key: cord-0893488-c6ms9zxa authors: nan title: Flavia Carriero, Laura Cortese, Valentina Rubino, Anna Teresa Palatucci, Angela Giovazzino, Giuseppina Ruggiero, Diego Piantedosi, Nadia Musco, Pietro Lombardi and Giuseppe Terrazzano: An Open Question in the COVID-19 Pandemic: Can Humans Transmit the Disease to Pets and Vice Versa? date: 2021-06-22 journal: J Comp Pathol DOI: 10.1016/j.jcpa.2021.05.008 sha: 8cc4bcdd431b08dc552ba2ac26f89d4745051cfb doc_id: 893488 cord_uid: c6ms9zxa nan SARS-CoV-2 infection apparently emerged in China in December 2019, causing the disease known as COVID-19, which can cause severe damage to vital organs (Ackermann et al, 2020) . Spillover of SARS-CoV-2 from bats to humans has been hypothesized (Ackermann et al, 2020) . The virus spike protein is the main determinant of viral tropism because it is responsible for binding to the angiotensin converting enzyme 2 (ACE2) and subsequent entry of SARS-CoV-2 to host cells in humans and several animal species (Sun et al, 2020) . Therefore, it is reasonable to hypothesize that the spike proteineACE2 receptor complex may represent evolutionary exploitation to overcome species barriers to infection, thus highlighting the zoonotic origin and transmission of the virus. SARS-CoV-2 infection mainly affects the human respiratory system following airborne transmission. The virus has also been detected in pet animals, perhaps due to their proximity to humans in the home environment, and particularly in regions of the world with higher rates of spread of this coronavirus among humans (de Morais et al, 2020). Therefore, it appears likely that pets may have received SARS-CoV-2 from their owners by airborne transmission. Other animals within the human environment, such as farmed mink, have also been reported to have been infected with SARS-CoV-2 (Shi et al, 2020) . A genomic sequencing study of mink and mink farm workers concluded that SARS-CoV-2 was initially introduced by humans and subsequently genetically evolved, resulting in widespread circulation among mink (Oude Munnink et al, 2021) . Interestingly, this study showed that some workers had become infected with SARS-CoV-2 variants with an animal sequence signature, which provides potential evidence of animal-to-human transmission of SARS-CoV-2 on mink farms. It seems reasonable to speculate that the infection of new animal species with SARS-CoV-2 represents an opportunity for this coronavirus to mutate in the novel host. Probably, when the animal population density is high, SARS-CoV-2 could evolve rapidly and even spread from animals to humans. Since intraand trans-species spread of SARS-CoV-2 appears likely, animal infection should be considered of epidemiological significance in the control of the COVID-19 pandemic (de Morais et al, 2020; Sun et al, 2020) . Humans are more likely to infect, or become infected by other humans, due to their lifestyle habits. Hence, humans may carry SARS-CoV-2 into the home environment and infect their pets. On the contrary, it appears likley that pets very rarely spread SARS-CoV-2 to other animals, because they usually do not live in communities and therefore lack the opportunities for spreading the virus that humans have (eg, work, school, university, shopping, cinema and other social environments). However, companion animals can become infected by their owners. Although it can be reasonably hypothesized that the risk of SARS-Cov-2 transmission from domestic animals to humans is very low or rare, it is essential to consider such a possibility in order to adopt the most appropriate epidemiological and preventive approaches, and to understand the infectivity profile of owners in terms of SARS-CoV-2 variants. Therefore, testing of symptomatic and asymptomatic pets living in proximity to social or work environments, where human COVID-19 cases have been identified, could be a rational preventive practice. While waiting to understand the actual extent of potential transmission of SARS-CoV-2 between pets and humans, we should plan to protect companion animals from SARS-CoV-2 infection. In this context, consideration should be given to designing effective animal vaccines, since a global herd immunity for all susceptible domestic animal species will presumably be important to minimize trans-species transmission. Flavia Carriero, Angela Giovazzino, Valentina Rubino and Giuseppina Ruggiero are immunologists at the Department of Translational Medical Sciences, University of Napoli Federico II, Napoli; Anna Teresa Palatucci and Giuseppe Terrazzano are immunologists at the Department of Science, University of Basilicata, Potenza; Laura Cortese, Pietro Lombardi, Nadia Musco and Diego Piantedosi are scientists involved in veterinary clinical practice and research at the Department of Veterinary Medicine and Animal Production, University of Napoli Federico II, Napoli, Italy: giuseppe. terrazzano@unibas.it. Natural infection by SARS-CoV-2 in companion animals: a review of case reports and current evidence of their role in the epidemiology of COVID-19 Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 COVID-19: epidemiology, evolution, and cross-disciplinary perspectives