key: cord-0893742-wagdvoag
authors: Schønning, Viktor; Dovran, Anders; Hysing, Mari; Hafstad, Gertrud Sofie; Stokke, Kristin; Aarø, Leif Edvard; Tobiassen, Stian; Jonassen, John Are Bjerge; Vedaa, Øystein; Sivertsen, Børge
title: Study protocol: the Norwegian Triple-S Cohort Study - establishing a longitudinal health survey of children and adolescents with experiences of maltreatment
date: 2021-06-05
journal: BMC Public Health
DOI: 10.1186/s12889-021-11125-9
sha: ecebe42ecf5412b1ef59f7282aa6c3b2eac946a2
doc_id: 893742
cord_uid: wagdvoag

BACKGROUND: Child maltreatment is prevalent and associated with both short- and long-term health problems. Previous studies have established child maltreatment as a risk factor for a wide range of problems over the life course such as mental- and somatic health problems, self-harm, alcohol- and drug abuse and decreased work-life participation. Still, there are few large and well-conducted longitudinal studies focusing on describing prevalence and identifying risk factors and long-term consequences of child maltreatment. The purpose of the current study is to recruit a large number of children and adolescents exposed to maltreatment and follow them long-term. METHODS/DESIGN: The current study is a longitudinal cohort study and will use a multi-informant design (child/adolescent, caregiver, and administrative data). Participants will be recruited from the Stine Sofie Centre (SSC), a learning and coping centre for children and adolescents (≤18 years) exposed to maltreatment, which includes physical and emotional abuse, neglect and/or sexual abuse. Questionnaire-based assessments from self-reports (as well as parent-reports) will be carried out at regular time intervals throughout their lives, on topics such as abuse, negative life events, mental and somatic health problems, resilience and coping, satisfaction with health services, social-, family-, and school function, as well as self-harm and substance abuse. Participants will be assessed upon entry to the centre and followed up annually until they reach 18 years and bi-annually after. Given written consent, participants’ responses will be linked to relevant national registries in order to examine predictive factors and important outcomes in terms of subsequent health, education, criminal records and work affiliation. DISCUSSION: This study will examine short- and long-term consequences of child maltreatment across a range of health-related outcomes in a longitudinal perspective. Results from the current study might have implications for the development of preventive and intervention programs related to child maltreatment and the organization and follow-up of the services these children receive. The current study will hopefully contribute with knowledge of risk-factors, short- and long-term health-related and other issues that can contribute to practices aimed at improving the overall life-course for children and adolescents who have experienced childhood maltreatment.

Discussion: This study will examine short-and long-term consequences of child maltreatment across a range of health-related outcomes in a longitudinal perspective. Results from the current study might have implications for the development of preventive and intervention programs related to child maltreatment and the organization and follow-up of the services these children receive. The current study will hopefully contribute with knowledge of riskfactors, short-and long-term health-related and other issues that can contribute to practices aimed at improving the overall life-course for children and adolescents who have experienced childhood maltreatment.

Keywords: Protocol, Childhood maltreatment, Adverse childhood experiences, Abuse, Adolescence, Longitudinal, Epidemiology, Mental health Background Child maltreatment is a global problem and associated with major long-term consequences. Child maltreatment includes all types of physical and/or emotional illtreatment, sexual abuse and neglect which occur in the context of a relationship of responsibility, trust or power, and which result in actual or potential harm to children's health, survival, development or dignity [1] . Exposure to childhood maltreatment is common, with prevalence rates varying across the different types of maltreatment [2, 3] . A review from 2009 estimated that in industrialized countries, 4-16% of children had been physically abused, 10% had been psychologically abused, while 5-10% had been sexually abused [4] . A review of a series of meta-analyses on global child maltreatment estimated prevalence rates of 13% for sexual abuse, 23% for physical abuse, 36% for emotional abuse, 16% for physical neglect and 18% for emotional neglect from self-report studies assessing maltreatment during childhood [5] . In contrast, a recent Norwegian study of the general adolescent population found that 19% had experienced some form of physical abuse (including mild and severe violence), 6% had experienced sexual abuse from adults, while 22% had experienced some form of sexual abuse from peers [6] .

Childhood maltreatment is associated with several adverse and potential life-long health consequences [7] [8] [9] [10] . Children and adolescents exposed to maltreatment have increased risk of later mental and somatic health problems and disorders [9, [11] [12] [13] and subsequent revictimization later in life [14] . Exposure to one type of maltreatment also increases the risk of polyvictimization [2, [14] [15] [16] [17] . However, as emphasized by Kessler et al. [9] , there is a lack of studies exploring potential mechanisms that could help explain these associations, and they advised that future studies should explore and identify mediators, modifiers and developmental sequences that might be of importance. A similar conclusion was drawn in a prospective study, where children with a history of sexual abuse developed more externalizing and internalizing problems in adolescence [18] . The authors of that study also emphasized the need for future studies to examine both mechanisms and possible gender differences in this age cohort [18] .

Lower socioeconomic status (SES) is associated with both increased exposure and reduced resources to cope with the stressors [19] , and higher SES has been found to have a protective effect on the health outcomes of childhood maltreatment [20] . However, the association between SES and childhood maltreatment is complex, and more research has been called for to further disentangle the mechanisms involved in this association [20] .

Given that childhood maltreatment is believed to be among the most potent risk factors for poor health and reduced daily functioning [4] , there are surprisingly few large and well-conducted studies focusing on identifying both risk factors, and long-term consequences of the specific types of childhood maltreatment. This leaves an inadequate knowledge base for developing effective interventions. A meta-analysis from 2017 stated that future studies would benefit from designs that allow stronger causal inference and control for factors that attenuate or amplify observed relations [21] . The traditional means of data collection to examine these issues are population-based health surveys, which are well-suited to establish prevalence estimates but rarely offer the opportunity to include many participants exposed to childhood maltreatment. Few studies to date have recruited a large number of children and adolescents with experiences of childhood maltreatment and followed them long-term, while identifying risk factors and subsequent health outcomes. Detailed knowledge of specific mechanisms and developmental trajectories of children exposed to maltreatment is pivotal to improve prevention of child maltreatment. The World Health Organization recently identified several gaps in this research field [22] , highlighting the need to identify both risk-and protective factors, help-seeking behaviors, long-term impact, and nuanced knowledge of different service needs across gender, ethnicity, sexual orientation, disability and socioeconomic status [22] . The importance of studies with longitudinal and prospective research designs, and the importance of accounting for pre-existing vulnerabilities has also been emphasized as a future research need [23] .

The main aim of the project is to establish a longitudinal health cohort of children and adolescents with experiences of maltreatment, as well as their close family members. The abbreviation "Triple-S" originates from the Norwegian name of the Stine Sofie Centre, "Stine Sofie senteret". The goal of the Norwegian Triple-S Cohort Study (Triple-S study) is to carry out data collections annually/biannually from children with experiences of maltreatment and their families (i.e., multi-informant design), and subsequently to link this information to official data from national registries on health, education, and work affiliation (among others). This will provide new knowledge on predictors and short-and long-term consequences of childhood maltreatment, and contribute to providing a scientific basis for policymaking, program planning and targeting service delivery. The project will also aim to identify mediators and modifiers to help explain the documented associations between childhood maltreatment and health-outcomes and compare to other relevant populations.

A longitudinal multi-informant cohort study on children and adolescents exposed to maltreatment, as well as their parents or legal guardian.

The SSC is run by The Stine Sofie Foundation (SSF) and was founded in 2000 after the Baneheia murders where 10-year-old Lena Sløgedal Paulsen and 8-year-old Stine Sofie Sørstrønen were raped and murdered. The SSF has since its establishment worked to strengthen the legal security of maltreated children/adolescents and their relatives, and for the prevention of child maltreatment. In 2016 the SSF established one of the world's first learning and coping centres for children and adolescents exposed to physical and emotional abuse, neglect and/or sexual abuse, the SSC, with financial support from the Norwegian government [24] . Children or adolescents who have been victims of either physical or psychological violence, sexual abuse or who have witnessed domestic violenceand have this confirmed by their primary physician, Child Welfare Services or other officialsare eligible course participants at the SSC. The children/families must complete an application for a place at the SSC before they are admitted as course participants.

The main aim of a stay at the centre is to help the child or adolescent with the recovery process from their maltreatment experience. This is done by strengthening the child's resilience to stress, where learning, copingfocused activities and positive experiences are pivotal. Children and adolescents who attend the centre receive ability-and age-appropriate teaching about brain functioning, ways of reacting and different techniques for emotional regulation. Throughout the stay, the participants are given the opportunity to challenge themselves both physically and creatively through tailored activities. The teaching takes place in small, short sequences, where visual aids such as videos, music, relaxation exercises, plays and outdoor excursions are used to reinforce the experience of learning in a non-judgmental and safe environment. The program is playful and positively charged, with a focus on coping-ability. A fundamental element is that all teaching and other activities at the SSC should be transferable to the home situation and help the children handle future difficulties. Currently, very few similar public or private services that cover all the needs demanded by this cohort exists. This is in sharp contrast to both the high incidence of violence and abuse against children, as well as the extent of the well-documented harmful effects.

The number of children and adolescents visiting the SSC has steadily increased over the last few years, and in 2019 more than 500 children and their caregivers stayed at the centre. It is estimated that this annual figure will continue to increase to approximately 700 children and their caregivers per year. As such, we aim to include around 2500 children and their caregivers for the present study during the recruitment phase. The recruitment phase commenced in January 2021. The number of families staying at the SSC has been downscaled because of restrictions related to the COVID-19 pandemic. As a result of this, the recruitment phase will be extended until we reach our aim of 2500 children and caregivers. The age distribution of participants at the SSC in 2016-2020 was 30% from 0 to 7 years, 40% from 8 to 11 years and 30% from 12 to 18 years. We estimate that the age distribution of recruited participants will be similar to prior years.

The SSC has a follow-up team which provides support and help for all former participants at the SSC. During the last 2 years, the follow-up team has supported over 50% of the participating families on the families' request. There is also an app named "My Stay" where the participants' can access course materials from the SSC.

All children and adolescents aged 5 to 18 years and their caregivers that have been approved for a stay at the SSC will be invited to participate in the study. Each potential participant will be personally invited when they are admitted as course participants prior to their arrival at the SSC. When the children and caregivers arrive at the SSC, ageappropriate written information about the project will be given by personnel at the SSC. Researchers and health personnel are available for further questions regarding participation. To avoid a feeling of coercion, children and families at the SSC are informed that participation in the study does not affect their stay at the SSC.

The current study is a longitudinal cohort study and will use a multi-informant design (child/adolescent, caregivers, and administrative information). We will cover several domains, including mental and physical health, resilience, adverse life events, and functioning (social, family, school, etc.). Administrative data on referral information and background information will also be collected. The first data collection will be conducted using tablets on a secure web-based platform during the participants' stay at the SSC. Subsequent data collections will be conducted annually until the participants turn 18 years, and then bi-annually, using the same secure web-based platform. Table 1 provides details of the planned assessments. The assessment batteries will include a combination of both questionnaires used in other large Norwegian epidemiological surveys (e.g. the Norwegian mother and child cohort study [46] , the Bergen Child Study [47] , and the Norwegian youth study on child maltreatment (the UEVO study) [6] ) to enable comparisons on key variables with age-matched peers, as well as questionnaires specifically relevant for this particular cohort. Data from the three mentioned epidemiological surveys will be used for comparisons on selected variables. Table 1 outlines an overview of key instruments to be included in the project. Note that this is not an exhaustive list of all included questionnaires and items. The participants will receive age-appropriate questionnaires, with adolescents from 12 to 18 years providing information through self-report and caregivers providing information on children from 5 to 11 years. Caregivers for adolescents from 12 to 18 years will provide information on their own mental and physical health, life events, drug use and functioning, in addition to some parentreported information on the adolescents. All caregivers will provide information of themselves.

Our aim is to include collection of biological material at a later time, to allow the examination of genetic work-up and neurobiology markers. At the current moment we do not have sufficient funding or ethical clearance to include these analyses.

The project will also allow linkages to several national registries in order to examine both predictive factors as well as to investigate important outcomes such as subsequent health, education, and work affiliation. The linkages to the national registries have been approved by the Regional Committees for Medical and Health Research Ethics. We have also conducted a Data Protection Impact Assessment which describes the handling of personal information. Table 2 provides an overview of planned linkages to possible registries.

The project will be a joint effort between the SSF and the Norwegian Institute of Public Health (NIPH). The initial funding is from the SSF the first 5 years (from Oct 1st, 2019 to Sept 30th, 2024), and we will apply for additional funding to ensure the continued activity of the project. The NIPH will be the responsible research institution and will collaborate closely with researchers from the SSC, the University of Bergen, the University of Agder, and the Norwegian Centre for Violence and Traumatic Stress Studies.

All parts of the project, including the planning of research questions, selection of questionnaires, collection of data, as well as utilization of data and findings, are conducted in close collaboration with the Triple-S study steering committee. The project group will routinely meet with the Triple-S study steering committee to discuss relevant aspects of this research. To ensure user involvement, a representative from the National Association for Child Welfare-Children will serve as an active member of the external work group. This is a user organization, and the representative has participated in a project seminar and provided feedback and input on study design and choice of questionnaires. Multilayered user involvement will be ensured by inviting representatives from involved families/ project participants to attend project seminars. Prior to commencing data collection, we conducted pilot-tests of the questionnaires, followed by focus-group discussions among user groups of children, adolescents and caregivers. In the focus group discussions, participants' gave feedback on study design, choice of questionnaire instruments and scales, and practical solutions which led to several changes in important aspects of the study. Furthermore, in this research project, it is seen as important that the child rights perspective is recognized, and the users involved at all levels and in all stages.

The study protocol has been approved by the Regional Committee for Ethics in Medical and Health Research in the south-eastern region of Norway (#95445). If participants wish to participate, children and adolescents from 12 to 18 years will be invited to provide an electronic consent. In Norway, adolescents from 12 years of age are allowed to independently provide a written consent to participation in health research when the topic of research is abuse, domestic violence or other issues where there might be a conflict of interest between child and parent, and the parent might have an interest in denying X X X Self-harm and suicidality is measured by CASE [39] . X X X X Resilience is measured by the Resilience Scale for Adolescents [40] .

X X ADHD ADHD symptoms is assessed using the Swanson, Nolan and Pelham Questionnaire (SNAP-IV) [41] .

X X ADHD symptoms is assessed using the Adult ADHD Self Report Scale (ASRS) [42] .

Help-seeking behavior is assessed by history and satisfaction with contact with health-care institutions. If X X X their child to participate in the study. For children between 5 and 11 years, legal guardians (parent, foster parent or other) will provide written consent as required by law. Adult caregivers will provide written consent on their own behalf. Participants must provide their unique national personal identification number when consenting to participate. The consent form includes two separate voluntary consents: 1) participation in the main survey, and 2) for linking their data from the survey to external registries. MBRN is a national health registry containing information about all births in Norway. The registry has been widely used to identify causes and consequences of health problems related to pregnancy and birth. The MBRN also includes information about maternal health before and during pregnancy.

The KUHR/KPR database The KUHR database is owned by the Norwegian Directorate of Health, and includes data on reimbursement to GPs for the health care service they provided to primary health care service users. The report sent by each GP contains detailed information about the diagnosis and treatment.

The NorPD monitors drugs dispensed by prescription in Norway, and contains data on all prescriptions, including type of medication (ATC-code), and dosage. All pharmacies in Norway register prescriptions electronically, and the information is sent in monthly reports to NorPD.

The NPR is a comprehensive registry of inpatient and outpatient hospital care in Norway. The registry contains detailed data on each individual's history of diagnose(s) and treatments from the high school years throughout his/her college/university education. Project management will receive the written consent directly without passing through health personnel at the SSC. For participants that have experienced maltreatment, questions on these sensitive subjects might be uncomfortable and difficult to answer. The current questionnaire can potentially be experienced as burdensome for the participants as the questions include personal subjects such as abuse, self-harm and mental health. We have conducted a pilot of the questionnaire with participants at the SSC and the overall feedback was that the sensitive nature of the questions were not experienced as particularly bothersome. The time to complete the questionnaire varied from 20 to 55 min across the age groups. To ensure adequate care for participants during the data collection, personnel from the SSC will be present during the first data collection and available via telephone during all later data collections to participants in need of support or debriefing. All collected data will be handled according to the newly adopted General Data Protection Regulation.

Participants' are informed that personnel at the SSC do not have the possibility to view their questionnaire data, and if they experience any immediate issues that will require involvement, they will have to contact the personnel directly. If any criminal incidents are discovered at the SSC, the relevant authorities will be contacted immediately according to national laws.

In addition to the specific focus of the potential individual studies, the design permits a comprehensive exploration of many critical issues in the field of child maltreatment on a sample comprising both children and parents of sufficient size for the most central purposes. Dimensionality and psychometric properties (including internal consistency) of scales will be examined. Depending on the purpose, sum scores or mean scores will be constructed or we will use latent variable approaches. In both of these cases, various forms of structural equation modeling will be applied. Since the project is based on a prospective longitudinal design (panel data), we will also use statistical tools such as growth curve modeling and state of the art approaches to cross-lagged analyses. This will allow us to investigate on possible causal processes. For handling data, for descriptive (frequency tables, means) and for statistical analyses like exploratory factor analysis, GLM and logistic regression analyses, STATA will be applied. When using structural equation modeling with latent variables we will use Mplus in addition to R-based Lavaan. Other statistical tools will be applied when deemed adequate. We have planned comparative data collections, in order to examine differences between our study population that has been subjected to maltreatment and general population samples across a wide range of health-related outcomes.

We aim to recruit participants over at least a 5-year time period, and based on the number of annual participants at the SSC (currently approx. 700) we aim to recruit 2500 children and adolescents. This number is estimated to be adequate to examine our main research questions. Providing statistical power analyses for each of the large number of possible research questions in this study is not possible. However, some indication of the level of statistical power can be provided. With a sample size as large as 2500 a 95% confidence interval (C.I.) for a 50% proportion is +/− 1.98% and of course smaller for proportions smaller or larger than 50%. As the current study population is highly selected, we expect most of the phenomena we wish to study to be sufficiently prevalent. When estimating proportions for subgroups as small as 10% of the sample (n = 250), the 95% C.I. for a 50% proportion is +/− 6.37%. The corresponding C.I.s for the mean of a metric variable are +/− 0.04 standard deviations (n = 2500) and 0.12 standard deviations (n = 250). Phrased slightly differently; with a significance level of 5%, statistical power of .80 and testing a 10percentage points difference between two proportions (55% versus 45%), the number of observations needed in each group is 392. In the context of latent variables and structural equation modeling, and even multiple linear regression analysis, samples as large as 1000 to 2500 are considered more than sufficient for most purposes. In a multiple linear regression analysis with 8 predictors, R square equal to 0.10, significance level of .05 and a sample size of only 150, the statistical power is as high as .82. In a study as broad and multi-faceted as the present one, new hypotheses and models to be examined will develop as the study unfolds. The larger sample, the more complex models involving various combinations of predictors, covariates, mediators and moderators can be examined, and the smaller subgroups can be subject to statistical analyses. An even larger sample could have permitted testing of more complex models and provided opportunities to examine even smaller subgroups. Availability of participants and time constraints prevent further expansion of the study sample.

With the current study we aim to gain knowledge and insight into the consequences of child maltreatment on a wide range of health-related outcomes. The longitudinal, multi-informant design and linkage to national registries allows examination of a wide range of research questions and relationships among variables. We will assess caregivers' health and maltreatment history, and thus examine inter-generational factors possibly contributing to childhood maltreatment, and children and adolescents' subsequent health. Experiencing childhood maltreatment has been found to be a robust predictor of subsequent revictimization, and the linkage to national registries and long-term follow up allows us to examine the frequency and severity of revictimization for individuals exposed to maltreatment in childhood [14] . An important issue for studies focusing on childhood maltreatment is being able to separate different kinds of maltreatment and their associated outcomes. Polyvictimization is common for this population, and there may be some challenges in separating which outcomes are related to which type of abuse in the situations where a participant has experienced poly-victimization. To meet this challenge we will analyze exposure to maltreatment using a cumulative and a dimensional approach [48] . We have also included a detailed assessment of the different kinds of maltreatment, including a timeline of the type of abuse, the number of times the abuse has happened and the participants' relation to the abuser. The questionnaire assesses physical-, sexual-, and emotional abuse, physical-and emotional neglect and witness to violence.

Identifying mediators, moderators and important developmental sequences is a focus in the current study, to be able to explain the documented associations between childhood maltreatment and later unfavorable health outcomes [9] . Some of the moderators we will examine are socio-economic status, gender, social support and follow-up by health care personnel, including the timing of receiving health care. These moderators are likely to be of importance, and have been found to moderate the association between maltreatment and negative health consequences [49] . The mediators of interests will be specific to the research question of the specific study. However, some prior research has identified life satisfaction [50] , interpersonal difficulties [51] and coping mechanisms [51] as possible mediators of the association between maltreatment and later depressive symptoms and emotional distress. These are examples of potential mediators we assess in the current study and have the possibility to include in sub-projects. We also wish to study the importance of developmental sequences and examine how children are affected by maltreatment at an early age (5-11 years) compared to during puberty or late-adolescence.

Even though the participants' stay at the SSC is not considered treatment, they may receive a boost to resilience during the visit and no longer be completely representative of most maltreated children. Any improvement to participants' resilience will most likely not have occurred at the time of the baseline data collection. Still, we cannot disregard the possibility that some participants' may experience long-term improvements in their resilience as a result of their stay at the SSC. To control for this possibility, we will compare our findings with similar data from three other studies, including the UEVO-study [6] which recruited 9240 adolescents from the general population, assessing maltreatment history in detail. The UEVO-study will provide important comparative data to help illuminate any differences between the general population and participants at the SSC.

Hopefully, the Triple-S study will help shed light on some of the unmet needs of children and adolescents experiencing maltreatment. Our aim is that results from the current project will help improve prevention of childhood abuse, treatment and overall life-course for children and adolescents who experience childhood maltreatment.

There are some challenges to the current study. Response rates tend to be low in health surveys, particularly over telephone or mail. As the participants are attending the SSC while answering the initial questionnaire we expect the response rate to be higher than usual for this population [52] . A comparable study, the UEVO study, delivered questionnaires with researchers physically present and obtained a response rate of 86%, which we believe is attainable [6] . The recruitment phase for the Triple-S study started in January 2021, and currently, our response rate is approximately 85%. Another possible limitation is that that children and adolescents who apply to and visit the centre might represent a selected and more resourceful group as compared to the entire population who experience maltreatment. However, 60-70% of the referrals received by the SSC comes from the child protection services and outpatient clinics, suggesting that the population at the SSC represents children and caregivers that really are in need of help and not necessarily more resourceful than others that experience childhood maltreatment. The current study mostly relies on self-report and parent-report data with its inherent limitations. However, we will also utilize supplemental administrative information which can provide more objective data than self-report as well as linkages to more objective registry data. A strength of the study is the planned utilization of registries which will provide antecedent and prospective information that allows long-term follow-up. More objective forms of data collection has been highlighted as needed in the research field of child maltreatment [23] . As in any longitudinal study there is the risk of drop-out. However, former data collections at the SSC suggests that the user group shows commitment to participate in studies on the subject matter. Preferred measures to decrease drop-out in a longitudinal perspective have been discussed through pilot testing and focus-group interviews with the user group. 

Child maltreatment: The World Health Organization

Traumatic events and posttraumatic stress in childhood

Trauma exposure and posttraumatic stress disorder in a national sample of adolescents

Burden and consequences of child maltreatment in high-income countries

The prevalence of child maltreatment across the globe: review of a series of meta-analyses

Cohort profile: Norwegian youth study on child maltreatment (the UEVO study)

The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes

Association of childhood trauma exposure with adult psychiatric disorders and functional outcomes

Childhood adversities and adult psychopathology in the WHO world mental health surveys

Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study

Timing and chronicity of child neglect and substance use in early adulthood

Correlates of suicidal ideation and self-harm in early childhood in a cohort at risk for child abuse and neglect

Long-term physical health consequences of adverse childhood experiences

Associations between adverse childhood experiences and adversities later in life. Survey data from a high-risk Norwegian sample

Poly-victimization: a neglected component in child victimization

Assessment of the harmful psychiatric and behavioral effects of different forms of child maltreatment

Poly-victimization in a national sample of children and youth

Does the impact of child sexual abuse differ from maltreated but non-sexually abused children? A prospective examination of the impact of child sexual abuse on internalizing and externalizing behavior problems

A revised inventory of adverse childhood experiences

Household and community-level adverse childhood experiences and adult health outcomes in a diverse urban population

The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis

World Health Organization. Responding to children and adolescents who have been sexually abused: WHO clinical guidelines

Annual research review: rethinking childhood trauma-new research directions for measurement, study design and analytical strategies

International development and psychometric properties of the child and adolescent trauma screen (CATS)

Childhood trauma questionnaire. Assessment of family violence: A handbook for researchers and practitioners

The juvenile victimization questionnaire: reliability, validity, and national norms

Violence against children in Sweden 2016. The Children's Welfare Foundation

Cohort profile: the HUNT study, Norway

The somatic symptom scale-8 (SSS-8): a brief measure of somatic symptom burden

Diagnostic and statistical manual of mental disorders (DSM-5®): American psychiatric pub

The Hopkins symptom checklist (HSCL): a self-report symptom inventory

Psychometric properties of the strength and difficulties questionnaire from five European countries

A rating scale for disruptive behavior disorders, based on the DSM-IV item pool

The appetitive aggression scale-development of an instrument for the assessment of human's attraction to violence

The DISC predictive scales (DPS): efficiently screening for diagnoses

The satisfaction with life scale

Symptoms of depression as reported by Norwegian adolescents on the short mood and feelings questionnaire

The chronological assessment of suicide events: a practical interviewing strategy for the elicitation of suicidal ideation

A validation study of the resilience scale for adolescents (READ)

Parent and teacher SNAP-IV ratings of attention deficit hyperactivity disorder symptoms: psychometric properties and normative ratings from a school district sample

The World Health Organization adult ADHD self-report scale (ASRS): a short screening scale for use in the general population

A short scale for measuring loneliness in large surveys: results from two population-based studies

A review of the psychometric properties of the CRAFFT instrument: 1999-2010

Psychometric properties of the Alabama parenting questionnaire

Cohort profile: the Norwegian mother and child cohort study (MoBa)

Socioeconomic status and children's mental health: results from the Bergen child study

Beyond cumulative risk: a dimensional approach to childhood adversity

The moderating effects of sex on consequences of childhood maltreatment: from clinical studies to animal models

Life satisfaction mediates the association between childhood maltreatment and depressive symptoms: a study in a sample of Brazilian adolescents

Mediators of the link between childhood sexual abuse and emotional distress: a critical review

Methodological issues in child sexual abuse research

Transparency in authors' contributions and responsibilities to promote integrity in scientific publication

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

We would like to acknowledge the Stine Sofie Foundation for funding and allowing the current study to take form. We would also like to thank all children, adolescent and families participating in the study.

Authors' contributions BS and AD was responsible for conceptualizing and developing the initial study idea. All authors (VS, AD, MH, GSH, KS, LEA, ST, JAJ, ØV, BS) were involved in further developing the study design and methods. VS drafted the manuscript and is responsible for the finalized version. All authors read, critically revised and finally approved the manuscript. All authors meet the criteria for authorship as stated in [53] .

The project is initially funded by the Stine Sofie Foundation the first 5 years (from Oct 1st 2019 to Sept 30th 2024), and we will apply for additional funding both during and after this time to ensure the continued activity of the project. None of the funders have been involved in the design of the study.

The data collected in this study are not publicly available because of privacy regulations from the Norwegian Regional Committees for Medical and Health Research Ethics (REC). Requests to access the datasets should be directed to the NIPH (Datatilgang@fhi.no). Guidelines for access to NIPH data are found at https://www.fhi.no/en/more/access-to-data. Approval from REC (https://helseforskning.etikkom.no) is a pre-requirement.

The study protocol has been approved by the Regional Committee for Ethics in Medical and Health Research in the south-eastern region of Norway (#95445). All participants will have completed an informed written consenting process with personnel at the SSC. Children from 5 to 11 years will need a written consent from one of their caregivers to participate. Adolescents from 12 years of age are allowed by law to independently provide a written consent to participate in particular studies such as the current. The Regional Committee for Ethics in Medical and Health Research in the south-eastern region of Norway has approved that study participants aged 12 years or older can participate without parental consent (#95445). All personal information will be securely stored at NIPH for analyzes.

Not applicable.

The authors declare that they have no competing interests.