by quantifying the independent association of underlying medical conditions with hospitalization relative to the community population at risk.

Similar to other studies (10, 11, 12, 13, 14) , we found that hypertension, obesity, and diabetes were common among COVID-19-associated hospitalizations. In our study, prevalences for use under a CC0 license.

This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . of all select underlying medical conditions was greatest among hospitalized COVID-19 patients compared to the COVID-NET catchment area and nationwide. Similar to nationwide estimates (16, 17), hypertension and diabetes were more common in middle and older aged adults with COVID-19-associated hospitalizations. Obesity was greatest in those 18-44 years old with COVID-19-associated hospitalizations, unlike nationwide estimates of obesity which are relatively similar across age groups (15) . The prevalence of chronic kidney disease among adults with COVID-19-associated hospitalizations was similar to national estimates of chronic kidney disease calculated from albuminuria or serum creatinine measures (23). However, these estimates were higher than self-reported estimates from the COVID-NET catchment area and nationwide derived estimates from BRFSS. This difference may be in part due to medical abstraction vs. self-report ascertainment; an estimated 90% of adults with chronic kidney disease do not know they have it (23).

The magnitude of risk for COVID-19-associated hospitalization was lower for coronary artery disease, stroke, asthma, and COPD than for other medical conditions (e.g., hypertension) in our analysis. Our prevalence estimates of asthma and/or COPD (18%) was similar to a study among adults who tested positive for SARS-CoV-2 (15%), which found that asthma or COPD was not independently associated with risk for hospitalization (20) . However, among hospitalized patients, coronary artery disease and COPD have both been found to be associated with intensive care unit admission, need for mechanical ventilation (24, 25) and mortality (24, 25, 26) .

We found that ages 45-64 years and 65+ years were independently associated with increased risk of hospitalization compared to ages 18-44 years after accounting for underlying medical conditions, sex, and race/ethnicity. Further, the magnitude of risk for hospitalization was greatest among adults 65 years and older, similar to other studies (19, 20) . It is important to note for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . that the additional risk of age 65 years and older, and of age 45-64 years, is relative to younger age (18-44 years) and should not be interpreted as absolute risk.

Males were 30% more likely to be hospitalized than females after accounting for age, race/ethnicity, and underlying medical conditions, similar to another study (20) . Non-biological factors may lead to a greater proportion of males being hospitalized (e.g., increased exposure or delays in care seeking). Biological factors could include immune function suppression by testosterone compared to estrogen (27) or lower expression of angiotensin-converting enzyme 2, a receptor that allows entry of SARS-CoV-2 into host cells, due to estrogen, potentially inhibiting severe clinical progression in females compared to males (28) .

Over-representation of non-Hispanic black adults among hospitalized COVID-19 patients has been hypothesized to be due to the higher prevalence of underlying medical conditions (10, 19) such as hypertension, obesity, diabetes, and chronic kidney disease among the non-Hispanic black population (15, 16, 17, 23) . While these conditions contributed to the total risk, we found that after accounting for underlying medical conditions, age, and sex, non-Hispanic black adults had four times greater risk of hospitalization than non-Hispanic white adults. Additionally, the magnitude of risk was similar across underlying medical conditions (aRR range: 4.0 to 4.7), suggesting that non-Hispanic black adults experience excess risk regardless of select underlying medical conditions. This association was also observed when controlling for the presence of any condition or the number of conditions. Black race was similarly associated with 3 times the risk of hospitalization in an Atlanta-based study (29) . It has been suggested that non-Hispanic black adults might be more likely to be hospitalized due to increased exposures (e.g., related to occupation or housing) that could lead to increased incidence or more severe illness; differences in health care access or utilization; or systemic social inequities, including racism and discrimination (30, 31, 32) . However, we were unable to assess these factors with our data.

for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . These factors may also explain similar findings of increased risk for hospitalization among other race/ethnicities.

Overall, these results have implications for clinical practice, as they identify high-risk patients who require closer monitoring and management of their chronic conditions during the ongoing COVID-19 pandemic. While specific underlying medical conditions studied imparted higher risk of hospitalization, we were unable to account for the duration of each condition or the degree to which each condition was controlled (e.g., glycemic control in diabetic patients).

Nevertheless, clinicians might prioritize more aggressive control of underlying conditions with available treatments and encourage their patients to remain engaged in care for management of their chronic conditions while practicing preventive measures, such as wearing a cloth face covering and social distancing. These groups may also benefit from targeted preventative and therapeutic interventions.

This study has several limitations. First, this analysis is based on data as of June 23, 2020 from COVID-NET, a surveillance system designed first to provide hospitalization rates.

Additional data such as underlying medical conditions is reliant on medical chart abstraction; approximately 60% of the total hospitalized cases have yet to be abstracted for underlying medical condition. Thus, included cases represent a convenience sample of hospitalizations with underlying medical conditions, which may have resulted in biased estimates of risk. However, bi-weekly updates of this analysis over a 2-month period with the most recently available COVID-NET data (i.e., additional chart abstractions) suggests consistent estimates of the frequency and distribution of underlying conditions and resulting rate ratios. Second, these data did not include institutionalized adults. Third, estimates of risk are restricted to the COVID-NET catchment area; the interpretation of rate ratios as risk in this analysis assumes that risk of SARS-CoV-2 infection is consistent across all groups. Fourth, we were unable to assess the association for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . of more granular race/ethnicity categories or co-occurring underlying health conditions due to small cell sizes from the COVID-NET catchment area; further investigation on both aspects is important. Fifth, COVID-NET likely under-ascertains COVID-19 cases as testing for SARS-CoV-2 is performed at treating health care providers' discretion and is subject to clinician bias as well as variability in testing practices and capabilities across providers and facilities. However, this probably had minimal impact on our findings as hospitalized individuals are more likely to be tested than those in the community. Finally, we used BRFSS to obtain estimates for underlying medical conditions in the COVID-NET catchment area. As the ascertainment of underlying medical conditions was different across the two data systems (self-report vs. medical chart abstraction), we may have introduced bias in the rate ratio estimation. Self-reported diabetes (33) and hypertension (34) have high correlation with medical examination estimates.

Self-report has been found to underestimate prevalence of chronic kidney disease (23) and obesity (34); thus, our rate ratios for these conditions may be overestimated.

This analysis quantifies associations of age, sex, race/ethnicity, and underlying medical conditions with risk of COVID-19 hospitalization relative to the non-hospitalized communitydwelling population. These data may aid clinicians in identifying individuals at higher risk for hospitalization who may require more vigilant care and monitoring, and groups that may benefit from preventive and therapeutic interventions.

for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . https://doi.org/10.1101/2020.07.27.20161810 doi: medRxiv preprint for use under a CC0 license.

This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. . †197 hospitalizations missing race/ethnicity information; Other race/ethnicity includes Alaskan Native/American Indian, Asian/Pacific Islander, Hispanic or Latino, multiple races ‡Variables with missing observations: Hypertension (n=8; 0.1%); Coronary Artery Disease (n=11; 0.2%), History of Stroke (n=11; 0.2%), Diabetes (n=14; 0.3%), Obesity (n=518; 10%), Severe Obesity (n=518; 10%), Chronic Kidney Disease (n=16; 0.3%), Asthma (n=12; 0.2%), COPD (n=12; 0.2%) § Data suppressed due to small cell sizes ||Any underlying medical condition excludes hypertension to align with 2018 BRFSS community estimates of underlying medical conditions; the most recent year of available BRFSS data for hypertension was 2017.

for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020.

. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. Adjusted Rate Ratios and 95% Confidence Intervals for use under a CC0 license. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted July 29, 2020. 

US Department of Health and Human Services, CDC; 2020

Clinical Characteristics of Coronavirus Disease 2019 in China

Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

COVID-19 Surveillance Group. Characteristics of COVID-19 patients dying in Italy: report based on available data on

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Severe outcomes among patients with coronavirus disease 2019 (COVID-19)-United States

Coronavirus Disease 2019 Case Surveillance -United States

Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 -United States

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 -COVID-NET, 14 States

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

Hospitalized patients with COVID-19 in

Prevalence of Self-Reported Hypertension and Antihypertensive Medication Use Among Adults -United States

Characteristics and Clinical Outcomes of Adult Patients Hospitalized with COVID-19 -Georgia

Hospitalization and Mortality among Black Patients and White Patients with Covid-19

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

Risk Factors for Intensive Care Unit Admission and Inhospital Mortality among Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)

Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID-19)

Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us

Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis D

Characteristics Associated with Hospitalization Among Patients with COVID-19

Variation in COVID-19 Hospitalizations and Deaths Across New York City Boroughs

COVID-19 and African Americans

Sharpening the global focus on ethnicity and race in the time of COVID-19

Validity and Reliability of Self-reported Diabetes in the Atherosclerosis Risk in Communities Study